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Now showing items 16721-16740 of 40729

Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

Slomp, Anne; Moesbergen, Laura M; Eldering, Eric; Kersten, Marie José; Minnema, Monique C; Peperzak, Victor (Nature Publishing Group, 2021-03-03)

Multiple myeloma (MM), a treatable but incurable malignancy, is characterized by the growth of clonal plasma cells in protective niches in the bone marrow. MM cells depend on expression of BCL-2 family proteins, in particular ...
Belantamab mafodotin in combination with novel agents in relapsed/refractory multiple myeloma: DREAMM-5 study design

Nooka, Ajay K; Weisel, Katja; van de Donk, Niels Wcj; Routledge, David; Otero, Paula Rodriguez; Song, Kevin; Quach, Hang; Callander, Natalie; Minnema, Monique C; Trudel, Suzanne; Jackson, Nicola A; Ahlers, Christoph M; Im, Ellie; Cheng, Shinta; Smith, L; Hareth, Nahi; Ferron-Brady, Geraldine; Brouch, Maria; de Oca, Rocio Montes; Paul, Sofia; Holkova, Beata; Gupta, Ira; Kremer, Brandon E; Richardson, Paul (Taylor and Francis Ltd., 2021-06)

Belantamab mafodotin (belamaf) is a BCMA-targeted antibody-drug conjugate recently approved as monotherapy for adults with relapsed/refractory multiple myeloma who have received ≥4 prior therapies. Belamaf binds to BCMA ...
COVID-19 and the Emerging Regulatory Guidance for Ongoing Clinical Trials in the European Union

Trials@Home Consortium (Wiley-Blackwell, 2021-06)

The coronavirus disease 2019 (COVID-19) pandemic and the accompanying control measures have significantly affected clinical trial (CT) conduct, and sponsors have needed to make rapid changes to their CT operations. As a ...
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

Wellcome Trust Case Control Consortium 2 (eLife Sciences Publications, 2021-02)

We performed a systematic analysis of blood DNA methylation profiles from 4,483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia ...
Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder (Jan, 10.1038/s41380-020-01006-9, 2021): Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder (Molecular Psychiatry, (2021), 26, 9, (5239-5250), 10.1038/s41380-020-01006-9)

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Springer Nature, 2021-09)

Correction to: Molecular Psychiatry, https://doi.org/10.1038/s41380-020-01006-9
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs

ENIGMA-CNV Working Group (Wiley-Liss Inc., 2022-01)

The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors ...
Reliability modelling of resting-state functional connectivity

Teeuw, Jalmar; Hulshoff Pol, Hilleke E.; Boomsma, Dorret I.; Brouwer, Rachel M. (Academic Press Inc., 2021-05-01)

Resting-state functional magnetic resonance imaging (rs-fMRI) has an inherently low signal-to-noise ratio largely due to thermal and physiological noise that attenuates the functional connectivity (FC) estimates. Such ...
Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem

Meerman, Manon; Bracco Gartner, Tom C L; Buikema, Jan Willem; Wu, Sean M; Siddiqi, Sailay; Bouten, Carlijn V C; Grande-Allen, K Jane; Suyker, Willem J L; Hjortnaes, Jesper (Frontiers Media S. A., 2021-02-12)

Radiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the ...
Timing of Intervention for Post-Hemorrhagic Ventricular Dilatation: An Ongoing Debate

Cizmeci, Mehmet N; Groenendaal, Floris; de Vries, Linda S (Mosby Inc., 2021-07)
Mammillary body injury in neonatal encephalopathy: a multicentre, retrospective study

Lequin, Maarten H; Steggerda, Sylke J; Severino, Mariasavina; Tortora, Domenico; Parodi, Alessandro; Ramenghi, Luca A; Groenendaal, Floris; Meys, Karlijn M E; Benders, Manon J N L; de Vries, Linda S; Vann, Seralynne D (Lippincott Williams & Wilkins, 2022-07)

BACKGROUND: The mammillary bodies (MBs) have repeatedly been shown to be critical for memory, yet little is known about their involvement in numerous neurological conditions linked to memory impairments, including neonatal ...
Polygenic Risk for Major Depression Interacts with Parental Criticism in Predicting Adolescent Depressive Symptom Development

Nelemans, Stefanie A.; Boks, Marco; Lin, Bochao; Oldehinkel, Tineke; van Lier, Pol; Branje, Susan; Meeus, Wim (Springer New York, 2021-01)

Research has focused more and more on the interplay between genetics and environment in predicting different forms of psychopathology, including depressive symptoms. While the polygenic nature of depressive symptoms is ...
Impact of the COVID-19 Pandemic on Antibiotic Prescribing for Common Infections in The Netherlands: A Primary Care-Based Observational Cohort Study

van de Pol, Alma C; Boeijen, Josi A; Venekamp, Roderick P; Platteel, Tamara; Damoiseaux, Roger A M J; Kortekaas, Marlous F; van der Velden, Alike W (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-18)

In 2020, the COVID-19 pandemic brought dramatic changes in the delivery of primary health care across the world, presumably changing the number of consultations for infectious diseases and antibiotic use. We aimed to assess ...
Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities

Otto, I. A.; Capendale, P. E.; Garcia, J. P.; de Ruijter, M.; van Doremalen, R. F.M.; Castilho, M.; Lawson, T.; Grinstaff, M. W.; Breugem, C. C.; Kon, M.; Levato, R.; Malda, J. (Elsevier, 2021-01)

Bioengineering of the human auricle remains a significant challenge, where the complex and unique shape, the generation of high-quality neocartilage, and shape preservation are key factors. Future regenerative medicine–based ...
Therapeutic outcome of early-phase clinical trials in multiple myeloma: a meta-analysis

van Nieuwenhuijzen, Niels; Frunt, Rowan; May, Anne M; Minnema, Monique C (Nature Publishing Group, 2021-03-01)

Great progress in the treatment of patients with multiple myeloma (MM) has been made due to the development of novel drugs. Patients with relapsed/refractory MM (RRMM) can be enrolled in early-phase clinical trials, but ...
Mammillary body atrophy and other MRI correlates of school-age outcome following neonatal hypoxic-ischemic encephalopathy

Annink, Kim V; de Vries, Linda S; Groenendaal, Floris; Eijsermans, Rian M J C; Mocking, Manouk; van Schooneveld, Monique M J; Dudink, Jeroen; van Straaten, Henrica L M; Benders, Manon J N L; Lequin, Maarten; van der Aa, Niek E (Nature Publishing Group, 2021-03-03)

The mammillary bodies (MB) and hippocampi are important for memory function and are often affected following neonatal hypoxic ischemic encephalopathy (HIE). The aim of this study was to assess neurodevelopmental outcome ...
Predictive value of endoscopic esophageal findings for residual esophageal cancer after neoadjuvant chemoradiotherapy

van der Bogt, Ruben D; van der Wilk, Berend J; Nikkessen, Suzan; Krishnadath, Kausilia K; Schoon, Erik J; Oostenbrug, Liekele E; Siersema, Peter D; Vleggaar, Frank P; Doukas, Michael; van Lanschot, J Jan B; Spaander, Manon C W (Georg Thieme Verlag, 2021-11)

Background Endoscopic evaluation of the esophageal mucosa may play a role in an active surveillance strategy after neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer. This study investigated the yield of endoscopic ...
Dual Antiretroviral Therapy—All Quiet Beneath the Surface?

van Welzen, Berend; Oomen, Patrick; Hoepelman, Andy (Frontiers Media S. A., 2021-02-12)

Infection with the human immunodeficiency virus (HIV) is characterized by progressive depletion of CD4+ lymphocytes cells as a result of chronic immune activation. Next to the decreases in the number of CD4+ cells which ...
Prophylactic cranial irradiation in patients with small cell lung cancer in The Netherlands: A population-based study

Tomassen, Mathijs L; Aarts, Mieke J; Peters, Max; van Lindert, Anne; De Ruysscher, Dirk K M; Verhoeff, Joost J C; van Rossum, Peter S N (Elsevier Ireland Ltd, 2021-03)

Introduction: Controversy has arisen regarding the benefit of prophylactic cranial irradiation (PCI) in patients with small cell lung cancer (SCLC), particularly since the 2017 Takahashi trial publication that supports MRI ...
Refractory neutrophils and monocytes in patients with inflammatory bowel disease after repeated bouts of prolonged exercise

Spijkerman, Roy; Hesselink, Lillian; Bertinetto, Carlo; Bongers, Coen C W G; Hietbrink, Falco; Vrisekoop, Nienke; Leenen, Luke P H; Hopman, Maria T E; Jansen, Jeroen J; Koenderman, Leo (Wiley-Liss Inc., 2021-11)

BACKGROUND: Neutrophils and monocytes are key immune effector cells in inflammatory bowel disease (IBD) that is associated with chronic inflammation in the gut. Patients with stable IBD who perform exercise have significantly ...
Reference values for maximum oxygen uptake relative to body mass in Dutch/Flemish subjects aged 6-65 years: the LowLands Fitness Registry

Takken, Tim (Springer-Verlag, 2021-04)

Background: The maximum oxygen uptake (VO 2max) during cardiopulmonary exercise testing (CPET) is considered the best measure of cardiorespiratory fitness. Aim: To provide up-to-date reference values for the VO 2max per ...

Now showing items 16721-16740 of 40729