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Now showing items 16641-16660 of 40729

Early discontinuation of PD-1 blockade upon achieving a complete or partial response in patients with advanced melanoma: the multicentre prospective Safe Stop trial

Mulder, E E A P; de Joode, K; Litière, S; Ten Tije, A J; Suijkerbuijk, K P M; Boers-Sonderen, M J; Hospers, G A P; de Groot, J W B; van den Eertwegh, A J M; Aarts, M J B; Piersma, D; van Rijn, R S; Kapiteijn, E; Vreugdenhil, G; van den Berkmortel, F W P J; Hoop, E Oomen-de; Franken, M G; Ryll, B; Rutkowski, P; Sleijfer, S; Haanen, J B A G; van der Veldt, A A M (BioMed Central, 2021-03-25)

BACKGROUND: The introduction of programmed cell death protein 1 (PD-1) blockers (i.e. nivolumab and pembrolizumab) has significantly improved the prognosis of patients with advanced melanoma. However, the long treatment ...
Effects of tDCS during inhibitory control training on performance and PTSD, aggression and anxiety symptoms: a randomized-controlled trial in a military sample

Smits, Fenne M; Geuze, Elbert; Schutter, Dennis J L G; van Honk, Jack; Gladwin, Thomas E (Cambridge University Press, 2022-12-24)

BACKGROUND: Post-traumatic stress disorder (PTSD), anxiety, and impulsive aggression are linked to transdiagnostic neurocognitive deficits. This includes impaired inhibitory control over inappropriate responses. Prior ...
Non-contrast dual-energy CT virtual ischemia maps accurately estimate ischemic core size in large-vessel occlusive stroke

Wolman, Dylan N.; van Ommen, Fasco; Tong, Elizabeth; Kauw, Frans; Dankbaar, Jan Willem; Bennink, E; de Jong, Hugo; Molvin, Lior; Wintermark, Max; Heit, Jeremy J (Nature Publishing Group, 2021-12)

Dual-energy CT (DECT) material decomposition techniques may better detect edema within cerebral infarcts than conventional non-contrast CT (NCCT). This study compared if Virtual Ischemia Maps (VIM) derived from non-contrast ...
Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Pei, J; Schuldt, M; Nagyova, E; Gu, Z; El Bouhaddani, S; Yiangou, L; Jansen, M; Calis, J J A; Dorsch, L M; Blok, C Snijders; van den Dungen, N A M; Lansu, N; Boukens, B J; Efimov, I R; Michels, M; Verhaar, M C; de Weger, R; Vink, A; van Steenbeek, F G; Baas, A F; Davis, R P; Uh, H W; Kuster, D W D; Cheng, C; Mokry, M; van der Velden, J; Asselbergs, F W; Harakalova, M (Springer-Verlag, 2021-12)

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common genetic disease of the cardiac muscle, frequently caused by mutations in MYBPC3. However, little is known about the upstream pathways and key regulators ...
Statistical integration of two omics datasets using GO2PLS

Gu, Zhujie; El Bouhaddani, Said; Pei, Jiayi; Houwing-Duistermaat, Jeanine; Uh, Hae-Won (BioMed Central, 2021-12)

BACKGROUND: Nowadays, multiple omics data are measured on the same samples in the belief that these different omics datasets represent various aspects of the underlying biological systems. Integrating these omics datasets ...
Disease burden and treatment history among adults with atopic dermatitis receiving systemic therapy: baseline characteristics of participants on the EUROSTAD prospective observational study

Bruin-Weller, M.D.; Pink, A.E.; Patrizi, A.; Gimenez-Arnau, A.M.; Agner, T.; Roquet-Gravy, P.-P.; Ferrucci, S.M.; Arenberger, P.; Svensson, A.; Schuttelaar, M.L.A.; Nosbaum, A.; Jayawardena, S.; Rizova, E.; Ardeleanu, M.; Eckert, L.; Ozturk, Z.E. (Informa Healthcare, 2021)

Background: Insights into the real-world treatment paradigm and long-term burden of atopic dermatitis (AD) are needed to inform clinical and health policy decisions. Methods: The prospective, observational EUROSTAD study ...
Supplemental Breast MRI for Women with Extremely Dense Breasts: Results of the Second Screening Round of the DENSE Trial

Veenhuizen, Stefanie G A; de Lange, Stéphanie V; Bakker, Marije F; Pijnappel, Ruud M; Mann, Ritse M; Monninkhof, Evelyn M; Emaus, Marleen J; de Koekkoek-Doll, Petra K; Bisschops, Robertus H C; Lobbes, Marc B I; de Jong, Mathijn D F; Duvivier, Katya M; Veltman, Jeroen; Karssemeijer, Nico; de Koning, Harry J; van Diest, Paul J; Mali, Willem P T M; van den Bosch, Maurice A A J; van Gils, Carla H; Veldhuis, Wouter B; DENSE Trial Study Group (Radiological Society of North America Inc., 2021-05)

Background: In the first (prevalent) supplemental MRI screening round of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial, a considerable number of breast cancers were found at the cost of an increased ...
Causal effects of lifetime smoking on breast and colorectal cancer risk: Mendelian randomization study

Dimou, Niki; Yarmolinsky, James; Bouras, Emmanouil; Tsilidis, Konstantinos K; Martin, Richard M; Lewis, Sarah J; Gram, Inger T; Bakker, Marije F; Brenner, Hermann; Figueiredo, Jane C; Fortner, Renée Turzanski; Gruber, Stephen B; Van Guelpen, Bethany; Hsu, Li; Kaaks, Rudolf; Kweon, Sun-Seog; Lin, Yi; Lindor, Noralane M; Newcomb, Polly A; Sanchez-Perez, Maria-Jose; Severi, Gianluca; Tindle, Hilary A; Tumino, Rosario; Weiderpass, Elisabete; Gunter, Marc J; Murphy, Neil (American Association for Cancer Research Inc., 2021-05-01)

Background: Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between smoking and risks of breast and ...
European Task Force on Atopic Dermatitis: position on vaccination of adult patients with atopic dermatitis against COVID-19 (SARS-CoV-2) being treated with systemic medication and biologics

Thyssen, J P; Vestergaard, C; Barbarot, S; de Bruin-Weller, M S; Bieber, T; Taieb, A; Seneschal, J; Cork, M J; Paul, C; Flohr, C; Weidinger, S; Trzeciak, M; Werfel, T; Heratizadeh, A; Darsow, U; Simon, D; Torrelo, A; Chernyshov, P V; Stalder, J-F; Gelmetti, C; Szalai, Z; Svensson, Å; von Kobyletzki, L B; De Raeve, L; Fölster-Holst, R; Christen-Zaech, S; Hijnen, D J; Gieler, U; Gutermuth, J; Bangert, C; Spuls, P I; Kunz, B; Ring, J; Wollenberg, A; Deleuran, M (Wiley-Blackwell, 2021-05)
Treat-to-Target in Atopic Dermatitis: An International Consensus on a Set of Core Decision Points for Systemic Therapies

De Bruin-Weller, Marjolein; Biedermann, Tilo; Bissonnette, Robert; Deleuran, Mette; Foley, Peter; Girolomoni, Giampiero; Hercogová, Jana; Hong, Chih-Ho; Katoh, Norito; Pink, Andrew E; Richard, Marie-Aleth; Shumack, Stephen; Silvestre, Juan F; Weidinger, Stephan (Medical Journals Sweden AB, 2021-02-17)

Currently no treat-to-target framework to guide systemic treatment in adults with moderate-to-severe atopic dermatitis exists. We sought to reach international consensus through an eDelphi process on a core set of ...
Dose-Response and Dose-Toxicity Relationships for Glass 90Y Radioembolization in Patients with Liver Metastases from Colorectal Cancer

Alsultan, Ahmed A; van Roekel, Caren; Barentsz, Maarten W; Smits, Maarten L J; Kunnen, Britt; Koopman, Miriam; Bruijnen, Rutger C G; de Keizer, Bart; Lam, Marnix G E H (Society of Nuclear Medicine Inc., 2021-11)

Radioembolization based on personalized treatment planning requires established dose-response and dose-toxicity relationships. The aim of this study was to investigate dose-response and dose-toxicity relationships in ...
A plug-and-play, lightweight, single-axis gradient insert design for increasing spatiotemporal resolution in echo planar imaging-based brain imaging

Versteeg, Edwin; van der Velden, Tijl A; van Leeuwen, Carel C; Borgo, Martino; Huijing, Erik R; Hendriks, Arjan D; Hendrikse, Jeroen; Klomp, Dennis W J; Siero, Jeroen C W (John Wiley & Sons Inc., 2021-06)

The goal of this study was to introduce and evaluate the performance of a lightweight, high-performance, single-axis (z-axis) gradient insert design primarily intended for high-resolution functional magnetic resonance ...
Association of White Matter Hyperintensity Markers on MRI and Long-term Risk of Mortality and Ischemic Stroke: The SMART-MR Study

UCC-SMART Study Group (Lippincott Williams & Wilkins, 2021-04-27)

OBJECTIVE: To determine whether white matter hyperintensity (WMH) markers on MRI are associated with long-term risk of mortality and ischemic stroke. METHODS: We included consecutive patients with manifest arterial disease ...
Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals

BioCog consortium (Elsevier, 2021-05)

The underlying structural correlates of predisposition to postoperative delirium remain largely unknown. A combined analysis of preoperative brain magnetic resonance imaging (MRI) markers could improve our understanding ...
Corrigendum to “Effects of hunger state on the brain responses to food cues across the life span” [NeuroImage 171 (2018) 246-255](S1053811918300144)(10.1016/j.neuroimage.2018.01.012)

Full4Health consortium (Academic Press Inc., 2021-06)

The authors regret that errors were made with regard to the reporting of several methodological details in the Materials and methods section. The authors would like to apologise for any inconvenience caused by this. ...
Dalteparin in Newborn Thrombosis, Time for a New Starting Dose

Steenman, Frouwke; Vijlbrief, Daniel C; Huisman, Albert; Bierings, Marc (S. Karger AG, 2021)

BACKGROUND: Neonatal thrombosis is a frequently encountered complication in a neonatal intensive care unit. Dalteparin can be used to treat thrombosis in newborn infants. OBJECTIVES: In this study, we evaluate the current ...
Comorbidities and complications in adults with pyruvate kinase deficiency

Boscoe, Audra N; Yan, Yan; Hedgeman, Elizabeth; van Beers, Eduard J; Al-Samkari, Hanny; Barcellini, Wilma; Eber, Stefan W; Glader, Bertil; Yaish, Hassan M; Chonat, Satheesh; Sharma, Mukta; Kuo, Kevin H M; Neufeld, Ellis J; Wang, Heng; Verhovsek, Madeleine; Sheth, Sujit; Grace, Rachael F (Wiley-Blackwell, 2021-04)

OBJECTIVES: Pyruvate kinase (PK) deficiency is caused by PKLR gene mutations, leading to defective red blood cell glycolysis and hemolytic anemia. Rates of comorbidities and complications by transfusion history and relative ...
Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Rab, Minke A E; Bos, Jennifer; van Oirschot, Brigitte; Straaten, Stephanie van; Kosinski, Penelope A; Chubukov, Victor; Kim, Hyeryun; Mangus, Heidi; Schutgens, Roger E G; Pasterkamp, Gerard; Dang, Lenny; Kung, Charles; van Beers, Eduard J; van Wijk, Richard (Elsevier, 2021-05-27)
Correction: First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAFV600-mutant advanced melanoma patients: a propensity-matched survival analysis

van Breeschoten, Jesper; Wouters, Michel W J M; Hilarius, Doranne L; Haanen, John B; Blank, Christian U; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; de Groot, Jan-Willem B; Hospers, Geke A P; Kapiteijn, Ellen; Piersma, Djura; van Rijn, Roos S; Suijkerbuijk, Karijn P M; Blokx, Willeke A M; Ten Tije, Bert-Jan J; van der Veldt, Astrid A M; Vreugdenhil, Art; Boers-Sonderen, Marye J; van den Eertwegh, Alfonsus J M (Springer Nature, 2021-05-11)

Correction to: British Journal of Cancer https://doi.org/10.1038/s41416-020-01229-1, published online 26 January 2021
When I say ... attitude

Valbuena, Gustavo; van der Schaaf, Marieke; O'Sullivan, Patricia; O'Brien, Bridget (Wiley-Blackwell, 2021-08)

Attitude is a ubiquitous term in health professions education (HPE). Accompanied by knowledge and skills, it rolls off the tongue when discussing competencies and educational objectives.1,2 As part of the tripartite structure ...

Now showing items 16641-16660 of 40729