Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Rab, Minke A E; Bos, Jennifer; van Oirschot, Brigitte; Straaten, Stephanie van; Kosinski, Penelope A; Chubukov, Victor; Kim, Hyeryun; Mangus, Heidi; Schutgens, Roger E G; Pasterkamp, Gerard; Dang, Lenny; Kung, Charles; van Beers, Eduard J; van Wijk, Richard

doi:https://doi.org/10.1182/blood.2020008635

Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

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Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Rab, Minke A E; Bos, Jennifer; van Oirschot, Brigitte; Straaten, Stephanie van; Kosinski, Penelope A; Chubukov, Victor; Kim, Hyeryun; Mangus, Heidi; Schutgens, Roger E G; Pasterkamp, Gerard; Dang, Lenny; Kung, Charles; van Beers, Eduard J; van Wijk, Richard

(2021) Blood, volume 137, issue 21, pp. 2997 - 3001

(Letter)

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Keywords: Biochemistry, Immunology, Hematology, Cell Biology

DOI: https://doi.org/10.1182/blood.2020008635

ISSN: 0006-4971

Publisher: American Society of Hematology

Note: Funding Information: This research has been funded, in part, by Agios Pharmaceuticals Inc and the Eurostars Program (SCOOP, ESTAR18105).

(Peer reviewed)