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UMC Repository: Recent submissions

  • A Dutch phase III randomized multicenter trial: whole brain radiotherapy versus stereotactic radiotherapy for 4-10 brain metastases 
    Hartgerink, Dianne; Bruynzeel, Anna; Eekers, Danielle; Swinnen, Ans; Hurkmans, Coen; Wiggenraad, Ruud; Swaak-Kragten, Annemarie; Dieleman, Edith; van der Toorn, Peter-Paul; Oei, Bing; van Veelen, Lieneke; Verhoeff, Joost; Lagerwaard, Frank; de Ruysscher, Dirk; Lambin, Philippe; Zindler, Jaap (Oxford University Press, 2021-01-01)
    Background: The clinical value of whole brain radiotherapy (WBRT) for brain metastases (BM) is a matter of debate due to the significant side effects involved. Stereotactic radiosurgery (SRS) is an attractive alternative ...
  • A randomised, open-label trial to assess the optimal treatment strategy in early diffuse cutaneous systemic sclerosis: The UPSIDE study protocol 
    Spierings, Julia; van Rhenen, Anna; Welsing, Paco Mw; Marijnissen, Anne Ca; De Langhe, Ellen; Del Papa, Nicoletta; Dierickx, Daan; Gheorghe, Karina R; Henes, Joerg; Hesselstrand, Roger; Kerre, Tessa; Ljungman, Per; van de Loosdrecht, Arjan A; Marijt, Erik Waf; Mayer, Miro; Schmalzing, Marc; Schroers, Roland; Smith, Vanessa; Voll, Reinhard E; Vonk, Madelon C; Voskuyl, Alexandre E; de Vries-Bouwstra, Jeska K; Walker, Ulrich A; Wuttge, Dirk M; van Laar, Jacob M (BMJ Publishing Group, 2021-03-18)
    Introduction Systemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease associated with high morbidity and mortality, especially in diffuse cutaneous SSc (dcSSc). Currently, there are several treatments ...
  • Predicting sentinel node positivity in patients with melanoma: external validation of a risk-prediction calculator (the Melanoma Institute Australia nomogram) using a large European population-based patient cohort 
    El Sharouni, M A; Varey, A H R; Witkamp, A J; Ahmed, T; Sigurdsson, V; van Diest, P J; Scolyer, R A; Thompson, J F; Lo, S N; van Gils, C H (Wiley-Blackwell, 2021-08)
    BACKGROUND: A nomogram to predict sentinel node (SN) positivity [the Melanoma Institute Australia (MIA) nomogram] was recently developed and externally validated using two large single-institution databases. However, there ...
  • Impact of renin-angiotensin system inhibitors on mortality during the COVID Pandemic among STEMI patients undergoing mechanical reperfusion: Insight from an international STEMI registry 
    De Luca, Giuseppe; Cercek, Miha; Okkels Jensen, Lisette; Bushljetikj, Oliver; Calmac, Lucian; Johnson, Tom; Gracida Blancas, Montserrat; Ganyukov, Vladimir; Wojakowski, Wojtek; von Birgelen, Clemens; IJsselmuiden, Alexander; Tuccillo, Bernardo; Versaci, Francesco; Ten Berg, Jurrien; Laine, Mika; Berkout, Tim; Casella, Gianni; Kala, Petr; López Ledesma, Bernabé; Becerra, Victor; Padalino, Roberto; Santucci, Andrea; Carrillo, Xavier; Scoccia, Alessandra; Amoroso, Giovanni; Lux, Arpad; Kovarnik, Tomas; Davlouros, Periklis; Gabrielli, Gabriele; Flores Rios, Xacobe; Bakraceski, Nikola; Levesque, Sébastien; Guiducci, Vincenzo; Kidawa, Michał; Marinucci, Lucia; Zilio, Filippo; Galasso, Gennaro; Fabris, Enrico; Menichelli, Maurizio; Manzo, Stephane; Caiazzo, Gianluca; Moreu, Jose; Sanchis Forés, Juan; Donazzan, Luca; Vignali, Luigi; Teles, Rui; Bosa Ojeda, Francisco; Lehtola, Heidi; Camacho-Freiere, Santiago; Kraaijeveld, Adriaan; Antti, Ylitalo; Visconti, Gabriella; Lozano Martínez-Luengas, Iñigo; Scheller, Bruno; Alexopulos, Dimitrios; Moreno, Raul; Kedhi, Elvin; Uccello, Giuseppe; Faurie, Benjamin; Gutierrez Barrios, Alejandro; Scotto Di Uccio, Fortunato; Wilbert, Bor; Cortese, Giuliana; Dirksen, Maurits T; Parodi, Guido; Verdoia, Monica (Elsevier Masson, 2021-06)
    Background: Concerns have been raised on a potential interaction between renin-angiotensin system inhibitors (RASI) and the susceptibility to coronavirus disease 2019 (COVID-19). No data have been so far reported on the ...
  • Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination 
    Bui, Bich Ngoc; Lensen, Sarah F; Gibreel, Ahmed; Martins, Wellington P; Torrance, Helen; Broekmans, Frank J (John Wiley & Sons Inc., 2022-10-24)
    BACKGROUND: Intentional endometrial injury is being proposed as a technique to improve the probability of pregnancy in women undergoing assisted reproductive technologies (ART) such as in vitro fertilisation (IVF). Endometrial ...
  • Increased obstetric and neonatal risks in artificial cycles for frozen embryo transfers? 
    ANTARCTICA trial study group (Elsevier, 2021-05)
    RESEARCH QUESTION: What are the obstetric and neonatal risks for women conceiving via frozen-thawed embryo transfer (FET) during a modified natural cycle compared with an artificial cycle method. DESIGN: A follow-up study ...
  • Reply: Endometrial scratching for embryo implantation failure 
    van Hoogenhuijze, N E; Eijkemans, M J C; Broekmans, F J M (Oxford University Press, 2021-04-20)
  • Preoperative misdiagnosis of pancreatic and periampullary cancer in patients undergoing pancreatoduodenectomy: A multicentre retrospective cohort study 
    for the Dutch Pancreatic Cancer Group (W.B. Saunders Ltd, 2021-10)
    Introduction: Whereas neoadjuvant chemo(radio)therapy is increasingly used in pancreatic cancer, it is currently not recommended for other periampullary (non-pancreatic) cancers. This has important implications for the ...
  • Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23 
    Garnier, Sophie; Harakalova, Magdalena; Weiss, Stefan; Mokry, Michal; Regitz-Zagrosek, Vera; Hengstenberg, Christian; Cappola, Thomas P; Isnard, Richard; Arbustini, Eloisa; Cook, Stuart A; van Setten, Jessica; Calis, Jorg J A; Hakonarson, Hakon; Morley, Michael P; Stark, Klaus; Prasad, Sanjay K; Li, Jin; O'Regan, Declan P; Grasso, Maurizia; Müller-Nurasyid, Martina; Meitinger, Thomas; Empana, Jean-Philippe; Strauch, Konstantin; Waldenberger, Melanie; Marguiles, Kenneth B; Seidman, Christine E; Kararigas, Georgios; Meder, Benjamin; Haas, Jan; Boutouyrie, Pierre; Lacolley, Patrick; Jouven, Xavier; Erdmann, Jeanette; Blankenberg, Stefan; Wichter, Thomas; Ruppert, Volker; Tavazzi, Luigi; Dubourg, Olivier; Roizes, Gérard; Dorent, Richard; de Groote, Pascal; Fauchier, Laurent; Trochu, Jean-Noël; Aupetit, Jean-François; Bilinska, Zofia T; Germain, Marine; Völker, Uwe; Hemerich, Daiane; Raji, Ibticem; Bacq-Daian, Delphine; Proust, Carole; Remior, Paloma; Gomez-Bueno, Manuel; Lehnert, Kristin; Maas, Renee; Olaso, Robert; Saripella, Ganapathi Varma; Felix, Stephan B; McGinn, Steven; Duboscq-Bidot, Laëtitia; van Mil, Alain; Besse, Céline; Fontaine, Vincent; Blanché, Hélène; Ader, Flavie; Keating, Brendan; Curjol, Angélique; Boland, Anne; Komajda, Michel; Cambien, François; Deleuze, Jean-François; Dörr, Marcus; Asselbergs, Folkert W; Villard, Eric; Trégouët, David-Alexandre; Charron, Philippe; Maas, Renee GC (Oxford University Press, 2021-05-21)
    AIMS : Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause of systolic heart failure. METHODS AND RESULTS : We conducted the largest genome-wide association study ...
  • A review of the sensitivity of metastatic colorectal cancer patients with deficient mismatch repair to standard-of-care chemotherapy and monoclonal antibodies, with recommendations for future research 
    Wensink, Emerens; Bond, Marinde; Kucukkose, Emre; May, Anne; Vink, Geraldine; Koopman, Miriam; Kranenburg, Onno; Roodhart, Jeanine (W.B. Saunders Ltd, 2021-04)
    In 5% of metastatic colorectal cancer (mCRC) patients, tumours display a deficient mismatch repair (dMMR) system. Immunotherapy is beneficial in dMMR mCRC patients and has recently been approved by the Food and Drug ...
  • Major differences in clinical presentation, diagnosis and management of men and women with autosomal inherited bleeding disorders 
    For the WiN, RBiN and TiN study groups (Elsevier, 2021-02)
    Background: In recent years, more awareness is raised about sex-specific dilemmas in inherited bleeding disorders. However, no large studies have been performed to assess differences in diagnosis, bleeding phenotype and ...
  • Reduction in the QRS area after cardiac resynchronization therapy is associated with survival and echocardiographic response 
    Ghossein, Mohammed A.; van Stipdonk, Antonius M.W.; Plesinger, Filip; Kloosterman, Mariëlle; Wouters, Philippe C.; Salden, Odette A.E.; Meine, Mathias; Maass, Alexander H.; Prinzen, Frits W.; Vernooy, Kevin (Wiley-Blackwell, 2021-03)
    INTRODUCTION: Recent studies have shown that the baseline QRS area is associated with the clinical response after cardiac resynchronization therapy (CRT). In this study, we investigated the association of QRS area reduction ...
  • Automatic quantification of lymphocyte vacuolization in peripheral blood smears of patients with Batten's disease (CLN3 disease) 
    Nonkes, Lourens J P; Kuper, Willemijn F E; Berrens-Hogenbirk, Karin; Musson, Ruben E A; van Hasselt, Peter M; Huisman, Albert (Springer Berlin, 2021-03-01)
    Quantifying lymphocyte vacuolization in peripheral blood smears (PBSs) serves as a measure for disease severity in CLN3 disease—a lysosomal storage disorder of childhood-onset. However, thus far quantification methods are ...
  • Network dynamics of momentary affect states and future course of psychopathology in adolescents 
    Kuranova, Anna; Wigman, Johanna T W; Menne-Lothmann, Claudia; Decoster, Jeroen; van Winkel, Ruud; Delespaul, Philippe; Drukker, Marjan; de Hert, Marc; Derom, Catherine; Thiery, Evert; Rutten, Bart P F; Jacobs, Nele; van Os, Jim; Oldehinkel, Albertine J; Booij, Sanne H; Wichers, Marieke (Public Library of Science, 2021-03)
    BACKGROUND: Recent theories argue that an interplay between (i.e., network of) experiences, thoughts and affect in daily life may underlie the development of psychopathology. OBJECTIVE: To prospectively examine whether ...
  • Prevalence and determinants of chewing khat among women in Ethiopia: data from Ethiopian demographic and health survey 2016 
    Yitayih, Yimenu; van Os, Jim (BioMed Central, 2021-03-04)
    BACKGROUND: In Ethiopia and other countries in eastern Africa, khat abuse is an increasing public health problem. Levels of use appear to be increasing in women, who are more vulnerable to khat-related problems. However, ...
  • Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association-The Example of Cannabis and Psychosis 
    van Os, Jim; Pries, Lotta-Katrin; Ten Have, Margreet; de Graaf, Ron; van Dorsselaer, Saskia; Bak, Maarten; Wittchen, Hans-Ulrich; Rutten, Bart P F; Guloksuz, Sinan (Oxford University Press, 2021-05)
    Hypotheses about the link between cannabis use and psychosis apply to the within-person level but have been tested mostly at the between-person level. We used a within-person design, in which a person serves as his own ...
  • Point-spread function of the BOLD response across columns and cortical depth in human extra-striate cortex 
    Fracasso, Alessio; Dumoulin, Serge O; Petridou, Natalia (Elsevier Limited, 2021-07)
    Columns and layers are fundamental organizational units of the brain. Well known examples of cortical columns are the ocular dominance columns (ODCs) in primary visual cortex and the column-like stripe-based arrangement ...
  • Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group 
    Grace, Sally; Rossetti, Maria Gloria; Allen, Nicholas; Batalla, Albert; Bellani, Marcella; Brambilla, Paolo; Chye, Yann; Cousijn, Janna; Goudriaan, Anna E.; Hester, Robert; Hutchison, Kent; Labuschagne, Izelle; Momenan, Reza; Martin-Santos, Rocio; Rendell, Peter; Solowij, Nadia; Sinha, Rajita; Li, Chiang shan Ray; Schmaal, Lianne; Sjoerds, Zsuzsika; Suo, Chao; Terrett, Gill; van Holst, Ruth J.; Veltman, Dick J.; Yücel, Murat; Thompson, Paul; Conrod, Patricia; Mackey, Scott; Garavan, Hugh; Lorenzetti, Valentina (Nature Publishing Group, 2021-03-04)
    Males and females with alcohol dependence have distinct mental health and cognitive problems. Animal models of addiction postulate that the underlying neurobiological mechanisms are partially distinct, but there is little ...
  • The effect of prednisolone on symptom severity in schizophrenia: A placebo-controlled, randomized controlled trial 
    Nasib, Lyliana G; Gangadin, Shiral S; Rossum, Inge Winter-van; Boudewijns, Zimbo S R M; de Witte, Lot D; Wilting, Ingeborg; Luykx, Jurjen; Somers, Metten; Veen, Natalie; van Baal, Caroline; Kahn, René S; Sommer, Iris E (Elsevier, 2021-04)
    Objective: Immune dysregulation may be involved in the pathophysiology of schizophrenia. Given the need for new treatment options in schizophrenia, anti-inflammatory medication could be a potential treatment in this illness. ...
  • Brain age prediction in schizophrenia: Does the choice of machine learning algorithm matter? 
    Lee, Won Hee; Antoniades, Mathilde; Schnack, Hugo G; Kahn, Rene S; Frangou, Sophia (Elsevier Ireland Ltd, 2021-04-30)
    Brain-predicted age difference (brainPAD) has been used in schizophrenia to assess individual-level deviation in the biological age of the patients' brain (i.e., brain-age) from normative reference brain structural datasets. ...