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UMC Repository: Recent submissions

  • Prosaposin mediates inflammation in atherosclerosis 
    van Leent, Mandy M T; Beldman, Thijs J; Toner, Yohana C; Lameijer, Marnix A; Rother, Nils; Bekkering, Siroon; Teunissen, Abraham J P; Zhou, Xianxiao; van der Meel, Roy; Malkus, Joost; Nauta, Sheqouia A; Klein, Emma D; Fay, Francois; Sanchez-Gaytan, Brenda L; Pérez-Medina, Carlos; Kluza, Ewelina; Ye, Yu-Xiang; Wojtkiewicz, Gregory; Fisher, Edward A; Swirski, Filip K; Nahrendorf, Matthias; Zhang, Bin; Li, Yang; Zhang, Bowen; Joosten, Leo A B; Pasterkamp, Gerard; Boltjes, Arjan; Fayad, Zahi A; Lutgens, Esther; Netea, Mihai G; Riksen, Niels P; Mulder, Willem J M; Duivenvoorden, Raphaël (American Association for the Advancement of Science, 2021-03-10)
    Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory properties of these cells are dictated by their metabolism, of which the mechanistic target of rapamycin (mTOR) signaling pathway is ...
  • Daily practice in guideline adherence to adjuvant chemotherapy in stage III colon cancer and predictors of outcome: Adjuvant chemotherapy in stage III colon cancer patients 
    van den Berg, I; van de Weerd, S; van Klaveren, D; Coebergh van den Braak, R R J; van Krieken, J H J M; Koopman, M; Roodhart, J M L; Medema, J P; IJzermans, J N M (W.B. Saunders Ltd, 2021-08)
    Introduction: Although guidelines recommend adjuvant chemotherapy for stage III colon cancer patients, many patients do not receive adjuvant chemotherapy. The aim of this study was to identify reasons for guideline ...
  • Reducing medical device alarms by an order of magnitude: A human factors approach 
    Koomen, Erik; Webster, Craig S; Konrad, David; van der Hoeven, Johannes G; Best, Thomas; Kesecioglu, Jozef; Gommers, Diederik Ampj; de Vries, Willem B; Kappen, Teus H (Australian Society of Anaesthetists, 2021-01)
    The intensive care unit (ICU) is one of the most technically advanced environments in healthcare, using a multitude of medical devices for drug administration, mechanical ventilation and patient monitoring. However, these ...
  • Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update 
    Alhazzani, Waleed; Evans, Laura; Alshamsi, Fayez; Møller, Morten Hylander; Ostermann, Marlies; Prescott, Hallie C; Arabi, Yaseen M; Loeb, Mark; Ng Gong, Michelle; Fan, Eddy; Oczkowski, Simon; Levy, Mitchell M; Derde, Lennie; Dzierba, Amy; Du, Bin; Machado, Flavia; Wunsch, Hannah; Crowther, Mark; Cecconi, Maurizio; Koh, Younsuck; Burry, Lisa; Chertow, Daniel S; Szczeklik, Wojciech; Belley-Cote, Emilie; Greco, Massimiliano; Bala, Malgorzata; Zarychanski, Ryan; Kesecioglu, Jozef; McGeer, Allison; Mermel, Leonard; Mammen, Manoj J; Nainan Myatra, Sheila; Arrington, Amy; Kleinpell, Ruth; Citerio, Giuseppe; Lewis, Kimberley; Bridges, Elizabeth; Memish, Ziad A; Hammond, Naomi; Hayden, Frederick G; Alshahrani, Muhammed; Al Duhailib, Zainab; Martin, Greg S; Kaplan, Lewis J; Coopersmith, Craig M; Antonelli, Massimo; Rhodes, Andrew (Lippincott Williams & Wilkins, 2021-03-01)
    BACKGROUND: The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients ...
  • The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness 
    Coopersmith, Craig M; Antonelli, Massimo; Bauer, Seth R; Deutschman, Clifford S; Evans, Laura E; Ferrer, Ricard; Hellman, Judith; Jog, Sameer; Kesecioglu, Jozef; Kissoon, Niranjan; Martin-Loeches, Ignacio; Nunnally, Mark E; Prescott, Hallie C; Rhodes, Andrew; Talmor, Daniel; Tissieres, Pierre; De Backer, Daniel (Lippincott Williams & Wilkins, 2021-04-01)
    OBJECTIVES: To identify research priorities in the management, pathophysiology, and host response of coronavirus disease 2019 in critically ill patients. DESIGN: The Surviving Sepsis Research Committee, a multiprofessional ...
  • Sharing ICU Patient Data Responsibly Under the Society of Critical Care Medicine/European Society of Intensive Care Medicine Joint Data Science Collaboration: The Amsterdam University Medical Centers Database (AmsterdamUMCdb) Example 
    Amsterdam University Medical Centers Database (AmsterdamUMCdb) Collaborators and the SCCM/ESICM Joint Data Science Task Force (Lippincott Williams & Wilkins, 2021-06)
    OBJECTIVES: Critical care medicine is a natural environment for machine learning approaches to improve outcomes for critically ill patients as admissions to ICUs generate vast amounts of data. However, technical, legal, ...
  • How the COVID-19 pandemic will change the future of critical care 
    Arabi, Yaseen M; Azoulay, Elie; Al-Dorzi, Hasan M; Phua, Jason; Salluh, Jorge; Binnie, Alexandra; Hodgson, Carol; Angus, Derek C; Cecconi, Maurizio; Du, Bin; Fowler, Rob; Gomersall, Charles D; Horby, Peter; Juffermans, Nicole P; Kesecioglu, Jozef; Kleinpell, Ruth M; Machado, Flavia R; Martin, Greg S; Meyfroidt, Geert; Rhodes, Andrew; Rowan, Kathryn; Timsit, Jean-François; Vincent, Jean-Louis; Citerio, Giuseppe (Springer-Verlag, 2021-03)
    Coronavirus disease 19 (COVID-19) has posed unprecedented healthcare system challenges, some of which will lead to transformative change. It is obvious to healthcare workers and policymakers alike that an effective critical ...
  • EBM leren toepassen door observatie, werkt dat? 
    Welink, Lisanne; Van Roy, Kaatje; Damoiseaux, Roger; Suijker, Hilde; Pype, Peter; de Groot, Esther; Bartelink, M. E.L. (Bohn Stafleu van Loghum, 2020-11-01)
  • Cost of childhood acute otitis media in primary care in the Netherlands: economic analysis alongside a cluster randomised controlled trial 
    van Uum, Rick T.; Venekamp, Roderick P.; Pasmans, Clémence T.B.; de Wit, G. Ardine; Sjoukes, Alies; van der Pol, Alma C.; Damoiseaux, Roger A.M.J.; Schilder, Anne G.M. (BioMed Central, 2021-03-04)
    Background: Acute otitis media (AOM) is among the most common paediatric conditions managed in primary care. Most recent estimates of the cost of AOM date from a decade ago and lack a full societal perspective. We therefore ...
  • Synthetic CT for single-fraction neoadjuvant partial breast irradiation on an MRI-linac 
    Groot Koerkamp, Maureen L; de Hond, Yvonne J M; Maspero, Matteo; Kontaxis, Charis; Mandija, Stefano; Vasmel, Jeanine E; Charaghvandi, Ramona K; Philippens, Marielle E P; van Asselen, Bram; van den Bongard, H J G Desirée; Hackett, Sara S; Houweling, Antonetta Christina (IOP Publishing Ltd., 2021-04-21)
    A synthetic computed tomography (sCT) is required for daily plan optimization on an MRI-linac. Yet, only limited information is available on the accuracy of dose calculations on sCT for breast radiotherapy. This work aimed ...
  • Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era 
    Pöntinen, Anna K; Top, Janetta; Arredondo-Alonso, Sergio; Tonkin-Hill, Gerry; Freitas, Ana R; Novais, Carla; Gladstone, Rebecca A; Pesonen, Maiju; Meneses, Rodrigo; Pesonen, Henri; Lees, John A; Jamrozy, Dorota; Bentley, Stephen D; Lanza, Val F; Torres, Carmen; Peixe, Luisa; Coque, Teresa M; Parkhill, Julian; Schürch, Anita C; Willems, Rob J L; Corander, Jukka (Nature Publishing Group, 2021-03-09)
    Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist microorganism. Here, we study E. faecalis isolates ranging from the ...
  • A Parathyroid-Gut Axis: Hypercalcemia and the Pathogenesis of Gastrinoma in Multiple Endocrine Neoplasia 1 
    Hackeng, Wenzel M; Dreijerink, Koen M A; Offerhaus, G Johan A; Brosens, Lodewijk A A (American Association for Cancer Research Inc., 2021-06)
    Patients with multiple endocrine neoplasia 1 (MEN1) syndrome have a germline mutation in the MEN1 gene. Loss of the wildtype allele can initiate endocrine tumorigenesis. Microscopic and macroscopic pituitary, parathyroid, ...
  • European consensus on essential steps of Minimally Invasive Ivor Lewis and McKeown Esophagectomy through Delphi methodology 
    MIE Delphi Collaboration (Springer New York, 2022-01)
    Background: Minimally invasive esophagectomy (MIE) is a complex and technically demanding procedure with a long learning curve, which is associated with increased morbidity and mortality. To master MIE, training in essential ...
  • A Phase II Study Demonstrates No Feasibility of Adjuvant Treatment with Six Cycles of S-1 and Oxaliplatin in Resectable Esophageal Adenocarcinoma, with ERCC1 as Biomarker for Response to SOX 
    Stroes, Charlotte I; Schokker, Sandor; Molenaar, Remco J; Mathôt, Ron A A; Bijlsma, Maarten F; van der Woude, Stephanie O; Belo Pereira, João P; Hooijer, Gerrit K J; Verhoeven, Rob H A; Cats, Annemieke; Grootscholten, Cecile; van Sandick, Johanna W; Creemers, Geert-Jan; Nieuwenhuijzen, Grard A P; Haj Mohammad, Nadia; Ruurda, Jelle P; Meijer, Sybren L; Hulshof, Maarten C C M; van Berge Henegouwen, Mark I; van Laarhoven, Hanneke W M (Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-17)
    We assessed the feasibility of adjuvant S-1 and oxaliplatin following neoadjuvant chemoradiotherapy (nCRT) and esophagectomy. Patients treated with nCRT (paclitaxel, carboplatin) and esophagectomy received six 21-day cycles ...
  • The presence of metastatic thoracic duct lymph nodes in Western esophageal cancer patients: A Multinational Observational Study 
    Defize, Ingmar L; Gorgels, Stijn M C; Mazza, Elena; Schurink, Bernadette; Strignano, Paolo; Catalano, Giorgia; Brosens, Lodewijk A A; Chiusa, Luigi; Bleys, Ronald L A W; Mook, Stella; Meijer, Gert J; Romagnoli, Renato; Ruurda, Jelle P; van Hillegersberg, Richard (Elsevier, 2022-02)
    BACKGROUND: The thoracic lymphadenectomy during an esophagectomy for esophageal cancer includes resection of the thoracic duct (TD) compartment containing the TD lymph nodes (TDLNs). The role of TD compartment resection ...
  • ModraDoc006, an oral docetaxel formulation in combination with ritonavir (ModraDoc006/r), in metastatic castration-resistant prostate cancer patients: A phase Ib study 
    Vermunt, Marit A C; Robbrecht, Debbie G J; Devriese, Lot A; Janssen, Julie M; Thijssen, Bas; Keessen, Marianne; van Eijk, Maarten; Kessels, Rob; Eskens, Ferry A L M; Beijnen, Jos H; Mehra, Niven; Bergman, Andries M (Wiley-Blackwell Publishing Ltd, 2021-08)
    BACKGROUND: ModraDoc006 is an oral formulation of docetaxel, which is co-administered with the cytochrome P450 3A4 and P-glycoprotein inhibitor ritonavir (r): ModraDoc006/r. Weekly treatment with ModraDoc006/r had been ...
  • Lower extremity compression garments use by athletes: why, how often, and perceived benefit 
    Franke, Thierry P C; Backx, Frank J G; Huisstede, Bionka M A (BioMed Central, 2021-12)
    BACKGROUND: Studies on the benefits of lower extremity compression garments (CGs) have focused on their effects on post-exercise recovery and performance improvement. Less is known about why athletes actually use CGs, the ...
  • Acardiac twin pregnancies part VI: Why does acardiac twinning occur only in the first trimester? 
    van Gemert, Martin J.C.; Ross, Michael G.; van den Wijngaard, Jeroen P.H.M.; Nikkels, Peter G.J. (John Wiley & Sons Inc., 2021-05-15)
    Background: Clinical observation suggests that acardiac twinning occurs only in the first trimester. In part, this contradicts our previous analysis (part IV) of Benirschke's concept that unequal embryonic splitting causes ...
  • Update and, internal and temporal-validation of the FRANCE-2 and ACC-TAVI early-mortality prediction models for Transcatheter Aortic Valve Implantation (TAVI) using data from the Netherlands heart registration (NHR) 
    NHR THI Registration Committee (Elsevier, 2021-02)
    Background: The predictive performance of the models FRANCE-2 and ACC-TAVI for early-mortality after Transcatheter Aortic Valve Implantation (TAVI) can decline over time and can be enhanced by updating them on new populations. ...
  • Diagnostic issues in difficult-to-treat rheumatoid arthritis: A systematic literature review informing the EULAR recommendations for the management of difficult-to-treat rheumatoid arthritis 
    Roodenrijs, Nadia M.T.; Kedves, Melinda; Hamar, Attila; Nagy, György; Van Laar, Jacob M.; Van Der Heijde, Désireé; Welsing, Paco M.J. (BMJ Publishing Group, 2021-01-29)
    Objectives To summarise the evidence on diagnostic issues in difficult-to-treat rheumatoid arthritis (D2T RA) informing the EULAR recommendations for the management of D2T RA. Methods A systematic literature review (SLR) ...