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UMC Repository: Recent submissions

  • MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy 
    Cornel, Annelisa M; Mimpen, Iris L; Nierkens, Stefan (Multidisciplinary Digital Publishing Institute (MDPI), 2020-07-02)
    In recent years, major advances have been made in cancer immunotherapy. This has led to significant improvement in prognosis of cancer patients, especially in the hematological setting. Nonetheless, translation of these ...
  • Clinical Grade Production of Wilms' Tumor-1 Loaded Cord Blood-Derived Dendritic Cells to Prevent Relapse in Pediatric AML After Cord Blood Transplantation 
    Plantinga, Maud; Lo Presti, Vania; de Haar, Colin G; Dünnebach, Ester; Madrigal, Alejandro; Lindemans, Caroline A; Boelens, Jaap Jan; Nierkens, Stefan (Frontiers Media S. A., 2020-09-25)
    Hematopoietic cell transplantation (HCT) is a last resort, potentially curative treatment option for pediatric patients with refractory acute myeloid leukemia (AML). Cord blood transplantation (CBT) results in less relapses ...
  • Immune Monitoring After Allogeneic Hematopoietic Cell Transplantation: Toward Practical Guidelines and Standardization 
    Boelens, Jaap Jan; Hosszu, Kinga K; Nierkens, Stefan (Frontiers Media S. A., 2020-08-21)
    Hematopoietic cell transplantation (HCT) is often a last resort, but potentially curative treatment option for children suffering from hematological malignancies and a variety of non-malignant disorders, such as bone marrow ...
  • Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation 
    Dekker, Linde; de Koning, Coco; Lindemans, Caroline; Nierkens, Stefan (Multidisciplinary Digital Publishing Institute (MDPI), 2020-07-20)
    Allogeneic (allo) hematopoietic cell transplantation (HCT) is the only curative treatment option for patients suffering from chemotherapy-refractory or relapsed hematological malignancies. The occurrence of morbidity and ...
  • CD4+ T-cell reconstitution predicts survival outcomes after acute graft-versus-host-disease: a dual-center validation 
    de Koning, Coco; Prockop, Susan; van Roessel, Ichelle; Kernan, Nancy; Klein, Elizabeth; Langenhorst, Jurgen; Szanto, Celina; Belderbos, Mirjam; Bierings, Marc; Boulad, Farid; Bresters, Dorine; Cancio, Maria; Curran, Kevin; Kollen, Wouter; O'Reilly, Richard; Scaradavou, Andromachi; Spitzer, Barbara; Versluijs, Birgitta; Huitema, Alwin; Lindemans, Caroline; Nierkens, Stefan; Boelens, Jaap Jan (Elsevier, 2021-02-11)
    Acute graft-versus-host-Disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). We previously showed that early CD4 + T-cell immune reconstitution (IR; CD4 + ...
  • Gene Augmentation and Editing to Improve TCR Engineered T Cell Therapy against Solid Tumors 
    Lo Presti, Vania; Buitenwerf, Frank; van Til, Niek P; Nierkens, Stefan (Multidisciplinary Digital Publishing Institute, 2020-12-03)
    Recent developments in gene engineering technologies have drastically improved the therapeutic treatment options for cancer patients. The use of effective chimeric antigen receptor T (CAR-T) cells and recombinant T cell ...
  • The immune landscape of neuroblastoma: Challenges and opportunities for novel therapeutic strategies in pediatric oncology 
    Wienke, Judith; Dierselhuis, Miranda P; Tytgat, Godelieve A M; Künkele, Annette; Nierkens, Stefan; Molenaar, Jan J (Elsevier Limited, 2021-02)
    Immunotherapy holds great promise for the treatment of pediatric cancers. In neuroblastoma, the recent implementation of anti-GD2 antibody Dinutuximab into the standard of care has improved patient outcomes substantially. ...
  • A Minimal Parameter Set Facilitating Early Decision-making in the Diagnosis of Hemophagocytic Lymphohistiocytosis 
    Smits, Bas M; van Montfrans, Joris; Merrill, Samuel A; van de Corput, Lisette; van Gijn, Mariëlle; de Vries, Andrica; van den Bos, Cor; Abbink, Floor; van der Molen, Renate G; Dors, Natasja; Lindemans, Caroline; Boelens, Jaap J; Nierkens, Stefan (Springer New York, 2021-08)
    Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune dysregulation syndrome characterized by uncontrolled immune cell activation. Timely diagnosis is important, since early treatment can improve survival ...
  • An elevated ankle-brachial index is not a valid proxy for peripheral medial arterial calcification 
    SMART Study Group (Elsevier, 2021-04)
    BACKGROUND AND AIMS: The ankle brachial index (ABI) is often used as a proxy for medial arterial calcification (MAC) in studies investigating MAC as a cardiovascular risk factor, but evidence supporting this hypothesis is ...
  • Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology 
    Spaan, Mandy; van den Belt-Dusebout, Alexandra W.; Lambalk, Cornelis B.; van Boven, Hester H.; Schats, Roel; Kortman, Marian; Broekmans, Frank J.M.; Laven, Joop S.E.; van Santbrink, Evert J.P.; Braat, Didi D.M.; van der Westerlaken, Lucette A.J.; Cohlen, Ben J.; Cantineau, Astrid E.P.; Smeenk, Jesper M.J.; van Rumste, Minouche M.; Goddijn, Mariëtte; van Golde, Ron J.T.; Meeuwissen, Paul A.M.; Hamilton, Carl J.C.M.; Ouwens, Gabriële M.; Gerritsma, Miranda A.; Schaapveld, Michael; Burger, Curt W.; van Leeuwen, Flora E. (Oxford University Press, 2021-06-01)
    BACKGROUND: Long-term effects of assisted reproductive technology (ART) on ovarian tumor risk are unknown. METHODS: This nationwide cohort study comprises 30 625 women who received ovarian stimulation for ART in 1983-2000 ...
  • Early Acute Kidney Injury in Preterm and Term Neonates: Incidence, Outcome, and Associated Clinical Features 
    Gallo, Dario; de Bijl-Marcus, Karen A; Alderliesten, Thomas; Lilien, Marc; Groenendaal, Floris (S. Karger AG, 2021)
    BACKGROUND: Critically ill neonates are at high risk of kidney injury, mainly in the first days of life. Acute kidney injury (AKI) may be underdiagnosed due to lack of a uniform definition. In addition, long-term renal ...
  • MetaboShiny: interactive analysis and metabolite annotation of mass spectrometry-based metabolomics data 
    Wolthuis, Joanna C; Magnusdottir, Stefania; Pras-Raves, Mia; Moshiri, Maryam; Jans, Judith J M; Burgering, Boudewijn; van Mil, Saskia; de Ridder, Jeroen (Springer New York, 2020-09-11)
    Direct infusion untargeted mass spectrometry-based metabolomics allows for rapid insight into a sample's metabolic activity. However, analysis is often complicated by the large array of detected m/z values and the difficulty ...
  • Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners 
    Metabolomics Quality Assurance, Quality Control Consortium (mQACC) (Springer New York, 2020-10-12)
    INTRODUCTION: The metabolomics quality assurance and quality control consortium (mQACC) evolved from the recognized need for a community-wide consensus on improving and systematizing quality assurance (QA) and quality ...
  • Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition 
    Ghosh, Shereen G; Lee, Sangmoon; Fabunan, Rudy; Chai, Guoliang; Zaki, Maha S; Abdel-Salam, Ghada; Sultan, Tipu; Ben-Omran, Tawfeg; Alvi, Javeria Raza; McEvoy-Venneri, Jennifer; Stanley, Valentina; Patel, Aakash; Ross, Danica; Ding, Jeffrey; Jain, Mohit; Pan, Daqiang; Lübbert, Philipp; Kammerer, Bernd; Wiedemann, Nils; Verhoeven-Duif, Nanda M; Jans, Judith J; Murphy, David; Toosi, Mehran Beiraghi; Ashrafzadeh, Farah; Imannezhad, Shima; Karimiani, Ehsan Ghayoor; Ibrahim, Khalid; Waters, Elizabeth R; Maroofian, Reza; Gleeson, Joseph G (Lippincott Williams & Wilkins, 2021-03)
    PURPOSE: Dioxygenases are oxidoreductase enzymes with roles in metabolic pathways necessary for aerobic life. 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL), encoded by HPDL, is an orphan paralogue of 4-hydroxyp ...
  • COVID-19 pandemic and allergen immunotherapy - an EAACI survey 
    Pfaar, Oliver; Agache, Ioana; Bonini, Matteo; Brough, Helen Annaruth; Chivato, Tomás; Del Giacco, Stefano R; Gawlik, Radoslaw; Gelincik, Aslı; Hoffmann-Sommergruber, Karin; Jutel, Marek; Klimek, Ludger; Knol, Edward F; Lauerma, Antti; Ollert, Markus; O'Mahony, Liam; Mortz, Charlotte G; Palomares, Oscar; Riggioni, Carmen; Schwarze, Jürgen; Skypala, Isabel; Torres, María José; Untersmayr, Eva; Walusiak-Skorupa, Jolanta; Chaker, Adam; Giovannini, Mattia; Heffler, Enrico; Jensen-Jarolim, Erika; Quecchia, Cristina; Sandoval-Ruballos, Mónica; Sahiner, Umit; Tomić Spirić, Vesna; Alvaro-Lozano, Montserrat (Wiley-Blackwell, 2021-11)
    Background: As in many fields of medical care, the coronavirus disease 2019 (COVID-19) resulted in an increased uncertainty regarding the safety of allergen immunotherapy (AIT). Therefore, the European Academy of Allergy ...
  • The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease 
    Demandt, J A F; Dubois, L J; van Kuijk, K; Zaťovičová, M; Jin, H; Parkkila, S; van der Laan, S W; Jelenska, L; Mees, B M E; Reutelingsperger, C P M; Cleutjens, K B J M; van der Kallen, C J H; Schalkwijk, C G; van Greevenbroek, M M J; Biessen, E A L; Pasterkamp, G; Pastoreková, S; Stehouwer, C D A; Sluimer, J C (Nature Publishing Group, 2021-01-11)
    Hypoxia is prevalent in atherosclerotic plaques, promoting plaque aggravation and subsequent cardiovascular disease (CVD). Transmembrane protein carbonic anhydrase IX (CAIX) is hypoxia-induced and can be shed into the ...
  • Preclinical Feasibility and Patency Analyses of a New Distal Coronary Connector: The ELANA Heart Bypass 
    Stecher, David; Hoogewerf, Marieke; Bronkers, Glenn; van Putte, Bart P; Doevendans, Pieter A; Tulleken, Cornelis A F; van Herwerden, Lex; Pasterkamp, Gerard; Buijsrogge, Marc P (Lippincott Williams & Wilkins, 2021-03)
    Objective: This preclinical study determines the feasibility and 6-month patency rates of a new distal coronary connector, the Excimer Laser Assisted Nonocclusive Anastomosis (ELANA) Heart Bypass. Methods: Twenty Dutch ...
  • Deep learning-based synthetic-CT generation in radiotherapy and PET: A review 
    Spadea, Maria Francesca; Maspero, Matteo; Zaffino, Paolo; Seco, Joao (John Wiley & Sons Inc., 2021-11)
    Recently,deep learning (DL)-based methods for the generation of synthetic computed tomography (sCT) have received significant research attention as an alternative to classical ones. We present here a systematic review of ...
  • Prosaposin mediates inflammation in atherosclerosis 
    van Leent, Mandy M T; Beldman, Thijs J; Toner, Yohana C; Lameijer, Marnix A; Rother, Nils; Bekkering, Siroon; Teunissen, Abraham J P; Zhou, Xianxiao; van der Meel, Roy; Malkus, Joost; Nauta, Sheqouia A; Klein, Emma D; Fay, Francois; Sanchez-Gaytan, Brenda L; Pérez-Medina, Carlos; Kluza, Ewelina; Ye, Yu-Xiang; Wojtkiewicz, Gregory; Fisher, Edward A; Swirski, Filip K; Nahrendorf, Matthias; Zhang, Bin; Li, Yang; Zhang, Bowen; Joosten, Leo A B; Pasterkamp, Gerard; Boltjes, Arjan; Fayad, Zahi A; Lutgens, Esther; Netea, Mihai G; Riksen, Niels P; Mulder, Willem J M; Duivenvoorden, Raphaël (American Association for the Advancement of Science, 2021-03-10)
    Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory properties of these cells are dictated by their metabolism, of which the mechanistic target of rapamycin (mTOR) signaling pathway is ...
  • Daily practice in guideline adherence to adjuvant chemotherapy in stage III colon cancer and predictors of outcome: Adjuvant chemotherapy in stage III colon cancer patients 
    van den Berg, I; van de Weerd, S; van Klaveren, D; Coebergh van den Braak, R R J; van Krieken, J H J M; Koopman, M; Roodhart, J M L; Medema, J P; IJzermans, J N M (W.B. Saunders Ltd, 2021-08)
    Introduction: Although guidelines recommend adjuvant chemotherapy for stage III colon cancer patients, many patients do not receive adjuvant chemotherapy. The aim of this study was to identify reasons for guideline ...