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UMC Repository: Recent submissions

  • Erratum: Unexpected low frequency of respiratory symptoms in an HIV-positive urban sub-Saharan population compared to an HIV-negative control group 
    Kummerow, Maren; Shaddock, Erica J; Klipstein-Grobusch, Kerstin; Barth, Roos B; Grobbee, Diederick E; Francois Venter, W D; Feldman, Charles; Vos, Alinda (AOSIS (Pty) Ltd, 2021-04-19)
    [This corrects the article DOI: 10.4102/sajhivmed.v20i1.1010.].
  • Patient-reported outcomes after oesophagectomy in the multicentre LASER study 
    Markar, S R; Sounderajah, V; Johar, A; Zaninotto, G; Castoro, C; Lagergren, P; Elliott, J A; Gisbertz, S S; Mariette, C; Alfieri, R; Huddy, J; Pinto, E; Scarpa, M; Klevebro, F; Sunde, B; Murphy, C F; Greene, C; Ravi, N; Piessen, G; Brenkman, H; Ruurda, J; van Hillegersberg, R; Lagarde, S M; Wijnhoven, B P; Pera, M; Roigg, J; Castro, S; Matthijsen, R; Findlay, J; Antonowicz, S; Maynard, N; McCormack, O; Ariyarathenam, A; Sanders, G; Cheong, E; Jaunoo, S; Allum, W; van Lanschot, J; Nilsson, M; Reynolds, J V; van Berge Henegouwen, M I; Hanna, G B (John Wiley & Sons Inc., 2021-09)
    BACKGROUND: Data on the long-term symptom burden in patients surviving oesophageal cancer surgery are scarce. The aim of this study was to identify the most prevalent symptoms and their interactions with health-related ...
  • DNA methylation as the link between migration and the major noncommunicable diseases: the RODAM study 
    Chilunga, Felix P; Henneman, Peter; Venema, Andrea; Meeks, Karlijn Ac; Gonzalez, Juan R; Ruiz-Arenas, Carlos; Requena-Méndez, Ana; Beune, Erik; Spranger, Joachim; Smeeth, Liam; Bahendeka, Silver; Owusu-Dabo, Ellis; Klipstein-Grobusch, Kerstin; Adeyemo, Adebowale; Mannens, Marcel Mam; Agyemang, Charles (Taylor and Francis Ltd., 2021-05)
    Aim: We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians. Materials & methods: We used the Illumina Infinium® HumanMethylation450 BeadChip to profile DNAm of 712 Ghanaians ...
  • The role of local therapy in the treatment of solitary melanoma progression on immune checkpoint inhibition: A multicentre retrospective analysis 
    Versluis, Judith M; Hendriks, Anne M; Weppler, Alison M; Brown, Lauren J; de Joode, Karlijn; Suijkerbuijk, Karijn P M; Zimmer, Lisa; Kapiteijn, Ellen W; Allayous, Clara; Johnson, Douglas B; Hepner, Adriana; Mangana, Joanna; Bhave, Prachi; Jansen, Yanina J L; Trojaniello, Claudia; Atkinson, Victoria; Storey, Lucy; Lorigan, Paul; Ascierto, Paolo A; Neyns, Bart; Haydon, Andrew; Menzies, Alexander M; Long, Georgina V; Lebbe, Celeste; van der Veldt, Astrid A M; Carlino, Matteo S; Sandhu, Shahneen; van Tinteren, Harm; de Vries, Elisabeth G E; Blank, Christian U; Jalving, Mathilde (Elsevier Limited, 2021-07)
    INTRODUCTION: In patients with metastatic melanoma, progression of a single tumour lesion (solitary progression) after response to immune checkpoint inhibition (ICI) is increasingly treated with local therapy. We evaluated ...
  • Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome: A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients 
    Claassens, Daniel M F; Gimbel, Marieke E; Bergmeijer, Thomas O; Vos, Gerrit J A; Hermanides, Renicus S; van der Harst, Pim; Barbato, Emanuele; Morisco, Carmine; Tjon Joe Gin, Richard M; de Vrey, Evelyn A; Heestermans, Ton A C M; Jukema, J Wouter; von Birgelen, Clemens; Waalewijn, Reinier A; Hofma, Sjoerd H; den Hartog, Frank R; Voskuil, Michiel; Van't Hof, Arnoud W J; Asselbergs, Folkert W; Mosterd, A; Herrman, Jean-Paul R; DeWilde, Willem; Mahmoodi, Bakhtawar K; Deneer, Vera H M; Ten Berg, Jurriën M (Elsevier Ireland Ltd, 2021-07-01)
    BACKGROUND: Patients with acute coronary syndrome (ACS) who are carrying CYP2C19 loss-of-function alleles derive less benefit from clopidogrel treatment. Despite this, in elderly patients, clopidogrel might be preferred ...
  • The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial 
    Lemkes, Jorrit S; Spoormans, Eva M; Demirkiran, Ahmet; Leutscher, Sophie; Janssens, Gladys N; van der Hoeven, Nina W; Jewbali, Lucia S D; Dubois, Eric A; Meuwissen, Martijn; Rijpstra, Tom A; Bosker, Hans A; Blans, Michiel J; Bleeker, Gabe B; Baak, Rémon; Vlachojannis, Georgios J; Eikemans, Bob J W; van der Harst, Pim; van der Horst, Iwan C C; Voskuil, Michiel; van der Heijden, Joris J; Beishuizen, Albertus; Stoel, Martin; Camaro, Cyril; van der Hoeven, Hans; Henriques, José P; Vlaar, Alexander P J; Vink, Maarten A; van den Bogaard, Bas; Heestermans, Ton A C M; de Ruijter, Wouter; Delnoij, Thijs S R; Crijns, Harry J G M; Jessurun, Gillian A J; Oemrawsingh, Pranobe V; Gosselink, Marcel T M; Plomp, Koos; Magro, Michael; Elbers, Paul W G; van de Ven, Peter M; van Loon, Ramon B; van Royen, Niels (Elsevier Ireland Ltd, 2021-07)
    Background: The effect of immediate coronary angiography and percutaneous coronary intervention (PCI) in patients who are successfully resuscitated after cardiac arrest in the absence of ST-segment elevation myocardial ...
  • Distinction between peanut allergy and tolerance by characterization of B-cell receptor repertoires 
    Ehlers, Anna; den Hartog Jager, CF; Knulst, André C.; Otten, Henny G. (Wiley-Blackwell, 2021-09)
    Background: Specific IgE against a peanut 2S albumin (Ara h 2 or 6) is the best predictor of clinically relevant peanut sensitization. However, sIgE levels of peanut allergic and those of peanut sensitized but tolerant ...
  • Comparison of Two Strategies to Generate Antigen-Specific Human Monoclonal Antibodies: Which Method to Choose for Which Purpose? 
    Ehlers, Anna (Frontiers Media S. A., 2021-05-04)
    Human monoclonal antibodies (mAbs) are valuable tools to link genetic information with functional features and to provide a platform for conformational epitope mapping. Additionally, combined data on genetic and functional ...
  • Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease 
    Shapiro, Jason M; de Zoete, Marcel R; Palm, Noah W; Laenen, Yaro; Bright, Rene; Mallette, Meaghan; Bu, Kevin; Bielecka, Agata A; Xu, Fang; Hurtado-Lorenzo, Andres; Shah, Samir A; Cho, Judy H; LeLeiko, Neal S; Sands, Bruce E; Flavell, Richard A; Clemente, J C (Cell Press, 2021-01-13)
    The immunopathogenesis of inflammatory bowel disease (IBD) has been attributed to a combination of host genetics and intestinal dysbiosis. Previous work in a small cohort of IBD patients suggested that pro-inflammatory ...
  • Isolation and contact tracing can tip the scale to containment of COVID-19 in populations with social distancing 
    Kretzschmar, Mirjam E.; Rozhnova, Ganna; van Boven, Michiel (Frontiers Media S. A., 2021-02-10)
    SARS-CoV-2 has established itself in all parts of the world, and many countries have implemented social distancing as a measure to prevent overburdening of health care systems. Here we evaluate whether and under which ...
  • Relevance of intra-hospital patient movements for the spread of healthcare-associated infections within hospitals - a mathematical modeling study 
    Tahir, Hannan; López-Cortés, Luis Eduardo; Kola, Axel; Yahav, Dafna; Karch, André; Xia, Hanjue; Horn, Johannes; Sakowski, Konrad; Piotrowska, Monika J; Leibovici, Leonard; Mikolajczyk, Rafael T; Kretzschmar, Mirjam E (Public Library of Science, 2021-02-03)
    The aim of this study is to analyze patient movement patterns between hospital departments to derive the underlying intra-hospital movement network, and to assess if movement patterns differ between patients at high or low ...
  • Targeted COVID-19 Vaccination (TAV-COVID) Considering Limited Vaccination Capacities-An Agent-Based Modeling Evaluation 
    Jahn, Beate; Sroczynski, Gaby; Bicher, Martin; Rippinger, Claire; Mühlberger, Nikolai; Santamaria, Júlia; Urach, Christoph; Schomaker, Michael; Stojkov, Igor; Schmid, Daniela; Weiss, Günter; Wiedermann, Ursula; Redlberger-Fritz, Monika; Druml, Christiane; Kretzschmar, Mirjam; Paulke-Korinek, Maria; Ostermann, Herwig; Czasch, Caroline; Endel, Gottfried; Bock, Wolfgang; Popper, Nikolas; Siebert, Uwe (Multidisciplinary Digital Publishing Institute, 2021-05)
    (1) Background: The Austrian supply of COVID-19 vaccine is limited for now. We aim to provide evidence-based guidance to the authorities in order to minimize COVID-19-related hospitalizations and deaths in Austria. (2) ...
  • Effects of incomplete inter-hospital network data on the assessment of transmission dynamics of hospital-acquired infections 
    Xia, Hanjue; Horn, Johannes; Piotrowska, Monika J; Sakowski, Konrad; Karch, André; Tahir, Hannan; Kretzschmar, Mirjam; Mikolajczyk, Rafael (Public Library of Science, 2021-05-06)
    In the year 2020, there were 105 different statutory insurance companies in Germany with heterogeneous regional coverage. Obtaining data from all insurance companies is challenging, so that it is likely that projects will ...
  • Call for a pan-European COVID-19 response must be comprehensive - Authors' reply 
    Priesemann, Viola; Brinkmann, Melanie M; Ciesek, Sandra; Cuschieri, Sarah; Czypionka, Thomas; Giordano, Giulia; Hanson, Claudia; Hens, Niel; Iftekhar, Emil; Klimek, Peter; Kretzschmar, Mirjam; Peichl, Andreas; Perc, Matjaž; Sannino, Francesco; Schernhammer, Eva; Schmidt, Alexander; Staines, Anthony; Szczurek, Ewa (Elsevier, 2021-04-24)
  • Forward thinking on backward tracing 
    Müller, Johannes; Kretzschmar, Mirjam (Nature Publishing Group, 2021-05)
    SARS, MERS and now SARS-CoV-2 are unlikely to be the last emerging infections we face during our lifetimes. Tracing contacts both forward and backward through our heterogeneous populations will prove essential to future ...
  • QUARANTINE Should I stay or should I go? 
    Kretzschmar, Mirjam; Müller, Johannes (eLife Sciences Publications, 2021-03-16)
    Analysing the characteristics of the SARS-CoV-2 virus makes it possible to estimate the length of quarantine that reduces the impact on society and the economy, while minimising infections.
  • CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils 
    Pascoal Ramos, M Inês; Keşmir, Can; Stok, Jorn E.; Geerdink, Ruben; Satravelas, Nikolaos; Westerlaken, Geertje H.A.; Meyaard, Linde; van der Vlist, Michiel (Oxford University Press, 2022-02)
    Inhibitory and activating immune receptors play a key role in modulating the amplitude and duration of immune responses during infection and in maintaining immune balance in homeostatic conditions. The CD200 Receptor ...
  • De‐identification procedures for magnetic resonance images and the impact on structural brain measures at different ages 
    Buimer, Elizabeth; Schnack, Hugo; Caspi, Yaron; van Haren, Neeltje; Milchenko, Mikhail; Pas, P; ADNI; Hulshoff Pol, Hilleke; Brouwer, Rachel (Wiley-Liss Inc., 2021-08-01)
    Surface rendering of MRI brain scans may lead to identification of the participant through facial characteristics. In this study, we evaluate three methods that overwrite voxels containing privacy‐sensitive information: ...
  • Allogeneic hematopoietic cell transplantation with cord blood versus mismatched unrelated donor with post-transplant cyclophosphamide in acute myeloid leukemia 
    Dholaria, Bhagirathbhai; Labopin, Myriam; Sanz, Jaime; Ruggeri, Annalisa; Cornelissen, Jan; Labussière-Wallet, Hélène; Blaise, Didier; Forcade, Edouard; Chevallier, Patrice; Grassi, Anna; Zubarovskaya, Ludmila; Kuball, Jürgen; Ceballos, Patrice; Ciceri, Fabio; Baron, Frederic; Savani, Bipin N; Nagler, Arnon; Mohty, Mohamad (BioMed Central Ltd., 2021-05-03)
    BACKGROUND: Allogeneic hematopoietic cell transplantation (allo-HCT) using a mismatched unrelated donor (MMUD) and cord blood transplantation (CBT) are valid alternatives for patients without a fully human leukocyte antigen ...
  • Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet Reactivity 
    Dutch COVID & Thrombosis Coalition (Frontiers Media S. A., 2021-04-22)
    Background: Coronavirus disease of 2019 (COVID-19) is associated with a prothrombotic state and a high incidence of thrombotic event(s) (TE). Objectives: To study platelet reactivity in hospitalized COVID-19 patients and ...