DNA methylation as the link between migration and the major noncommunicable diseases: the RODAM study

DSpace/Manakin Repository

DNA methylation as the link between migration and the major noncommunicable diseases: the RODAM study
 
Chilunga, Felix P; Henneman, Peter; Venema, Andrea; Meeks, Karlijn Ac; Gonzalez, Juan R; Ruiz-Arenas, Carlos; Requena-Méndez, Ana; Beune, Erik; Spranger, Joachim; Smeeth, Liam; Bahendeka, Silver; Owusu-Dabo, Ellis; Klipstein-Grobusch, Kerstin; Adeyemo, Adebowale; Mannens, Marcel Mam; Agyemang, Charles
(2021) Epigenomics, volume 13, issue 09, pp. 653 - 666
(Article)
Abstract
Aim: We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians. Materials & methods: We used the Illumina Infinium® HumanMethylation450 BeadChip to profile DNAm of 712 Ghanaians in whole blood. We used linear models to detect differentially methylated positions (DMPs) associated with migration. We performed multiple post hoc ... read more
Download/Full Text
The full text of this publication is not available.
Version on publisher website for UU-students and staff
Version on publisher website
 
Keywords: DNA methylation, RODAM study, migrants, noncommunicable diseases, sub-Saharan Africans, Genetics, Cancer Research
DOI: https://doi.org/10.2217/epi-2020-0329
ISSN: 1750-192X
Publisher: Future Medicine Ltd.
Note: Funding Information: This work was supported by the European Commission under the Framework Programme (grant no.: 278901) and European Research Council Consolidation (grant no.: 772244). FP Chilunga is supported by the Erasmus Mundus Joint Doctorate Programme of the European Union through the Amsterdam Institute of Global Health and Development (AIGHD; grant agreement 2015– 1595). A.A. and K.A.C.M. are supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2021 Future Medicine Ltdl. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
(Peer reviewed)