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Now showing items 16361-16380 of 40729

The effects of wheelchair mobility skills and exercise training on physical activity, fitness, skills and confidence in youth using a manual wheelchair

Fit-for-the-Future Consortium (Informa Healthcare, 2022-07-31)

Purpose: To evaluate the effects of a combination of wheelchair mobility skills (WMS) training and exercise training on physical activity (PA), WMS, confidence in wheelchair mobility, and physical fitness. Methods: Youth ...
Velocity and Pulsatility Measures in the Perforating Arteries of the Basal Ganglia at 3T MRI in Reference to 7T MRI

Arts, Tine; Meijs, Timion A; Grotenhuis, Heynric; Voskuil, Michiel; Siero, Jeroen; Biessels, Geert Jan; Zwanenburg, Jaco (Frontiers Media S. A., 2021-04-26)

Cerebral perforating artery flow velocity and pulsatility can be measured using 7 tesla (T) MRI. Enabling these flow metrics on more widely available 3T systems would make them more employable. It is currently unknown ...
Challenges Associated with the Safety Signal Detection Process for Medical Devices

Pane, Josep; Verhamme, Katia M.C.; Villegas, Dorian; Gamez, Laura; Rebollo, Irene; Sturkenboom, Miriam C.J.M. (Dove Medical Press Ltd., 2021-02-24)

Background: Previous safety issues involving medical devices have stressed the need for better safety signal detection. Various European Union (EU) national competent authorities have started to focus on strengthening the ...
The critical role of background rates of possible adverse events in the assessment of COVID-19 vaccine safety

Black, Steven B; Law, Barbara; Chen, Robert T; Dekker, Cornelia L; Sturkenboom, Miriam; Huang, Wan-Ting; Gurwith, Marc; Poland, Greg (Elsevier, 2021-05-06)

Beginning in December of 2019, a novel coronavirus, SARS-CoV-2, emerged in China and is now a global pandemic with extensive morbidity and mortality. With the emergence of this threat, an unprecedented effort to develop ...
Microbiota-based markers predictive of development of Clostridioides difficile infection

the ANTICIPATE study group (Nature Publishing Group, 2021-04-14)

Antibiotic-induced modulation of the intestinal microbiota can lead to Clostridioides difficile infection (CDI), which is associated with considerable morbidity, mortality, and healthcare-costs globally. Therefore, ...
Experiences and needs of persons living with a household member infected with SARS-CoV-2: A mixed method study

Verberk, Janneke D M; Anthierens, Sibyl A; Tonkin-Crine, Sarah; Goossens, Herman; Kinsman, John; de Hoog, Marieke L A; Bielicki, Julia A; Bruijning-Verhagen, Patricia C J L; Gobat, Nina H (Public Library of Science, 2021-03-31)

BACKGROUND: Households are important sites for transmission of SARS-CoV-2 and preventive measures are recommended. This study aimed to 1) investigate the impact of living with a person infected with SARS-CoV-2; 2) understand ...
Management of a hospital-wide vancomycin-resistant Enterococcus faecium outbreak in a Dutch general hospital, 2014-2017: successful control using a restrictive screening strategy

Weterings, Veronica; van Oosten, Anita; Nieuwkoop, Ellen; Nelson, Jolande; Voss, Andreas; Wintermans, Bas; van Lieshout, Joris; Kluytmans, Jan; Veenemans, Jacobien (BioMed Central Ltd., 2021-02-18)

BACKGROUND: The emergence of vancomycin resistant enterococci poses a major problem in healthcare settings. Here we describe a hospital-wide outbreak of vancomycin-resistant Enterococcus faecium in a general hospital in ...
Genome-wide analysis in Escherichia coli unravels a high level of genetic homoplasy associated with cefotaxime resistance

Coolen, Jordy P.M.; den Drijver, Evert P.M.; Verweij, Jaco J.; Schildkraut, Jodie A.; Neveling, Kornelia; Melchers, Willem J.G.; Kolwijck, Eva; Wertheim, Heiman F.L.; Kluytmans, Jan A.J.W.; Huynen, Martijn A. (Microbiology Society, 2021-04)

Cefotaxime (CTX) is a third-generation cephalosporin (3GC) commonly used to treat infections caused by Escherichia coli. Two genetic mechanisms have been associated with 3GC resistance in E. coli. The first is the conjugative ...
Distinguishing blaKPC gene-containing IncF plasmids from epidemiologically related and unrelated enterobacteriaceae based on short- And long-read sequence data

Stohr, Joep J.J.M.; Kluytmans-Van den Bergh, Marjolein F.Q.; Weterings, Veronica A.T.C.; Rossen, John W.A.; Kluytmans, Jan A.J.W. (American Society for Microbiology, 2021-06)

Limited information is available on whether blaKPC-containing plasmids from isolates in a hospital outbreak can be differentiated from epidemiologically unrelated blaKPC-containing plasmids based on sequence data. This ...
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

Wheatley, Rachel; Diaz Caballero, Julio; Kapel, Natalia; de Winter, Fien H R; Jangir, Pramod; Quinn, Angus; Del Barrio-Tofiño, Ester; López-Causapé, Carla; Hedge, Jessica; Torrens, Gabriel; Van der Schalk, Thomas; Xavier, Basil Britto; Fernández-Cuenca, Felipe; Arenzana, Angel; Recanatini, Claudia; Timbermont, Leen; Sifakis, Frangiscos; Ruzin, Alexey; Ali, Omar; Lammens, Christine; Goossens, Herman; Kluytmans, Jan; Kumar-Singh, Samir; Oliver, Antonio; Malhotra-Kumar, Surbhi; MacLean, Craig (Nature Publishing Group, 2021-04-28)

It is well established that antibiotic treatment selects for resistance, but the dynamics of this process during infections are poorly understood. Here we map the responses of Pseudomonas aeruginosa to treatment in high ...
Evaluation of the test accuracy of a SARS-CoV-2 rapid antigen test in symptomatic community dwelling individuals in the Netherlands

Van der Moeren, Nathalie; Zwart, Vivian F; Lodder, Esther B; Van den Bijllaardt, Wouter; Van Esch, Harald R J M; Stohr, Joep J J M; Pot, Joost; Welschen, Ineke; Van Mechelen, Petra M F; Pas, Suzan D; Kluytmans, Jan A J W (Public Library of Science, 2021-05-13)

BACKGROUND: SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is well suited for the diagnosis of clinically ill patients requiring treatment. Application for community testing of symptomatic ...
Evidence-Based Assessment of Genes in Dilated Cardiomyopathy

Jordan, Elizabeth; Peterson, Laiken; Ai, Tomohiko; Asatryan, Babken; Bronicki, Lucas; Brown, Emily; Celeghin, Rudy; Edwards, Matthew; Fan, Judy; Ingles, Jodie; James, Cynthia A; Jarinova, Olga; Johnson, Renee; Judge, Daniel P; Lahrouchi, Najim; Lekanne Deprez, Ronald H; Lumbers, R Thomas; Mazzarotto, Francesco; Medeiros Domingo, Argelia; Miller, Rebecca L; Morales, Ana; Murray, Brittney; Peters, Stacey; Pilichou, Kalliopi; Protonotarios, Alexandros; Semsarian, Christopher; Shah, Palak; Syrris, Petros; Thaxton, Courtney; van Tintelen, J Peter; Walsh, Roddy; Wang, Jessica; Ware, James; Hershberger, Ray E (Lippincott Williams & Wilkins, 2021-07-06)

BACKGROUND: Each of the cardiomyopathies, classically categorized as hypertrophic cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular cardiomyopathy, has a signature genetic theme. Hypertrophic ...
MATISSE: a method for improved single cell segmentation in imaging mass cytometry

Baars, Matthijs J D; Sinha, Neeraj; Amini, Mojtaba; Pieterman-Bos, Annelies; van Dam, Stephanie; Ganpat, Maroussia M P; Laclé, Miangela M; Oldenburg, Bas; Vercoulen, Yvonne (BioMed Central Ltd., 2021-12)

BACKGROUND: Visualizing and quantifying cellular heterogeneity is of central importance to study tissue complexity, development, and physiology and has a vital role in understanding pathologies. Mass spectrometry-based ...
L’hypoxémie pendant la sédation chez le patient adulte: une étude observationnelle rétrospective

van Schaik, Eva P C; Blankman, Paul; Van Klei, Wilton A; Knape, Hans J T A; Vaessen, Paul H H B; Braithwaite, Sue A; van Wolfswinkel, Leo; Schellekens, Willem-Jan M (Springer New York, 2021-09)

Purpose: Since 2010, new guidelines for procedural sedation and the Helsinki Declaration on Patient Safety have increased patient safety, comfort, and acceptance considerably. Nevertheless, the administration of sedatives ...
Long-term exposure to fine particle elemental components and natural and cause-specific mortality—a pooled analysis of eight european cohorts within the ELAPSE project

ELAPSE (Public Health Services, US Dept of Health and Human Services, 2021-04)

BACKGROUND: Inconsistent associations between long-term exposure to particles with an aerodynamic diameter ≤ 2.5 μ m [fine particulate matter ( PM 2.5 )] components and mortality have been reported, partly related to ...
Sleep problems in children with cerebral palsy and their parents

Hulst, Raquel Y; Gorter, Jan Willem; Voorman, Jeanine M; Kolk, Eveline; Van Der Vossen, Sanne; Visser-Meily, Johanna M A; Ketelaar, Marjolijn; Pillen, Sigrid; Verschuren, Olaf (Wiley-Blackwell, 2021-11)

Aim: To describe: (1) the frequency and types of sleep problems, (2) parent-rated satisfaction with their child’s and their own sleep, and (3) child factors related to the occurrence of sleep problems in children with ...
Clinical Significance of Shared T Cell Epitope Analysis in Early De Novo Donor-Specific Anti-HLA Antibody Production After Kidney Transplantation and Comparison With Shared B cell Epitope Analysis

Tomosugi, Toshihide; Iwasaki, Kenta; Sakamoto, Shintaro; Niemann, Matthias; Spierings, Eric; Nahara, Isao; Futamura, Kenta; Okada, Manabu; Hiramitsu, Takahisa; Takeda, Asami; Goto, Norihiko; Narumi, Shunji; Watarai, Yoshihiko; Kobayashi, Takaaki (Frontiers Media S. A., 2021-03-26)

In pre-sensitizing events, immunological memory is mainly created via indirect allorecognition where CD4+ T cells recognize foreign peptides in the context of self-HLA class II (pHLA) presented on antigen-presenting cells. ...
Extension of early esophageal squamous cell neoplasia into ducts and submucosal glands and the role of endoscopic ablation therapy

Overwater, Anouk; van Munster, Sanne N.; Offerhaus, G. Johan A.; Seldenrijk, Cees A.; Raicu, G. Mihaela; Koch, Arjun D.; Bergman, Jacques J.G.H.M.; Pouw, Roos E.; Brosens, Lodewijk A.A.; Jansen, Marnix; Weusten, Bas L.A.M. (Mosby Inc., 2021-10)

Background and Aims: Early esophageal squamous cell neoplasia (ESCN) is preferably treated with en-bloc endoscopic resection. Ablation might be an alternative for flat ESCN, but ESCN extension along the epithelial lining ...
Carbohydrate-dense snacks are a key feature of the nutrition transition among Ghanaian adults – findings from the RODAM study

Assmus, Frauke; Galbete, Cecilia; Knueppel, Sven; Schulze, Matthias B.; Beune, Erik; Meeks, Karlijn; Nicolaou, Mary; Amoah, Stephen; Agyemang, Charles; Klipstein-Grobusch, Kerstin; Bahendeka, Silver; Spranger, Joachim; Mockenhaupt, Frank P.; Smeeth, Liam; Stronks, Karien; Danquah, Ina (2021-05-06)

Background: African populations in sub-Saharan Africa and African migrants in Europe are facing a rapid upsurge in obesity. This trend has been related to urbanization, migration and associated shifts in lifestyle, including ...
Obesity and adiposity of 3- to 6-year-old children born to mothers with hyperglycaemia first detected in pregnancy in an urban South African setting

Soepnel, Larske M; Nicolaou, Veronique; Slater, Christine; Chidumwa, Glory; Levitt, Naomi S; Klipstein-Grobusch, Kerstin; Norris, Shane A (Informa Healthcare, 2021-05)

BACKGROUND: Understanding the association between maternal metabolic conditions in pregnancy and the risk of childhood overweight, a growing concern in sub-Saharan Africa (SSA), helps to identify opportunities for childhood ...

Now showing items 16361-16380 of 40729