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Tailoring cardiopulmonary bypass pump flow and mean arterial pressure to maintain renal oxygenation

Joles, Jaap A (Wiley, 2021-04)
Dietary salt modifies the blood pressure response to renin-angiotensin inhibition in experimental chronic kidney disease

Bovée, Dominique M; Uijl, Estrellita; Severs, David; Rubio-Beltrán, Eloisa; van Veghel, Richard; Maassen van den Brink, Antoinette; Joles, Jaap A; Zietse, Robert; Cuevas, Catherina A; Danser, A H Jan; Hoorn, Ewout J (American Physiological Society, 2021-04)

Chronic kidney disease contributes to hypertension, but the mechanisms are incompletely understood. To address this, we applied the 5/6th nephrectomy rat model to characterize hypertension and the response to dietary salt ...
Fighting Oxidative Stress with Sulfur: Hydrogen Sulfide in the Renal and Cardiovascular Systems

Scammahorn, Joshua J; Nguyen, Isabel T N; Bos, Eelke M; Van Goor, Harry; Joles, Jaap A (Multidisciplinary Digital Publishing Institute (MDPI), 2021-03-02)

Hydrogen sulfide (H2S) is an essential gaseous signaling molecule. Research on its role in physiological and pathophysiological processes has greatly expanded. Endogenous enzymatic production through the transsulfuration ...
Skin microvascular function and renal hemodynamics in overweight patients with type 2 diabetes: A cross-sectional study

Bouman, Emma J; Smits, Mark M; van Bommel, Erik J; Muskiet, Marcel H A; Hesp, Anne C; Serné, Erik H; Joles, Jaap A; van Raalte, Daniël H (Wiley-Blackwell, 2021-08)

Objective: Diabetic kidney disease is a microvascular complication of diabetes. Here, we assessed the association between skin microvascular function and renal hemodynamic function in a cohort of well-phenotyped adults ...
The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes

Sivalingam, Suvanjaa; Larsen, Emil List; van Raalte, Daniel H; Muskiet, Marcel H A; Smits, Mark M; Tonneijck, Lennart; Joles, Jaap A; von Scholten, Bernt Johan; Zobel, Emilie Hein; Persson, Frederik; Henriksen, Trine; Diaz, Lars Jorge; Hansen, Tine W; Poulsen, Henrik Enghusen; Rossing, Peter (Nature Publishing Group, 2021-05-19)

Glucagon-like peptide 1 receptor agonists have shown cardioprotective effects which have been suggested to be mediated through inhibition of oxidative stress. We investigated the effect of treatment with a glucagon-like ...
Simplified Iohexol-Based Method for Measurement of Glomerular Filtration Rate in Goats and Pigs

van Gelder, Maaike K; Stevens, Jasper; Pieters, Tobias T; Vaessen, Koen R D; Joles, Jaap A; Verhaar, Marianne C; Gerritsen, Karin G F (MDPI Multidisciplinary Digital Publishing Institute, 2021-05-23)

The preclinical evaluation of novel therapies for chronic kidney disease requires a simple method for the assessment of kidney function in a uremic large animal model. An intravenous bolus of iohexol was administered to ...
Morning pulmonary artery pressure measurements by CardioMEMS are most stable and recommended for pressure trends monitoring

Crnko, S; Brugts, J J; Veenis, J F; de Jonge, N; Sluijter, J P G; Oerlemans, M I F; van Laake, L W (Bohn Stafleu van Loghum, 2021-07)

Aims: The CardioMEMS HF system is used to measure pulmonary artery (PA) pressures of patients with heart failure (HF). The goal of this study was to determine the impact of time in the daily PA pressure measurements, ...
Intracellular and Extracellular Roles of Granzyme K

Bouwman, Annemieke C.; van Daalen, Kim R.; Crnko, Sandra; ten Broeke, Toine; Bovenschen, Niels (Frontiers Media S. A., 2021-05-04)

Granzymes are a family of serine proteases stored in granules inside cytotoxic cells of the immune system. Granzyme K (GrK) has been only limitedly characterized and knowledge on its molecular functions is emerging. ...
Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine

Grigorian-Shamagian, Lilian; Sanz-Ruiz, Ricardo; Climent, Andreu; Badimon, Lina; Barile, Lucio; Bolli, Roberto; Chamuleau, Steven; Grobbee, Diederick E; Janssens, Stefan; Kastrup, Jens; Kragten-Tabatabaie, Leyla; Madonna, Rosalinda; Mathur, Anthony; Menasché, Philippe; Pompilio, Giulio; Prosper, Felipe; Sena, Emily; Smart, Nicola; Zimmermann, Wolfgram-Hubertus; Fernández-Avilés, Francisco (Oxford University Press, 2021-06-01)

Great expectations have been set around the clinical potential of regenerative and reparative medicine in the treatment of cardiovascular diseases [i.e. in particular, heart failure (HF)]. Initial excitement, spurred by ...
Associations between the built environment and obesity: an umbrella review

Lam, Thao Minh; Vaartjes, Ilonca; Grobbee, Diederick E.; Karssenberg, Derek; Lakerveld, Jeroen (BioMed Central Ltd., 2021-12)

Background: In the past two decades, the built environment emerged as a conceptually important determinant of obesity. As a result, an abundance of studies aiming to link environmental characteristics to weight-related ...
Determinants of food choice and perceptions of supermarket-based nudging interventions among adults with low socioeconomic position: The supreme nudge project

Harbers, Marjolein C.; Middel, Cédric N.H.; Stuber, Josine M.; Beulens, Joline W.J.; Rutters, Femke; van der Schouw, Yvonne T. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-07)

Nudging has received ample attention in scientific literature as an environmental strategy to promote healthy diets, and may be effective for reaching populations with low socioeconomic position (SEP). Therefore, the ...
Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study

EU-GEI WP2 Group (Oxford University Press, 2021-11-01)

Duration of untreated psychosis (DUP) is associated with clinical outcomes in people with a diagnosis of first-episode psychosis (FEP), but factors associated with length of DUP are still poorly understood. Aiming to obtain ...
Emerging Processes Within Peer-Support Hearing Voices Groups: A Qualitative Study in the Dutch Context

Schaefer, Barbara; Boumans, Jenny; van Os, Jim; van Weeghel, Jaap (Frontiers Research Foundation, 2021-04-21)

Purpose/Aims: This study aimed to gain insight into the value of Hearing Voices Groups (HVGs) in the Dutch context. Specifically, we aimed to learn more about the meaning of HVG participation, as well as the aspects that ...
The Independent Effects of Psychosocial Stressors on Subclinical Psychosis: Findings From the Multinational EU-GEI Study

Pignon, Baptiste; Lajnef, Mohamed; Kirkbride, James B; Peyre, Hugo; Ferchiou, Aziz; Richard, Jean-Romain; Baudin, Grégoire; Tosato, Sarah; Jongsma, Hannah; de Haan, Lieuwe; Tarricone, Ilaria; Bernardo, Miguel; Velthorst, Eva; Braca, Mauro; Arango, Celso; Arrojo, Manuel; Bobes, Julio; Del-Ben, Cristina Marta; Di Forti, Marta; Gayer-Anderson, Charlotte; Jones, Peter B; La Cascia, Caterina; Lasalvia, Antonio; Menezes, Paulo Rossi; Quattrone, Diego; Sanjuán, Julio; Selten, Jean-Paul; Tortelli, Andrea; Llorca, Pierre-Michel; van Os, Jim; Rutten, Bart P F; Murray, Robin M; Morgan, Craig; Leboyer, Marion; Szöke, Andrei; Schürhoff, Franck (Oxford University Press, 2021-11-01)

The influence of psychosocial stressors on psychosis risk has usually been studied in isolation and after the onset of the disorder, potentially ignoring important confounding relationships or the fact that some stressors ...
Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: Findings from the EU-GEI High Risk Study

EU-GEI High Risk Study (Cambridge University Press, 2021-05-28)

AIMS: Childhood trauma is associated with an elevated risk for psychosis, but the psychological mechanisms involved remain largely unclear. This study aimed to investigate emotional and psychotic stress reactivity in daily ...
Prevalence and correlates of anxiety and depression in frontline healthcare workers treating people with COVID-19 in Bangladesh

Tasnim, Rafia; Sujan, Md Safaet Hossain; Islam, Md Saiful; Ritu, Asmaul Husna; Siddique, Md Abid Bin; Toma, Tanziha Yeasmin; Nowshin, Rifat; Hasan, Abid; Hossain, Sahadat; Nahar, Shamsun; Islam, Salequl; Islam, Muhammad Sougatul; Potenza, Marc N; van Os, Jim (BioMed Central, 2021-05-25)

BACKGROUND: Healthcare workers (HCWs) who are in the frontline during the COVID-19 pandemic are often under significant pressures that may predispose them to symptoms of poor mental health. This study aimed to investigate ...
Adherence to drinking guidelines and reasons for alcohol consumption cessation in the southern cone of latin America – Findings from the CESCAS study

van de Luitgaarden, Inge A.T.; Gulayin, Pablo E.; Gutierrez, Laura; Calandrelli, Matías; Mores, Nora; Ponzo, Jacqueline; Lanas, Fernando; Schrieks, Ilse C.; Grobbee, Diederick E.; Beulens, Joline W.J.; Irazola, Vilma (Elsevier Science & Technology, 2021-01-04)

Introduction: Alcohol consumption is a risk factor for morbidity and mortality globally. Consumption levels in Southern Latin America are among the highest in the world. Objectives: To describe consumption patterns and ...
Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance

Nicholls, Stephen J.; Lincoff, A. Michael; Bays, Harold E.; Cho, Leslie; Grobbee, Diederick E.; Kastelein, John JP; Libby, Peter; Moriarty, Patrick M.; Plutzky, Jorge; Ray, Kausik K.; Thompson, Paul D.; Sasiela, William; Mason, Denise; McCluskey, Jaclyn; Davey, Deborah; Wolski, Kathy; Nissen, Steven E. (Mosby Inc., 2021-05)

Although statins play a pivotal role in the prevention of atherosclerotic cardiovascular disease, many patients fail to achieve recommended lipid levels due to statin-associated muscle symptoms. Bempedoic acid is an oral ...
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry

EU-AIMS LEAP group (Springer Nature, 2021-05-14)

Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural ...
Relationship between social cognition, general cognition, and risk for suicide in individuals with a psychotic disorder

Dickhoff, Justine; Opmeer, Esther Marije; Heering, Henriette Dorotheé; Bruggeman, Richard; van Amelsvoort, Therese; Bartels-Velthuis, Agna A.; Cahn, Wiepke; de Haan, Lieuwe; Schirmbeck, Frederike; Simons, Claudia J.P.; van Os, Jim; Aleman, André; van Tol, Marie José (Elsevier, 2021-05)

OBJECTIVE: Cognitive alterations putatively contribute to the risk for suicide in individuals with psychosis. Yet, a comprehensive assessment of social- and general-cognitive abilities in a large sample is lacking. METHODS: ...

Now showing items 16221-16240 of 40729