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UMC Repository: Recent submissions

  • Comparing methods of detecting and segmenting unruptured intracranial aneurysms on TOF-MRAS: The ADAM challenge 
    Timmins, Kimberley; van der Schaaf, Irene; Bennink, E; Ruigrok, Ynte; Velthuis, BK; Kuijf, Hugo (Academic Press Inc., 2021-09)
    Accurate detection and quantification of unruptured intracranial aneurysms (UIAs) is important for rupture risk assessment and to allow an informed treatment decision to be made. Currently, 2D manual measures used to assess ...
  • Disruption of RFX family transcription factors causes autism, attention-deficit/hyperactivity disorder, intellectual disability, and dysregulated behavior 
    Harris, Holly K; Nakayama, Tojo; Lai, Jenny; Zhao, Boxun; Argyrou, Nikoleta; Gubbels, Cynthia S; Soucy, Aubrie; Genetti, Casie A; Suslovitch, Victoria; Rodan, Lance H; Tiller, George E; Lesca, Gaetan; Gripp, Karen W; Asadollahi, Reza; Hamosh, Ada; Applegate, Carolyn D; Turnpenny, Peter D; Simon, Marleen E H; Volker-Touw, Catharina M L; Gassen, Koen L I van; Binsbergen, Ellen van; Pfundt, Rolph; Gardeitchik, Thatjana; Vries, Bert B A de; Immken, LaDonna L; Buchanan, Catherine; Willing, Marcia; Toler, Tomi L; Fassi, Emily; Baker, Laura; Vansenne, Fleur; Wang, Xiadong; Ambrus, Julian L; Fannemel, Madeleine; Posey, Jennifer E; Agolini, Emanuele; Novelli, Antonio; Rauch, Anita; Boonsawat, Paranchai; Fagerberg, Christina R; Larsen, Martin J; Kibaek, Maria; Labalme, Audrey; Poisson, Alice; Payne, Katelyn K; Walsh, Laurence E; Aldinger, Kimberly A; Balciuniene, Jorune; Skraban, Cara; Gray, Christopher; Murrell, Jill; Bupp, Caleb P; Pascolini, Giulia; Grammatico, Paola; Broly, Martin; Küry, Sébastien; Nizon, Mathilde; Rasool, Iqra Ghulam; Zahoor, Muhammad Yasir; Kraus, Cornelia; Reis, André; Iqbal, Muhammad; Uguen, Kevin; Audebert-Bellanger, Severine; Ferec, Claude; Redon, Sylvia; Baker, Janice; Wu, Yunhong; Zampino, Guiseppe; Syrbe, Steffan; Brosse, Ines; Jamra, Rami Abou; Dobyns, William B; Cohen, Lilian L; Blomhoff, Anne; Mignot, Cyril; Keren, Boris; Courtin, Thomas; Agrawal, Pankaj B; Beggs, Alan H; Yu, Timothy W (Lippincott Williams & Wilkins, 2021-06)
    PURPOSE: We describe a novel neurobehavioral phenotype of autism spectrum disorder (ASD), intellectual disability, and/or attention-deficit/hyperactivity disorder (ADHD) associated with de novo or inherited deleterious ...
  • Childhood trauma is associated with reduced frontal gray matter volume: a large transdiagnostic structural MRI study 
    Begemann, Marieke J H; Schutte, Maya J L; van Dellen, Edwin; Abramovic, Lucija; Boks, Marco P; van Haren, Neeltje E M; Mandl, Rene C W; Vinkers, Christiaan H; Bohlken, Marc M; Sommer, Iris E C (Cambridge University Press, 2023-02-03)
    BACKGROUND: Childhood trauma increases risk for psychopathology and cognitive impairment. Prior research mainly focused on the hippocampus and amygdala in single diagnostic categories. However, other brain regions may be ...
  • Preoperative serum ADAM12 levels as a stromal marker for overall survival and benefit of adjuvant therapy in patients with resected pancreatic and periampullary cancer 
    Dutch Pancreatic Cancer Group (John Wiley & Sons Inc., 2021-12)
    BACKGROUND: We evaluated the stroma marker A Disintegrin And Metalloprotease 12 (ADAM12) as a preoperative prognostic and treatment-predictive marker for overall survival (OS) in pancreatic ductal adenocarcinoma (PDAC) and ...
  • Predicting overall survival and resection in patients with locally advanced pancreatic cancer treated with FOLFIRINOX: Development and internal validation of two nomograms 
    Dutch Pancreatic Cancer Group (Wiley-Liss Inc., 2021-09-15)
    BACKGROUND AND OBJECTIVES: Patients with locally advanced pancreatic cancer (LAPC) are increasingly treated with FOLFIRINOX, resulting in improved survival and resection of tumors that were initially unresectable. It remains ...
  • Nitrofurantoin 100 mg versus 50 mg prophylaxis for urinary tract infections, a cohort study 
    Ten Doesschate, Thijs; Hendriks, Kelly; van Werkhoven, Cornelis H; van der Hout, Evelien C; Platteel, Tamara N; Groenewegen, Irene A M; Muller, Anouk E; Hoepelman, Andy I M; Bonten, Marc J M; Geerlings, Suzanne E (Elsevier, 2022-02)
    OBJECTIVES: Guidelines do not distinguish between 50 mg or 100 mg nitrofurantoin as daily prophylaxis for recurrent urinary tract infection (UTI), although 50 mg might have a better safety profile. Our objective was to ...
  • Allogeneic Stem Cell Transplantation Platforms with Ex Vivo and in Vivo Immune Manipulations: Count and Adjust 
    de Witte, Moniek; Daenen, Laura G M; van der Wagen, Lotte; van Rhenen, Anna; Raymakers, Reiner; Westinga, Kasper; Kuball, Jürgen (Wolters Kluwer Health, 2021-06)
    Various allogeneic (allo) stem cell transplantation platforms have been developed over the last 2 decades. In this review we focus on the impact of in vivo and ex vivo graft manipulation on immune reconstitution and clinical ...
  • Chromosomal copy number heterogeneity predicts survival rates across cancers 
    van Dijk, Erik; van den Bosch, Tom; Lenos, Kristiaan J; El Makrini, Khalid; Nijman, Lisanne E; van Essen, Hendrik F B; Lansu, Nico; Boekhout, Michiel; Hageman, Joris H; Fitzgerald, Rebecca C; Punt, Cornelis J A; Tuynman, Jurriaan B; Snippert, Hugo J G; Kops, Geert J P L; Medema, Jan Paul; Ylstra, Bauke; Vermeulen, Louis; Miedema, Daniël M (Nature Publishing Group, 2021-12)
    Survival rates of cancer patients vary widely within and between malignancies. While genetic aberrations are at the root of all cancers, individual genomic features cannot explain these distinct disease outcomes. In contrast, ...
  • ABCDEF Bundle and Supportive ICU Practices for Patients With Coronavirus Disease 2019 Infection: An International Point Prevalence Study 
    Liu, Keibun; Nakamura, Kensuke; Katsukawa, Hajime; Elhadi, Muhammed; Nydahl, Peter; Ely, Eugene Wesley; Kudchadkar, Sapna R; Takahashi, Kunihiko; Inoue, Shigeaki; Lefor, Alan Kawarai; Kesecioglu, Jozef; Nishida, Osamu (Lippincott Williams & Wilkins, 2021-03)
    Objectives: To investigate implementation of evidence-based and supportive cares in ICUs, such as the ABCDEF, nutrition therapy, and ICU diary, for patients with coronavirus disease 2019 infection in ICUs and their association ...
  • Diversity and inclusivity: the way to multidisciplinary intensive care medicine in Europe 
    European Society of Intensive Care Medicine (Springer-Verlag, 2021-05)
  • Ionized and not total magnesium as a discriminating biomarker for hypomagnesaemia in continuous venovenous haemofiltration patients 
    Hutten, Tim J.A.; Sikma, Maaike A.; Stokwielder, Ron H.; Wesseling, Marjon; Hoefer, Imo E.; Tiel Groenestege, Wouter M. (Oxford University Press, 2021-04)
  • Developing Entrustable Professional Activities for the Training of Translational Scientists: A Modified Delphi Study 
    Weggemans, Margot M; Ter Haar, Nienke M; Prakken, Berent; Ten Cate, Olle (Wolters Kluwer, 2021-10-01)
    Purpose Improved training for translational scientists is important to help address the waste of resources and irreproducibility of research outcomes in current translational medicine. However, there are a lack of training ...
  • Added value of subjective assessed functional capacity before non-cardiac surgery in predicting postoperative myocardial injury 
    Marsman, Marije; van Waes, Judith A R; Grobben, Remco B; Weersink, Corien S A; van Klei, Wilton A (Oxford University Press, 2021-03)
    Background: Functional capacity is used as an indicator for cardiac testing before non-cardiac surgery and is often performed subjectively. However, the value of subjectively estimated functional capacity in predicting ...
  • Propensity score-based analysis of long-term outcome of patients on HeartWare and HeartMate 3 left ventricular assist device support 
    Numan, Lieke; Ramjankhan, Faiz Z.; Oberski, Daniel L.; Oerlemans, Martinus I.F.J.; Aarts, Emmeke; Gianoli, Monica; Van Der Heijden, Joris J.; De Jonge, Nicolaas; Van Der Kaaij, Niels P.; Meuwese, Christiaan L.; Mokhles, Mostafa M.; Oppelaar, Anne Marie; De Waal, Eric E.C.; Asselbergs, Folkert W.; Van Laake, Linda W. (John Wiley & Sons Inc., 2021-04)
    Aims: Left ventricular assist device therapy has become the cornerstone in the treatment of end-stage heart failure and is increasingly used as destination therapy next to bridge to transplant or recovery. HeartMate 3 (HM3) ...
  • Genome-wide DNA methylation analysis on C-reactive protein among Ghanaians suggests molecular links to the emerging risk of cardiovascular diseases 
    Chilunga, Felix P; Henneman, Peter; Venema, Andrea; Meeks, Karlijn A C; Requena-Méndez, Ana; Beune, Erik; Mockenhaupt, Frank P; Smeeth, Liam; Bahendeka, Silver; Danquah, Ina; Klipstein-Grobusch, Kerstin; Adeyemo, Adebowale; Mannens, Marcel M A M; Agyemang, Charles (Nature Publishing Group, 2021-06-11)
    Molecular mechanisms at the intersection of inflammation and cardiovascular diseases (CVD) among Africans are still unknown. We performed an epigenome-wide association study to identify loci associated with serum C-reactive ...
  • Handen wassen, handschoenen en mondkapjes op de OK: Eens omstreden, nu routine 
    van Gulik, Thomas M.; de Ridder, Victor (Bohn Stafleu van Loghum, 2021-05-21)
    Handen wassen vóór en het dragen van handschoenen en mondkapjes tijdens operaties werden in de tweede helft van de 19e eeuw ingevoerd in het kader van antisepsis en asepsis. Het doel van deze maatregelen was om besmetting ...
  • Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics 
    Dona, Margo; Waaijers, Selma; Richter, Susan; Eisenhofer, Graeme; Korving, Jeroen; Kamel, Sarah M.; Bakkers, Jeroen; Rapizzi, Elena; Rodenburg, Richard J.; Zethof, Jan; Gorissen, Marnix; Flik, Gert; Deen, Peter M.T.; Timmers, Henri J.L.M. (BioScientifica Ltd., 2021-01)
    Pheochromocytomas and paragangliomas (PPGLs) caused by mutations in the B-subunit of the succinate dehydrogenase (SDHB) have the highest metastatic rate among PPGLs, and effective systemic therapy is lacking. To unravel ...
  • Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients 
    Takada, Toshihiko; Damen, Johanna A.A.G.; Tambas, Makbule; Spijker, René; Steenbakkers, Roel J.H.M.; Sharabiani, Marjan; Clementel, Enrico; Langendijk, Johannes A.; Moons, Karel G.M.; Schuit, Ewoud (John Wiley & Sons Inc., 2021-05-17)
    Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. Primary objective The review question is “Which prognostic models are available to predict the risk of radiation-induced ...
  • Chromosomal instability by mutations in the novel minor spliceosome component CENATAC 
    de Wolf, Bas; Oghabian, Ali; Akinyi, Maureen V.; Hanks, Sandra; Tromer, Eelco C.; van Hooff, Jolien J.E.; van Voorthuijsen, Lisa; van Rooijen, Laura E.; Verbeeren, Jens; Uijttewaal, Esther C.H.; Baltissen, Marijke P.A.; Yost, Shawn; Piloquet, Philippe; Vermeulen, Michiel; Snel, Berend; Isidor, Bertrand; Rahman, Nazneen; Frilander, Mikko J.; Kops, Geert J.P.L. (Springer Science and Business Media Deutschland GmbH, 2021-07-15)
    Aneuploidy is the leading cause of miscarriage and congenital birth defects, and a hallmark of cancer. Despite this strong association with human disease, the genetic causes of aneuploidy remain largely unknown. Through ...
  • The Organoid Cell Atlas 
    the Human Cell Atlas ‘Biological Network’ Organoids (Nature Research, 2021-01)