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De jeugd heeft de toekomst?: Over armoede, hersenontwikkeling en psychiatrie

Zinkstok, Janneke R. (Uitgeverij Boom, 2021-05)
Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group

Rossetti, Maria Gloria; Mackey, Scott; Patalay, Praveetha; Allen, Nicholas B.; Batalla, Albert; Bellani, Marcella; Chye, Yann; Conrod, Patricia; Cousijn, Janna; Garavan, Hugh; Goudriaan, Anna E.; Hester, Robert; Martin-Santos, Rocio; Solowij, Nadia; Suo, Chao; Thompson, Paul M.; Yücel, Murat; Brambilla, Paolo; Lorenzetti, Valentina (Nature Publishing Group, 2021-06)

Males and females show different patterns of cannabis use and related psychosocial outcomes. However, the neuroanatomical substrates underlying such differences are poorly understood. The aim of this study was to map sex ...
Extracellular vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain

Dekker, Mirthe; Waissi, Farahnaz; Van Bennekom, Joelle; Silvis, Max J.M.; Timmerman, Nathalie; Schoneveld, Arjan H.; Grobbee, Diederick E.; De Winter, Robbert J.; Mosterd, Arend; Timmers, Leo; De Kleijn, Dominique P.V. (Public Library of Science, 2020-08-05)

Background Despite the use of high-sensitive cardiac troponin there remains a group of high-sensitive cardiac troponin negative patients with unstable angina with a non-neglectable risk for future adverse cardiovascular ...
Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19

Janssen, Nico A.F.; Grondman, Inge; de Nooijer, Aline H.; Boahen, Collins K.; Koeken, Valerie A.C.M.; Matzaraki, Vasiliki; Kumar, Vinod; He, Xuehui; Kox, Matthijs; Koenen, Hans J.P.M.; Smeets, Ruben L.; Joosten, Irma; Brüggemann, Roger J.M.; Kouijzer, Ilse J.E.; van der Hoeven, Hans G.; Schouten, Jeroen A.; Frenzel, Tim; Reijers, Monique H.E.; Hoefsloot, Wouter; Dofferhoff, Anton S.M.; van Apeldoorn, Marjan J.; Blaauw, Marc J.T.; Veerman, Karin; Maas, Coen; Schoneveld, Arjan H.; Hoefer, Imo E.; Derde, Lennie P.G.; van Deuren, Marcel; van der Meer, Jos W.M.; van Crevel, Reinout; Giamarellos-Bourboulis, Evangelos J.; Joosten, Leo A.B.; van den Heuvel, Michel M.; Hoogerwerf, Jacobien; de Mast, Quirijn; Pickkers, Peter; Netea, Mihai G.; van de Veerdonk, Frank L. (Oxford University Press, 2021-04-23)

The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive proinflammatory immune ...
Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial

Ferris, Robert L; Spanos, William C; Leidner, Rom; Gonçalves, Anthony; Martens, Uwe M; Kyi, Chrisann; Sharfman, William; Chung, Christine H; Devriese, Lot A; Gauthier, Helene; Chiosea, Simon I; Vujanovic, Lazar; Taube, Janis M; Stein, Julie E; Li, Jun; Li, Bin; Chen, Tian; Barrows, Adam; Topalian, Suzanne L (BioMed Central Ltd., 2021-06)

Background Head and neck squamous cell carcinomas (HNSCCs) are common malignancies caused by carcinogens, including tobacco and alcohol, or infection with human papillomavirus (HPV). Immune checkpoint inhibitors targeting ...
Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma: A Systematic Review

de Kort, W. W.B.; Spelier, S.; Devriese, L. A.; van Es, R. J.J.; Willems, S. M. (Adis, 2021-03)

Background: Understanding molecular pathogenesis of head and neck squamous cell carcinomas (HNSCC) has considerably improved in the last decades. As a result, novel therapeutic strategies have evolved, amongst which are ...
Toxicity, response and survival in older patients with metastatic melanoma treated with checkpoint inhibitors†

de Glas, Nienke A.; Bastiaannet, Esther; van den Bos, Frederiek; Mooijaart, Simon P.; van der Veldt, Astrid A.M.; Suijkerbuijk, Karlijn P.M.; Aarts, Maureen J.B.; van den Berkmortel, Franchette W.P.J.; Blank, Christian U.; Boers-Sonderen, Marye J.; van den Eertwegh, Alfonsus J.M.; de Groot, Jan Willem B.; Haanen, John B.A.G.; Hospers, Geke A.P.; Jalving, Hilde; Piersma, Djura; van Rijn, Rozemarijn S.; Ten Tije, Albert J.; Vreugdenhil, Gerard; Wouters, Michel W.J.M.; Portielje, Johanneke E.A.; Kapiteijn, Ellen W. (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-01)

Background: Previous trials suggest no differences in immunotherapy treatment between older and younger patients, but mainly young patients with a good performance status were included. The aim of this study was to describe ...
Internet and smartphone-based ecological momentary assessment and personalized advice (PROfeel) in adolescents with chronic conditions: A feasibility study

Nap-van der Vlist, Merel M.; Houtveen, Jan; Dalmeijer, Geertje W.; Grootenhuis, Martha A.; van der Ent, Cornelis K.; van Grotel, Martine; Swart, Joost F.; van Montfrans, Joris M.; van de Putte, Elise M.; Nijhof, Sanne L. (Elsevier, 2021-09)

Objective: Growing up with a chronic disease comes with challenges, such as coping with fatigue. Many adolescents are severely fatigued, though its associated factors exhibit considerable interpersonal and longitudinal ...
Daily life participation in childhood chronic disease: A qualitative study on the child's and parent's perspective

Nap-Van Der Vlist, Merel M.; Berkelbach Van Der Sprenkel, Emma E.; Nijhof, Linde N.; Grootenhuis, Martha A.; Van Der Ent, Cornelis K.; Swart, Joost F.; Van Royen-Kerkhof, Annet; Van Grotel, Martine; Van De Putte, Elise M.; Nijhof, Sanne L.; Kars, Marijke C. (BMJ Publishing Group, 2021-05-18)

Objective To understand how a child with a stable chronic disease and his/her parents shape his/her daily life participation, we assessed: (1) the parents' goals regarding the child's daily life participation, (2) parental ...
Role of parents in fatigue of children with a chronic disease: A cross-sectional study

Kramer, Niels; Nijhof, Sanne L.; Van De Putte, Elise M.; Ketelaar, Marjolijn; Grootenhuis, Martha A.; Van Der Ent, Kors; Swart, Joost F.; Van Grotel, Martine; Dalmeijer, Geertje W.; Nap-Van Der Vlist, Merel M. (BMJ Publishing Group, 2021-05-21)

Objective As parents majorly impact their child's well-being, and as fatigue is a highly prevalent threat to the well-being of children with a chronic disease, we aimed to explore the association between parental factors ...
A scoping review of practice recommendations for clinicians' communication of uncertainty

Medendorp, Niki M; Stiggelbout, Anne M; Aalfs, Cora M; Han, Paul K J; Smets, Ellen M A; Hillen, Marij A (Wiley-Blackwell, 2021-08)

BACKGROUND: Health-care providers increasingly have to discuss uncertainty with patients. Awareness of uncertainty can affect patients variably, depending on how it is communicated. To date, no overview existed for health-care ...
TNF inhibition for immune checkpoint inhibitor-induced irAEs: the jury is still out

Suijkerbuijk, Karijn P M; Verheijden, Rik J (Nature Research, 2021-08)
The Systemic Immune Response in COVID-19 Is Associated with a Shift to Formyl-Peptide Unresponsive Eosinophils

Koenderman, Leo; Siemers, Maarten J; van Aalst, Corneli; Bongers, Suzanne H; Spijkerman, Roy; Bindels, Bas J J; Giustarini, Giulio; van Goor, Harriët M R; Kaasjager, Karin A H; Vrisekoop, Nienke (Multidisciplinary Digital Publishing Institute (MDPI), 2021-05-05)

A malfunction of the innate immune response in COVID-19 is associated with eosinopenia, particularly in more severe cases. This study tested the hypothesis that this eosinopenia is COVID-19 specific and is associated with ...
Outcomes for systemic therapy in older patients with metastatic melanoma: Results from the Dutch Melanoma Treatment Registry

Jochems, Anouk; Bastiaannet, Esther; Aarts, Maureen J B; van Akkooi, Alexander C J; van den Berkmortel, Franchette W P J; Boers-Sonderen, Marye J; van den Eertwegh, Alfonsus J M; de Glas, Nienke G; de Groot, Jan Willem B; Haanen, John B A G; Hospers, Geke A P; van der Hoeven, Jacobus J M; Piersma, Djura; van Rijn, Rozemarijn S; Suijkerbuijk, Karijn P M; Ten Tije, Albert J; van der Veldt, Astrid A M; Vreugdenhil, Gerard; van Zeijl, Michiel C T; Kapiteijn, Ellen; Wouters, Michel W J M (Elsevier, 2021-09)

Background: The incidence of metastatic melanoma is increasing in all ages. Multiple trials with targeted drugs and immune checkpoint inhibitors showed improved survival in metastatic melanoma. However, patients aged ≥75 ...
Nationwide epidemiological approach to identify associations between keratoconus and immune-mediated diseases

Claessens, Janneau L J; Godefrooij, Daniel A; Vink, Gerko; Frank, Laurence E; Wisse, Robert P L (BMJ Publishing Group, 2022-10)

BACKGROUND: The aetiology of keratoconus (KC) remains poorly understood. KC has typically been described as a non-inflammatory disorder of the cornea. Nonetheless, there is increasing presumptive evidence for the role of ...
Long Term Survival and Limb Salvage in Patients With Non-Revascularisable Chronic Limb Threatening Ischaemia

Verwer, Maarten C; Wijnand, Joep G J; Teraa, Martin; Verhaar, Marianne C; de Borst, Gert J (W.B. Saunders Ltd, 2021-08)

OBJECTIVE: The aim of this study was to provide long term survival and limb salvage rates for patients with non-revascularisable (NR) chronic limb threatening ischaemia (CLTI). METHODS: This was a retrospective review of ...
Rationale and design of the OPTIMIZE trial: OPen label multicenter randomized trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen In combination with everolimus in de novo renal transplantation in Elderly patients

de Boer, S E; Sanders, J S F; Bemelman, F J; Betjes, M G H; Burgerhof, J G M; Hilbrands, L; Kuypers, D; van Munster, B C; Nurmohamed, S A; de Vries, A P J; van Zuilen, A D; Hesselink, D A; Berger, S P (BioMed Central, 2021-06-02)

Background: In 2019, more than 30 % of all newly transplanted kidney transplant recipients in The Netherlands were above 65 years of age. Elderly patients are less prone to rejection, and death censored graft loss is less ...
Familial Occurrence of Adult Granulosa Cell Tumors: Analysis of Whole-Genome Germline Variants

Roze, Joline F; Kutzera, Joachim; Koole, Wouter; Ausems, Margreet G E M; Engelstad, Kristi; Piek, Jurgen M J; de Kroon, Cor D; Verheijen, René H M; van Haaften, Gijs; Zweemer, Ronald P; Monroe, Glen R (Multidisciplinary Digital Publishing Institute (MDPI), 2021-05-02)

Adult granulosa cell tumor (AGCT) is a rare ovarian cancer subtype, with a peak incidence around 50-55 years. Although AGCT can occur in specific syndromes, a genetic predisposition for AGCT has not been identified. The ...
Environmental factors associated with participation and its related concepts among children and youth with cerebral palsy: a rapid review

van der Kemp, Jet; Ketelaar, Marjolijn; Gorter, Jan Willem (Informa Healthcare, 2022-05)

PURPOSE: To provide an overview of environmental factors associated with participation and participation-related constructs in children and youth with cerebral palsy (CP). METHODS: A rapid review following the principles ...
Outcome and Predictors for Mortality in Patients with Cardiogenic Shock: A Dutch Nationwide Registry-Based Study of 75,407 Patients with Acute Coronary Syndrome Treated by PCI

Karami, Mina; Peters, Elma J; Lagrand, Wim K; Houterman, Saskia; den Uil, Corstiaan A; Engström, Annemarie E; Otterspoor, Luuk C; Ottevanger, Jan Paul; Ferreira, Irlando A; Montero-Cabezas, Jose M; Sjauw, Krischan; van Ramshorst, Jan; Kraaijeveld, Adriaan O; Verouden, Niels J W; Lipsic, Erik; Vlaar, Alexander P; Henriques, Jose P S; On Behalf Of The Pci Registration Committee Of The Netherlands Heart Registration (Multidisciplinary Digital Publishing Institute (MDPI), 2021-05-11)

It is important to gain more insight into the cardiogenic shock (CS) population, as currently, little is known on how to improve outcomes. Therefore, we assessed clinical outcome in acute coronary syndrome (ACS) patients ...

Now showing items 16241-16260 of 40729