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UMC Repository: Recent submissions

  • 75-plussers met een doodswens zonder dat ze ernstig ziek zijn 
    Zomers, Margot; van Thiel, Ghislaine; Hartog, Iris; Van Den Berg, Vera; Leget, Carlo; Sachs, Alfred; Uiterwaal, Cuno; van Wijngaarden, Els (Bohn Stafleu van Loghum, 2021-06-03)
    OBJECTIVE: To provide insight into the prevalence of persistent death wishes without being severely ill among Dutch older persons aged 75 and above; to describe the characteristics and circumstances of this group; to improve ...
  • Information technology aspects of large-scale implementation of automated surveillance of healthcare-associated infections 
    PRAISE network (Elsevier, 2021-07-01)
    INTRODUCTION: Healthcare-associated infections (HAI) are a major public health concern. Monitoring of HAI rates, with feedback, is a core component of infection prevention and control programmes. Digitalization of healthcare ...
  • Ultrasound measurements of brain structures differ between moderate-late preterm and full-term infants at term equivalent age 
    Boswinkel, Vivian; Sok, Femke I.; Krüse-Ruijter, Martine F.; Nijholt, Ingrid M.; Jansen, Fenna A.R.; Haak, Monique C.; Boomsma, Martijn F.; de Vries, Linda S.; Steggerda, Sylke J.; van Wezel-Meijler, Gerda (Elsevier Ireland Ltd, 2021-09)
    Background: Brain growth in moderate preterm (MP; gestational age (GA) 32+0–33+6 weeks) and late preterm infants (LP; GA 34+0–36+6 weeks) may be impaired, even in the absence of brain injury. Aims: The aims of this study ...
  • Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning - The Medea-7T study 
    Zwartbol, Maarten Ht; Rissanen, Ina; Ghaznawi, Rashid; de Bresser, Jeroen; Kuijf, Hugo J; Blom, Kim; Witkamp, Theo D; Koek, Huiberdina L; Biessels, Geert Jan; Hendrikse, Jeroen; Geerlings, Mirjam I (SAGE Publications Inc., 2021-11-01)
    We determined the occurrence and association of cortical cerebral microinfarcts (CMIs) at 7 T MRI with risk factors, neuroimaging markers of small and large vessel disease, and cognitive functioning. Within the Medea-7T ...
  • Association of Ischemic Imaging Phenotype With Progression of Brain Atrophy and Cerebrovascular Lesions on MRI: The SMART-MR Study 
    Rissanen, Ina; Lucci, Carlo; Ghaznawi, Rashid; Hendrikse, Jeroen; Kappelle, L. Jaap; Geerlings, Mirjam I.; UCC-SMART Study Group (Lippincott Williams & Wilkins, 2021-09-14)
    BACKGROUND AND OBJECTIVE: To investigate the association of silent vascular lesions, imaging negative ischemia, and symptomatic cerebrovascular disease with long-term progression of brain atrophy and cerebrovascular lesions ...
  • Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy 
    Zimmer, Till S; David, Bastian; Broekaart, Diede W M; Schidlowski, Martin; Ruffolo, Gabriele; Korotkov, Anatoly; van der Wel, Nicole N; van Rijen, Peter C; Mühlebner, Angelika; van Hecke, Wim; Baayen, Johannes C; Idema, Sander; François, Liesbeth; van Eyll, Jonathan; Dedeurwaerdere, Stefanie; Kessels, Helmut W; Surges, Rainer; Rüber, Theodor; Gorter, Jan A; Mills, James D; van Vliet, Erwin A; Aronica, Eleonora (Springer, 2021-10)
    Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in ...
  • Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors 
    Beekhof, Gerrit Cornelis; Osório, Catarina; White, Joshua J; van Zoomeren, Scott; van der Stok, Hannah; Xiong, Bilian; Nettersheim, Ingo Hms; Mak, Willem Ashwin; Runge, Marit; Fiocchi, Francesca Romana; Boele, Henk-Jan; Hoebeek, Freek E; Schonewille, Martijn (eLife Sciences Publications, 2021-05-11)
    Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ...
  • Protein phosphatase 2b dual function facilitates synaptic integrity and motor learning 
    Lin, Zhanmin; Wu, Bin; Paul, Maarten W; Li, Ka Wan; Yao, Yao; Smal, Ihor; Proietti Onori, Martina; Hasanbegovic, Hana; Bezstarosti, Karel; Demmers, Jeroen; Houtsmuller, Adriaan B; Meijering, Erik; Hoebeek, Freek E; Schonewille, Martijn; Smit, August B; Gao, Zhenyu; De Zeeuw, Chris I (Society for Neuroscience, 2021-06-30)
    Protein phosphatase 2B (PP2B) is critical for synaptic plasticity and learning, but the molecular mechanisms involved remain unclear. Here we identified different types of proteins that interact with PP2B, including various ...
  • Single-pulse stimulation of cerebellar nuclei stops epileptic thalamic activity 
    Eelkman Rooda, Oscar H J; Kros, Lieke; Faneyte, Sade J; Holland, Peter J; Gornati, Simona V; Poelman, Huub J; Jansen, Nico A; Tolner, Else A; van den Maagdenberg, Arn M J M; De Zeeuw, Chris I; Hoebeek, Freek E (Elsevier, 2021-07-01)
    BACKGROUND: Epileptic (absence) seizures in the cerebral cortex can be stopped by pharmacological and optogenetic stimulation of the cerebellar nuclei (CN) neurons that innervate the thalamus. However, it is unclear how ...
  • Hofbauer cells and COVID-19 in pregnancy: Molecular pathology analysis of villous macrophages, endothelial cells, and placental findings from 22 placentas infected by SARS-CoV-2 with and without fetal transmission 
    Schwartz, David A; Baldewijns, Marcella; Benachi, Alexandra; Bugatti, Mattia; Bulfamante, Gaetano; Cheng, Ke; Collins, Rebecca R J; Debelenko, Larisa; De Luca, Danièle; Facchetti, Fabio; Fitzgerald, Brendan; Levitan, Daniel; Linn, Rebecca L; Marcelis, Lukas; Morotti, Denise; Morotti, Raffaella; Patanè, Luisa; Prevot, Sophie; Pulinx, Bianca; Saad, Ali G; Schoenmakers, Sam; Strybol, David; Thomas, Kristen; Tosi, Delfina; Toto, Valentina; van der Meeren, Lotte E; Verdijk, Robert M; Vivanti, Alexandre J; Zaigham, Mehreen (College of American Pathologists, 2021-11-01)
    Context.-SARS-CoV-2 can undergo maternal-fetal transmission, heightening interest in the placental pathology findings from this infection. Transplacental SARS-CoV-2 transmission is typically accompanied by chronic histiocytic ...
  • Rationale and design of the PHOspholamban RElated CArdiomyopathy intervention STudy (i-PHORECAST) 
    te Rijdt, W. P.; Hoorntje, E. T.; de Brouwer, R.; Oomen, A.; Amin, A.; van der Heijden, J. F.; Karper, J. C.; Westenbrink, B. D.; Silljé, H. H.W.; te Riele, A. S.J.M.; Wiesfeld, A. C.P.; van Gelder, I. C.; Willems, T. P.; van der Zwaag, P. A.; van Tintelen, J. P.; Hillege, J. H.; Tan, H. L.; van Veldhuisen, D. J.; Asselbergs, F. W.; de Boer, R. A.; Wilde, A. A.M.; van den Berg, M. P. (Bohn Stafleu van Loghum, 2022-02)
    BACKGROUND: The p.Arg14del (c.40_42delAGA) phospholamban (PLN) pathogenic variant is a founder mutation that causes dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM). Carriers are at increased risk of ...
  • Switching TNFα inhibitors: Patterns and determinants 
    Meijboom, Rosanne W; Gardarsdottir, Helga; Becker, Matthijs L; de Groot, Mark C H; Movig, Kris L L; Kuijvenhoven, Johan; Egberts, Toine C G; Leufkens, Hubert G M; Giezen, Thijs J (Wiley-Blackwell Publishing Ltd, 2021-08)
    The aim of this study was to assess switching patterns and determinants for switching in patients initiating TNFα inhibitor (TNFα-i) treatment. Patients were included who started TNFα-i treatment between July 1, 2012 and ...
  • Doxorubicin-induced cardiomyopathy: TERT gets to the heart of the matter 
    De Geest, Bart; Mishra, Mudit (Cell Press, 2021-04-07)
  • Outcomes linked to eligibility for stem cell transplantation trials in diffuse cutaneous systemic sclerosis 
    Spierings, Julia; Nihtyanova, Svetlana I; Derrett-Smith, Emma; Clark, Kristina E N; van Laar, Jacob M; Ong, Voon; Denton, Christopher P (Oxford University Press, 2022-05)
    OBJECTIVES: The aim of this study was to explore outcomes in a cohort of dcSSc patients fulfilling eligibility criteria for stem cell transplantation (SCT) studies but receiving standard immunosuppression. METHODS: From a ...
  • Systemic and local evidence for complement involvement in chronic spontaneous urticaria 
    Alizadeh Aghdam, Mehran; van den Elzen, Mignon; van Os-Medendorp, Harmieke; van Dijk, Marijke R; Knol, Edward F; Knulst, André C; Röckmann, Heike; Otten, Henny G (BioMed Central, 2021-07)
    Background: The pathogenesis of chronic spontaneous urticaria (CSU), including the mechanism of action of omalizumab, remain unclear. We hypothesized complement system involvement given the often fast clinical response ...
  • Management of comfort and sedation in neonates with neonatal encephalopathy treated with therapeutic hypothermia 
    Newborn Brain Society Guidelines and Publications Committee (W.B. Saunders Ltd, 2021-08)
    Ensuring comfort for neonates undergoing therapeutic hypothermia (TH) after neonatal encephalopathy (NE) exemplifies a vital facet of neonatal neurocritical care. Physiologic markers of stress are frequently present in ...
  • Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts 
    Trzcionkowska, Kasia; Groenendaal, Floris; Andriessen, Peter; Dijk, Peter H; van den Dungen, Frank A M; van Hillegersberg, Jacqueline L; Koole, Sanne; Kornelisse, René F; van Westering-Kroon, Elke; von Lindern, Jeanette S; Meijssen, Clemens B; Schuerman, Frank A B A; Steiner, Katerina; van Tuyl, Minke W G; Witlox, Ruben S G M; Schalij-Delfos, Nicoline E; Termote, Jacqueline U M (S. Karger AG, 2021-08-01)
    INTRODUCTION: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants ...
  • A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial 
    Lansky, Alexandra J; Makkar, Rajendra; Nazif, Tamim; Messé, Steven; Forrest, John; Sharma, Rahul; Schofer, Joachim; Linke, Axel; Brown, David; Dhoble, Abhijeet; Horwitz, Phillip; Zang, Ming; DeMarco, Frederico; Rajagopal, Vivek; Dwyer, Michael G; Zivadinov, Robert; Stella, Pieter; Rovin, Joshua; Parise, Helen; Kodali, Susheel; Baumbach, Andreas; Moses, Jeffrey (Oxford University Press, 2021-07-14)
    Aims: The REFLECT I trial investigated the safety and effectiveness of the TriGuard™ HDH (TG) cerebral embolic deflection device in patients undergoing transcatheter aortic valve replacement (TAVR). Methods and results: ...
  • Impact of anemia on short-term outcomes after TAVR: A subgroup analysis from the BRAVO-3 randomized trial 
    Razuk, Victor; Camaj, Anton; Cao, Davide; Nicolas, Johny; Hengstenberg, Christian; Sartori, Samantha; Zhang, Zhongjie; Power, David; Beerkens, Frans; Chiarito, Mauro; Meneveau, Nicolas; Tron, Christophe; Dumonteil, Nicolas; Widder, Julian D.; Ferrari, Markus; Violini, Roberto; Stella, Pieter R.; Jeger, Raban; Anthopoulos, Prodromos; Mehran, Roxana; Dangas, George D. (John Wiley & Sons Inc., 2021-11-15)
    OBJECTIVES: To determine the prognostic impact of anemia in patients randomized to bivalirudin or unfractionated heparin (UFH) during transcatheter aortic valve replacement (TAVR). BACKGROUND: Whether the periprocedural ...
  • Safety and efficacy of coronary sinus narrowing in chronic refractory angina: Insights from the RESOURCE study 
    Ponticelli, Francesco; Khokhar, Arif A.; Leenders, Geert; Konigstein, Maayan; Zivelonghi, Carlo; Agostoni, Pierfrancesco; van Kuijk, Jan Peter; Ajmi, Issameddine; Lindsay, Steven; Bunc, Matjaž; Tebaldi, Matteo; Cafaro, Alessandro; Cheng, Kevin; Ielasi, Alfonso; Patterson, Tiffany; Wolter, Jan Sebastian; Sgura, Fabio; De Marco, Federico; Ioanes, Dan; D'Amico, Gianpiero; Ciardetti, Marco; Berti, Sergio; Guarracini, Stefano; Di Mauro, Michele; Gallone, Guglielmo; Dekker, Mirthe; Silvis, Max J.M.; Tarantini, Giuseppe; Redwood, Simon; Colombo, Antonio; Liebetrau, Christoph; de Silva, Ranil; Rapezzi, Claudio; Ferrari, Roberto; Campo, Gianluca; Schnupp, Steffen; Timmers, Leo; Verheye, Stefan; Stella, Pieter; Banai, Shmuel; Giannini, Francesco (Elsevier Ireland Ltd, 2021-08-15)
    Introduction: Refractory angina (RA) is considered the end-stage of coronary artery disease, and often has no interventional treatment options. Coronary sinus Reducer (CSR) is a recent addition to the therapeutic arsenal, ...