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UMC Repository: Recent submissions

  • Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo 
    Mester, Simone; Evers, Mitchell; Meyer, Saskia; Nilsen, Jeannette; Greiff, Victor; Sandlie, Inger; Leusen, Jeanette; Andersen, Jan Terje (Landes Bioscience, 2021-01-01)
    Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A ...
  • Complement receptor 3 mediates both sinking phagocytosis and phagocytic cup formation via distinct mechanisms 
    Walbaum, Stefan; Ambrosy, Benjamin; Schütz, Paula; Bachg, Anne C.; Horsthemke, Markus; Leusen, Jeanette H.W.; Mócsai, Attila; Hanley, Peter J. (American Society for Biochemistry and Molecular Biology Inc., 2021-01-01)
    A long-standing hypothesis is that complement receptors (CRs), especially CR3, mediate sinking phagocytosis, but evidence is lacking. Alternatively, CRs have been reported to induce membrane ruffles or phagocytic cups, ...
  • Synergestic Tumor-Killing Effect by Cross-Hybrid IgGA Fc 
    Hamdan, Firas; Ylosmaki, Erkko; Chiaro, Jacopo; Giannoula, Yvonne; Long, Maeve; Fusciello, Manlio; Feola, Sara; Martins, Beatriz; Feodoroff, Michaela; Antignani, Gabriella; Kari, Otto; Lee, Moon Hee; Jarvinen, Petrus; Nisen, Harry; Kreutzman, Anna; Leusen, Jeanette; Mustjoki, Satu; McWilliams, Thomas; Gronholm, Mikaela; Cerullo, Vincenzo (Cell Press, 2021-04-27)
    Despite the success of immune checkpoint inhibitors in the clinic, only a fraction of patients benefit from these therapies. A theoretical strategy to increase efficacy would be to enhance such antibodies with Fc-mediated ...
  • Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions 
    Baumann, Niklas; Roesner, Thies; Jansen, J. H. Marco; Chan, Chilam; Eichholz, Klara Marie; Klausz, Katja; Winterberg, Dorothee; Mueller, Kristina; Humpe, Andreas; Burger, Renate; Peipp, Matthias; Schewe, Denis M.; Kellner, Christian; Leusen, Jeanette H. W.; Valerius, Thomas (Wiley-Blackwell, 2021-08)
    Integrin associated protein (CD47) is an important target in immunotherapy, as it is expressed as a “don't eat me” signal on many tumor cells. Interference with its counter molecule signal regulatory protein alpha (SIRPα), ...
  • Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis 
    ANDROMEDA Trial Investigators (Massachussetts Medical Society, 2021-07-01)
    BACKGROUND Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting antibody, may ...
  • Detection of tumor-derived cell-free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluid 
    van't Erve, Iris; Rovers, Koen P.; Constantinides, Alexander; Bolhuis, Karen; Wassenaar, Emma C.E.; Lurvink, Robin J.; Huysentruyt, Clément J.; Snaebjornsson, Petur; Boerma, Djamila; van den Broek, Daan; Buffart, Tineke E.; Lahaye, Max J.; Aalbers, Arend G.J.; Kok, Niels F.M.; Meijer, Gerrit A.; Punt, Cornelis J.A.; Kranenburg, Onno; de Hingh, Ignace H.J.T.; Fijneman, Remond J.A. (Wiley-Blackwell Publishing Ltd, 2021-05)
    Tumor-derived cell-free DNA (cfDNA) is an emerging biomarker for guiding the personalized treatment of patients with metastatic colorectal cancer (CRC). While patients with CRC liver metastases (CRC-LM) have relatively ...
  • Clinicopathological features and risk factors for developing colorectal neoplasia in Hodgkin’s lymphoma survivors 
    Ykema, Berbel L.M.; Rigter, Lisanne S.; Spaander, Manon C.W.; Moons, Leon M.G.; Bisseling, Tanya M.; Aleman, Berthe M.P.; Dekker, Evelien; Verbeek, Wieke H.M.; Kuipers, Ernst J.; de Boer, Jan Paul; Lugtenburg, Pieternella J.; Janus, Cecile P.M.; Petersen, Eefke J.; Roesink, Judith M.; van der Maazen, Richard W.M.; Meijer, Gerrit A.; Schaapveld, Michael; van Leeuwen, Flora E.; Carvalho, Beatriz; Snaebjornsson, Petur; van Leerdam, Monique E. (John Wiley & Sons Inc., 2022-01)
    BACKGROUND: Hodgkin's lymphoma (HL) survivors treated with abdominal radiotherapy and/or procarbazine have an increased risk of developing colorectal neoplasia. AIMS: We evaluated the clinicopathological characteristics ...
  • Connective Tissue Growth Factor Is Overexpressed in Explant Lung Tissue and Broncho-Alveolar Lavage in Transplant-Related Pulmonary Fibrosis 
    Vanstapel, Arno; Goldschmeding, Roel; Broekhuizen, Roel; Nguyen, Tri; Sacreas, Annelore; Kaes, Janne; Heigl, Tobias; Verleden, Stijn E.; De Zutter, Alexandra; Verleden, Geert; Weynand, Birgit; Verbeken, Erik; Ceulemans, Laurens J.; Van Raemdonck, Dirk E.; Neyrinck, Arne P.; Schoemans, Helene M.; Vanaudenaerde, Bart M.; Vos, Robin (Frontiers Media S. A., 2021-05-25)
    Background: Connective tissue growth factor (CTGF) is an important mediator in several fibrotic diseases, including lung fibrosis. We investigated CTGF-expression in chronic lung allograft dysfunction (CLAD) and pulmonary ...
  • PAI-1 induction during kidney injury promotes fibrotic epithelial dysfunction via deregulation of klotho, p53, and TGF-beta 1-receptor signaling 
    Gifford, Cody C.; Lian, Fei; Tang, Jiaqi; Costello, Angelica; Goldschmeding, Roel; Samarakoon, Rohan; Higgins, Paul J. (John Wiley & Sons Inc., 2021-07)
    Renal fibrosis leads to chronic kidney disease, which affects over 15% of the U.S. population. PAI-1 is highly upregulated in the tubulointerstitial compartment in several common nephropathies and PAI-1 global ablation ...
  • Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes 
    Marquez-Exposito, Laura; Tejedor-Santamaria, Lucia; Santos-Sanchez, Laura; Valentijn, Floris A.; Cantero-Navarro, Elena; Rayego-Mateos, Sandra; Rodrigues-Diez, Raul R.; Tejera-Muñoz, Antonio; Marchant, Vanessa; Sanz, Ana B.; Ortiz, Alberto; Goldschmeding, Roel; Ruiz-Ortega, Marta (Frontiers Media S. A., 2021-06-22)
    Acute kidney injury (AKI) is more frequent in elderly patients. Mechanisms contributing to AKI (tubular cell death, inflammatory cell infiltration, impaired mitochondrial function, and prolonged cell-cycle arrest) have ...
  • Elastosis in ER alpha-positive male breast cancer 
    Vermeulen, Marijn A.; van Deurzen, Carolien H.M.; van Leeuwen-Stok, A. Elise; van Diest, Paul J. (Springer-Verlag, 2021-02)
    In female breast cancer (BC), elastosis is strongly related to estrogen receptor alpha (ERα) expression. Male breast cancers almost invariably express ERα; so, the aim of this study was to investigate elastosis frequency ...
  • The increasing importance of histologic grading in tailoring adjuvant systemic therapy in 30,843 breast cancer patients 
    van Dooijeweert, C.; Baas, I. O.; Deckers, I. A.G.; Siesling, S.; van Diest, P. J.; van der Wall, E. (Springer New York, 2021-06)
    Purpose: The large variation in histologic grading of invasive breast cancer (IBC) that has been reported likely influences tailoring adjuvant therapy. The role of grading in therapeutic decision-making in daily practice, ...
  • Rocky road to digital diagnostics: Implementation issues and exhilarating experiences 
    Stathonikos, Nikolaos; Nguyen, Tri Q.; Van Diest, Paul J. (BMJ Publishing Group, 2021-07-01)
    Since 2007, we have gradually been building up infrastructure for digital pathology, starting with a whole slide scanner park to build up a digital archive to streamline doing multidisciplinary meetings, student teaching ...
  • Pregnancy-associated breast cancer: nationwide Dutch study confirms a discriminatory aggressive histopathologic profile 
    Suelmann, B. B.M.; van Dooijeweert, C.; van der Wall, E.; Linn, S.; van Diest, P. J. (Springer New York, 2021-04)
    PURPOSE: Breast cancer is the most common type of malignancy in pregnant women, occurring approximately once in every 3000 pregnancies. Pregnancy-associated breast cancer (PABC) is commonly defined as breast cancer diagnosed ...
  • Heterogeneity in signaling pathway activity within primary and between primary and metastatic breast cancer 
    Inda, Márcia A.; van Swinderen, Paul; van Brussel, Anne; Moelans, Cathy B.; Verhaegh, Wim; van Zon, Hans; Den Biezen, Eveline; Bikker, Jan Willem; van Diest, Paul J.; van de Stolpe, Anja (Multidisciplinary Digital Publishing Institute (MDPI), 2021-03-16)
    Targeted therapy aims to block tumor-driving signaling pathways and is generally based on analysis of one primary tumor (PT) biopsy. Tumor heterogeneity within PT and between PT and metastatic breast lesions may, however, ...
  • Evidence and consensus-based recommendations for non-pharmacological treatment of fatigue, hand function loss, Raynaud's phenomenon, and digital ulcers in patients with systemic sclerosis 
    Arthritis Research and Collaboration Hub study group (Oxford University Press, 2022-04-11)
    Objective: SSc is a complex CTD affecting mental and physical health. Fatigue, hand function loss, and RP are the most prevalent disease-specific symptoms of systemic sclerosis. This study aimed to develop consensus and ...
  • Musculoskeletal ultrasound in hemophilia: Results and recommendations from a global survey and consensus meeting 
    Bakeer, Nihal; Dover, Saunya; Babyn, Paul; Feldman, Brian M; von Drygalski, Annette; Doria, Andrea S; Ignas, Danial M; Abad, Audrey; Bailey, Cindy; Beggs, Ian; Chang, Eric Y; Dunn, Amy; Funk, Sharon; Gibikote, Sridhar; Goddard, Nicholas; Hilliard, Pamela; Keshava, Shyamkumar N; Kruse-Jarres, Rebecca; Li, Yingjia; Lobet, Sébastien; Manco-Johnson, Marilyn; Martinoli, Carlo; O'Donnell, James S; Papakonstantinou, Olympia; Pergantou, Helen; Poonnoose, Pradeep; Querol, Felipe; Srivastava, Alok; Steiner, Bruno; Strike, Karen; Timmer, Merel; Tyrrell, Pascal N; Vidarsson, Logi; Blanchette, Victor S (Elsevier, 2021-07)
    Introduction: For persons with hemophilia, optimization of joint outcomes is an important unmet need. The aim of this initiative was to determine use of ultrasound in evaluating arthropathy in persons with hemophilia, and ...
  • Clinical characteristics and outcomes of children with WAGR syndrome and Wilms tumor and/or nephroblastomatosis: The 30-year SIOP-RTSG experience 
    for the International Society of Pediatric Oncology Renal Tumor Study Group (SIOP-RTSG) (John Wiley & Sons Inc., 2021-02-15)
    Background: WAGR syndrome (Wilms tumor, aniridia, genitourinary anomalies, and range of developmental delays) is a rare contiguous gene deletion syndrome with a 45% to 60% risk of developing Wilms tumor (WT). Currently, ...
  • Clinical Characteristics and Genetic Etiology of Children With Developmental Language Disorder 
    Plug, Marielle B.; van Wijngaarden, Vivian; de Wilde, Hester; van Binsbergen, Ellen; Stegeman, Inge; van den Boogaard, Marie José H.; Smit, Adriana L. (Frontiers Media S. A., 2021-07-01)
    Objective: Developmental language delay (DLD) is one of the most common disabilities in childhood and can negatively affect a child's communication skills and academic and/or psychosocial development. To date, an increasing ...
  • Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li–Fraumeni syndrome 
    Winter, Greta; Kirschner-Schwabe, Renate; Groeneveld-Krentz, Stefanie; Escherich, Gabriele; Möricke, Anja; von Stackelberg, Arend; Stanulla, Martin; Bailey, Simon; Richter, Lisa; Steinemann, Doris; Ripperger, Tim; Escudero, Adela; Farah, Roula; Lohi, Olli; Wadt, Karin; Jongmans, Marjolijn; van Engelen, Nienke; Eckert, Cornelia; Kratz, Christian Peter (Springer Nature, 2021-05)