Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning - The Medea-7T study
Zwartbol, Maarten Ht; Rissanen, Ina; Ghaznawi, Rashid; de Bresser, Jeroen; Kuijf, Hugo J; Blom, Kim; Witkamp, Theo D; Koek, Huiberdina L; Biessels, Geert Jan; Hendrikse, Jeroen; Geerlings, Mirjam I
(2021) Journal of Cerebral Blood Flow and Metabolism, volume 41, issue 11, pp. 3127 - 3138
(Article)
Abstract
We determined the occurrence and association of cortical cerebral microinfarcts (CMIs) at 7 T MRI with risk factors, neuroimaging markers of small and large vessel disease, and cognitive functioning. Within the Medea-7T study, a diverse cohort of older persons with normal cognition, patients with vascular disease, and memory clinic patients, we
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included 386 participants (68 ± 9 years) with available 7 T and 1.5 T/3T brain MRI, and risk factor and neuropsychological data. CMIs were found in 10% of participants and were associated with older age (RR = 1.79 per +10 years, 95%CI 1.28-2.50), history of stroke or TIA (RR = 4.03, 95%CI 2.18-7.43), cortical infarcts (RR = 5.28, 95%CI 2.91-9.55), lacunes (RR = 5.66, 95%CI 2.85-11.27), cerebellar infarcts (RR = 2.73, 95%CI 1.27-5.84) and decreased cerebral blood flow (RR = 1.35 per -100 ml/min, 95%CI 1.00-1.83), after adjustment for age and sex. Furthermore, participants with >2 CMIs had 0.5 SD (95%CI 0.05-0.91) lower global cognitive performance, compared to participants without CMIs. Our results indicate that CMIs on 7 T MRI are observed in vascular and memory clinic patients with similar frequency, and are associated with older age, history of stroke or TIA, other brain infarcts, and poorer global cognitive functioning.
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Keywords: Microinfarcts, cerebrovascular disease, cognitive functioning, dementia, cardiovascular risk factors, Clinical Neurology, Neurology, Cardiology and Cardiovascular Medicine, Journal Article
ISSN: 0271-678X
Publisher: Nature Publishing Group
Note: Funding Information: We thank all participants. Furthermore, we would like to thank all general practitioners from the general practice ?Huisartsenpraktijk Bosboomstraat? for their help in inclusion of the participants. Furthermore, we would like to thank all the people involved in data acquisition in the participating general practices, memory clinics, and people involved in the data acquisition of the PREDICT-MR study. Moreover, we gratefully acknowledge the contribution of the SMART research nurses; R. van Petersen (data-manager); B.G.F. Dinther (vascular manager) and the members of the Utrecht Cardiovascular Cohort-Second Manifestations of ARTerial disease-Study Group (UCC-SMART-Study Group): F.W. Asselbergs and H.M. Nathoe, Department of Cardiology; G.J. de Borst, Department of Vascular Surgery; M.L. Bots and M.I. Geerlings, Julius Center for health Sciences and Primary Care; M.H. Emmelot, Department of Geriatrics; P.A. de Jong and T. Leiner, Department of Radiology; A.T. Lely, Department of Obstetrics & Gynecology; N.P. van der Kaaij, Department of Cardiothoracic Surgery; L.J. Kappelle and Y.M. Ruigrok, Department of Neurology; M.C. Verhaar, Department of Nephrology, F.L.J. Visseren (chair) and J. Westerink, Department of Vascular Medicine, University Medical Center Utrecht and Utrecht University. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Financial support was received by the Alzheimer Nederland ? Internationale Stichting Alzheimer Onderzoek (AN-ISAO) (Grant number 12504). The research of Jeroen Hendrikse has received funding from the European Research Council under the European Union's Horizon 2020 Programme (H2020)/ERC grant agreement n?637024 (HEARTOFSTROKE) and H2020 grant agreement No 666881, SVDs@target. Jeroen Hendrikse is supported by the Netherlands Organization for Scientific Research (NWO) under grant n?91712322. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Financial support was received by the Alzheimer Nederland – Internationale Stichting Alzheimer Onderzoek (AN-ISAO) (Grant number 12504). The research of Jeroen Hendrikse has received funding from the European Research Council under the European Union's Horizon 2020 Programme (H2020)/ERC grant agreement n°637024 (HEARTOFSTROKE) and H2020 grant agreement No 666881, SVDs@target. Jeroen Hendrikse is supported by the Netherlands Organization for Scientific Research (NWO) under grant n°91712322. Acknowledgements Publisher Copyright: © The Author(s) 2021.
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