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Now showing items 15781-15800 of 40729

Dementia risk in the general population: large-scale external validation of prediction models in the AGES-Reykjavik study

Vonk, Jet M J; Greving, Jacoba P; Gudnason, Vilmundur; Launer, Lenore J; Geerlings, Mirjam I (Springer Netherlands, 2021-10)

We aimed to evaluate the external performance of prediction models for all-cause dementia or AD in the general population, which can aid selection of high-risk individuals for clinical trials and prevention. We identified ...
Perceptions of involvement in advance care planning and emotional functioning in patients with advanced cancer

on behalf of the eQuiPe study group (Springer, 2021-06)

PURPOSE: Advance Care Planning (ACP) is positively associated with the quality of care, but its impact on emotional functioning is ambiguous. This study investigated the association between perceptions of ACP involvement ...
Considerable interlaboratory variation in PD-L1 positivity in a nationwide cohort of non-small cell lung cancer patients

Koomen, Bregje M.; Voorham, Quirinus J.M.; Epskamp-Kuijpers, Chantal C.H.J.; van Dooijeweert, Carmen; van Lindert, Anne S.R.; Deckers, Ivette A.G.; Willems, Stefan M. (Elsevier Ireland Ltd, 2021-09)

Objectives: Immunohistochemical expression of programmed death-ligand 1 (PD-L1) is used as a predictive biomarker for prescription of immunotherapy to non-small cell lung cancer (NSCLC) patients. Accurate assessment of ...
Empagliflozin in Heart Failure With Predicted Preserved Versus Reduced Ejection Fraction: Data From the EMPA-REG OUTCOME Trial

Savarese, Gianluigi; Uijl, Alicia; Lund, Lars H; Anker, Stefan D; Asselbergs, Folkert; Fitchett, David; Inzucchi, Silvio E; Koudstaal, Stefan; Ofstad, Anne Pernille; Schrage, Benedikt; Vedin, Ola; Wanner, Christoph; Zannad, Faiez; Zwiener, Isabella; Butler, Javed (Churchill Livingstone, 2021-08)

Background: In the EMPA-REG OUTCOME trial, ejection fraction (EF) data were not collected. In the subpopulation with heart failure (HF), we applied a new predictive model for EF to determine the effects of empagliflozin ...
Evaluating communication partner training in healthcare centres: Understanding the mechanisms of behaviour change

van Rijssen, Maren; Ketelaar, Marjolijn; Vandenborre, Dorien; Oostveen, Judith; Veldkamp, Marloes; van Ewijk, Lizet; Visser-Meily, Johanna M A; Gerrits, Ellen (Wiley-Blackwell, 2021-11-01)

BACKGROUND: Communication between people with aphasia and their healthcare professionals (HCPs) can be greatly improved when HCPs are trained in using supportive conversation techniques and tools. Communication partner ...
Optimization of whole-brain rabies virus tracing technology for small cell populations

Roelofs, Theresia J.M.; Menting-Henry, Shanice; Gol, Lieke M.; Speel, Annelijn M.; Wielenga, Vera H.; Garner, Keith M.; Luijendijk, Mieneke C.M.; Hennrich, Alexandru A.; Conzelmann, Karl Klaus; Adan, Roger A.H. (Nature Publishing Group, 2021-05-17)

The lateral hypothalamus (LH) is critically involved in the regulation of homeostatic energy balance. Some neurons in the LH express receptors for leptin (LepRb), a hormone known to increase energy expenditure and decrease ...
Acceptance procedure for the linear accelerator component of the 1.5 T MRI-linac

Woodings, Simon J.; de Vries, J. H.Wilfred; Kok, Jan M.G.; Hackett, Sara L.; van Asselen, Bram; Bluemink, Johanna J.; van Zijp, Helena M.; van Soest, Theo L.; Roberts, David A.; Lagendijk, Jan J.W.; Raaymakers, Bas W.; Wolthaus, Jochem W.H. (John Wiley & Sons Inc., 2021-08)

Purpose: To develop and implement an acceptance procedure for the new Elekta Unity 1.5 T MRI-linac. Methods: Tests were adopted and, where necessary adapted, from AAPM TG106 and TG142, IEC 60976 and NCS 9 and NCS 22 ...
A multicenter observational survey of management strategies in 442 pregnancies with suspected placenta accreta spectrum

International Society of Placenta Accreta Spectrum (IS-PAS) group (Wiley-Blackwell, 2021-03-01)

INTRODUCTION: Management options for women with placenta accreta spectrum (PAS) comprise termination of pregnancy before the viable gestational age, leaving the placenta in situ for subsequent reabsorption of the placenta ...
Tenofovir disoproxil fumarate in pregnancy for prevention of mother to child transmission of hepatitis B in a rural setting on the Thailand-Myanmar border: a cost-effectiveness analysis

Bierhoff, Marieke; Angkurawaranon, Chaisiri; Rijken, Marcus J; Sriprawa, Kanlaya; Kobphan, Pachinee; Nosten, Francois N; van Vugt, Michèle; McGready, Rose; Devine, Angela (BioMed Central, 2021-02-22)

BACKGROUND: Hepatitis B Virus (HBV) is transmitted from mother to child which can be prevented via birth dose vaccine combined with three follow up hepatitis B vaccines, hepatitis B immunoglobulins (HBIG), and maternal ...
Association of peripartum management and high maternal blood loss at cesarean delivery for placenta accreta spectrum (PAS): A multinational database study

International Society for Placenta accreta spectrum (IS-PAS) (Wiley-Blackwell, 2021-03)

INTRODUCTION: Placenta accreta spectrum (PAS) carries a high burden of adverse maternal outcomes, especially significant blood loss, which can be life-threatening. Different management strategies have been proposed but the ...
The relation between maternal obesity and placenta accreta spectrum: A multinational database study

International Society for Placenta accreta spectrum (IS-PAS) (Wiley-Blackwell, 2021-03)

INTRODUCTION: It has been suggested that women with obesity have increased risk of developing placenta accreta spectrum (PAS). It is unclear if this is independent of the increased risk of cesarean delivery seen with obesity ...
Falciparum but not vivax malaria increases the risk of hypertensive disorders of pregnancy in women followed prospectively from the first trimester

Harrington, Whitney E; Moore, Kerryn A; Min, Aung Myat; Gilder, Mary Ellen; Tun, Nay Win; Paw, Moo Kho; Wiladphaingern, Jacher; Proux, Stephane; Chotivanich, Kesinee; Rijken, Marcus J; White, Nicholas J; Nosten, François; McGready, Rose (BioMed Central Ltd., 2021-04-27)

BACKGROUND: Malaria and hypertensive disorders of pregnancy (HDoP) affect millions of pregnancies worldwide, particularly those of young, first-time mothers. Small case-control studies suggest a positive association between ...
A mixed methods evaluation of Advanced Life Support in Obstetrics (ALSO) and Basic Life Support in Obstetrics (BLSO) in a resource-limited setting on the Thailand-Myanmar border

McGready, Rose; Rijken, Marcus J; Turner, Claudia; Than, Hla Hla; Tun, Nay Win; Min, Aung Myat; Hla, Sophia; Wai, Nan San; Proux, Kieran; Min, Thaw Htway; Gilder, Mary Ellen; Sneddon, Anne (F1000 Research Ltd., 2021)

Background: Short emergency obstetric care (EmOC) courses have demonstrated improved provider confidence, knowledge and skills but impact on indicators such as maternal mortality and stillbirth is less substantial. This ...
Transformation of primary care during the COVID-19 pandemic: Experiences of healthcare professionals in eight European countries

Wanat, Marta; Hoste, Melanie; Gobat, Nina; Anastasaki, Marilena; Böhmer, Femke; Chlabicz, Slawomir; Colliers, Annelies; Farrell, Karen; Karkana, Maria Nefeli; Kinsman, John; Lionis, Christos; Marcinowicz, Ludmila; Reinhardt, Katrin; Skoglund, Ingmarie; Sundvall, Pär Daniel; Vellinga, Akke; Verheij, Theo J.M.; Goossens, Herman; Butler, Christopher C.; van der Velden, Alike; Anthierens, Sibyl; Tonkin-Crine, Sarah (Royal College of General Practitioners, 2021-08)

Background Primary care has a crucial role in responding to the COVID-19 pandemic as the first point of patient care and gatekeeper to secondary care. Qualitative studies exploring the experiences of healthcare professionals ...
The effect of extended c, E and K matching in females under 45 years of age on the incidence of transfusion-induced red blood cell alloimmunisation

Oud, Josine A.; Evers, Dorothea; de Haas, Masja; de Vooght, Karen M.K.; van de Kerkhof, Daan; Som, Nel; Péquériaux, Nathalie C.V.; Hudig, Francisca; Albersen, Arjan; van der Bom, Johanna G.; Zwaginga, Jaap Jan (Wiley-Blackwell, 2021-11)

Maternal alloantibodies directed against fetal red blood cell (RBC) antigens may cause potentially life-threatening haemolytic disease of the fetus and newborn (HDFN). Dutch transfusion guidelines therefore prescribe ...
Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery

van der Meel, Roy; Chen, Sam; Zaifman, Josh; Kulkarni, Jayesh A; Zhang, Xu Ran S; Tam, Ying K; Bally, Marcel B; Schiffelers, Raymond M; Ciufolini, Marco A; Cullis, Pieter R; Tam, Yuen Yi C (Landes Bioscience, 2021-09-16)

Successfully employing small interfering RNA (siRNA) therapeutics requires the use of nanotechnology for efficient intracellular delivery. Lipid nanoparticles (LNPs) have enabled the approval of various nucleic acid ...
Evaluation of Oncological Outcomes and Data Quality in Studies Assessing Nerve-sparing Versus Non-Nerve-sparing Radical Prostatectomy in Nonmetastatic Prostate Cancer: A Systematic Review

Moris, Lisa; Gandaglia, Giorgio; Vilaseca, Antoni; Van den Broeck, Thomas; Briers, Erik; De Santis, Maria; Gillessen, Silke; Grivas, Nikos; O'Hanlon, Shane; Henry, Ann; Lam, Thomas B; Lardas, Michael; Mason, Malcolm; Oprea-Lager, Daniela; Ploussard, Guillaume; Rouviere, Olivier; Schoots, Ivo G; van der Poel, Henk; Wiegel, Thomas; Willemse, Peter-Paul; Yuan, Cathy Y; Grummet, Jeremy P; Tilki, Derya; van den Bergh, Roderick C N; Cornford, Philip; Mottet, Nicolas (Elsevier, 2022-05)

CONTEXT: Surgical techniques aimed at preserving the neurovascular bundles during radical prostatectomy (RP) have been proposed to improve functional outcomes. However, it remains unclear if nerve-sparing (NS) surgery ...
De medicamenteuze behandeling bij stoornis in het gebruik van cocaïne en amfetamine

Neven, Arjen; Zonnenberg, Cherryl; Steenkist, Cassandra; Batalla, Albert (Uitgeverij Boom, 2021)
Neuro-immune interactions in paclitaxel-induced peripheral neuropathy

Vermeer, Cornelia J C; Hiensch, Anouk E; Cleenewerk, Laurence; May, Anne M; Eijkelkamp, Niels (Informa Healthcare, 2021-10)

BACKGROUND: Paclitaxel is a taxane-based chemotherapeutic agent used as a treatment in breast cancer. There is no effective prevention or treatment strategy for the most common side effect of peripheral neuropathy. In this ...
Key elements in selection of pre-dialysis patients for home dialysis

Bonenkamp, Anna A; Reijnders, Tom D Y; der Sluijs, Anita van Eck van; Hagen, E Christiaan; Abrahams, Alferso C; van Ittersum, Frans J; van Jaarsveld, Brigit C (Multimed Inc., 2021-09)

BACKGROUND: Most pre-dialysis patients are medically eligible for home dialysis, and home dialysis has several advantages over incentre dialysis. However, accurately selecting patients for home dialysis appears to be ...

Now showing items 15781-15800 of 40729