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Alcohol use and brain morphology in adolescence: a longitudinal study in three different cohorts

El Marroun, Hanan; Klapwijk, Eduard T; Koevoets, Martijn; Brouwer, Rachel M; Peters, Sabine; van 't Ent, Dennis; Boomsma, Dorret I; Muetzel, Ryan; Crone, Eveline A; Hulshoff Pol, Hilleke E; Franken, Ingmar H A (Wiley-Blackwell, 2021-09)

Alcohol consumption is commonly initiated during adolescence, but the effects on human brain development remain unknown. In this multisite study, we investigated the longitudinal associations of adolescent alcohol use and ...
Pharmacokinetics and Associated Efficacy of Emicizumab in Humans: A Systematic Review

Donners, Anouk A.M.T.; Rademaker, Carin M.A.; Bevers, Lisanne A.H.; Huitema, Alwin D.R.; Schutgens, Roger E.G.; Egberts, Toine C.G.; Fischer, Kathelijn (Adis, 2021-11)

Introduction: Emicizumab is an effective new treatment option for people with hemophilia A (PwHA). The approved dosing regimens are based on body weight, without the necessity for laboratory monitoring. This assumes a clear ...
Effect of parental and ART treatment characteristics on perinatal outcomes

Pontesilli, M.; Hof, M. H.; Ravelli, A. C.J.; van Altena, A. J.; Soufan, A. T.; Mol, B. W.; Kostelijk, E. H.; Slappendel, E.; Consten, D.; Cantineau, A. E.P.; van der Westerlaken, L. A.J.; van Inzen, W.; Dumoulin, J. C.M.; Ramos, L.; Baart, E. B.; Broekmans, F. J.M.; Rijnders, P. M.; Curfs, M. H.J.M.; Mastenbroek, S.; Repping, S.; Roseboom, T. J.; Painter, R. C. (Oxford University Press, 2021-05-17)

STUDY QUESTION: Do parental characteristics and treatment with ART affect perinatal outcomes in singleton pregnancies? SUMMARY ANSWER: Both parental and ART treatment characteristics affect perinatal outcomes in singleton ...
Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis

LITMUS Investigators (Elsevier, 2021-10)

Background and Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), 2-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance ...
Splice variants of metabolic nuclear receptors: Relevance for metabolic disease and therapeutic targeting

Mukha, Anna; Kalkhoven, Eric; van Mil, Saskia W.C. (Elsevier, 2021-10-01)

Metabolic nuclear receptors are ligand-activated transcription factors which control a wide range of metabolic processes and signaling pathways in response to nutrients and xenobiotics. Targeting these NRs is at the forefront ...
Breast milk nutrients driving intestinal epithelial layer maturation via Wnt and Notch signaling: Implications for necrotizing enterocolitis

de Jong, Judith C.W.; Ijssennagger, Noortje; van Mil, Saskia W.C. (Elsevier, 2021-11-01)

Necrotizing enterocolitis (NEC) is an often lethal, inflammatory disease of the preterm intestine. The underdeveloped immune system plays an important role; however, the initial trigger for NEC development is likely a ...
Siglec-1 expression on monocytes is associated with the interferon signature in juvenile dermatomyositis and can predict treatment response

Lerkvaleekul, Butsabong; Veldkamp, Saskia R; van der Wal, Maria M; Schatorjé, Ellen J H; Kamphuis, Sylvia S M; van den Berg, J Merlijn; Muller, Petra C E Hissink; Armbrust, Wineke; Vastert, Sebastiaan J; Wienke, Judith; Jansen, Marc H A; van Royen-Kerkhof, Annet; van Wijk, Femke (Oxford University Press, 2022-05-05)

OBJECTIVE: JDM is a rare chronic immune-mediated inflammatory disease with a predominant role for type I IFN responses. We aimed to determine the potential of Siglec-1 expression on monocytes as a novel IFN-inducible ...
Correction to "Reactivity of (Vicinal) Carbonyl Compounds with Urea"

Driest, Piet J; Jong, Jacobus A W; Smakman, Robert; Moret, Marc-Etienne; Verhaar, Marianne C; Hennink, Wim E; Gerritsen, Karin G F; van Nostrum, Cornelus F (American Chemical Society, 2021-08-10)

[This corrects the article DOI: 10.1021/acsomega.9b01177.].
Diagnostic accuracy of Ara h 2 for detecting peanut allergy in children

Kansen, Hannah M.; van Erp, Francine C.; Meijer, Yolanda; Gorissen, Dianne M.W.; Stadermann, Marike; van Velzen, Maartje F.; Keusters, Willem R.; Frederix, Geert W.J.; Knulst, André C.; van der, Cornelis K.; Le, Thuy My (Wiley-Blackwell, 2021-08)

Background: Specific IgE to Ara h 2 is a diagnostic test for peanut allergy which may reduce the need for double-blind placebo-controlled food challenges (DBPCFC); however, guidance for using Ara h 2 in place of DBPCFCs ...
Poor understanding of allergen labelling by allergic and non-allergic consumers

Holleman, Bregje C.; van Os-Medendorp, Harmieke; van den Bergh, Huub; van Dijk, Liselotte M.; Linders, Yvette F.M.; Blom, W. Marty; Verhoeckx, Kitty C.M.; Michelsen-Huisman, Anouska; Houben, Geert F.; Knulst, André C.; Lentz, Leo R. (Wiley-Blackwell, 2021-10)

BACKGROUND: Understanding consumers' interpretation of allergy information is crucial for effective food safety policies. We evaluated consumer understanding of allergy information on foods in controlled, experimental ...
Birth asphyxia-induced brain damage: The long road to optimal reduction and prevention!

Van Bel, Frank; Groenendaal, Floris (AME Publishing Company, 2020-05)

Moderate hypothermia (HT) is the only established therapy to reduce birth asphyxia-induced brain injury in (near) term neonates, but it is conceivable that pharmacological add-on therapy during or after HT can further ...
Serum docosahexaenoic acid levels are associated with brain volumes in extremely preterm born infants

Hortensius, Lisa M; Hellström, William; Sävman, Karin; Heckemann, Rolf A; Björkman-Burtscher, Isabella M; Groenendaal, Floris; Andersson, Mats X; Nilsson, Anders K; Tataranno, Maria Luisa; van Elburg, Ruurd M; Hellström, Ann; Benders, Manon J N L (Lippincott Williams & Wilkins, 2021-12)

Background: Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important for fetal brain growth and development. Our aim was to evaluate the association between serum DHA and AA levels and brain volumes in extremely ...
Dorsal root ganglia macrophages maintain osteoarthritis pain

Raoof, Ramin; Gil, Christian Martin; Lafeber, Floris P.J.G.; De Visser, Huub; Prado, Judith; Versteeg, Sabine; Pascha, Mirte N.; Heinemans, Anne L.P.; Adolfs, Youri; Pasterkamp, Jeroen; Wood, John N.; Mastbergen, Simon C.; Eijkelkamp, Niels (Society for Neuroscience, 2021-09-29)

Pain is the major debilitating symptom of osteoarthritis (OA), which is difficult to treat. In OA patients joint tissue damage only poorly associates with pain, indicating other mechanisms contribute to OA pain. Immune ...
Development of the First Patient-centred Set of Outcomes for Muscle-invasive and Metastatic Bladder Cancer: A Multicentre Initiative

Reesink, Daan J.; van de Garde, Ewoudt M.W.; Somford, Diederik M.; Meijer, Richard P.; Los, Maartje; Biesma, Douwe H.; Horenblas, Simon; van Melick, Harm H.E.; van der Nat, Paul B.; for the Santeon MIBC Study Group (Elsevier, 2021-04)

Background: To improve and compare outcomes in healthcare, it is necessary to standardise outcome measurements. There are no widely accepted standardised outcome measures reflecting quality of care for bladder cancer (BCa) ...
Biomarkers of Alzheimer's Disease and Cerebrovascular Lesions and Clinical Progression in Patients with Subjective Cognitive Decline: A Systematic Review

Scarth, Morgan; Rissanen, Ina; Scholten, Rob J P M; Geerlings, Mirjam I (IOS Press, 2021)

BACKGROUND: Early identification of Alzheimer's disease (AD) may be extremely beneficial for delaying disease progression. Subjective cognitive decline (SCD) may be an early indicator of AD pathology. Not all individuals ...
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

EU-GEI collaborators (Nature Publishing Group, 2021-08-10)

Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis ...
Incidentie van psychose onder migranten in Nederland: Resultaten van de EU-GEI-studie

Termorshuizen, Fabian; van der Ven, Els M.A.; Velthorst, Eva; van Dam, Daniëlla S.; Rutten, Bart P.; van Os, Jim; de Haan, Lieuwe; Selten, Jean Paul (Bohn Stafleu van Loghum, 2021-09-03)

OBJECTIVE: To compare the incidence of psychosis among migrants with the incidence among the native Dutch in Amsterdam, Gouda and Voorhout. DESIGN: We identified patients with a first treated episode of psychosis (ICD-10 ...
A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

Schizophrenia Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (Elsevier, 2021-11-01)

Background: Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease, are calculated as a weighted count of risk alleles identified in genome-wide association studies. PGS methods differ in which ...
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Schizophrenia Working Group of the Psychiatric Genomics Consortium; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium; iPSYCH (Elsevier, 2022-01-01)

BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences ...
Colorectal Cancer Care and Patients' Perceptions Before and During COVID-19: Implications for Subsequent SARS-CoV-2 Infection Waves

Derksen, Jeroen W G; May, Anne M; van de Poll-Franse, Lonneke V; de Rooij, Belle H; Hafkenscheid, Dorothee A; Verkooijen, Helena M; Koopman, Miriam; Vink, Geraldine R (Oxford University Press, 2021-08)

Background: Changes in colorectal cancer (CRC) care planning because of the coronavirus disease 2019 (COVID-19) pandemic and associated health-related quality of life (HRQoL) and well-being of patients with CRC are unknown. ...

Now showing items 15761-15780 of 40729