Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 11161-11180 of 40729

Symptom evolution in the dying

Heijltjes, Madelon T.; Van Zuylen, Lia; Van Thiel, Ghislaine J.M.W.; Van Delden, Johannes J.M.; Van Der Heide, Agnes (BMJ Publishing Group, 2023-02-20)

Objective Provide insight in the prevalence of symptoms in patients who are in the last days of life. Methods A retrospective descriptive analysis of data on patients who died between 2012 and 2019 at the age of 18 or older ...
CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research

Kotecha, Dipak; Asselbergs, Folkert W.; Achenbach, Stephan; Anker, Stefan D.; Atar, Dan; Baigent, Colin; Banerjee, Amitava; Beger, Birgit; Brobert, Gunnar; Casadei, Barbara; Ceccarelli, Cinzia; Cowie, Martin R.; Crea, Filippo; Cronin, Maureen; Denaxas, Spiros; Derix, Andrea; Fitzsimons, Donna; Fredriksson, Martin; Gale, Chris P.; Gkoutos, Georgios V.; Goettsch, Wim; Hemingway, Harry; Ingvar, Martin; Jonas, Adrian; Kazmierski, Robert; Løgstrup, Susanne; Lumbers, R. Thomas; Lüscher, Thomas F.; McGreavy, Paul; Piña, Ileana L.; Roessig, Lothar; Steinbeisser, Carl; Sundgren, Mats; Tyl, Benoît; Van Thiel, Ghislaine; Van Bochove, Kees; Vardas, Panos E.; Villanueva, Tiago; Vrana, Marilena; Weber, Wim; Weidinger, Franz; Windecker, Stephan; Wood, Angela; Grobbee, Diederick E. (BMJ Publishing Group, 2022-08-29)

Big data is central to new developments in global clinical science aiming to improve the lives of patients. Technological advances have led to the routine use of structured electronic healthcare records with the potential ...
CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research

Innovative Medicines Initiative BigData@Heart Consortium, European Society of Cardiology, CODE-EHR international consensus group (Oxford University Press, 2022-10-07)

Big data is central to new developments in global clinical science aiming to improve the lives of patients. Technological advances have led to the routine use of structured electronic healthcare records with the potential ...
The reimbursement for expensive medicines: stakeholder perspectives on the SMA medicine nusinersen and the Dutch Coverage Lock policy

Scheijmans, Féline E.V.; Zomers, Margot L.; Fadaei, Sina; Onrust, Marthe R.; van der Graaf, Rieke; Delden, Johannes J.M.van; van der Pol, W. Ludo; van Thiel, Ghislaine J.M.W. (BioMed Central, 2022-11-04)

Background: The reimbursement for expensive medicines poses a growing challenge to healthcare worldwide. In order to increase its control over the costs of medicines, the Dutch government introduced the Coverage Lock (CL) ...
Lifelong versus not lifelong death wishes in older adults without severe illness: a cross-sectional survey

Elzinga, Elke; Zomers, Margot; van der Burg, Kiki; van Veen, Sisco; Schweren, Lizanne; van Thiel, Ghislaine; van Wijngaarden, Els (BioMed Central, 2022-11-21)

Background: Some older adults with a persistent death wish without being severely ill report having had a death wish their whole lives (lifelong persistent death wish; L-PDW). Differentiating them from older adults without ...
Challenging behavior in children and adolescents with Dravet syndrome: Exploring the lived experiences of parents

Postma, Amber; Milota, Megan; Jongmans, Marian J; Brilstra, Eva H; Zinkstok, Janneke R (Academic Press Inc., 2023-01)

BACKGROUND: Dravet syndrome (DS) is a monogenic syndrome associated with SCN1A mutations in the majority of patients and characterized by devastating epilepsy, that may be life-threatening. Aside from refractory seizures, ...
In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Hinrichs, Anneline C; Kruize, Aike A; Leavis, Helen L; van Roon, Joel A G (Frontiers Media S. A., 2022-11-24)

Introduction: Mucosal-associated invariant T (MAIT) cells might play a role in B cell hyperactivity and local inflammation in primary Sjögren’s syndrome (pSS), just like previously studied mucosa-associated CCR9+ and CXCR5+ ...
LV systolic dysfunction stands to gain the most post transcatheter aortic valve implantation (TAVI)

Soon, Kean H; Kooistra, Nynke H M; Voskuil, Michiel; Kraaijeveld, Adriaan O; Stella, Pieter R (Europa Group, 2019-07)

AIMS: We aimed to evaluate the extent of left ventricular (LV) recovery post transcatheter aortic valve implantation (TAVI) and its clinical predictors. METHODS AND RESULTS: This was a retrospective study on patients treated ...
Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial

Azizi, Michel; Sanghvi, Kintur; Saxena, Manish; Gosse, Philippe; Reilly, John P; Levy, Terry; Rump, Lars C; Persu, Alexandre; Basile, Jan; Bloch, Michael J; Daemen, Joost; Lobo, Melvin D; Mahfoud, Felix; Schmieder, Roland E; Sharp, Andrew S P; Weber, Michael A; Sapoval, Marc; Fong, Pete; Pathak, Atul; Lantelme, Pierre; Hsi, David; Bangalore, Sripal; Witkowski, Adam; Weil, Joachim; Kably, Benjamin; Barman, Neil C; Reeve-Stoffer, Helen; Coleman, Leslie; McClure, Candace K; Kirtane, Ajay J; RADIANCE-HTN Investigators (Elsevier, 2021-06-26)

BACKGROUND: Endovascular renal denervation reduces blood pressure in patients with mild-to-moderate hypertension, but its efficacy in patients with true resistant hypertension has not been shown. We aimed to assess the ...
Effects of Renal Denervation vs Sham in Resistant Hypertension After Medication Escalation: Prespecified Analysis at 6 Months of the RADIANCE-HTN TRIO Randomized Clinical Trial

Azizi, Michel; Mahfoud, Felix; Weber, Michael A; Sharp, Andrew S P; Schmieder, Roland E; Lurz, Philipp; Lobo, Melvin D; Fisher, Naomi D L; Daemen, Joost; Bloch, Michael J; Basile, Jan; Sanghvi, Kintur; Saxena, Manish; Gosse, Philippe; Jenkins, J Stephen; Levy, Terry; Persu, Alexandre; Kably, Benjamin; Claude, Lisa; Reeve-Stoffer, Helen; McClure, Candace; Kirtane, Ajay J; RADIANCE-HTN Investigators (American Medical Association, 2022-12-01)

IMPORTANCE: Although early trials of endovascular renal denervation (RDN) for patients with resistant hypertension (RHTN) reported inconsistent results, ultrasound RDN (uRDN) was found to decrease blood pressure (BP) vs ...
Towards sustainability and affordability of expensive cell and gene therapies? Applying a cost-based pricing model to estimate prices for Libmeldy and Zolgensma

Thielen, Frederick W F; Heine, R.J.; van den Berg, Sibren; ten Ham, RMT; Uyl-de Groot, Carin A (Informa Healthcare, 2022-12)

Background aims: Drug prices are regarded as one of the most influential factors in determining accessibility and affordability to novel therapies. Cell and gene therapies such as OTL-200 (brand name: Libmeldy) and AVXS-101 ...
Liver oligometastatic disease in synchronous metastatic gastric cancer patients: a nationwide population-based cohort study

Kroese, Tiuri E; Takahashi, Yuko; Lordick, Florian; van Rossum, Peter S N; Ruurda, Jelle P; Lagarde, Sjoerd M; van Hillegersberg, Richard; Verhoeven, Rob H A; van Laarhoven, Hanneke W M (Elsevier Limited, 2023-01)

INTRODUCTION: This population-based cohort study analysed treatment, overall survival (OS), and independent prognostic factors for OS in gastric cancer patients with liver metastases. METHODS: Between 2015 and 2017, patients ...
Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care

Cuppen, Edwin; Elemento, Olivier; Rosenquist, Richard; Nikic, Svetlana; IJzerman, Maarten; Zaleski, Isabelle Durand; Frederix, Geert; Levin, Lars-Åke; Mullighan, Charles G; Buettner, Reinhard; Pugh, Trevor J; Grimmond, Sean; Caldas, Carlos; Andre, Fabrice; Custers, Ilse; Campo, Elias; van Snellenberg, Hans; Schuh, Anna; Nakagawa, Hidewaki; von Kalle, Christof; Haferlach, Torsten; Fröhling, Stefan; Jobanputra, Vaidehi (Lippincott Williams & Wilkins, 2022-12)

PURPOSE: The combination of whole-genome and transcriptome sequencing (WGTS) is expected to transform diagnosis and treatment for patients with cancer. WGTS is a comprehensive precision diagnostic test that is starting to ...
Congenital anomalies and genetic disorders in neonates and infants: a single-center observational cohort study

Marouane, A.; Olde Keizer, R. A.C.M.; Frederix, G. W.J.; Vissers, L.E.L.M.; Boode, W. P.de; Zelst-Stams, W. A.G.van (Springer-Verlag, 2022-01)

Neonates with genetic disorders or congenital anomalies (CA) contribute considerably to morbidity and mortality in neonatal intensive care units (NICUs). The objective of this study is to study the prevalence of genetic ...
Cost-effectiveness of whole-exome sequencing in progressive neurological disorders of children: WES cost-effectiveness in children's encephalopathies

Aaltio, Juho; Hyttinen, Virva; Kortelainen, Mika; Frederix, Gerardus W.J.; Lönnqvist, Tuula; Suomalainen, Anu; Isohanni, Pirjo (W.B. Saunders Ltd, 2022-01)

Objectives: To clarify the diagnostic utility and the cost-effectiveness of whole-exome sequencing (WES) as a routine early-diagnostic tool in children with progressive neurological disorders. Methods: Patients with ...
The Pharmacoeconomic Benefits of Pemetrexed Dose Individualization in Patients With Lung Cancer

de Rouw, Nikki; de Boer, Merel; Boosman, René J.; van den Heuvel, Michel M.; Burger, David M.; Lieverse, Joris E.; Derijks, Hieronymus J.; Frederix, Geert W.J.; ter Heine, Rob (Wiley-Blackwell, 2022-05)

Neutropenia is a dose-related treatment-limiting and costly adverse event of pemetrexed. We postulate that individualized dosing reduces the incidence of neutropenia. The aims of this study were (i) to investigate the costs ...
Market access to new anticancer medicines for children and adolescents with cancer in Europe

Schoot, Reineke A.; Otth, Maria A.; Frederix, Gerardus W.J.; Leufkens, Hubert G.M.; Vassal, Gilles (Elsevier Limited, 2022-04)

Background and aims: There is an alarming delay in Europe for anticancer medicines becoming accessible for children. Following a paediatric European Union marketing authorisation, national Health Technology Assessment (HTA) ...
Cost-Effectiveness of a Multidisciplinary Lifestyle-Enhancing Treatment for Inpatients with Severe Mental Illness: The MULTI Study v

Deenik, Jeroen; Van Lieshout, Chris; Van Driel, Harold F.; Frederix, Geert W.J.; Hendriksen, Ingrid J.M.; Van Harten, Peter N.; Tenback, Diederik E. (Oxford University Press, 2022-01-01)

Economic evaluations of lifestyle interventions for people with mental illness are needed to inform policymakers and managers about implementing such interventions and corresponding reforms in routine mental healthcare. ...
Medical costs of children admitted to the neonatal intensive care unit: The role and possible economic impact of WES in early diagnosis

Olde Keizer, Richelle A.C.M.; Marouane, Abderrahim; Deden, A. Chantal; van Zelst-Stams, Wendy A.G.; de Boode, Willem P.; Keusters, Willem R.; Henneman, Lidewij; van Amstel, Johannes Kristian Ploos; Frederix, Gerardus W.J.; Vissers, Lisenka E.L.M. (Elsevier Masson SAS, 2022-05)

It has been estimated that at least 6.0% of neonates admitted to the Neonatal Intensive Care Unit remains genetically undiagnosed because genetic testing is not routinely performed. The objective of this study is to provide ...
Animal Models of Osteoarthritis Part 1–Preclinical Small Animal Models: Challenges and Opportunities for Drug Development

Rios, Jaqueline Lourdes; Sapède, Dora; Djouad, Farida; Rapp, Anna E.; Lang, Annemarie; Larkin, Jonathan; Ladel, Christoph; Mobasheri, Ali (John Wiley & Sons Inc., 2022-11)

Osteoarthritis (OA) is the most common form of arthritis and a major source of pain and disability in the adult population. There is a significant unmet medical need for the development of effective pharmacological therapies ...

Now showing items 11161-11180 of 40729