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UMC Repository: Recent submissions

  • Respiratory muscle function in patients with nemaline myopathy 
    van Kleef, Esmee S B; van Doorn, Jeroen L M; Gaytant, Michael A; de Weerd, Willemien; Vosse, Bettine A H; Wallgren-Pettersson, Carina; van Engelen, Baziel G M; Ottenheijm, Coen A C; Voermans, Nicol C; Doorduin, Jonne (Elsevier Limited, 2022-08)
    In this cross-sectional study, we comprehensively assessed respiratory muscle function in various clinical forms of nemaline myopathy (NM) including non-volitional tests for diaphragm function. Forty-two patients with NM ...
  • Starting HMV at home: a reasonable option for many patients? 
    van den Biggelaar, Ries J M; Hazenberg, A; Cobben, N A M; Gaytant, M A; Gommers, D A M P J; Wijkstra, P J (BioMed Central, 2022-12)
    BACKGROUND AND OBJECTIVE: In the current study, we undertook a more detailed exploration of the reasons why patients undergoing HMV were screened out of a recently published study in order to better understand how applicable ...
  • Estimation and expected sample size in Simon's two-stage designs that stop as early as possible 
    Daletzakis, Antonios; van den Bor, Rutger; Jonker, Marianne A; Roes, Kit C B; van Tinteren, Harm (John Wiley & Sons Inc., 2022-09-01)
    In early phase clinical studies in oncology, Simon's two-stage designs are widely used. The trial design could be made more efficient by stopping early in the second stage when the required number of responses is reached, ...
  • Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease 
    den Exter, Paul L; Woller, Scott C; Robert-Ebadi, Helia; Masias, Camila; Morange, Pierre-Emmanuel; Castelli, David; Hansen, John-Bjarne; Geersing, Geert-Jan; Siegal, Deborah M; de Wit, Kerstin; Klok, Frederikus A (Wiley-Blackwell, 2022-08)
    Patients with acute venous thromboembolism (VTE) require anticoagulant therapy to prevent recurrent VTE and death, which exposes them to an inherent increased risk of bleeding. Identification of patients at high risk of ...
  • Safety of off-label dose reduction of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation 
    van den Dries, Carline J; Pajouheshnia, Romin; van den Ham, Hendrika A; Souverein, Patrick; Moons, Karel G M; Hoes, Arno W; Geersing, Geert-Jan; van Doorn, Sander (Wiley-Blackwell, 2023-02)
    AIM: To investigate the effects of off-label non-vitamin K oral anticoagulant (NOAC) dose reduction compared with on-label standard dosing in atrial fibrillation (AF) patients in routine care. METHODS: Population-based ...
  • Alignment of vaccine codes using an ontology of vaccine descriptions 
    Becker, Benedikt F. H.; Kors, Jan A.; van Mulligen, Erik M.; Sturkenboom, Miriam C. J. M. (BioMed Central Ltd., 2022-10-18)
    Background: Vaccine information in European electronic health record (EHR) databases is represented using various clinical and database-specific coding systems and drug vocabularies. The lack of harmonization constitutes ...
  • Normative mammillary body volumes: From the neonatal period to young adult 
    Vann, Seralynne D; Zachiu, Cornel; Meys, Karlijn M E; Ambrosino, Sara; Durston, Sarah; de Vries, Linda S; Groenendaal, Floris; Lequin, Maarten H (Elsevier, 2022-12)
    The mammillary bodies may be small, but they have an important role in encoding complex memories. Mammillary body pathology often occurs following thiamine deficiency but there is increasing evidence that the mammillary ...
  • The effect of COVID-19 on transplant function and development of CLAD in lung transplant patients: A multicenter experience 
    Roosma, Elizabeth; van Gemert, Johanna P.; de Zwart, Auke E.S.; van Leer-Buter, Coretta C.; Hellemons, Merel E.; Berg, Elize M.; Luijk, Bart; Hoek, Rogier A.S.; van Kessel, Diana A.; Akkerman, Onno W.; Kerstjens, Huib A.M.; Verschuuren, Erik A.M.; Gan, C. Tji (Elsevier, 2022-09)
    Background: Concerns have been raised on the impact of coronavirus disease (COVID-19) on lung transplant (LTx) patients. The aim of this study was to evaluate the transplant function pre- and post-COVID-19 in LTx patients. ...
  • ECFS standards of care on CFTR-related disorders: Diagnostic criteria of CFTR dysfunction 
    Sermet-Gaudelus, I.; Girodon, E.; Vermeulen, F.; Solomon, G. M.; Melotti, P.; Graeber, S. Y.; Bronsveld, I.; Rowe, S. M.; Wilschanski, M.; Tümmler, B.; Cutting, G. R.; Gonska, T. (Elsevier, 2022-11)
    The spectrum of disorders involving CFTR (cystic fibrosis transmembrane conductance regulator) dysfunction correlates with a continuous gradient of CFTR function defined by the combination of two allelic CFTR variants. ...
  • Protocol ter preventie van perioperatieve pulmonale complicaties 
    Miggelbrink, Lynn Ann; Marsman, Marije; Senff, Jasper R.; van Waes, Judith A.R.; Bronsveld, Inez; van Klei, Wilton; Kappen, Teus (Bohn Stafleu van Loghum, 2022-10-20)
    INTRODUCTION: Patients with a history of chronic obstructive pulmonary disease (COPD) or asthma undergoing surgery are at risk for developing postoperative pulmonary complications, associated with morbidity and mortality. ...
  • Effects of long-term tobramycin inhalation solution (TIS) once daily on exacerbation rate in patients with non-cystic fibrosis bronchiectasis 
    Terpstra, Lotte C.; Altenburg, Josje; Bronsveld, Inez; de Kruif, Martijn D.; Berk, Yvonne; Snijders, Dominic; Rozemeijer, Wouter; Heijerman, Harry G.M.; Boersma, Wim G. (BioMed Central Ltd., 2022-12)
    Background: Use of long-term tobramycin inhalation solution (TIS) has been shown beneficial in cystic fibrosis (CF) and earlier findings also suggest a benefit in non-CF bronchiectasis. We investigated the efficacy and ...
  • Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51 
    Heijink, Anne Margriet; Stok, Colin; Porubsky, David; Manolika, Eleni Maria; de Kanter, Jurrian K.; Kok, Yannick P.; Everts, Marieke; de Boer, H. Rudolf; Audrey, Anastasia; Bakker, Femke J.; Wierenga, Elles; Tijsterman, Marcel; Guryev, Victor; Spierings, Diana C.J.; Knipscheer, Puck; van Boxtel, Ruben; Ray Chaudhuri, Arnab; Lansdorp, Peter M.; van Vugt, Marcel A.T.M. (Nature Publishing Group, 2022-12)
    Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are considered to form through homologous recombination (HR). Indeed, SCE induction upon irradiation requires the canonical HR factors ...
  • MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling 
    Zimmerli, Dario; Brambillasca, Chiara S.; Talens, Francien; Bhin, Jinhyuk; Linstra, Renske; Romanens, Lou; Bhattacharya, Arkajyoti; Joosten, Stacey E.P.; Da Silva, Ana Moises; Padrao, Nuno; Wellenstein, Max D.; Kersten, Kelly; de Boo, Mart; Roorda, Maurits; Henneman, Linda; de Bruijn, Roebi; Annunziato, Stefano; van der Burg, Eline; Drenth, Anne Paulien; Lutz, Catrin; Endres, Theresa; van de Ven, Marieke; Eilers, Martin; Wessels, Lodewyk; de Visser, Karin E.; Zwart, Wilbert; Fehrmann, Rudolf S.N.; van Vugt, Marcel A.T.M.; Jonkers, Jos (Nature Publishing Group, 2022-12)
    The limited efficacy of immune checkpoint inhibitor treatment in triple-negative breast cancer (TNBC) patients is attributed to sparse or unresponsive tumor-infiltrating lymphocytes, but the mechanisms that lead to a therapy ...
  • Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS G12D glycolytic colorectal tumors 
    Ludikhuize, Marlies C.; Gevers, Sira; Nguyen, Nguyen T.B.; Meerlo, Maaike; Roudbari, S. Khadijeh Shafiei; Gulersonmez, M. Can; Stigter, Edwin C.A.; Drost, Jarno; Clevers, Hans; Burgering, Boudewijn M.T.; Rodríguez Colman, Maria J. (Springer Nature, 2022-12)
    Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying 5-FU toxicity are debated, limiting the ...
  • Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts 
    De Coster, Tine; Masset, Heleen; Tšuiko, Olga; Catteeuw, Maaike; Zhao, Yan; Dierckxsens, Nicolas; Aparicio, Ainhoa Larreategui; Dimitriadou, Eftychia; Debrock, Sophie; Peeraer, Karen; de Ruijter-Villani, Marta; Smits, Katrien; Van Soom, Ann; Vermeesch, Joris Robert (BioMed Central, 2022-12)
    Background: During normal zygotic division, two haploid parental genomes replicate, unite and segregate into two biparental diploid blastomeres. Results: Contrary to this fundamental biological tenet, we demonstrate here ...
  • Molecular characterization of colorectal cancer related peritoneal metastatic disease 
    Lenos, Kristiaan J.; Bach, Sander; Ferreira Moreno, Leandro; ten Hoorn, Sanne; Sluiter, Nina R.; Bootsma, Sanne; Vieira Braga, Felipe A.; Nijman, Lisanne E.; van den Bosch, Tom; Miedema, Daniel M.; van Dijk, Erik; Ylstra, Bauke; Kulicke, Ruth; Davis, Fred P.; Stransky, Nicolas; Smolen, Gromoslaw A.; Coebergh van den Braak, Robert R.J.; IJzermans, Jan N.M.; Martens, John W.M.; Hallam, Sally; Beggs, Andrew D.; Kops, Geert J.P.L.; Lansu, Nico; Bastiaenen, Vivian P.; Klaver, Charlotte E.L.; Lecca, Maria C.; El Makrini, Khalid; Elbers, Clara C.; Dings, Mark P.G.; van Noesel, Carel J.M.; Kranenburg, Onno; Medema, Jan Paul; Koster, Jan; Koens, Lianne; Punt, Cornelis J.A.; Tanis, Pieter J.; de Hingh, Ignace H.; Bijlsma, Maarten F.; Tuynman, Jurriaan B.; Vermeulen, Louis (Nature Publishing Group, 2022-08-04)
    A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease ...
  • A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant 
    Chiu, Man Chun; Li, Cun; Liu, Xiaojuan; Yu, Yifei; Huang, Jingjing; Wan, Zhixin; Xiao, Ding; Chu, Hin; Cai, Jian Piao; Zhou, Biao; Sit, Ko Yung; Au, Wing Kuk; Wong, Kenneth Kak Yuen; Li, Gang; Chan, Jasper Fuk Woo; To, Kelvin Kai Wang; Chen, Zhiwei; Jiang, Shibo; Clevers, Hans; Yuen, Kwok Yung; Zhou, Jie (Springer Nature, 2022-06-17)
    The airways and alveoli of the human respiratory tract are lined by two distinct types of epithelium, which are the primary targets of respiratory viruses. We previously established long-term expanding human lung epithelial ...
  • Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients 
    Tellegen, Anna R; Rudnik-Jansen, Imke; Utomo, Lizette; Versteeg, Sabine; Beukers, Martijn; Maarschalkerweerd, Roelof; van Zuilen, Dick; van Klaveren, Nicoline J; Houben, Kaat; Teske, Erik; René van Weeren, P; Karssemakers-Degen, Nina; Mihov, George; Thies, Jens; Eijkelkamp, Niels; Creemers, Laura B; Meij, Björn P; Tryfonidou, Marianna A (W.B. Saunders Ltd, 2023-03)
    OBJECTIVE: Drug delivery platforms that allow for gradual drug release after intra-articular administration have become of much interest as a treatment strategy for osteoarthritis (OA). The aim of this study was to investigate ...
  • Longitudinal changes of thoracic aortic diameters in the general population aged 55 years or older 
    Thijssen, Carlijn G E; Mutluer, Ferit O; van der Toorn, Janine E; Bons, Lidia R; Gökalp, Arjen L; Takkenberg, Johanna Jm; Mokhles, Mostafa M; van Kimmenade, Roland R J; Vernooij, Meike W; van der Lugt, Aad; Budde, Ricardo P J; Roos-Hesselink, Jolien W; Kavousi, Maryam; Bos, Daniel (BMJ Publishing Group, 2022-04-28)
    OBJECTIVE: Longitudinal data on age-related changes in the diameters of the thoracic aorta are scarce. To better understand normal variation and to identify factors influencing this process, we aimed to report male-female-specific ...
  • Cerebral protection in aortic arch surgery: systematic review and meta-analysis 
    Abjigitova, Djamila; Veen, Kevin M; van Tussenbroek, Gabriëlle; Mokhles, Mostafa M; Bekkers, Jos A; Takkenberg, Johanna J M; Bogers, Ad J J C (Oxford University Press, 2022-09-01)
    Consensus regarding optimal cerebral protection strategy in aortic arch surgery is lacking. We therefore performed a systematic review and meta-analysis to assess outcome differences between unilateral antegrade cerebral ...