Animal Models of Osteoarthritis Part 1–Preclinical Small Animal Models: Challenges and Opportunities for Drug Development
Rios, Jaqueline Lourdes; Sapède, Dora; Djouad, Farida; Rapp, Anna E.; Lang, Annemarie; Larkin, Jonathan; Ladel, Christoph; Mobasheri, Ali
(2022) Current Protocols, volume 2, issue 11, pp. 1 - 20
(Article)
Abstract
Osteoarthritis (OA) is the most common form of arthritis and a major source of pain and disability in the adult population. There is a significant unmet medical need for the development of effective pharmacological therapies for the treatment of OA. In addition to spontaneously occurring animal models of OA, many
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experimental animal models have been developed to provide insights into mechanisms of pathogenesis and progression. Many of these animal models are also being used in the drug development pipeline. Here, we provide an overview of commonly used and emerging preclinical small animal models of OA and highlight the strengths and limitations of small animal models in the context of translational drug development. There is limited information in the published literature regarding the technical reliability of these small animal models and their ability to accurately predict clinical drug development outcomes. The cost and complexity of the available models however is an important consideration for pharmaceutical companies, biotechnology startups, and contract research organizations wishing to incorporate preclinical models in target validation, discovery, and development pipelines. Further considerations relevant to industry include timelines, methods of induction, the key issue of reproducibility, and appropriate outcome measures needed to objectively assess outcomes of experimental therapeutics. Preclinical small animal models are indispensable tools that will shine some light on the pathogenesis of OA and its molecular endotypes in the context of drug development. This paper will focus on small animal models used in preclinical OA research. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.
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Keywords: drug development, guinea pig, mouse, osteoarthritis, preclinical animal model, rabbit, rat, zebrafish, Osteoarthritis/drug therapy, Reproducibility of Results, Animals, Drug Development, Arthritis, Experimental/drug therapy, Disease Models, Animal, Medical Laboratory Technology, General Biochemistry,Genetics and Molecular Biology, General Immunology and Microbiology, Health Informatics, General Neuroscience, Pharmacology, Toxicology and Pharmaceutics(all), Journal Article
ISSN: 2691-1299
Publisher: John Wiley & Sons Inc.
Note: Funding Information: The authors wish to acknowledge their institutions and members of their research laboratories for support. JL, CL, and AM wish to acknowledge financial support from the Innovative Medicines Initiative Joint Undertaking under grant agreement 115770, the resources of which are composed of financial contributions from the European Union's Seventh Framework Programme (FP7/2007–2013) and EFPIA companies’ in‐kind contribution. See http://www.imi.europa.eu/ and http://www.approachproject.eu/ . AM wishes to acknowledge financial support from the European Structural and Social Funds through the Research Council of Lithuania (Lietuvos Mokslo Taryba) according to the Programme Attracting Foreign Researchers for Research Implementation, grant no. 01.2.2‐LMT‐K‐718‐02‐0022. AM also wishes to acknowledge the financial support of the Academy of Finland through a research grant starting September 2022 and the Profi6 336449 grant awarded to the University of Oulu. JLR wishes to acknowledge financial support from the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska Curie grant agreement 955335 (CARTHAGO) and 956477 (PIANO). DS wishes to acknowledge financial support from the Agence Nationale pour la Recherche (ANR‐18‐CE18‐0010). Publisher Copyright: © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.
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