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UMC Repository: Recent submissions

  • A multinational Delphi consensus to end the COVID-19 public health threat 
    Lazarus, Jeffrey V; Romero, Diana; Kopka, Christopher J; Karim, Salim Abdool; Abu-Raddad, Laith J; Almeida, Gisele; Baptista-Leite, Ricardo; Barocas, Joshua A; Barreto, Mauricio L; Bar-Yam, Yaneer; Bassat, Quique; Batista, Carolina; Bazilian, Morgan; Chiou, Shu-Ti; Del Rio, Carlos; Dore, Gregory J; Gao, George F; Gostin, Lawrence O; Hellard, Margaret; Jimenez, Jose L; Kang, Gagandeep; Lee, Nancy; Matičič, Mojca; McKee, Martin; Nsanzimana, Sabin; Oliu-Barton, Miquel; Pradelski, Bary; Pyzik, Oksana; Rabin, Kenneth; Raina, Sunil; Rashid, Sabina Faiz; Rathe, Magdalena; Saenz, Rocio; Singh, Sudhvir; Trock-Hempler, Malene; Villapol, Sonia; Yap, Peiling; Binagwaho, Agnes; Kamarulzaman, Adeeba; El-Mohandes, Ayman; COVID-19 Consensus Statement Panel (Nature Research, 2022-11-10)
    Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic 1,2. Here we convened, as part of this Delphi study, a ...
  • Comparison between an in-house SARS-CoV-2 ELISpot and the T-Spot® Discovery SARS-CoV-2 for the assessment of T cell responses in prior SARS-CoV-2-infected individuals 
    Mak, Willem A; Koeleman, Johannes G M; Ong, David S Y (Elsevier, 2022-06)
  • Development of an in-house SARS-CoV-2 interferon-gamma ELISpot and plate reader-free spot detection method 
    Mak, Willem A; Koeleman, Johannes G M; Ong, David S Y (Elsevier, 2022-02)
    Coronavirus disease 2019 (COVID-19) vaccination programs rolled out in an attempt to stop the COVID-19 pandemic. Besides neutralising antibodies, effective T cell responses are also crucial for protection against severe ...
  • Airborne SARS-CoV-2 RNA excretion by patients with COVID-19 on different oxygen-delivery systems: a prospective observational study 
    Janssen, M L; Klazen, Y P; de Man, P; Hanselaar, W; Ong, D S Y; Wils, E-J (W.B. Saunders Ltd, 2022-05)
    BACKGROUND: Concerns persist regarding the risk of airborne SARS-CoV-2 transmission by patients with COVID-19 on various modalities of oxygen therapy, such as high-flow nasal cannula (HFNC). AIM: We aimed to compare the ...
  • ESCMID guidelines on testing for SARS-CoV-2 in asymptomatic individuals to prevent transmission in the health care setting 
    Carrara, Elena; Ong, David S Y; Hussein, Khetam; Keske, Siran; Johansson, Anders F; Presterl, Elisabeth; Tsioutis, Constantinos; Tschudin-Sutter, Sarah; Tacconelli, Evelina (Elsevier, 2022-05)
    SCOPE: This guideline addresses the indications for direct testing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic individuals in health care facilities, with the aim to prevent SARS-CoV-2 ...
  • Performance of point-of care molecular and antigen-based tests for SARS-CoV-2: a living systematic review and meta-analysis 
    European Society of Clinical Microbiology and Infection Study Group for Respiratory Viruses (Elsevier, 2023-03)
    BACKGROUND: Molecular and antigen point-of-care tests (POCTs) have augmented our ability to rapidly identify and manage SARS-CoV-2 infection. However, their clinical performance varies among individual studies. OBJECTIVES: ...
  • Clostridioides difficile infection with isolates of cryptic clade C-II: a genomic analysis of polymerase chain reaction ribotype 151 
    Ducarmon, Quinten R.; van der Bruggen, Tjomme; Harmanus, Céline; Sanders, Ingrid M.J.G.; Daenen, Laura G.M.; Fluit, Ad C.; Vossen, Rolf H.A.M.; Kloet, Susan L.; Kuijper, Ed J.; Smits, Wiep Klaas (Elsevier, 2023-04)
    Objectives: We report a patient case of pseudomembranous colitis associated with a monotoxin-producing Clostridioides difficile belonging to the very rarely diagnosed polymerase chain reaction (PCR) ribotype (RT) 151. To ...
  • Theory for a non-invasive diagnostic biomarker for craniospinal diseases 
    Karimi, Fariba; Neufeld, Esra; Fallahi, Arya; Boraschi, Andrea; Zwanenburg, Jaco J M; Spiegelberg, Andreas; Kurtcuoglu, Vartan; Kuster, Niels (Elsevier, 2023-01)
    Monitoring intracranial pressure (ICP) and craniospinal compliance (CC) is frequently required in the treatment of patients suffering from craniospinal diseases. However, current approaches are invasive and cannot provide ...
  • Patients' and parents' satisfaction to improve patient care in JIA: factors determining acceptable symptom state measured with JAMAR 
    Del Giudice, Emanuela; de Roock, Sytze; Vastert, Sebastiaan J; Wulffraat, Nico M; Swart, Joost F; van Dijkhuizen, Evert H P (Oxford University Press, 2023-05-02)
    OBJECTIVES: The aim of this study was to identify factors associated with patients' and parents' reported satisfaction with JIA care, measured with the juvenile arthritis child and parent acceptable symptom state (JA-CASS ...
  • CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation 
    Rodrigues-Díez, Raúl R.; Tejera-Muñoz, Antonio; Esteban, Vanesa; Steffensen, Lasse B.; Rodrigues-Díez, Raquel; Orejudo, Macarena; Rayego-Mateos, Sandra; Falke, Lucas L.; Cannata-Ortiz, Pablo; Ortiz, Alberto; Egido, Jesus; Mallat, Ziad; Briones Ana, M.; Bajo, M. Auxiliadora; Goldschmeding, Roel; Ruiz-Ortega, Marta (Lippincott Williams & Wilkins, 2022-03-01)
    Background: CCN2 (cellular communication network factor 2) is a matricellular protein involved in cell communication and microenvironmental signaling responses. CCN2 is known to be overexpressed in several cardiovascular ...
  • Oxidative Stress and Cellular Senescence Are Involved in the Aging Kidney 
    Marquez-Exposito, Laura; Tejedor-Santamaria, Lucia; Valentijn, Floris A.; Tejera-Muñoz, Antonio; Rayego-Mateos, Sandra; Marchant, Vanessa; Rodrigues-Diez, Raul R.; Rubio-Soto, Irene; Knoppert, Sebastiaan N.; Ortiz, Alberto; Ramos, Adrian M.; Goldschmeding, Roel; Ruiz-Ortega, Marta (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02)
    Chronic kidney disease (CKD) can be considered as a clinical model for premature aging. However, non‐invasive biomarkers to detect early kidney damage and the onset of a senescent phenotype are lacking. Most of the preclinical ...
  • Effectiveness of self-financing patient-led support groups in the management of hypertension and diabetes in low- and middle-income countries: systematic review 
    Sanya, Richard E; Johnston, Erin Stewart; Kibe, Peter; Werfalli, Mahmoud; Mahone, Sloan; Levitt, Naomi S; Klipstein-Grobusch, Kerstin; Asiki, Gershim (Wiley-Blackwell, 2023-02)
    OBJECTIVE: There is insufficient evidence on the role of self-financing patient support groups in the control of blood pressure (BP) and/or diabetes in low- and middle-income countries (LMICs). We conducted a systematic ...
  • Associations of psychosocial stress with type 2 diabetes and glycaemic control among Ghanaians: The RODAM study 
    Chilunga, Felix P; Schwerzel, Pleun S; Meeks, Karlijn A C; Beune, Erik; Bahendeka, Silver; Mockenhaupt, Frank; Klipstein-Grobusch, Kerstin; Agyemang, Charles (Wiley-Blackwell, 2023-01)
    BACKGROUND: The extent to which psychosocial stress relates to type 2 diabetes among sub-Saharan Africans is not well understood. We assessed associations of psychosocial stresses with type 2 diabetes status and glycaemic ...
  • Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury 
    Valentijn, Floris A; Knoppert, Sebastiaan N; Marquez-Exposito, Laura; Rodrigues-Diez, Raúl R; Pissas, Georgios; Tang, Jiaqi; Tejedor-Santamaria, Lucia; Broekhuizen, Roel; Samarakoon, Rohan; Eleftheriadis, Theodoros; Goldschmeding, Roel; Nguyen, Tri Q; Ruiz-Ortega, Marta; Falke, Lucas L (Elsevier, 2022-12)
    Chronic allograft dysfunction with progressive fibrosis of unknown cause remains a major issue after kidney transplantation, characterized by ischemia-reperfusion injury (IRI). One hypothesis to account for this is that ...
  • Convolutional Neural Networks for the Evaluation of Chronic and Inflammatory Lesions in Kidney Transplant Biopsies 
    Hermsen, Meyke; Ciompi, Francesco; Adefidipe, Adeyemi; Denic, Aleksandar; Dendooven, Amélie; Smith, Byron H; van Midden, Dominique; Bräsen, Jan Hinrich; Kers, Jesper; Stegall, Mark D; Bándi, Péter; Nguyen, Tri; Swiderska-Chadaj, Zaneta; Smeets, Bart; Hilbrands, Luuk B; van der Laak, Jeroen A W M (Elsevier, 2022-10)
    In kidney transplant biopsies, both inflammation and chronic changes are important features that predict long-term graft survival. Quantitative scoring of these features is important for transplant diagnostics and kidney ...
  • Urinary KIM-1 Correlates with the Subclinical Sequelae of Tubular Damage Persisting after the Apparent Functional Recovery from Intrinsic Acute Kidney Injury 
    Cuesta, Cristina; Fuentes-Calvo, Isabel; Sancho-Martinez, Sandra M; Valentijn, Floris A; Düwel, Annette; Hidalgo-Thomas, Omar A; Agüeros-Blanco, Consuelo; Benito-Hernández, Adalberto; Ramos-Barron, María A; Gómez-Alamillo, Carlos; Arias, Manuel; Nguyen, Tri Q; Goldschmeding, Roel; Martínez-Salgado, Carlos; López-Hernández, Francisco J (MDPI AG, 2022-05)
    Acute kidney injury (AKI) poses an increased risk factor for new AKI episodes, progression to chronic kidney disease, and death. A worsened evolution has been linked to an incomplete renal repair beyond the apparent ...
  • A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics 
    Yang, Yi; Mihajlovic, Milos; Valentijn, Floris; Nguyen, Tri Q; Goldschmeding, Roel; Masereeuw, Rosalinde (Frontiers Media S. A., 2022-03-29)
    Accumulating evidence suggests that senescence of kidney tubule epithelial cells leads to fibrosis. These cells secrete senescence-associated secretory phenotype (SASP) factors that are involved in diverse signaling pathways, ...
  • Two-year follow-up of KTE-X19 in patients with relapsed or refractory adult B-cell acute lymphoblastic leukemia in ZUMA-3 and its contextualization with SCHOLAR-3, an external historical control study 
    Shah, Bijal D; Ghobadi, Armin; Oluwole, Olalekan O; Logan, Aaron C; Boissel, Nicolas; Cassaday, Ryan D; Leguay, Thibaut; Bishop, Michael R; Topp, Max S; Tzachanis, Dimitrios; O'Dwyer, Kristen M; Arellano, Martha L; Lin, Yi; Baer, Maria R; Schiller, Gary J; Park, Jae H; Subklewe, Marion; Abedi, Mehrdad; Minnema, Monique C; Wierda, William G; DeAngelo, Daniel J; Stiff, Patrick; Jeyakumar, Deepa; Dong, Jinghui; Adhikary, Sabina; Zhou, Lang; Schuberth, Petra C; Faghmous, Imi; Masouleh, Behzad Kharabi; Houot, Roch (BioMed Central Ltd., 2022-12-10)
    BACKGROUND: Brexucabtagene autoleucel (KTE-X19) is an autologous anti-CD19 CAR T-cell therapy approved in the USA to treat adult patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (R/R B-ALL) ...
  • Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma 
    Chari, Ajai; Minnema, Monique C; Berdeja, Jesus G; Oriol, Albert; van de Donk, Niels W C J; Rodríguez-Otero, Paula; Askari, Elham; Mateos, María-Victoria; Costa, Luciano J; Caers, Jo; Verona, Raluca; Girgis, Suzette; Yang, Shiyi; Goldsmith, Rachel B; Yao, Xiang; Pillarisetti, Kodandaram; Hilder, Brandi W; Russell, Jeffery; Goldberg, Jenna D; Krishnan, Amrita (Massachussetts Medical Society, 2022-12-15)
    BACKGROUND: G protein-coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor expressed in malignant plasma cells. Talquetamab, a bispecific antibody against CD3 and GPRC5D, redirects T cells to mediate ...
  • CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research 
    Kotecha, Dipak; Asselbergs, Folkert W.; Achenbach, Stephan; Anker, Stefan D.; Atar, Dan; Baigent, Colin; Banerjee, Amitava; Beger, Birgit; Brobert, Gunnar; Casadei, Barbara; Ceccarelli, Cinzia; Cowie, Martin R.; Crea, Filippo; Cronin, Maureen; Denaxas, Spiros; Derix, Andrea; Fitzsimons, Donna; Fredriksson, Martin; Gale, Chris P.; Gkoutos, Georgios, V; Goettsch, Wim; Hemingway, Harry; Ingvar, Martin; Jonas, Adrian; Kazmierski, Robert; Logstrup, Susanne; Lumbers, R. Thomas; Luescher, Thomas F.; McGreavy, Paul; Pina, Ileana L.; Roessig, Lothar; Steinbeisser, Carl; Sundgren, Mats; Tyl, Benoit; van Thiel, Ghislaine; van Bochove, Kees; Vardas, Panos E.; Villanueva, Tiago; Vrana, Marilena; Weber, Wim; Weidinger, Franz; Windecker, Stephan; Wood, Angela; Grobbee, Diederick E. (Elsevier, 2022-10)
    Big data is important to new developments in global clinical science that aim to improve the lives of patients. Technological advances have led to the regular use of structured electronic health-care records with the ...