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Now showing items 3841-3860 of 40729

Biphenotypic sinonasal sarcoma: demographics, clinicopathological characteristics, molecular features, and prognosis of a recently described entity

Andreasen, Simon; Bishop, Justin A.; Hellquist, Henrik; Hunt, Jennifer; Kiss, Katalin; Rinaldo, Alessandra; Skálová, Alena; Willems, Stefan M.; Williams, Michelle; Ferlito, Alfio (Springer-Verlag, 2018-11)

Biphenotypic sinonasal sarcoma (BSNS) is a recently recognized type of sarcoma arising exclusively in the sinonasal tract displaying unique clinical course, histopathology, and genetics. Due to its rarity, only case series ...
Effect of formulation and processing parameters on the size of mPEG-b-p(HPMA-Bz) polymeric micelles

Bagheri, Mahsa; Bresseleers, Jaleesa; Varela-Moreira, Aida; Sandre, Olivier; Meeuwissen, Silvie A.; Schiffelers, Raymond M.; Metselaar, Josbert M.; Van Nostrum, Cornelus F.; Van Hest, Jan C.M.; Hennink, Wim E. (American Chemical Society, 2018-12-18)

Micelles composed of block copolymers of poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) have shown great promise as drug-delivery carriers due to their excellent stability and high ...
Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Parmar, Priyanka; Lowry, Estelle; Cugliari, Giovanni; Suderman, Matthew; Wilson, Rory; Karhunen, Ville; Andrew, Toby; Wiklund, Petri; Wielscher, Matthias; Guarrera, Simonetta; Teumer, Alexander; Lehne, Benjamin; Milani, Lili; de Klein, Niek; Mishra, Pashupati P; Melton, Phillip E; Mandaviya, Pooja R; Kasela, Silva; Nano, Jana; Zhang, Weihua; Zhang, Yan; Uitterlinden, Andre G; Peters, Annette; Schöttker, Ben; Gieger, Christian; Anderson, Denise; Boomsma, Dorret I; Grabe, Hans J; Panico, Salvatore; Veldink, Jan H; van Meurs, Joyce B J; van den Berg, Leonard; Beilin, Lawrence J; Franke, Lude; Loh, Marie; van Greevenbroek, Marleen M J; Nauck, Matthias; Kähönen, Mika; Hurme, Mikko A; Raitakari, Olli T; Franco, Oscar H; Slagboom, P Eline; van der Harst, Pim; Kunze, Sonja; Felix, Stephan B; Zhang, Tao; Chen, Wei; Mori, Trevor A; Bonnefond, Amelie; Heijmans, Bastiaan T; BIOS Consortium (Elsevier, 2018-12)

Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal ...
Diagnostic accuracy of functional magnetic resonance imaging, Wada test, magnetoencephalography, and functional transcranial Doppler sonography for memory and language outcome after epilepsy surgery: A systematic review

Schmid, Elisabeth; Thomschewski, Aljoscha; Taylor, Alexandra; Zimmermann, Georg; Kirschner, Margarita; Kobulashvili, Teia; Brigo, Francesco; Rados, Matea; Helmstaedter, Christoph; Braun, Kees; Trinka, Eugen; on behalf of the E-PILEPSY consortium (Wiley-Blackwell, 2018-12)

Objective: The European Union–funded E-PILEPSY project was launched to develop guidelines and recommendations for epilepsy surgery. In this systematic review, we aimed to assess the diagnostic accuracy of functional magnetic ...
Blood Pressure-Lowering Treatment after Subacute Stroke to Prevent Recurrent Stroke, Major Vascular Events, and Dementia

Zonneveld, Thomas P.; Richard, Edo; Vergouwen, Mervyn D.I.; Nederkoorn, Paul J.; De Haan, Rob J.; Roos, Yvo B.W.E.M.; Kruyt, Nyika D. (Lippincott Williams & Wilkins, 2018-11)
Cancer prevention by aspirin in children with Constitutional Mismatch Repair Deficiency (CMMRD)

Leenders, Erika K S M; Westdorp, Harm; Brüggemann, Roger J; Loeffen, Jan; Kratz, Christian; Burn, John; Hoogerbrugge, Nicoline; Jongmans, Marjolijn C J (Springer Nature, 2018-10-01)

Constitutional MisMatch Repair Deficiency (CMMRD) is caused by homozygous or compound heterozygous germline variants in one of the mismatch repair (MMR) genes (MSH2, MSH6, PMS2, MLH1). This syndrome results in early onset ...
A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity

De Bruyne, Marieke; Bogaert, Delfien J.; Venken, Koen; Van den Bossche, Lien; Bonroy, Carolien; Roels, Lisa; Tavernier, Simon J.; van de Vijver, Els; Driessen, Ann; van Gijn, Marielle; Gámez-Diaz, Laura; Elewaut, Dirk; Grimbacher, Bodo; Haerynck, Filomeen; Moes, Nicolette; Dullaers, Melissa (Mosby Inc., 2018-12)
Adjuvant Vascular Endothelial Growth Factor-targeted Therapy in Renal Cell Carcinoma: A Systematic Review and Pooled Analysis: A Systematic Review and Pooled Analysis [Figure presented]

Sun, Maxine; Marconi, Lorenzo; Eisen, Tim; Escudier, Bernard; Giles, Rachel H; Haas, Naomi B; Harshman, Lauren C; Quinn, David I; Larkin, James; Pal, Sumanta K; Powles, Thomas; Ryan, Christopher W; Sternberg, Cora N; Uzzo, Robert; Choueiri, Toni K; Bex, Axel (Elsevier, 2018-11)

CONTEXT: Contradictory data exist with regard to adjuvant vascular endothelial growth factor receptor (VEGFR)-targeted therapy in surgically managed patients for localized renal cell carcinoma (RCC). OBJECTIVE: To ...
An interdisciplinary consensus on the management of bone metastases from renal cell carcinoma

Grünwald, Viktor; Eberhardt, Berit; Bex, Axel; Flörcken, Anne; Gauler, Thomas; Derlin, Thorsten; Panzica, Martin; Dürr, Hans Roland; Grötz, Knut Achim; Giles, Rachel H; von Falck, Christian; Graser, Anno; Muacevic, Alexander; Staehler, Michael (Nature Research, 2018-08)

Bone is a major site of haematogenous tumour cell spread in renal cell carcinoma (RCC), and most patients with RCC will develop painful and functionally disabling bone metastases at advanced disease stages. The prognosis ...
A Joint Statement from the European Association of Urology Renal Cell Cancer Guidelines Panel and the International Kidney Cancer Coalition: The Rejection of Ipilimumab and Nivolumab for Renal Cancer by the Committee for Medicinal Products for Human Use Does not Change Evidence-based Guideline Recommendations

Bex, Axel; Albiges, Laurence; Staehler, Michael; Bensalah, Karim; Giles, Rachel H; Dabestani, Saeed; Hofmann, Fabian; Hora, Milan; Kuczyk, Markus A; Lam, Thomas B; Marconi, Lorenzo; Merseburger, Axel S; Fernández-Pello, Sergio; Tahbaz, Rana; Abu-Ghanem, Yasmin; Volpe, Alessandro; Ljungberg, Börje; Escudier, Bernard; Powles, Thomas (Elsevier, 2018-12)
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal

Rindi, Guido; Klimstra, David S.; Abedi-Ardekani, Behnoush; Asa, Sylvia L.; Bosman, Frederik T.; Brambilla, Elisabeth; Busam, Klaus J.; de Krijger, Ronald R.; Dietel, Manfred; El-Naggar, Adel K.; Fernandez-Cuesta, Lynnette; Klöppel, Günter; McCluggage, W. Glenn; Moch, Holger; Ohgaki, Hiroko; Rakha, Emad A.; Reed, Nicholas S.; Rous, Brian A.; Sasano, Hironobu; Scarpa, Aldo; Scoazec, Jean Yves; Travis, William D.; Tallini, Giovanni; Trouillas, Jacqueline; van Krieken, J. Han; Cree, Ian A. (Elsevier, 2018-12)

The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform classification framework for NENs at any anatomical location may reduce inconsistencies ...
Differences in injury risk and characteristics of injuries between novice and experienced runners over a 4-year period

Kemler, Ellen; Blokland, Donna; Backx, Frank; Huisstede, Bionka (Taylor and Francis Ltd., 2018-11)

OBJECTIVES: Running is increasingly popular, but also carries a high injury risk, especially in novice runners. This study investigates differences in incidence and characteristics of running-related injuries (RRIs) between ...
Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort: The ABIDE Project

de Wilde, Arno; van der Flier, Wiesje M; Pelkmans, Wiesje; Bouwman, Femke; Verwer, Jurre; Groot, Colin; van Buchem, Marieke M; Zwan, Marissa; Ossenkoppele, Rik; Yaqub, Maqsood; Kunneman, Marleen; Smets, Ellen M A; Barkhof, Frederik; Lammertsma, Adriaan A; Stephens, Andrew; van Lier, Erik; Biessels, Geert Jan; van Berckel, Bart N; Scheltens, Philip (American Medical Association, 2018-09)

Importance: Previous studies have evaluated the diagnostic effect of amyloid positron emission tomography (PET) in selected research cohorts. However, these research populations do not reflect daily practice, thus hampering ...
Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

Biessels, Geert Jan; Despa, Florin (Nature Publishing Group, 2018-10)

Cognitive dysfunction is increasingly recognized as an important comorbidity of diabetes mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with different cognitive features, affected age ...
Energy expenditure and muscle activity during lying, sitting, standing, and walking in people with motor-incomplete spinal cord injury

Dekker, Bart; Verschuren, Olaf; Balemans, Astrid C.J.; Baart, Nadia; Tubbing, Frank; van Koppenhagen, Casper F.; Post, Marcel W.M. (Springer Nature, 2018-10)

Study design: Cross-sectional exploratory study. Objectives: To determine oxygen uptake (VO2), energy expenditure (EE), and muscle activity (MA) during lying (rest), sitting, standing, and walking among ambulatory individuals ...
Biallelic B3GALT6 mutations cause spondylodysplastic Ehlers-Danlos syndrome

Van Damme, Tim; Pang, Xiaomeng; Guillemyn, Brecht; Gulberti, Sandrine; Syx, Delfien; De Rycke, Riet; Kaye, Olivier; de Die-Smulders, Christine E M; Pfundt, Rolph; Kariminejad, Ariana; Nampoothiri, Sheela; Pierquin, Geneviève; Bulk, Saskia; Larson, Austin A; Chatfield, Kathryn C; Simon, Marleen; Legrand, Anne; Gerard, Marion; Symoens, Sofie; Fournel-Gigleux, Sylvie; Malfait, Fransiska (Oxford University Press, 2018-10-15)

Proteoglycans are among the most abundant and structurally complex biomacromolecules and play critical roles in connective tissues. They are composed of a core protein onto which glycosaminoglycan (GAG) side chains are ...
Cell Therapy for Chronic Limb-Threatening Ischemia: Current Evidence and Future Directions

Teraa, Martin; Gremmels, Hendrik; Wijnand, Joep G J; Verhaar, Marianne C (Oxford University Press, 2018-12)

Cell-based therapies have gained interest as a potential treatment method in cardiovascular disease in the past two decades, peripheral artery disease amongst others. Initial pre-clinical and small pilot clinical studies ...
Evoked directional network characteristics of epileptogenic tissue derived from single pulse electrical stimulation

van Blooijs, Dorien; Leijten, Frans S.S.; van Rijen, Peter C.; Meijer, Hil G.E.; Huiskamp, Geertjan J.M. (Wiley-Liss Inc., 2018-11)

We investigated effective networks constructed from single pulse electrical stimulation (SPES) in epilepsy patients who underwent intracranial electrocorticography. Using graph analysis, we compared network characteristics ...
Expanding the phenotypic spectrum of variants in PDE4D/PRKAR1A: from acrodysostosis to acroscyphodysplasia

Michot, Caroline; Le Goff, Carine; Blair, Edward; Blanchet, Patricia; Capri, Yline; Gilbert-Dussardier, Brigitte; Goldenberg, Alice; Henderson, Alex; Isidor, Bertrand; Kayserili, Hulya; Kinning, Esther; Le Merrer, Martine; Lyonnet, Stanislas; Odent, Sylvie; Simsek-Kiper, Pelin Ozlem; Quelin, Chloé; Savarirayan, Ravi; Simon, Marleen; Splitt, Miranda; M.A. Verhagen, Judith; Verloes, Alain; Munnich, Arnold; Baujat, Geneviève; Cormier-Daire, Valérie (Springer Nature, 2018-11)

Acrodysostosis (MIM 101800) is a dominantly inherited condition associating (1) skeletal features (short stature, facial dysostosis, and brachydactyly with cone-shaped epiphyses), (2) resistance to hormones and (3) possible ...
Cortical Microinfarcts on 3T Magnetic Resonance Imaging in Cerebral Amyloid Angiopathy: Relations With Other Magnetic Resonance Imaging Markers of Cerebral Amyloid Angiopathy and Cognition

van den Brink, Hilde; Zwiers, Angela; Switzer, Aaron R; Charlton, Anna; McCreary, Cheryl R; Goodyear, Bradley G; Frayne, Richard; Biessels, Geert Jan; Smith, Eric E (Lippincott Williams & Wilkins, 2018-08)

Background and Purpose- Cerebral microinfarcts are small ischemic lesions that are found in cerebral amyloid angiopathy (CAA) patients at autopsy. The current study aimed to detect cortical microinfarcts (CMI) on in vivo ...

Now showing items 3841-3860 of 40729