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Lower body mass index and mortality in older adults starting dialysis

Polinder-Bos, Harmke A.; Diepen, Merel van; Dekker, Friedo W.; Hoogeveen, Ellen K.; Franssen, Casper F.M.; Gansevoort, Ron T.; Gaillard, Carlo A.J.M.; de Jonge, I. (Nature Publishing Group, 2018-08-27)

Lower body mass index (BMI) has consistently been associated with mortality in elderly in the general and chronic disease populations. Remarkably, in older incident dialysis patients no association of BMI with mortality ...
Association of different iron deficiency cutoffs with adverse outcomes in chronic kidney disease

Eisenga, Michele F.; Nolte, Ilja M.; Van Der Meer, Peter; Bakker, Stephan J.L.; Gaillard, Carlo A.J.M. (BioMed Central, 2018-09-12)

Background: Iron deficiency is highly prevalent in chronic kidney disease (CKD) patients. In clinical practice, iron deficiency is defined based on a combination of two commonly used markers, ferritin and transferrin ...
Association of plasma somatostatin with disease severity and progression in patients with autosomal dominant polycystic kidney disease 11 Medical and Health Sciences 1103 Clinical Sciences

Lianne Messchendorp, A.; Spithoven, Edwin M.; Casteleijn, Niek F.; Dam, Wendy A.; Van Den Born, Jacob; Tonnis, Wouter F.; Gaillard, Carlo A.J.M.; Meijer, Esther; Drenth, Joost; De Fijter, Johan W.; Gansevoort, Ron T.; Peters, Dorien J.M.; Wetzels, Jack F.M.; Zietse, Robert (BioMed Central, 2018-12-19)

Background: Somatostatin (SST) inhibits intracellular cyclic adenosine monophosphate (cAMP) production and thus may modify cyst formation in autosomal dominant polycystic kidney disease (ADPKD). We investigated whether ...
Cerebrospinal fluid leakage, an uncommon complication of fetal blood sampling: A case report and review of the literature

Schaap, Timme P.; Moormann, Karlijn A.; Becker, Jeroen H.; Westerhuis, Michelle E.M.H.; Evers, Annemieke; Brouwers, Hens A.A.; Schuitemaker, Nico W.E.; Visser, Gerard H.A.; Kwee, Anneke (Lippincott Williams & Wilkins, 2011-01-01)

In a recently published randomized clinical trial on intrapartum fetal monitoring, fetal blood samples were obtained in 879 women. One serious complication of fetal blood sampling (FBS) was reported, a case in which physical ...
Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection

Ulfman, Laurien H; Leusen, Jeanette H W; Savelkoul, Huub F J; Warner, John O; van Neerven, R J Joost (Frontiers Media S. A., 2018)

This review aims to provide an in depth overview of the current knowledge of the effects of bovine immunoglobulins on the human immune system. The stability and functional effects of orally ingested bovine immunoglobulins ...
Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest

Yuan, Ruixue; Vos, Harmjan R.; van Es, Robert M.; Chen, Jing; Burgering, Boudewijn M.T.; Westendorp, Bart; de Bruin, Alain (Springer Science and Business Media Deutschland GmbH, 2018-03-01)

The atypical E2Fs, E2F7 and E2F8, act as potent transcriptional repressors of DNA replication genes providing them with the ability to induce a permanent S-phase arrest and suppress tumorigenesis. Surprisingly in human ...
Assessment of Functional Phosphatidylinositol 3-Kinase Pathway Activity in Cancer Tissue Using Forkhead Box-O Target Gene Expression in a Knowledge-Based Computational Model

van Ooijen, Henk; Hornsveld, Marten; Dam-de Veen, Christa; Velter, Rick; Dou, Meng; Verhaegh, Wim; Burgering, Boudewijn; van de Stolpe, Anja (Elsevier, 2018-09-01)

The phosphatidylinositol 3-kinase (PI3K) pathway is commonly activated in cancer. Tumors are potentially sensitive to PI3K pathway inhibitors, but reliable diagnostic tests that assess functional PI3K activity are lacking. ...
Expression of hypoxia-induced proteins in ductal carcinoma in situ and invasive cancer of the male breast

Vermeulen, Marijn A.; Van Deurzen, Carolien H.M.; Schroder, Carolien P.; Martens, John W.M.; Van Diest, Paul J. (BMJ Publishing Group, 2020-04-01)

Aims The aim of this study was to determine the role of hypoxia in male breast carcinogenesis by evaluating the expression of the hypoxia-related proteins, hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase IX (CAIX) ...
Efficacy and safety of infliximab biosimilar Inflectra ® in severe sarcoidosis

Schimmelpennink, Milou C.; Vorselaars, Adriane D.M.; van Beek, Frouke T.; Crommelin, Heleen A.; Deneer, Vera H.M.; Keijsers, Ruth G.M.; Veltkamp, Marcel (W.B. Saunders Ltd, 2018-05-01)

Background: Infliximab, a monoclonal antibody against tumor necrosis factor alpha (TNF-α) is effective third-line therapy in severe sarcoidosis. The originator product of Infliximab, Remicade ® , is expensive, limiting ...
Development of a standardized chart review method to identify drug-related hospital admissions in older people

Thevelin, Stefanie; Spinewine, Anne; Beuscart, Jean Baptiste; Boland, Benoit; Marien, Sophie; Vaillant, Fanny; Wilting, Ingeborg; Vondeling, Ariel; Floriani, Carmen; Schneider, Claudio; Donzé, Jacques; Rodondi, Nicolas; Cullinan, Shane; O'Mahony, Denis; Dalleur, Olivia (Wiley-Blackwell, 2018-11-01)

Aims: We aimed to develop a standardized chart review method to identify drug-related hospital admissions (DRA) in older people caused by non-preventable adverse drug reactions and preventable medication errors including ...
Digital PCR as a tool to measure HIV persistence

Rutsaert, Sofie; Bosman, Kobus; Trypsteen, Wim; Nijhuis, Monique; Vandekerckhove, Linos (BioMed Central, 2018-01-30)

Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped. In order to find a cure that can eradicate the latent reservoir, one must ...
Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis: A Randomized Clinical Trial

Bhattacharyya, Sagnik; Wilson, Robin; Appiah-Kusi, Elizabeth; O'Neill, Aisling; Brammer, Michael; Perez, Jesus; Murray, Robin; Allen, Paul; Bossong, Matthijs G; McGuire, Philip (American Medical Association, 2018-11-01)

Importance: Cannabidiol (CBD) has antipsychotic effects in humans, but how these are mediated in the brain remains unclear. Objective: To investigate the neurocognitive mechanisms that underlie the therapeutic effects of ...
Antithymocyte Globulin: Steps Toward Individualized Dosing

Admiraal, Rick; Boelens, Jaap J. (Elsevier, 2018-03)
A human monoclonal antibody that specifically binds and inhibits the staphylococcal complement inhibitor protein SCIN

Hoekstra, Hedzer; Romero Pastrana, Francisco; Bonarius, Hendrik P.J.; van Kessel, Kok P.M.; Elsinga, Goffe S.; Kooi, Neeltje; Groen, Herman; van Dijl, Jan Maarten; Buist, Girbe (Landes Bioscience, 2018-01-01)

Staphylococcus aureus is a serious public health burden causing a wide variety of infections. Earlier detection of such infections could result in faster and more directed therapies that also prevent resistance development. ...
Autologous hematopoietic stem cell transplantation in systemic sclerosis: A reset to tolerance?

van Rhijn-Brouwer, Femke C C; Spierings, Julia; van Laar, Jacob M (Elsevier, 2018-03)

Autologous hematopoietic stem cell transplantation (ASCT) is an effective therapy for refractory autoimmune disease, in particular diffuse cutaneous systemic sclerosis (dcSSc). ASCT is the only treatment that can induce ...
Use of Exogenous Hormones and Risks of Breast and Ovarian Cancers in BRCA1/2 Mutation Carriers; Methodological and Clinical Considerations

Schrijver, Lieske H.; Jansen, Susanne; van der Baan, FH; Rookus, Matti A. (Current Science, Inc., 2014-05-02)

Risks of breast and ovarian cancer among BRCA1/2 mutation carriers are high, even for the young. Recommendations for use of exogenous hormones designed for BRCA1/2 mutation carriers may therefore be appropriate. Here we ...
A single complex AGPAT2 allele in a patient with partial lipodystrophy

Broekema, Marjoleine F.; Massink, Maarten P.G.; De Ligt, Joep; Stigter, Edwin C.A.; Monajemi, Houshang; De Ridder, Jeroen; Burgering, Boudewijn M.T.; Van Haaften, Gijs W.; Kalkhoven, Eric (Frontiers Research Foundation, 2018-09-26)

Genetic lipodystrophies are a group of rare syndromes associated with major metabolic complications - including severe insulin resistance, type 2 diabetes mellitus, and hypertriglyceridemia - which are classified according ...
Erratum to: Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton–Valentine leukocidin (Nature Microbiology, (2018), 3, 6, (708-717), 10.1038/s41564-018-0159-x)

Tromp, Angelino T.; Van Gent, Michiel; Abrial, Pauline; Martin, Amandine; Jansen, Joris P.; De Haas, Carla J.C.; Van Kessel, Kok P.M.; Bardoel, Bart W.; Kruse, Elisabeth; Bourdonnay, Emilie; Boettcher, Michael; McManus, Michael T.; Day, Christopher J.; Jennings, Michael P.; Lina, Gérard; Vandenesch, François; Van Strijp, Jos A.G.; Lebbink, Robert Jan; Haas, Pieter Jan A.; Henry, Thomas; Spaan, András N. (Nature Research, 2018-10-01)

In the version of this Article originally published, the name of author Robert Jan Lebbink was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no ...
Guidance for the governance of public-private collaborations in vaccine post-marketing settings in Europe

Torcel-Pagnon, Laurence; Bauchau, Vincent; Mahy, Patrick; Tin Tin Htar, Myint; van der Sande, Marianne; Mahé, Cédric; Krause, Tyra Grove; Charrat, Anne; Simondon, François; Kurz, Xavier (Elsevier, 2019-05-31)

Introduction: The 2009 influenza pandemic highlighted challenges for vaccine post-marketing monitoring in Europe, particularly the need to have appropriate infrastructures to strengthen public-private collaborations ...
Dialysis associated β2-microglobulin amyloidosis occurs even in the era of high-flux dialyzers

Falke, Lucas L; Maas, Sybren L N; Rosati, Stefano; Logtenberg, Susan J J (Informa Healthcare, 2018)

Now showing items 3821-3840 of 40729