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Predicting treatment benefit in multiple myeloma through simulation of alternative treatment effects

Ubels, Joske; Sonneveld, Pieter; van Beers, Erik H.; Broijl, Annemiek; van Vliet, Martin H.; de Ridder, Jeroen (Nature Publishing Group, 2018-07-27)

Many cancer treatments are associated with serious side effects, while they often only benefit a subset of the patients. Therefore, there is an urgent clinical need for tools that can aid in selecting the right treatment ...
Targetclone: A multi-sample approach for reconstructing subclonal evolution of tumors

Nieboer, Marleen M.; Dorssers, Lambert C.J.; Straver, Roy; Looijenga, Leendert H.J.; De Ridder, Jeroen (Public Library of Science, 2018-11)

Most tumors are composed of a heterogeneous population of subclones. A more detailed insight into the subclonal evolution of these tumors can be helpful to study progression and treatment response. Problematically, tumor ...
A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma

Ranzani, Marco; Alifrangis, Constantine; Thompson, Nicola A.; Rust, Alistair G.; Allahyar, Amin; Iyer, Vivek; Price, Stacey; Ellis, Peter; Turner, Gemma; de Ridder, Jeroen; McDermott, Ultan; Adams, David J. (Wiley-Blackwell, 2019-03-01)
Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development

Dorssers, Lambert C.J.; Gillis, Ad J.M.; Stoop, Hans; van Marion, Ronald; Nieboer, Marleen M.; van Riet, Job; van de Werken, Harmen J.G.; Oosterhuis, J. Wolter; de Ridder, Jeroen; Looijenga, Leendert H.J. (Springer Nature, 2019-02-19)

Background: Testicular germ cell cancer (TGCC), being the most frequent malignancy in young Caucasian males, is initiated from an embryonic germ cell. This study determines intratumour heterogeneity to unravel tumour ...
A data-driven interactome of synergistic genes improves network-based cancer outcome prediction

Allahyar, Amin; Ubels, Joske; de Ridder, Jeroen (Public Library of Science, 2019-02)

Robustly predicting outcome for cancer patients from gene expression is an important challenge on the road to better personalized treatment. Network-based outcome predictors (NOPs), which considers the cellular wiring ...
sv-callers: A highly portable parallel workflow for structural variant detection in whole-genome sequence data

Kuzniar, Arnold; Maassen, Jason; Verhoeven, Stefan; Santuari, Luca; Shneider, Carl; Kloosterman, Wigard P.; de Ridder, Jeroen (PeerJ, 2020-01-06)

Structural variants (SVs) are an important class of genetic variation implicated in a wide array of genetic diseases including cancer. Despite the advances in whole genome sequencing, comprehensive and accurate detection ...
Rainforest: A random forest approach to predict treatment benefit in data from (failed) clinical drug trials

Ubels, Joske; Schaefers, Tilman; Punt, Cornelis; Guchelaar, Henk Jan; de Ridder, Jeroen (Oxford University Press, 2020-12-01)

Motivation: When phase III clinical drug trials fail their endpoint, enormous resources are wasted. Moreover, even if a clinical trial demonstrates a significant benefit, the observed effects are often small and may not ...
svMIL: Predicting the pathogenic effect of TAD boundary-disrupting somatic structural variants through multiple instance learning

Nieboer, Marleen M.; de Ridder, Jeroen (Oxford University Press, 2020-12-01)

Motivation: Despite the fact that structural variants (SVs) play an important role in cancer, methods to predict their effect, especially for SVs in non-coding regions, are lacking, leaving them often overlooked in the ...
Gene networks constructed through simulated treatment learning can predict proteasome inhibitor benefit in multiple myeloma

Ubels, Joske; Sonneveld, Pieter; van Vliet, Martin H.; de Ridder, Jeroen (American Association for Cancer Research Inc., 2020-11-15)

Purpose: Proteasome inhibitors are widely used in treating multiple myeloma, but can cause serious side effects and response varies among patients. It is, therefore, important to gain more insight into which patients will ...
Breast tissue imaging atlas using ultra-fast confocal microscopy to identify cancer lesions

Mathieu, Marie-Christine; Ragazzi, Moira; Ferchiou, Malek; van Diest, Paul J; Casiraghi, Odile; Lakhdar, Aicha Ben; Labaied, Nizar; Conversano, Angelica; Abbaci, Muriel (Springer-Verlag, 2025-02)

New generation ultra-fast fluorescence confocal microscopy (UFCM) allows to image histological architecture of fresh breast tissue and may be used for ex vivo intraoperative analysis for margin status. The criteria to ...
Interprofessional education for healthcare professionals. A BEME realist review of what works, why, for whom and in what circumstances in undergraduate health sciences education: BEME Guide No. 83

Krystallidou, Demi; Kersbergen, Maria J; de Groot, Esther; Fluit, Cornelia R M G; Kuijer-Siebelink, Wietske; Mertens, Fien; Oosterbaan-Lodder, Saskia C M; Scherpbier, Nynke; Versluis, Marco A C; Pype, Peter (Informa Healthcare, 2024-12)

AIM: To provide an evidence-informed program theory (PT) for Interprofessional Education (IPE) that adds to the knowledge base of how IPE in undergraduate health sciences education works. METHODS: We undertook a realist ...
Assessment of the optimal cerebral perfusion pressure in head-injured patients

Nordström, Carl Henrik; Cremer, O. L. (Lippincott Williams & Wilkins, 2005-07)
A stroke of insight from genetics

Visscher, Peter M.; Veldink, Jan H. (Elsevier Limited, 2016-06)
31 P MR Spectroscopy in the Pancreas: Repeatability, Comparison With Liver, and Pilot Pancreatic Cancer Data.

Seelen, Leonard W F; van den Wildenberg, Lieke; Gursan, Ayhan; Froeling, Martijn; Gosselink, Mark W J M; van der Kemp, Wybe J M; Haj Mohammad, Nadia; Molenaar, I Quintus; van Santvoort, Hjalmar C; Klomp, Dennis W J; Prompers, Jeanine J (John Wiley & Sons Inc., 2024-12)

Background: Non-invasive evaluation of phosphomonoesters (PMEs) and phosphodiesters (PDEs) by 31-phosphorus MR spectroscopy (31P MRS) may have potential for early therapy (non-)response assessment in cancer. However, 31P ...
Cost-effectiveness of low-dose colchicine in patients with chronic coronary disease in the netherlands

Fiolet, Aernoud T L; Keusters, Willem; Blokzijl, Johan; Nidorf, S Mark; Eikelboom, John E; Budgeon, Charley A; Tijssen, Jan G P; Römer, Tjeerd; Westendorp, Iris; Cornel, Jan Hein; Thompson, Peter L; Frederix, Geert W J; Mosterd, Arend; de Wit, G Ardine (Oxford University Press, 2025-01-16)

Aims Recent trials have shown that low-dose colchicine (0.5 mg once daily) reduces major cardiovascular events in patients with acute and chronic coronary syndromes. We aimed to estimate the cost-effectiveness of low-dose ...
Riding waves to improve functioning: a quantitative evaluation of a Surf Week in individuals with chronic phase brain injury with six months follow-up

Denneman, Rosalie P M; van Bezeij, Tijs; Kal, Elmar C; Marshall, Jamie; Pisters, Martijn F (Informa Healthcare, 2024)

PURPOSE: Environmental enrichment seems to enable people in the chronic phase of acquired brain injury (ABI) to experience new functional abilities and motor/coping strategies and consequently to become more adaptable which ...
Erratum: Life satisfaction and return to work after aneurysmal subarachnoid hemorrhage (Journal of Stroke and Cerebrovascular Diseases (2011) 20 (324-329))

Visser-Meily, Johanna M.A. (W.B. Saunders, 2011-09)
A simple bedside test for upper extremity impairment after stroke: Validation of the Utrecht Armhand test

Reenen, E. Th Kruitwagen Van; Post, M. W.M.; Mulder-Bouwens, K.; Visser-Meily, J. M.A. (Informa Healthcare, 2009)

Purpose. To examine the intra- and inter-rater reliability, criterion validity and responsiveness of the Utrecht Armhand Test UAT, a quick and easy assessment method for upper extremity impairment after stroke. Method. ...
How do patients with rheumatoid arthritis perceive their self-care and self-care support?: A mixed-method study

Westland, Heleen; Kuiper, Stefan; van den Bovenkamp, Cheryl; Blaas, Etienne; Jaarsma, Tiny (Wiley-Blackwell, 2024-10)

AIM: To explore self-care and needs and preferences towards tailored self-care support of patients with rheumatoid arthritis at the outpatient clinic. DESIGN: A sequential explanatory mixed method design. METHODS: The ...
The relation between vascular risk factors and flow in cerebral perforating arteries. A 7 Tesla MRI study

Heart-Brain Connection-study group (S. Karger AG, 2025)

INTRODUCTION: Cerebral perforating arteries provide blood supply to the deep regions of the brain. Recently, it became possible to measure blood flow velocity and pulsatility in these small arteries. It is unknown if ...

Now showing items 3281-3300 of 40729