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Now showing items 3301-3320 of 40729

Factors related to high-risk movement behaviour in people with stroke who are highly sedentary and inactive

Hendrickx, Wendy; Wondergem, Roderick; Pisters, Martijn F.; Lecluse, Céline; English, Coralie; Visser-Meily, Johanna M.A.; Veenhof, Cindy (Informa Healthcare, 2024-11)

Purpose: To identify Capabilities, Opportunities, and Motivational factors influencing movement behaviour throughout the day in people with stroke who are highly sedentary and inactive to enable intervention development. ...
Sequence analysis of members of the human Ig VH4 gene family derived from a single VH locus: Identification of novel germ-line members

Van Es, Johan H.; Heutink, Marja; Aanstoot, Henk; Logtenberg, Ton (American Association of Immunologists, 1992-07-15)

We have generated a mouse × human heterohybridoma that contains a single copy of chromosome 14 and, thus, a haploid set of Ig VH genes. This cell line was used to investigate the germ-line content and nucleotide sequences ...
A human systemic lupus erythematosus-related anti-cardiolipin/single-stranded DNA autoantibody is encoded by a somatically mutated variant of the developmentally restricted 51P1 VH gene

Van Es, Johan H.; Aanstoot, Henk; Gmelig-Meyling, Frits H.J.; Derksen, Ronald H.W.M.; Logtenberg, Ton (American Association of Immunologists, 1992-09-15)

We report the Ig H and L chain V region sequences from the cDNAs encoding a monoclonal human IgG anti-cardiolipin/ssDNA autoantibody (R149) derived from a patient with active SLE. Comparison with the germ-line V-gene ...
High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire

Van Es, Johan H.; Meyling, Frits H.J.Gmeli; Logtenberg, Ton (Wiley-VCH Verlag, 1992-10)

Nucleotide sequence analysis of cDNA encoded by the single member of the human immunoglobulin VH6 gene family show that blood B cells in adults, but not in neonates, frequently express somatically mutated IgM molecules. ...
Deletion mapping of Ig VH gene segments expressed in human cds b cell lines: JH proximity is not the sole determinant of the restricted fetal VH gene repertoire

Schutte, Mieke E.M.; Ebeling, Saskia B.; Akkermans-Koolhaas, Karine E.; Logtenberg, Ton (American Association of Immunologists, 1992)

VH gene segments expressed in a panel of monoclonal human CD5 B cell lines have been positioned on the IgH locus by deletion mapping. The analysis yielded a relative order of VH fragments of the VH2, VH4, VH5, and VH6 gene ...
Peripheral human CD5+ and CD5- B cells may express somatically mutated VH5- and VH6-encoded IgM receptors

Ebeling, Saskia B.; Schutte, Mieke E.M.; Logtenberg, Ton (American Association of Immunologists, 1993-12-15)

Previous studies have indicated that a sizable fraction of adult human peripheral blood B cells may express IgM receptors encoded by somatically mutated V regions. From these studies it was unclear whether this phenomenon ...
The majority of human tonsillar CD5+ B cells express somatically mutated Vχ4 genes

Ebeling, Saskia B.; Schutte, Mieke E.M.; Logtenberg, Ton (Wiley-VCH Verlag, 1993-06)

We have fractionated human tonsillar B cells on the basis of CD5 expression and determined the nucleotide sequences of immunoglobin light chain variable (V) regions encoded by the single member of the Vχ4 gene family in ...
VH4.21-Encoded Natural Autoantibodies with Anti-i Specificity Mirror those Associated with Cold Hemagglutinin Disease

Schutte, Mieke E.M.; Van Es, Johan H.; Silberstein, Leslie E.; Logtenberg, Ton (American Association of Immunologists, 1993-12-01)

The Ig VH regions of virtually all human pathogenic cold agglutinin (CA) anti-i/I autoantibodies are encoded by a single Ig VH gene segment, VH4.21, in conjunction with a highly variable CDR3 structure. The ant,-I specificity ...
Molecular analysis of VH and VL regions expressed in IgG-bearing chronic lymphocytic leukemia (CLL): Further evidence that CLL is a heterogeneous group of tumors

Ebeling, Saskia B.; Schutte, Mieke E.M.; Logtenberg, Ton (Elsevier, 1993-09-01)

We report the heavy (H) and light (L) chain variable (V) region sequences of cDNAs encoding the Ig receptor of two cases of CD5+ IgG-bearing CLL P87 and P103. In both CLL cases the H chain was encoded by members of the VH3 ...
Expression pattern of the most JH-proximal human VH gene segment (VH6) in the B cell and antibody repertoire suggests a role of VH6-encoded IgM antibodies in early ontogeny

Van Es, Johan H.; Raaphorst, Frank M.; Van Tol, Maarten J.D.; Gmelig Meyling, Frits H.J.; Logtenberg, Ton (American Association of Immunologists, 1993)

We have developed a mAb (JE-6) that recognizes an Id encoded by the most JH-proximal human VH gene segment (VH6) in or near germ-line configuration. This mAb was used to determine the frequency of Id JE6+ B cells in large ...
Molecular evolution of the human immunoglobulin E response: High incidence of shared mutations and clonal relatedness among ∈ VH5 transcripts from three unrelated patients with atopic dermatitis

Van Der Stoep, Nienke; Van Der Linden, Joke; Logtenberg, Ton (Rockefeller University Press, 1993-01-01)

We have analyzed the nucleotide sequences of 19 ∈ VH5 transcripts derived from in vivo isotype switched peripheral blood B cells of three patients with atopic dermatitis. Comparison with the patients' own germline VH5 gene ...
In vivo and in vitro IgE isotype switching in human B lymphocytes: Evidence for a predominantly direct IgM to IgE class switch program

Van Der Stoep, Nienke; Korver, Wouter; Logtenberg, Ton (Wiley-VCH Verlag, 1994-06)

Molecular analysis of circular excision products and composite genomic switch regions has demonstrated that in mice, immunoglobulin (Ig) isotype switching from IgM to IgE often proceeds sequentially via IgG1. Based on ...
How unique are pathogenic anti-DNA autoantibody V regions?

Logtenberg, Ton (Elsevier Limited, 1994-12)

Unique characteristics of the molecular structure of V regions encoding pathogenic anti-DNA autoantibodies have become apparent upon comparison of a large number of nucleotide sequences encoding this autospecificity. ...
Increased frequencies of HPRT mutant T lymphocytes in patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy: further evidence for a role of T cells in the etiopathogenesis of peripheral demyelinating diseases

Van den Berg, L. H.; Mollee, I.; Wokke, J. H.J.; Logtenberg, T. (Elsevier, 1995-04)

We have used the HPRT mutant clonal assay to determine the frequency of mutant T lymphocytes (FMC), as a measure of recent T cell stimulation, in the blood of patients with Guillain-Barré syndrome (GBS) and chronic ...
Selective expansion and long‐term culture of human schwann cells from sural nerve biopsies

Van den Berg, Leonard H.; Bär, Peter R.; Sodaar, Peter; Mollee, Isabel; Wokke, John J.H.; Logtenberg, Ton (John Wiley & Sons Inc., 1995-10)

Fragments of sural nerve biopsy specimens were cultured in the presence of the supernatant of lymphokine‐activated killer cells, resulting in the selective outgrowth of cells with bipolar or tripolar morphology, reminiscent ...
Molecular Analysis of VH Regions Expressed in the Adult B‐Cell Repertoire

VAN DER STOEP, NIENKE; EBELING, SASKIA B.; LOGTENBERG, TON (Wiley-Blackwell, 1995-09)
Poststroke fatigue: Who is at risk for an increase in fatigue?

Van Eijsden, Hanna Maria; Van De Port, Ingrid Gerrie Lambert; Visser-Meily, Johanna Maria August; Kwakkel, Gert (2012)

Background. Several studies have examined determinants related to post-stroke fatigue. However, it is unclear which determinants can predict an increase in poststroke fatigue over time. Aim. This prospective cohort study ...
Risk Factors for Medial and Intimal Intracranial Internal Carotid Artery Calcification in Men and Women with Cardiovascular Disease: The Ucc-smart Study

Lucci, Carlo; Rissanen, Ina; van den Beukel, Tim C; Takx, Richard; de Jong, Pim A; Hendrikse, Jeroen; Geerlings, Mirjam I; UCC-SMART Study Group (S. Karger AG, 2024-12)

Introduction: Calcifications of the intracranial internal carotid artery (iICA) can lead to an increased risk for stroke. Two types of iICA calcification are known: those affecting the tunica intima or the tunica media. ...
Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

Hombrink, Pleun; Helbig, Christina; Backer, Ronald A; Piet, Berber; Oja, Anna E; Stark, Regina; Brasser, Giso; Jongejan, Aldo; Jonkers, René E; Nota, Benjamin; Basak, Onur; Clevers, Hans C; Moerland, Perry D; Amsen, Derk; van Lier, René A W (Nature Research, 2016-12)

Tissue-resident memory T cells (TRM cells) in the airways mediate protection against respiratory infection. We characterized TRM cells expressing integrin αE (CD103) that reside within the epithelial barrier of human lungs. ...
Determinants affecting pregnant women's utilization of prenatal screening for Down syndrome: a review of the literature

Crombag, Neeltje M; Bensing, Jozien M; Iedema-Kuiper, Rita; Schielen, Peter C; Visser, Gerard H (Informa Healthcare, 2013-11)

OBJECTIVE: Uptake rates for Down syndrome screening (DSS) in the Netherlands are low compared with those in Northern European countries (27% versus 61% in the United Kingdom and 90% in Denmark). These differences are ...

Now showing items 3301-3320 of 40729