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UMC Repository: Recent submissions

  • Drug retention after intradiscal administration 
    Rudnik-Jansen, Imke; Du, Jie; Karssemakers-Degen, Nina; Tellegen, Anna R; Wadhwani, Parvesh; Zuncheddu, Daniele; Meij, Björn P; Thies, Jens; Emans, Pieter; Öner, Fetullah C; Mihov, George; Garcia, Joao Pedro; Ulrich, Anne S; Grad, Sibylle; Tryfonidou, Marianna A; Ingen, Hugo van; Creemers, Laura B (Informa Healthcare, 2024-12)
    Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding ...
  • Validation of 11 added items of the outpatient version of the Utrecht Symptom Diary in patients receiving chemotherapy or targeted therapy 
    Koldenhof, Josephine J; Akpobome, Bernice O; Zweers, Danielle; Klaasse, Stance; Teunissen, Saskia C C M; Witteveen, Petronella O; Suijkerbuijk, Karijn P M; de Graeff, Alexander; van der Baan, Frederieke H (Springer International Publishing AG, 2024-10-18)
    INTRODUCTION: The Utrecht Symptom Diary (USD) is a validated Dutch patient-reported outcome measurement (PROM) tool - based on the Edmonton Symptom Assessment System - to assess and monitor symptoms in cancer patients. The ...
  • Next-generation IgA-SEQ allows for high-throughput, anaerobic, and metagenomic assessment of IgA-coated bacteria 
    van Gogh, Merel; Louwers, Jonas M; Celli, Anna; Gräve, Sanne; Viveen, Marco C; Bosch, Sofie; de Boer, Nanne K H; Verheijden, Rik J; Suijkerbuijk, Karijn P M; Brand, Eelco C; Top, Janetta; Oldenburg, Bas; de Zoete, Marcel R (BioMed Central Ltd., 2024-10-21)
    Background: The intestinal microbiota plays a significant role in maintaining systemic and intestinal homeostasis, but can also influence diseases such as inflammatory bowel disease (IBD) and cancer. Certain bacterial ...
  • Methylomic signature of current cannabis use in two first-episode psychosis cohorts 
    Dempster, Emma L; Wong, Chloe C Y; Burrage, Joe; Hannon, Eilis; Quattrone, Diego; Trotta, Giulia; Rodriguez, Victoria; Alameda, Luis; Spinazzola, Edoardo; Tripoli, Giada; Austin-Zimmerman, Isabelle; Li, Zhikun; Gayer-Anderson, Charlotte; Freeman, Tom P; Johnson, Emma C; Jongsma, Hannah E; Stilo, Simona; La Cascia, Caterina; Ferraro, Laura; La Barbera, Daniele; Lasalvia, Antonio; Tosato, Sarah; Tarricone, Ilaria; D'Andrea, Giuseppe; Galatolo, Michela; Tortelli, Andrea; Pompili, Maurizio; Selten, Jean-Paul; de Haan, Lieuwe; Menezes, Paulo Rossi; Del Ben, Cristina M; Santos, Jose Luis; Arrojo, Manuel; Bobes, Julio; Sanjuán, Julio; Bernardo, Miguel; Arango, Celso; Jones, Peter B; Breen, Gerome; Mondelli, Valeria; Dazzan, Paola; Iyegbe, Conrad; Vassos, Evangelos; Morgan, Craig; Mukherjee, Diptendu; van Os, Jim; Rutten, Bart; O'Donovan, Michael C; Sham, Pak; Mill, Jonathan; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Springer Nature, 2025)
    The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA ...
  • Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses 
    Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Elsevier, 2025-01)
    There is no multi-country/multi-language study testing a-priori multivariable associations between non-modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 ...
  • Correction: Electroconvulsive Therapy Versus Aripiprazole Addition to Clozapine in Patients with Clozapine-Resistant Symptoms (EMECLO): A Protocol of a Single-Blind, Multicenter, Randomized-Controlled Feasibility Trial 
    den Toom, Manouk; Blanken, Laura; Horn, Inge; Veerman, Selene; van der Vlugt-Molenaar, Joris J B; de Koning, Mariken B; Bogers, Jan; Enterman, John; de Jonge, Martin; Cianci, Daniela; Frederix, Gerardus W J; de Haas, Hans J; Storosum, Bram W; Veereschild, Mike; Javadzadeh, Martin; Schulte, Peter F J; Cohen, Dan; van Os, Jim; Cahn, Wiepke; de Haan, Lieuwe; Zantvoord, Jasper B; Luykx, Jurjen J (Georg Thieme Verlag, 2024-11)
  • COVID in een ‘psychiatrisch verpleeghuis’: een exploratief onderzoek 
    van Wulfften Palthe, J. E.; Joling, K. J.; Wouters, F.; Everaerd, D. S.; Schellekens, A.; Zinkstok, J.; Cahn, W.; Tendolkar, I.; Visser, D.; Cath, D. C.; Straathof, S.; Kok, R. M. (Uitgeverij Boom, 2024)
    Ernstige psychiatrische aandoeningen zijn geassocieerd met verhoogd risico op COVID-19-gerelateerde sterfte. COVID-19-onderzoek onder verpleeghuisbewoners met ernstige psychiatrische aandoeningen, of ‘dubbelezorgvragers’, ...
  • Environmental Outcomes of Reducing Medication Waste by Redispensing Unused Oral Anticancer Drugs 
    Smale, Elisabeth M.; Ottenbros, Anne B.; van den Bemt, Bart J.F.; Heerdink, Eibert R.; Verploegen, Jelle; van Zelm, Rosalie; Egberts, Toine C.G.; Bekker, Charlotte L. (American Medical Association, 2024-10-01)
    Importance: Medications are associated with substantial environmental outcomes, yet frequently end up being unused by patients. Waste-minimizing interventions, such as redispensing of quality-approved oral anticancer drugs ...
  • Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708) 
    Zwart, K.; Braat, M. N.G.J.A.; van der Baan, F. H.; May, A. M.; Roodhart, J. M.L.; Al-Toma, D.; Otten, J. M.M.B.; Los, M.; Oostergo, T.; Fijneman, R. J.A.; van Dodewaard-de Jong, J. M.; Punt, C. J.A.; Meijer, G.; Lagendijk, J. J.W.; Koopman, M.; Intven, M.; Bol, G. M. (Elsevier Ireland Ltd, 2024-11)
    Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study ...
  • Clinical exome sequencing data from patients with inborn errors of immunity: Cohort level diagnostic yield and the benefit of systematic reanalysis 
    on behalf of all members of the Radboud University Medical Center multidisciplinary immune-disease board (Academic Press Inc., 2024-11)
    While next generation sequencing has expanded the scientific understanding of Inborn Errors of Immunity (IEI), the clinical use and re-use of exome sequencing is still emerging. We revisited clinical exome data from 1300 ...
  • Beyond resorption: osteoclasts as drivers of bone formation 
    Xiang, Qianfeng; Li, Lei; Ji, Wei; Gawlitta, Debby; Walboomers, X. Frank; van den Beucken, Jeroen J.J.P. (Springer, 2024-10-11)
    Emerging evidence illustrates that osteoclasts (OCs) play diverse roles beyond bone resorption, contributing significantly to bone formation and regeneration. Despite this, OCs remain mysterious cells, with aspects of their ...
  • Exploring unsupervised feature extraction of IMU-based gait data in stroke rehabilitation using a variational autoencoder 
    Felius, Richard; Punt, Michiel; Geerars, Marieke; Wouda, Natasja; Rutgers, Rins; Bruijn, Sjoerd; David, Sina; van Dieën, Jaap (Public Library of Science, 2024-10-04)
    Background Variational AutoEncoders (VAE) might be utilized to extract relevant information from an IMU-based gait measurement by reducing the sensor data to a low-dimensional representation. The present study explored ...
  • Reirradiation − still navigating uncharted waters? 
    Andratschke, Nicolaus; Willmann, Jonas; Appelt, Ane L.; Day, Madalyne; Kronborg, Camilla; Massaccesi, Mariangela; Ozsahin, Mahmut; Pasquier, David; Petric, Primoz; Riesterer, Oliver; De Ruysscher, Dirk; M Van der Velden, Joanne; Guckenberger, Matthias (Elsevier Ireland Ltd, 2024-11)
    With the emergence of high-precision radiotherapy technologies such as stereotactic ablative radiotherapy (SABR), MR guided brachytherapy, image guided intensity modulated photon and proton radiotherapy and most recently ...
  • Exploration of the regional effects of colchicine in the LoDoCo2 trial 
    Budgeon, Charley A.; Nidorf, Stefan; Mosterd, Arend; Fiolet, Aernoud; Eikelboom, John; O'Halloran, Sean; Joyce, David; Schut, Astrid; Tijssen, Jan; Cornel, Jan H.; Murray, Kevin; Thompson, Peter (Mosby Inc., 2024-12)
    Background: The Low Dose Colchicine 2 (LoDoCo2) trial randomized 5,522 patients with chronic coronary disease to colchicine 0.5mg daily or placebo in a 1:1 ratio and demonstrated the cardiovascular benefits of colchicine. ...
  • The lived experience of patients with bipolar disorder with adapting their lifestyle to their condition 
    Eikelenboom-Valk, Johanna J.; Goossens, Peter J.J.; Daggenvoorde, Thea H. (W.B. Saunders, 2024-12)
    Background: An important element of self-management strategies for people with bipolar disorder is adapting their lifestyle to their condition, since this improves their quality of life. However, not all people with bipolar ...
  • The association between first trimester blood pressure, blood pressure trajectory, mid-pregnancy blood pressure drop and maternal and fetal outcomes: A systematic review and meta-analysis 
    Moes, Shinta L.; van de Kam, Lieke; Lely, A. Titia; Bekker, Mireille N.; Depmann, Martine (Elsevier, 2024-12)
    Background: Hypertensive disorders of pregnancy occur in 5–10 % of pregnancies and are associated with an increased risk of adverse perinatal outcomes. Objectives: This review investigates the association between first ...
  • GenSynthPop: generating a spatially explicit synthetic population of individuals and households from aggregated data 
    de Mooij, Jan; Sonnenschein, Tabea; Pellegrino, Marco; Dastani, Mehdi; Ettema, Dick; Logan, Brian; Verstegen, Judith A. (Springer Netherlands, 2024-10-03)
    Synthetic populations are representations of actual individuals living in a specific area. They play an increasingly important role in studying and modeling individuals and are often used to build agent-based social ...
  • The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning 
    Kleinbongard, Petra; Arriola, Carlos Galán; Badimon, Lina; Crisostomo, Veronica; Giricz, Zoltán; Gyöngyösi, Mariann; Heusch, Gerd; Ibanez, Borja; Kiss, Attila; de Kleijn, Dominique P V; Podesser, Bruno K; Carracedo, Rafael Ramírez; Rodríguez-Sinovas, Antonio; Ruiz-Meana, Marisol; Sanchez Margallo, Francisco M; Vilahur, Gemma; Zamorano, José Luis; Zaragoza, Carlos; Ferdinandy, Peter; Hausenloy, Derek J (Springer Science and Business Media Deutschland GmbH, 2024)
    Numerous cardioprotective interventions have been reported to reduce myocardial infarct size (IS) in pre-clinical studies. However, their translation for the benefit of patients with acute myocardial infarction (AMI) has ...
  • Reimagining Initial Certification as a Process That Begins during Residency to Support Continuous Development Across Training and Practice 
    Carraccio, Carol; Schumacher, Daniel J.; Ten Cate, Olle (Wolters Kluwer, 2024-10)
    In the United States, initial board certification remains focused on a high-stakes knowledge examination after completion of training. A more contemporary view supports a program of assessment that includes multiple types ...
  • Mortality Associated with Infectious Diseases in Dutch Nursing Homes 
    Manyam, Meghanadh; Biesheuvel, Mirthe; Haenen, Anja; van Asten, Liselotte; van Werkhoven, C. H.Henri; van de Kassteele, Jan; van Gageldonk-Lafeber, Rianne; de Greeff, Sabine; van Houten, Paul; van den Bos, Marieke; Roeloffzen, Petra; Salomons, Hedy; Debast, Sylvia; Beckers, Astrid; Teeuw, Alfred; Hertogh, Cees (Elsevier, 2024-11)
    Background: Although older people in nursing homes have a larger susceptibility to infectious diseases, the extent to which infectious diseases contribute to their mortality is unknown. Therefore, we quantified the ...