Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)

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Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)
 
Zwart, K.; Braat, M. N.G.J.A.; van der Baan, F. H.; May, A. M.; Roodhart, J. M.L.; Al-Toma, D.; Otten, J. M.M.B.; Los, M.; Oostergo, T.; Fijneman, R. J.A.; van Dodewaard-de Jong, J. M.; Punt, C. J.A.; Meijer, G.; Lagendijk, J. J.W.; Koopman, M.; Intven, M.; Bol, G. M.
(2024) Clinical and translational radiation oncology, volume 49, pp. 1 - 5
(Article)
Abstract
Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.
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Keywords: Oligometastases, phase I, SBRT, Single fraction, Systemic therapy, Oncology, Radiology Nuclear Medicine and imaging
DOI: https://doi.org/10.1016/j.ctro.2024.100874
ISSN: 2405-6308
Publisher: Elsevier Ireland Ltd
Note: Publisher Copyright: © 2024 The Authors
(Peer reviewed)