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UMC Repository: Recent submissions

  • No immunological changes after factor VIII product switch: An in depth analysis in haemophilia A patients 
    Schep, Sarah J; Fischer, Kathelijn; Boes, Marianne; Schutgens, Roger E G (Wiley-Blackwell, 2023-07)
    BACKGROUND: A challenging complication in the treatment of haemophilia A is the formation of neutralizing anti-FVIII antibodies (inhibitors). There is ongoing debate on the effect of FVIII product and inhibitor risk, ...
  • In-vitro and in-silico evidence for oxidative stress as drivers for RDW 
    Joosse, Huibert Jan; van Oirschot, Brigitte A.; Kooijmans, Sander A.A.; Hoefer, Imo E.; van Wijk, Richard A.H.; Huisman, Albert; van Solinge, Wouter W.; Haitjema, Saskia (Nature Publishing Group, 2023-06-07)
    Red blood cell distribution width (RDW) is a biomarker associated with a variety of clinical outcomes. While anemia and subclinical inflammation have been posed as underlying pathophysiology, it is unclear what mechanisms ...
  • First report of the International Council of Cardiovascular Prevention and Rehabilitation’s Registry (ICRR) 
    on behalf of the ICRR collaborators (Taylor and Francis Ltd., 2023-04-06)
    Objectives: Cardiac rehabilitation–programs comprehensively delivering outpatient secondary prevention–is under-available and under-studied in the resource-poor settings where it is needed most. This report summarizes the ...
  • Influence of cannabis use on incidence of psychosis in people at clinical high risk 
    for the EU-GEI High Risk Study Group (Wiley-Blackwell, 2023-09)
    Aims: Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains ...
  • Age-Related Social Cognitive Performance in Individuals With Psychotic Disorders and Their First-Degree Relatives 
    GROUP Investigators (Oxford University Press, 2023-11-29)
    BACKGROUND: Social cognitive impairment is a recognized feature of psychotic disorders. However, potential age-related differences in social cognitive impairment have rarely been studied. STUDY DESIGN: Data came from 905 ...
  • Clinician and patient perspectives on the ontology of mental disorder: a qualitative study 
    Kohne, Annemarie Catharina Johanna; de Graauw, Lukas Peter; Leenhouts-van der Maas, Reina; Van Os, Jim (Frontiers Research Foundation, 2023)
    BACKGROUND: Psychiatry may face an "identity crisis" regarding its very foundations. The lack of consensus regarding the theoretical grounds of psychiatry as a discipline has its epicenter in the discussion about the ...
  • STOPP/START criteria for potentially inappropriate prescribing in older people: version 3 
    O'Mahony, Denis; Cherubini, Antonio; Guiteras, Anna Renom; Denkinger, Michael; Beuscart, Jean-Baptiste; Onder, Graziano; Gudmundsson, Adalsteinn; Cruz-Jentoft, Alfonso J; Knol, Wilma; Bahat, Gülistan; van der Velde, Nathalie; Petrovic, Mirko; Curtin, Denis (Springer Science and Business Media Deutschland GmbH, 2023-08)
    PURPOSE: STOPP/START is a physiological systems-based explicit set of criteria that attempts to define the clinically important prescribing problems relating to potentially inappropriate medications (PIMs-STOPP criteria) ...
  • Evaluation and Management of Bing-Neel Syndrome 
    Schep, Sarah J; Vos, Josephine M I; Minnema, Monique C (W.B. Saunders, 2023-08)
    Bing-Neel syndrome is a rare manifestation of Waldenström macroglobulinemia (WM), which is caused by infiltration of the malignant lymphoplasmacytic cells in the central nervous system. Patients can present with a diverse ...
  • Survival with Axicabtagene Ciloleucel in Large B-Cell Lymphoma 
    ZUMA-7 Investigators and Kite Members (Massachussetts Medical Society, 2023-07-13)
    Background: In an analysis of the primary outcome of this phase 3 trial, patients with early relapsed or refractory large B-cell lymphoma who received axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric ...
  • Ischemic stroke recurrence and mortality in different imaging phenotypes of ischemic cerebrovascular disease: The SMART-MR Study 
    Lucci, Carlo; Rissanen, Ina; de Jong, Pim A; Kappelle, L Jaap; Hendrikse, Jeroen; Geerlings, Mirjam I (SAGE Publications Inc., 2023-06)
    BACKGROUND: Diagnosis of cerebrovascular disease is based on both clinical and radiological findings, however, they do not always correlate. AIMS: To investigate ischemic stroke recurrence and mortality in patients with ...
  • Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation 
    Mocholi, Enric; Russo, Laura; Gopal, Keshav; Ramstead, Andrew G; Hochrein, Sophia M; Vos, Harmjan R; Geeven, Geert; Adegoke, Adeolu O; Hoekstra, Anna; van Es, Robert M; Pittol, Jose Ramos; Vastert, Sebastian; Rutter, Jared; Radstake, Timothy; van Loosdregt, Jorg; Berkers, Celia; Mokry, Michal; Anderson, Colin C; O'Connell, Ryan M; Vaeth, Martin; Ussher, John; Burgering, Boudewijn M T; Coffer, Paul J (Cell Press, 2023-06-27)
    Upon antigen-specific T cell receptor (TCR) engagement, human CD4 + T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming. Here, we show that the generation ...
  • Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders 
    Dreyer, Henriette H.M.; van Tuyll van Serooskerken, Eleonora Sofie; Rodenburg, Lisa W.; Bittermann, Arnold J.N.; Arets, Hubertus G.M.; Reuling, Ellen M.B.P.; Verweij, Johannes W.; Haarman, Eric G.; van der Zee, David C.; Tytgat, Stefaan H.A.J.; van der Ent, Cornelis K.; Beekman, Jeffrey M.; Amatngalim, Gimano D.; Lindeboom, Maud Y.A. (MDPI AG, 2023-06-05)
    Esophageal atresia (EA) is a rare birth defect in which respiratory tract disorders are a major cause of morbidity. It remains unclear whether respiratory tract disorders are in part caused by alterations in airway epithelial ...
  • Brain injury and long-term outcome after neonatal surgery for non-cardiac congenital anomalies 
    Aalten, Mark; Tataranno, Maria Luisa; Dudink, Jeroen; Lemmers, Petra M A; Lindeboom, Maud Y A; Benders, Manon J N L (Lippincott Williams & Wilkins, 2023-10)
    BACKGROUND: There is growing evidence that neonatal surgery for non-cardiac congenital anomalies (NCCAs) in the neonatal period adversely affects long-term neurodevelopmental outcome. However, less is known about acquired ...
  • Neuroimaging standards for research into small vessel disease-advances since 2013 
    Duering, Marco; Biessels, Geert Jan; Brodtmann, Amy; Chen, Christopher; Cordonnier, Charlotte; de Leeuw, Frank-Erik; Debette, Stéphanie; Frayne, Richard; Jouvent, Eric; Rost, Natalia S; Ter Telgte, Annemieke; Al-Shahi Salman, Rustam; Backes, Walter H; Bae, Hee-Joon; Brown, Rosalind; Chabriat, Hugues; De Luca, Alberto; deCarli, Charles; Dewenter, Anna; Doubal, Fergus N; Ewers, Michael; Field, Thalia S; Ganesh, Aravind; Greenberg, Steven; Helmer, Karl G; Hilal, Saima; Jochems, Angela C C; Jokinen, Hanna; Kuijf, Hugo; Lam, Bonnie Y K; Lebenberg, Jessica; MacIntosh, Bradley J; Maillard, Pauline; Mok, Vincent C T; Pantoni, Leonardo; Rudilosso, Salvatore; Satizabal, Claudia L; Schirmer, Markus D; Schmidt, Reinhold; Smith, Colin; Staals, Julie; Thrippleton, Michael J; van Veluw, Susanne J; Vemuri, Prashanthi; Wang, Yilong; Werring, David; Zedde, Marialuisa; Akinyemi, Rufus O; Del Brutto, Oscar H; Markus, Hugh S; Zhu, Yi-Cheng; Smith, Eric E; Dichgans, Martin; Wardlaw, Joanna M (Elsevier Limited, 2023-07)
    Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can ...
  • Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes 
    DCCT/EDIC Research Group (American Medical Association, 2023-06-01)
    Importance: Little is known about structural brain changes in type 1 diabetes (T1D) and whether there are early manifestations of a neurodegenerative condition like Alzheimer disease (AD) or evidence of premature brain ...
  • Cognitive Impairment in Patients With Cardiac Disease: Implications for Clinical Practice 
    Heart-Brain Connection Consortium (Lippincott Williams & Wilkins, 2023-08-01)
    Cognitive impairment is common in patients with cardiovascular disease. One in 3 patients presenting at cardiology clinics have some degree of cognitive impairment, depending on the cardiac condition, comorbidities, and ...
  • Retinitis Pigmentosa: Current Clinical Management and Emerging Therapies 
    Nguyen, Xuan Thanh An; Moekotte, Lude; Plomp, Astrid S.; Bergen, Arthur A.; van Genderen, Maria M.; Boon, Camiel J.F. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-04-02)
    Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies characterized by the degeneration of rod photoreceptors, followed by the degeneration of cone photoreceptors. As a result of photoreceptor ...
  • Exploring Imaging Characteristics Associated With Disease Activity in Idiopathic Multifocal Choroiditis: A Multimodal Imaging Approach 
    de Groot, Evianne L.; ten Dam-van Loon, Ninette H.; Kouwenberg, Carlyn V.; de Boer, Joke H.; Ossewaarde-van Norel, Jeannette (Elsevier, 2023-08)
    Purpose: To identify characteristics on multimodal imaging (MMI) in idiopathic multifocal choroiditis (MFC) that can identify inflammatory activity and distinguish choroidal neovascularization (CNV) activity from inflammatory ...
  • Transcriptome network analysis implicates CX3CR1-positive type 3 dendritic cells in non-infectious uveitis 
    Hiddingh, S.; Pandit, A.; Verhagen, F. H.; Rijken, R.; Servaas, N. H.; Wichers, C. G.K.; Ten Dam-Van Loon, N. H.; Imhof, S. M.; Radstake, T. R.D.J.; de Boer, J. H.; Kuiper, J. J.W. (eLife Sciences Publications, 2023-04-12)
    BACKGROUND: Type I interferons (IFNs) promote the expansion of subsets of CD1c+ conventional dendritic cells (CD1c+ DCs), but the molecular basis of CD1c+ DCs involvement in conditions not associated without elevated type ...
  • Different levels of ultraprocessed food and beverage consumption and associations with environmental sustainability and all-cause mortality in EPIC-NL 
    Vellinga, Reina E; van den Boomgaard, Iris; M A Boer, Jolanda; van der Schouw, Yvonne T; Harbers, Marjolein C; Verschuren, W M Monique; van 't Veer, Pieter; H M Temme, Elisabeth; Biesbroek, Sander (Elsevier, 2023-07)
    BACKGROUND: The adverse health effects of high ultraprocessed food and drink (UPFD) consumption are well documented. However, the environmental impact remains unclear, and the separate effects of ultraprocessed foods (UPFs) ...