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Morphine exposure and neurodevelopmental outcome in infants born extremely preterm

Luzzati, Michele; Coviello, Caterina; De Veye, Henriette Swarenburg; Dudink, Jeroen; Lammertink, Femke; Dani, Carlo; Koopmans, Corine; Benders, Manon; Tataranno, Maria Luisa (Wiley-Blackwell, 2023-08)

AIM: To investigate the association between morphine exposure in the neonatal period and neurodevelopment at 2 and 5 years of age while controlling for potential confounders. METHOD: We performed a retrospective, single-centre ...
Outcomes after robotic thymectomy in nonthymomatous versus thymomatous patients with acetylcholine-receptor-antibody-associated myasthenia gravis

Marcuse, Florit; Hoeijmakers, Janneke G.J.; Hochstenbag, Monique; Hamid, Myrurgia Abdul; Keijzers, Marlies; Mané-Damas, Marina; Martinez-Martinez, Pilar; Verschuuren, Jan; Kuks, Jan; Beekman, Roy; van der Kooi, Anneke J.; van Doorn, Pieter; van Es, Michael; Maessen, Jos J.G.; De Baets, Marc H.V. (Elsevier Limited, 2023-05)

The aim of this study was to investigate the surgical and long-term neurological outcomes of patients with acetylcholine-receptor-antibody-associated myasthenia gravis (AChR-MG) who underwent robotic thymectomy (RATS). We ...
Ion suppression, reduced long-term robustness and leakage current of the spray voltage during the ionization of trichloroacetic acid; a case study with a methylmalonic acid assay

Punt, Arjen M.; van der Elst, Kim C.M.; Huitema, Alwin D.R.; Lentjes, Eef G.W.M. (Elsevier, 2023-05-30)

Sample clean-up with the protein precipitation solvent trichloroacetic acid (TCA), combined with a stable isotope labeled internal standard, is widely used for the analysis of endogenous and exogenous compounds in serum ...
LC-MS/MS in clinical chemistry: Did it live up to its promise?: Consideration from the Dutch EQAS organisation

Lentjes, E. G.W.M.; Bui, H. N.; Ruhaak, L. R.; Kema, I. P.; Coene, K. L.M.; van den Ouweland, J. M.W. (Elsevier, 2023-06-01)

Background: Over the past decade the use of LC-MS/MS has increased significantly in the hospital laboratories. Clinical laboratories have switched from immunoassays to LC-MS/MS methods due to the promise of improvements ...
Stereotactic Body radiotherapy and pedicLE screw fixatioN During one hospital visit for patients with symptomatic unstable spinal metastases: a randomized trial (BLEND RCT) using the Trials within Cohorts (TwiCs) design

Huele, E H; van der Velden, J M; Kasperts, N; Eppinga, W S C; Grutters, J P C; Suelmann, B B M; Weening, A A; Delawi, D; Teunissen, S C C M; Verkooijen, H M; Verlaan, J J; Gal, R (BioMed Central, 2023-05-04)

BACKGROUND: Spinal metastases can lead to unremitting pain and neurological deficits, which substantially impair daily functioning and quality of life. Patients with unstable spinal metastases receive surgical stabilization ...
A Machine Learning Algorithm for Predicting 6-Week Survival in Spinal Metastasis: An External Validation Study Using 2,768 Taiwanese Patients

Su, Chih-Chi; Lin, Yen-Po; Yen, Hung-Kuan; Pan, Yu-Ting; Zijlstra, Hester; Verlaan, Jorrit-Jan; Schwab, Joseph H; Lai, Cheng-Yo; Hu, Ming-Hsiao; Yang, Shu-Hua; Groot, Olivier Q (Lippincott Williams & Wilkins, 2023-09-01)

INTRODUCTION: There are predictive algorithms for predicting 3-month and 1-year survival in patients with spinal metastasis. However, advance in surgical technique, immunotherapy, and advanced radiation therapy has enabled ...
Neurologic Outcomes After Radiation Therapy for Severe Spinal Cord Compression in Multiple Myeloma: A Study of 162 Patients

Zijlstra, H; Striano, B M; Crawford, A M; Groot, O Q; Raje, N; Tobert, D G; Patel, C G; Wolterbeek, N; Delawi, D; Kempen, D H R; Verlaan, J J; Schwab, J H (Lippincott Williams & Wilkins, 2023-08-16)

BACKGROUND: Bone destruction is the most frequent disease-defining clinical feature of multiple myeloma (MM), resulting in skeletal-related events such as back pain, pathological fractures, or neurologic compromise including ...
254th ENMC international workshop. Formation of a European network to initiate a European data collection, along with development and sharing of treatment guidelines for adult SMA patients. Virtual meeting 28 – 30 January 2022

254th ENMC Workshop Study Group (Elsevier Limited, 2023-06)
Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort

Jansen, Mylène P.; Wirth, Wolfgang; Bacardit, Jaume; van Helvoort, Eefje M.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco, Francisco J.; Haugen, Ida K.; Berenbaum, Francis; Ladel, Cristoph H.; Loef, Marieke; Lafeber, Floris P.J.G.; Welsing, Paco M.; Mastbergen, Simon C.; Roemer, Frank W. (AME Publishing Company, 2023-05-01)

In the Innovative Medicine’s Initiative Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee osteoarthritis (OA) study, machine learning models were trained to predict the probability ...
MRI-based synthetic CT in the detection of knee osteoarthritis: Comparison with CT

Arbabi, Saeed; Foppen, Wouter; Gielis, Willem Paul; van Stralen, Marijn; Jansen, Mylène; Arbabi, Vahid; de Jong, Pim A; Weinans, Harrie; Seevinck, Peter (John Wiley & Sons Inc., 2023-11)

Magnetic resonance Imaging is the gold standard for assessment of soft tissues; however, X-ray-based techniques are required for evaluating bone-related pathologies. This study evaluated the performance of synthetic computed ...
Relevance of Biomarkers in Serum vs. Synovial Fluid in Patients with Knee Osteoarthritis

Kalogera, Stefania; Jansen, Mylène P.; Bay-Jensen, Anne Christine; Frederiksen, Peder; Karsdal, Morten A.; Thudium, Christian S.; Mastbergen, Simon C. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-05-30)

The association between structural changes and pain sensation in osteoarthritis (OA) remains unclear. Joint deterioration in OA leads to the release of protein fragments that can either systemically (serum) or locally ...
Joint distraction using a purpose-built device for knee osteoarthritis: A prospective 2-year follow-up

Struik, Thijmen; Mastbergen, Simon C.; Brouwer, Reinoud W.; Custers, Roel J.H.; Van Geenen, Rutger C.I.; Heusdens, Christiaan H.W.; Emans, Pieter J.; Huizinga, Maarten R.; Jansen, Mylène P. (BMJ Publishing Group, 2023-06-08)

Objective Knee distraction treatment for end-stage osteoarthritis successfully postpones arthroplasty for years. Studies performed thus far used general intended use, patient-personalised or custom-made devices. In this ...
Medical Residents’ Informal Learning from Pharmacists in the Clinical Workplace

Floren, Leslie Carstensen; Pittenger, Amy L.; Wilting, Ingeborg; Irby, David M.; Cate, Olle ten (Springer New York, 2023-06)

UNLABELLED: Workplace-based interactions between residents and pharmacists, though relatively underexplored, might contribute substantially to learning. This international study sought to investigate the affordances residents ...
The experiences of patients ill with COVID-19-like symptoms and the role of testing for SARS-CoV-2 in supporting them: A qualitative study in eight European countries during the first wave of the pandemic

Hoste, Melanie E; Wanat, Marta; Gobat, Nina; Anastasaki, Marilena; Böhmer, Femke; Chlabicz, Sławomir; Colliers, Annelies; Farrell, Karen; Karkana, Maria-Nefeli; Kinsman, John; Lionis, Christos; Marcinowicz, Ludmila; Reinhardt, Katrin; Skoglund, Ingmarie; Sundvall, Pär-Daniel; Vellinga, Akke; Goossens, Herman; Butler, Christopher C; van der Velden, Alike; Tonkin-Crine, Sarah; Anthierens, Sibyl (Informa Healthcare, 2023-05-30)

BACKGROUND: Access to testing during the first wave of the COVID-19 pandemic was limited, impacting patients with COVID-19-like symptoms. Current qualitative studies have been limited to one country or were conducted outside ...
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation

CARDIoGRAMPlusC4D; MEGASTROKE; International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group; DISCO register (Nature Research, 2023-06)

Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, ...
Deep learning supported mitoses counting on whole slide images: A pilot study for validating breast cancer grading in the clinical workflow

van Bergeijk, Stijn A; Stathonikos, Nikolas; Ter Hoeve, Natalie D; Lafarge, Maxime W; Nguyen, Tri Q; van Diest, Paul J; Veta, Mitko (Elsevier, 2023-01)

INTRODUCTION: Breast cancer (BC) prognosis is largely influenced by histopathological grade, assessed according to the Nottingham modification of Bloom-Richardson (BR). Mitotic count (MC) is a component of histopathological ...
CONFIDENT-trial protocol: A pragmatic template for clinical implementation of artificial intelligence assistance in pathology

Flach, Rachel N; Stathonikos, Nikolas; Nguyen, Tri Q; Ter Hoeve, Natalie D; van Diest, Paul J; van Dooijeweert, Carmen (BMJ Publishing Group, 2023-06-07)

Introduction Artificial intelligence (AI) has been on the rise in the field of pathology. Despite promising results in retrospective studies, and several CE-IVD certified algorithms on the market, prospective clinical ...
A Phase I Trial of the Dual MET Kinase/OCT-2 Inhibitor OMO-1 in Metastatic Solid Malignancies Including MET Exon 14 Mutated Lung Cancer

Pruis, Melinda A; Krebs, Matthew G; Plummer, Ruth; De Vos, Filip; Angevin, Eric; Prenen, Hans; Forster, Martin D; Clack, Glen; Van der Aa, Annegret; Tjwa, Marc; Jansen, Ellen; Perera, Timothy; Lolkema, Martijn P (AlphaMed Press, 2023-12-11)

INTRODUCTION: Targeted therapy in non-small cell lung cancer (NSCLC) patients with mesenchymal epithelial transition (MET) exon 14 skipping mutations (METex14) and MET amplifications has improved patients' outcomes. The ...
Evaluation of Outcomes Following Focal Ablative Therapy for Treatment of Localized Clinically Significant Prostate Cancer in Patients >70 Years: A Multi-institute, Multi-energy 15-Year Experience

Habashy, David; Reddy, Deepika; Peters, Max; Shah, Taimur T; van Son, Marieke; van Rossum, Peter; Tanaka, Mariana Bertoncelli; Cullen, Emma; Engle, Ryan; McCracken, Stuart; Greene, Damian; Hindley, Richard G; Emara, Amr; Nigam, Raj; Orczyk, Clement; Shergill, Iqbal; Persad, Raj; Virdi, Jaspal; Moore, Caroline M; Arya, Manit; Winkler, Mathias; Emberton, Mark; Ahmed, Hashim U; Dudderidge, Tim (Elsevier, 2023-07)

Purpose:In older patients who do not wish to undergo watchful waiting, focal therapy could be an alternative to the more morbid radical treatment. We evaluated the role of focal therapy in patients 70 years and older as ...
Syntactic Network Analysis in Schizophrenia-Spectrum Disorders

Ciampelli, Silvia; de Boer, Janna N; Voppel, Alban E; Corona Hernandez, Hugo; Brederoo, Sanne G; van Dellen, Edwin; Mota, Natalia B; Sommer, Iris E C (Oxford University Press, 2023-03-01)

BACKGROUND: Language anomalies are a hallmark feature of schizophrenia-spectrum disorders (SSD). Here, we used network analysis to examine possible differences in syntactic relations between patients with SSD and healthy ...

Now showing items 9801-9820 of 40729