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UMC Repository: Recent submissions

  • Epidemiology of substance and opium use among adult residents of Tehran; a comprehensive report from Tehran cohort study (TeCS) 
    Masoudkabir, Farzad; Shafiee, Akbar; Heidari, Amirhossein; Mohammadi, Negin Sadat Hosseini; Tavakoli, Kiarash; Jalali, Arash; Nayebirad, Sepehr; Alaeddini, Farshid; Saadat, Soheil; Vasheghani-Farahani, Ali; Sadeghian, Saeed; Arita, Vicente Artola; Boroumand, Mohamamdali; Karimi, Abbasali (BioMed Central, 2024-02-16)
    Background: The prevalence and burden of substance and opium use have increased worldwide over the past decades. In light of rapid population changes in Tehran, we aimed to evaluate the prevalence of opium and other substance ...
  • International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts 
    Timmins, Iain R; Jones, Michael E; O'Brien, Katie M; Adami, Hans-Olov; Aune, Dagfinn; Baglietto, Laura; Bertrand, Kimberly A; Brantley, Kristen D; Chen, Yu; Clague DeHart, Jessica; Clendenen, Tess V; Dossus, Laure; Eliassen, A Heather; Fletcher, Olivia; Fournier, Agnès; Håkansson, Niclas; Hankinson, Susan E; Houlston, Richard S; Joshu, Corinne E; Kirsh, Victoria A; Kitahara, Cari M; Koh, Woon-Puay; Linet, Martha S; Park, Hannah Lui; Lynch, Brigid M; May, Anne M; Mellemkjær, Lene; Milne, Roger L; Palmer, Julie R; Ricceri, Fulvio; Rohan, Thomas E; Ruddy, Kathryn J; Sánchez, Maria-Jose; Shu, Xiao-Ou; Smith-Byrne, Karl; Steindorf, Karen; Sund, Malin; Vachon, Celine M; Vatten, Lars J; Visvanathan, Kala; Weiderpass, Elisabete; Willett, Walter C; Wolk, Alicja; Yuan, Jian-Min; Zheng, Wei; Nichols, Hazel B; Sandler, Dale P; Swerdlow, Anthony J; Schoemaker, Minouk J (Lippincott Williams & Wilkins, 2024-03-10)
    PURPOSE: There is strong evidence that leisure-time physical activity is protective against postmenopausal breast cancer risk but the association with premenopausal breast cancer is less clear. The purpose of this study ...
  • Why we should not mistake accuracy of medical AI for efficiency 
    Jongsma, Karin Rolanda; Sand, Martin; Milota, Megan (Nature Publishing Group, 2024-03-04)
    In the medical literature, promising results regarding accuracy of medical AI are presented as claims for its potential to increase efficiency. This elision of concepts is misleading and incorrect. First, the promise that ...
  • Nature-versus-nurture considered harmful: Actionability as an alternative tool for understanding the exposome from an ethical perspective 
    Safarlou, Caspar Willem; Bredenoord, Annelien; Vermeulen, Roel; Jongsma, Karin (Wiley-Blackwell, 2024-05)
    Exposome research is put forward as a major tool for solving the nature-versus-nurture debate because the exposome is said to represent “the nature of nurture.” Against this influential idea, we argue that the adoption of ...
  • The Association between Intracranial Calcifications and Symptoms in Patients with Primary Familial Brain Calcification 
    Mathijssen, Gini; van Valen, Evelien; de Jong, Pim A; Golüke, Nienke M S; van Maren, Emiel A; Snijders, Birgitta M G; Brilstra, Eva H; Ruigrok, Ynte M; Bakker, Susan; Goto, Renzo W; Emmelot-Vonk, Marielle H; Koek, Huiberdina L (Multidisciplinary Digital Publishing Institute (MDPI), 2024-01-31)
    (1) Background: Primary Familial Brain Calcification (PFBC) is a neurodegenerative disease characterized by bilateral calcifications of the basal ganglia and other intracranial areas. Many patients experience symptoms of ...
  • Ophthalmologic adverse events in childhood head and neck rhabdomyosarcoma survivors treated according to four different local treatment strategies 
    Morfouace, Michele; Hol, Marinka L.F.; Arruti, Natalia; Bowman, Richard; Kolb, Frederic; Minard, Veronique; Pieters, Bradley; Gaze, Mark; Mandeville, Henry; Sandler, Eric; Smeele, Ludwig E.; Bradley, Julie; Indelicato, Daniel J.; Slater, Olga; Merks, Johannes H.M.; Schoot, Reineke A.; Saeed, Peerooz (Elsevier, 2024-12)
    Introduction: Ophthalmological adverse events (OAEs) are known to frequently occur following local treatment for pediatric head and neck rhabdomyosarcoma (HNRMS). The exact nature of these OAEs and the burden they put on ...
  • The effects of etidronate on brain calcifications in Fahr's disease or syndrome: rationale and design of the randomised, placebo-controlled, double-blind CALCIFADE trial 
    Snijders, Birgitta Mg; Mathijssen, Gini; Peters, Mike Jl; Emmelot-Vonk, Marielle H; de Jong, Pim A; Bakker, Susan; Crommelin, Heleen A; Ruigrok, Ynte M; Brilstra, Eva H; Schepers, Vera Pm; Spiering, Wilko; van Valen, Evelien; Koek, Huiberdina L (BioMed Central, 2024-02-07)
    BACKGROUND: Fahr's disease and syndrome are rare disorders leading to calcification of the small arteries in the basal ganglia of the brain, resulting in a wide range of symptoms comprising cognitive decline, movement ...
  • Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial—statistical analysis plan for a multicenter randomized controlled trial 
    Willemsen, Sten P.; Knol, Ronny; Brouwer, Emma; van den Akker, Thomas; DeKoninck, Philip L.J.; Lopriore, Enrico; Onland, Wes; de Boode, Willem P.; van Kaam, Anton H.; Nuytemans, Debbie H.; Reiss, Irwin K.M.; Hutten, G. Jeroen; Prins, Sandra A.; Mulder, Estelle E.M.; Hulzebos, Christian V.; van Sambeeck, Sam J.; van der Putten, Mayke E.; Zonnenberg, Inge A.; te Pas, Arjan B.; Vermeulen, Marijn J. (BioMed Central, 2024-03-04)
    Background: Mortality, cerebral injury, and necrotizing enterocolitis (NEC) are common complications of very preterm birth. An important risk factor for these complications is hemodynamic instability. Pre-clinical studies ...
  • Collaborative research in myositis-related disorders: MIHRA, a global shared community model 
    Saketkoo, Lesley Ann; Paik, Julie J; Alexanderson, Helene; Dimachkie, Mazen M; Ernste, Floranne C; Naddaf, Elie; Shafranski, Barbara; Gupta, Latika; Mecoli, Christopher A; Saygin, Didem; Albayda, Jemima; Basharat, Pari; Day, Jessica A; Valenzuela, Antonia; Bromley, Rachel; de Groot, Ingrid; Edison, Suzanne E; Lanis, Aviya; Lood, Christian; Regardt, Malin; Yi, Belina Y; Benitez, Alejandro C; Chinoy, Hector; Christopher-Stine, Lisa; Isenberg, David A; Lang, Bianca; Oddis, Chester V; van Royen, Annet; Vencovsky, Jiri; Werth, Victoria P; Machado, Pedro M (Clinical and Experimental Rheumatology S.A.S., 2024-02-01)
    Myositis International Health and Research Collaborative Alliance (MIHRA) is a newly formed purpose-built non-profit charitable research organisation dedicated to accelerating international clinical trial readiness, global ...
  • Plasma Markers of Alzheimer's Disease Pathology, Neuronal Injury, and Astrocytic Activation and MRI Load of Vascular Pathology and Neurodegeneration: The SMART-MR Study 
    Twait, Emma L; Gerritsen, Lotte; Moonen, Justine E F; Verberk, Inge M W; Teunissen, Charlotte E; Visser, Pieter Jelle; van der Flier, Wiesje M; Geerlings, Mirjam I; UCC SMART Study Group, the NCDC Consortium (Wiley-Blackwell, 2024-02-20)
    BACKGROUND: Two of the main causes for dementia are Alzheimer's disease (AD) and vascular pathology, with most patients showing mixed pathology. Plasma biomarkers for Alzheimer's disease-related pathology have recently ...
  • RESCEU and PROMISE: The Success of 8 Years of European Public-Private Partnership to Prevent RSV 
    Vernhes, Charlotte; Bont, Louis; Demont, Clarisse; Nair, Harish (Oxford University Press, 2024-03-15)
  • Controversy on the CONVINCE study findings: the PRO take 
    Canaud, Bernard; Blankestijn, Peter (Sociedade Brasileira de Nefrologia, 2024-04)
    The CONVINCE study, recently published in the New England Journal of Medicine, reveals a groundbreaking 23% reduction in the relative risk of all-cause mortality among end-stage kidney patients undergoing high convective ...
  • A Genome-Wide Association Study of Respiratory Syncytial Virus Infection Severity in Infants 
    Johnson, Mari; Chelysheva, Irina; Öner, Deniz; McGinley, Joseph; Lin, Gu-Lung; O'Connor, Daniel; Robinson, Hannah; Drysdale, Simon B; Gammin, Emma; Vernon, Sophie; Muller, Jill; Wolfenden, Helen; Westcar, Sharon; Anguvaa, Lazarus; Thwaites, Ryan S; Bont, Louis; Wildenbeest, Joanne; Martinón-Torres, Federico; Aerssens, Jeroen; Openshaw, Peter J M; Pollard, Andrew J (Oxford University Press, 2024-03-15)
    Background. Respiratory syncytial virus (RSV) is a significant cause of infant morbidity and mortality worldwide. Most children experience at least one 1 RSV infection by the age of two 2 years, but not all develop severe ...
  • Cost-utility analysis of TAVI compared with surgery in patients with severe aortic stenosis at low risk of surgical mortality in the Netherlands 
    Eerdekens, Rob; Kats, Suzanne; Grutters, Janneke P.C.; Green, Michelle; Shore, Judith; Candolfi, Pascal; Oortwijn, Wija; Harst, Pim Van Der; Tonino, Pim (BioMed Central, 2024-03-26)
    Background: There is growing evidence to support the benefits of transcatheter aortic valve implantation (TAVI) over surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis (sSAS) who ...
  • CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology 
    Glavan, Martina; Jelic, Ana; Levard, Damien; Frösen, Juhana; Keränen, Sara; Franx, Bart A.A.; Bras, Ana Rita; Louet, Estelle R.; Dénes, Ádám; Merlini, Mario; Vivien, Denis; Rubio, Marina (BioMed Central, 2024-03-18)
    Intracerebral aneurysms (IAs) are pathological dilatations of cerebral arteries whose rupture leads to subarachnoid hemorrhage, a significant cause of disability and death. Inflammation is recognized as a critical contributor ...
  • UPLC-Orbitrap-HRMS application for analysis of plasma sterols 
    van der Ham, Maria; Gerrits, Johan; Prinsen, Berthil; van Hasselt, Peter; Fuchs, Sabine; Jans, Judith; Willems, Anke; de Sain-van der Velden, Monique (Elsevier, 2024-04-01)
    Correct identification and quantification of different sterol biomarkers can be used as a first-line diagnostic approach for inherited metabolic disorders (IMD). The main drawbacks of current methodologies are related to ...
  • Limited incremental predictive value of the frailty index and other vulnerability measures from routine care data for mortality risk prediction in older patients with COVID-19 in primary care 
    la Roi-Teeuw, Hannah M; Luijken, Kim; Blom, Marieke T; Gussekloo, Jacobijn; Mooijaart, Simon P; Polinder-Bos, Harmke A; van Smeden, Maarten; Geersing, Geert-Jan; van den Dries, Carline J (BioMed Central Ltd., 2024-02-23)
    BACKGROUND: During the COVID-19 pandemic, older patients in primary care were triaged based on their frailty or assumed vulnerability for poor outcomes, while evidence on the prognostic value of vulnerability measures in ...
  • The impact of chromatin on double-strand break repair: Imaging tools and discoveries 
    van Bueren, Marit A E; Janssen, Aniek (2024-01)
    Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain optimal cell function. To overcome the ...
  • The psychosocial impact of male infertility on men undergoing ICSI treatment: a qualitative study 
    de Vries, Carmen E.J.; Veerman-Verweij, Esther M.; van den Hoogen, Agnes; de Man-van Ginkel, Janneke M.; Ockhuijsen, Henriëtta D.L. (BioMed Central Ltd., 2024-02-19)
    Background: Male infertility is in 20–70% of cases the cause of a couple’s infertility. Severe forms of male infertility are best treated with Intracytoplasmic Sperm Injection (ICSI). The psychosocial impact of infertility ...
  • Role of patent ductus arteriosus in preterms in long-term outcome 
    Veldhuis, Moniek S.; Dix, Laura M.L.; Breur, Johannes M.P.J.; de Vries, Willem B.; Koopman, Corine; Eijsermans, Maria J.C.; Swanenburg de Veye, Henriette F.N.; Molenschot, Mirella C.; Lemmers, Petra M.A.; van Bel, Frank; Vijlbrief, Daniel C. (Elsevier Ireland Ltd, 2024-03)
    Objective: This study aimed to determine long-term neurodevelopmental outcome and cerebral oxygenation in extremely preterm infants, comparing those with a hemodynamic significant patent ductus arteriosus (hsPDA) to those ...