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Towards Personalized Treatment in Haemophilia: The Role of Genetic Factors in Iron and Heme Control to Identify Patients at Risk for Haemophilic Arthropathy

van Vulpen, Lize F D; Mastbergen, Simon C; Foppen, Wouter; Fischer, Kathelijn; Lafeber, Floris P J G; Schutgens, Roger E G (MDPI Multidisciplinary Digital Publishing Institute, 2024-01-28)

The treatment landscape for haemophilia is changing rapidly, creating opportunities for personalized treatment. As major morbidity is still caused by haemophilic arthropathy, understanding the factors affecting joint damage ...
Remission definitions guiding immunosuppressive therapy in rheumatoid arthritis: which is best fitted for the purpose?

Duarte, Catia; Ferreira, Ricardo J.O.; Welsing, Paco M.J.; Jacobs, Johannes W.G.; Gossec, Laure; MacHado, Pedro M.; Van Der Heijde, Désirée; Da Silva, Jose Antonio Pereira (BMJ Publishing Group, 2024-03-04)

Objective To assess which definition of remission best predicts good radiographic outcome (GRO) and good functional outcome (GFO) in rheumatoid arthritis, focusing the updated American College of Rheumatology/European ...
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Welsh, Joshua A.; Goberdhan, Deborah C.I.; O’Driscoll, Lorraine; Buzas, Edit I.; Blenkiron, Cherie; Bussolati, Benedetta; Cai, Houjian; Di Vizio, Dolores; Driedonks, Tom A.P.; Erdbrügger, Uta; Falcon-Perez, Juan M.; Fu, Qing Ling; Hill, Andrew F.; Lenassi, Metka; Lim, Sai Kiang; M˜y, G. Mahoney; Mohanty, Sujata; Möller, Andreas; Nieuwland, Rienk; Ochiya, Takahiro; Sahoo, Susmita; Torrecilhas, Ana C.; Zheng, Lei; Zijlstra, Andries; Abuelreich, Sarah; Bagabas, Reem; Bergese, Paolo; Bridges, Esther M.; Brucale, Marco; Burger, Dylan; Carney, Randy P.; Cocucci, Emanuele; Crescitelli, Rossella; Hanser, Edveena; Harris, Adrian L.; Haughey, Norman J.; Hendrix, An; Ivanov, Alexander R.; Jovanovic-Talisman, Tijana; Kruh-Garcia, Nicole A.; MISEV Consortium (John Wiley & Sons Inc., 2024-02-07)

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic ...
Rationale and design for the randomized placebo-controlled double-blind trial studying the effect of single antiplatelet therapy (clopidogrel) versus dual antiplatelet therapy (clopidogrel/acetylsalicylic acid) on the occurrence of atherothrombotic events following lower extremity peripheral transluminal angioplasty (CLEAR-PATH)

Wegerif, Emilien C.J.; Ünlü, Çağdaş; Generaal, Manon I.; van den Bor, Rutger M.; van de Ven, Peter M.; Bots, Michiel L.; de Borst, Gert J. (Mosby Inc., 2024-07)

Rationale: Antiplatelet therapy (APT) is the standard of care after endovascular revascularization (EVR) in patients with peripheral artery disease (PAD). APT aims to prevent both major adverse cardiovascular events (MACE) ...
Effectiveness of antibacterial therapeutic clothing vs. nonantibacterial therapeutic clothing in patients with moderate-to-severe atopic dermatitis: a randomized controlled observer-blind pragmatic trial (ABC trial)

Ragamin, Aviël; Schappin, Renske; de Graaf, Marlies; Tupker, Ron A.; Fieten, Karin B.; van Mierlo, Minke M.F.; Bronner, Madelon B.; Romeijn, Geertruida L.E.; Sloot, Manon M.; Boesjes, Celeste M.; van der Rijst, Lisa P.; Arents, Bernd W.M.; Rustemeyer, Thomas; Schuttelaar, Marie L.A.; Pasmans, Suzanne G.M.A. (Wiley-Blackwell, 2024-03)

Background Increased Staphylococcus aureus (SA) colonization is considered an important factor in the pathogenesis of atopic dermatitis (AD). Antibacterial therapeutic clothing aims to reduce SA colonization and AD ...
Reply: Endometrial scratching: the light at the end of the tunnel

van Hoogenhuijze, N. E.; Broekmans, F. J.M. (Oxford University Press, 2024-03-01)
Missense variants in ANO4 cause sporadic encephalopathic or familial epilepsy with evidence for a dominant-negative effect

EuroEPINOMICS-RES Dravet working group (Cell Press, 2024-06-06)

Anoctamins are a family of Ca 2+-activated proteins that may act as ion channels and/or phospholipid scramblases with limited understanding of function and disease association. Here, we identified five de novo and two ...
Corrigendum to “Activation of pyruvate kinase as therapeutic option for rare hemolytic anemias: Shedding new light on an old enzyme” [Blood Rev. 2023 Sep:61:101103] (Blood Reviews (2023) 61, (S0268960X23000644), (10.1016/j.blre.2023.101103))

van Dijk, Myrthe J.; de Wilde, Jonathan R.A.; Bartels, Marije; Kuo, Kevin H.M.; Glenthøj, Andreas; Rab, Minke A.E.; van Beers, Eduard J.; van Wijk, Richard (Churchill Livingstone, 2024-03)

The authors regret that in the published article, a part of Table 2 titled ‘Main clinical study results of subjects treated with PK activators in hereditary hemolytic anemia’ was missing. A correction has therefore been ...
Allogeneic haematopoietic cell transplantation for therapy-related myeloid neoplasms arising following treatment for lymphoma: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Nabergoj, Mitja; Eikema, Diderik-Jan; Koster, Linda; Platzbecker, Uwe; Sockel, Katja; Finke, Jürgen; Kröger, Nicolaus; Forcade, Edouard; Nagler, Arnon; Eder, Matthias; Tischer, Johanna; Broers, Annoek E C; Kuball, Jürgen; Wilson, Keith M O; Hunault-Berger, Mathilde; Collin, Matthew; Russo, Domenico; Corral, Lucía López; Helbig, Grzegorz; Mussetti, Alberto; Scheid, Christof; Gurnari, Carmelo; Raj, Kavita; Drozd-Sokolowska, Joanna; Yakoub-Agha, Ibrahim; Robin, Marie; McLornan, Donal P (Springer Nature, 2024-03)

Therapy-related myeloid neoplasms (t-MN), either myelodysplastic neoplasms (t-MDS) or acute myeloid leukemias (t-AML), have a poor prognosis and allogeneic haematopoietic cell transplantation (allo-HCT) represents the only ...
The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A

Oomen, Ilja; Verhagen, Marieke; Miranda, Mariarosaria; Allacher, Peter; Beckers, Erik A M; Blijlevens, Nicole M A; van der Bom, Johanna G; Coppens, Michiel; Driessens, Mariëtte; Eikenboom, Jeroen C J; Fijnvandraat, Karin; Hassan, Shermarke; van Heerde, Waander L; Hooimeijer, H Louise; Jansen, Joop H; Kaijen, Paul; Leebeek, Frank W G; Meijer, Daniëlle; Paul, Helmut; Rijpma, Sanna R; Rosendaal, Frits R; Smit, Cees; van Vulpen, Lize F D; Voorberg, Jan; Schols, Saskia E M; Gouw, Samantha C (Frontiers Media S. A., 2024)

Objectives: Anti-factor VIII (FVIII) antibodies have been reported to exhibit both neutralizing and non-neutralizing characteristics. This is the first study investigating the full spectrum of FVIII-specific antibodies, ...
Vancomycin flushing reaction after intraperitoneal vancomycin: A case report

Möhlmann, Julia; Daza Zabaleta, Amely; van Luin, Matthijs; Abrahams, AC (Multimed Inc., 2024-03)

Vancomycin has been reported to cause vancomycin flushing reaction (VFR), a hypersensitivity reaction that mostly occurs after intravenous administration. The incidence of VFR in a patient receiving intraperitoneal vancomycin ...
Qualitative flow metabolic phenotype of pancreatic cancer. A new prognostic biomarker?

Riviere, Deniece; Aarntzen, Erik; van Geenen, Erwin; Chang, David; de Geus-Oei, Lioe-Fee; Brosens, Lodewijk; van Laarhoven, Kees; Gotthardt, Martin; Hermans, John (John Wiley & Sons Inc., 2024-03)

BACKGROUND: Retrospective analysis to investigate the relationship between the flow-metabolic phenotype and overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) and its potential clinical utility. METHODS: ...
Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations

Werren, Elizabeth A; Peirent, Emily R; Jantti, Henna; Guxholli, Alba; Srivastava, Kinshuk Raj; Orenstein, Naama; Narayanan, Vinodh; Wiszniewski, Wojciech; Dawidziuk, Mateusz; Gawlinski, Pawel; Umair, Muhammad; Khan, Amjad; Khan, Shahid Niaz; Geneviève, David; Lehalle, Daphné; van Gassen, K L I; Giltay, Jacques C; Oegema, Renske; van Jaarsveld, Richard H; Rafiullah, Rafiullah; Rappold, Gudrun A; Rabin, Rachel; Pappas, John G; Wheeler, Marsha M; Bamshad, Michael J; Tsan, Yao-Chang; Johnson, Matthew B; Keegan, Catherine E; Srivastava, Anshika; Bielas, Stephanie L (Nature Publishing Group, 2024-05-30)

CSMD1 (Cub and Sushi Multiple Domains 1) is a well-recognized regulator of the complement cascade, an important component of the innate immune response. CSMD1 is highly expressed in the central nervous system (CNS) where ...
Potency of quality indicators in Dutch and international diabetes registries

Bak, Jessica C.G.; Serné, Erik H.; Wouters, M.W.J.M.; de Valk, Harold W.; Mul, Dick; Sas, Theo C.J.; Kramer, Mark H.H.; Nieuwdorp, Max; Verheugt, Carianne L. (Elsevier, 2024-01)

Background: Diabetes mellitus forms a slow pandemic. Cardiovascular risk and quality of diabetes care are strongly associated. Quality indicators improve diabetes management and reduce mortality and costs. Various national ...
A mixed methods analysis of the medication review intervention centered around the use of the ‘Systematic Tool to Reduce Inappropriate Prescribing’ Assistant (STRIPA) in Swiss primary care practices

Jungo, Katharina Tabea; Deml, Michael J.; Schalbetter, Fabian; Moor, Jeanne; Feller, Martin; Lüthold, Renata Vidonscky; Huibers, Johanna Alida Corlina; Sallevelt, Bastiaan Theodoor Gerard Marie; Meulendijk, Michiel C.; Spruit, Marco; Schwenkglenks, Matthias; Rodondi, Nicolas; Streit, Sven (BioMed Central, 2024-03-18)

Background: Electronic clinical decision support systems (eCDSS), such as the ‘Systematic Tool to Reduce Inappropriate Prescribing’ Assistant (STRIPA), have become promising tools for assisting general practitioners (GPs) ...
It's all about time: evaluation of the updated Zhongshan colorectal endoscopic submucosal dissection model in Western endoscopic submucosal dissection practice

Verhoeven, Daan A.; Moons, Leon M.G.; Koch, Arjun D.; Hardwick, James C.H.; Boonstra, Jurjen J.; Dang, Hao (Mosby Inc., 2024-06)
Nasal cathelicidin is expressed in early life and is increased during mild, but not severe respiratory syncytial virus infection

Sintoris, Sofia; Binkowska, Justyna M.; Gillan, Jonathan L.; Zuurbier, Roy P.; Twynam-Perkins, Jonathan; Kristensen, Maartje; Melrose, Lauren; Parga, Paula Lusaretta; Rodriguez, Alicia Ruiz; Chu, Mei Ling; van Boeckel, Sara R.; Wildenbeest, Joanne G.; Bowdish, Dawn M.E.; Currie, Andrew J.; Thwaites, Ryan S.; Schwarze, Jurgen; van Houten, Marlies A.; Boardman, James P.; Cunningham, Steve; Bogaert, Debby; Davidson, Donald J. (Nature Publishing Group, 2024-06-17)

Respiratory syncytial virus is the major cause of acute lower respiratory tract infections in young children, causing extensive mortality and morbidity globally, with limited therapeutic or preventative options. Cathelicidins ...
Safety and immunogenicity of Ad26.COV2.S in adults: A randomised, double-blind, placebo-controlled Phase 2a dose-finding study

Cárdenas, Vicky; Le Gars, Mathieu; Truyers, Carla; Ruiz-Guiñazú, Javier; Struyf, Frank; Colfer, Alicia; Bonten, Marc; Borobia, Alberto; Reisinger, Emil C; Kamerling, Ingrid M C; Douoguih, Macaya; Sadoff, Jerald (Elsevier, 2024-06-11)

BACKGROUND: A single dose of Ad26.COV2.S is well-tolerated and effective in preventing moderate-to-severe disease outcomes due to COVID-19. We evaluated the impact of dose level, number of doses, and dose interval on ...
A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders

Gandhi, Prafull S.; Zivkovic, Minka; Østergaard, Henrik; Bonde, Amalie C.; Elm, Torben; Løvgreen, Monika N.; Schluckebier, Gerd; Johansson, Eva; Olsen, Ole H.; Olsen, Eva H.N.; de Bus, Ian Arris; Bloem, Karien; Alskär, Oskar; Rea, Catherine J.; Bjørn, Søren E.; Schutgens, Roger E.; Sørensen, Benny; Urbanus, Rolf T.; Faber, Johan H. (Nature Publishing Group, 2024-02)

Inherited bleeding disorders such as Glanzmann thrombasthenia (GT) lack prophylactic treatment options. As a result, serious bleeding episodes are treated acutely with blood product transfusions or frequent, repeated ...
In-hospital mortality of patients with acute coronary syndrome (ACS) after implementation of national health insurance (NHI) in Indonesia

Qalby, Nurul; Arsyad, Dian S.; Qanitha, Andriany; Cramer, Maarten J.; Appelman, Yolande; Pabittei, Dara R.; Doevendans, Pieter A.; Mappangara, Idar; Muzakkir, Akhtar Fajar (BioMed Central, 2024-03-05)

Background: The National Health Insurance (NHI) was implemented in Indonesia in 2014, and cardiovascular diseases are one of the diseases that have overburdened the healthcare system. However, data concerning the relationship ...

Now showing items 7001-7020 of 40729