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Now showing items 6961-6980 of 40729

Prognosticating the outcome of intensive care in older patients—a narrative review

Beil, Michael; Moreno, Rui; Fronczek, Jakub; Kogan, Yuri; Moreno, Rui Paulo Jorge; Flaatten, Hans; Guidet, Bertrand; de Lange, Dylan; Leaver, Susannah; Nachshon, Akiva; van Heerden, Peter Vernon; Joskowicz, Leo; Sviri, Sigal; Jung, Christian; Szczeklik, Wojciech (Springer-Verlag GmbH and Co. KG, 2024-06-22)

Prognosis determines major decisions regarding treatment for critically ill patients. Statistical models have been developed to predict the probability of survival and other outcomes of intensive care. Although they were ...
Correction: Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

for the ALBINO Study Group (BioMed Central, 2024-03-15)

Correction: Trials 25, 81 (2024) https://doi.org/10.1186/s13063-023-07828-6
Influence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial

Alves Costa Silva, Carolina; Piccinno, Gianmarco; Suissa, Déborah; Bourgin, Mélanie; Schreibelt, Gerty; Durand, Sylvère; Birebent, Roxanne; Fidelle, Marine; Sow, Cissé; Aprahamian, Fanny; Manghi, Paolo; Punčochář, Michal; Asnicar, Francesco; Pinto, Federica; Armanini, Federica; Terrisse, Safae; Routy, Bertrand; Drubay, Damien; Eggermont, Alexander M.M.; Kroemer, Guido; Segata, Nicola; Zitvogel, Laurence; Derosa, Lisa; Bol, Kalijn F.; de Vries, I. Jolanda M. (Nature Publishing Group, 2024-02-23)

Tumor immunosurveillance plays a major role in melanoma, prompting the development of immunotherapy strategies. The gut microbiota composition, influencing peripheral and tumoral immune tonus, earned its credentials among ...
Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

Smabers, Lidwien P; Wensink, Emerens; Verissimo, Carla S; Koedoot, Esmee; Pitsa, Katerina-Chara; Huismans, Maarten A; Higuera Barón, Celia; Doorn, Mayke; Valkenburg-van Iersel, Liselot B; Cirkel, Geert A; Brousali, Anneta; Overmeer, René; Koopman, Miriam; Braat, Manon N; Penning de Vries, Bas; Elias, Sjoerd G; Vries, Robert G; Kranenburg, Onno; Boj, Sylvia F; Roodhart, Jeanine M (2024-02-27)

BACKGROUND: The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising ...
Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure

Walle, Roman; Petitbon, Anna; Fois, Giulia R.; Varin, Christophe; Montalban, Enrica; Hardt, Lola; Contini, Andrea; Angelo, Maria Florencia; Potier, Mylène; Ortole, Rodrigue; Oummadi, Asma; De Smedt-Peyrusse, Véronique; Adan, Roger A.; Giros, Bruno; Chaouloff, Francis; Ferreira, Guillaume; de Kerchove d’Exaerde, Alban; Ducrocq, Fabien; Georges, François; Trifilieff, Pierre (Nature Publishing Group, 2024-03-21)

Accumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution to ED symptomatic dimensions remains unclear. Using chemogenetic manipulations in ...
Validation of image-derived input function using a long axial field of view PET/CT scanner for two different tracers

Palard-Novello, Xavier; Visser, Denise; Tolboom, Nelleke; Smith, Charlotte L.C.; Zwezerijnen, Gerben; van de Giessen, Elsmarieke; den Hollander, Marijke E.; Barkhof, Frederik; Windhorst, Albert D.; van Berckel, Bart N.M.; Boellaard, Ronald; Yaqub, Maqsood (Springer International Publishing AG, 2024-03-13)

Background: Accurate image-derived input function (IDIF) from highly sensitive large axial field of view (LAFOV) PET/CT scanners could avoid the need of invasive blood sampling for kinetic modelling. The aim is to validate ...
Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family

Li, Heng Zhen; Zhang, Jing Lve; Yuan, Dong Liang; Xie, Wen Qing; Ladel, Christoph H.; Mobasheri, Ali; Li, Yu Sheng (BioMed Central Ltd., 2024-06-21)

Fibroblast growth factor (FGF) signaling encompasses a multitude of functions, including regulation of cell proliferation, differentiation, morphogenesis, and patterning. FGFs and their receptors (FGFR) are crucial for ...
Recurrent disease detection after resection of pancreatic ductal adenocarcinoma using a recurrence-focused surveillance strategy (RADAR-PANC): protocol of an international randomized controlled trial according to the Trials within Cohorts design

Dutch Pancreatic Cancer Group (BioMed Central, 2024-06-20)

BACKGROUND: Disease recurrence remains one of the biggest concerns in patients after resection of pancreatic ductal adenocarcinoma (PDAC). Despite (neo)adjuvant systemic therapy, most patients experience local and/or distant ...
Validation of an automated dispensing system for subsequent dose dispensing of different radionuclides

Cao, T. T.; Aalbersberg, E. A.; Geluk-Jonker, M. M.; Hendrikx, J. J.M.A. (2024-02-12)

Background: Automated dispensing systems (ADSs) for radiopharmaceuticals have been developed to reduce the radiation exposure of personnel, to improve the accuracy of the dispensed dose and to limit the microbiological ...
Contextualizing sociocultural beliefs about cleft, knowledge of the treatments, and factors associated with delay of treatment in Eastern Indonesia

H, Hasanuddin; Ruslin, Muhammad; Al-Jamaei, Aisha AH; Van Cann, Ellen M.; Helder, Marco N.; Tajrin, Andi; Forouzanfar, Tymour (2024-12)

Introduction: Indonesia is a multicultural Asian country with a high incidence of cleft. This study contextualizes how patients' sociocultural backgrounds hinder cleft management in a diverse nation. Material and methods: ...
Association Between Seizures and Neurodevelopmental Outcome at Two and Five Years in Asphyxiated Newborns With Therapeutic Hypothermia

Langeslag, Juliette F; Onland, Wes; Groenendaal, Floris; de Vries, Linda S; van Kaam, Anton H; de Haan, Timo R; PharmaCool study group (Elsevier, 2024-04)

OBJECTIVE: To investigate the association between the presence and severity of seizures in asphyxiated newborns and their neurodevelopmental outcome at ages two and five years. METHODS: Retrospective data analysis from a ...
Accuracy of urgency allocation in patients with shortness of breath calling out-of-hours primary care: a cross-sectional study

Spek, Michelle; Venekamp, Roderick P; de Groot, Esther; Geersing, Geert-Jan; Erkelens, Daphne C A; van Smeden, Maarten; Dobbe, Anna S M; Delissen, Mathé; Rutten, Frans H; Zwart, Dorien L (BioMed Central Ltd., 2024-03-27)

Background: In out-of-hours primary care (OHS-PC), semi-automatic decision support tools are often used during telephone triage. In the Netherlands, the Netherlands Triage Standard (NTS) is used. The NTS is mainly expert-based ...
Colonization of vancomycin-resistant Enterococcus faecium in human-derived colonic epithelium: Unraveling the transcriptional dynamics of host-enterococcal interactions

Stege, Paul B.; Beekman, Jeffrey M.; Hendrickx, Antoni P.A.; Van Eijk, Laura; Rogers, Malbert R.C.; Suen, Sylvia W.F.; Vonk, Annelotte M.; Willems, Rob J.L.; Paganelli, Fernanda L. (Oxford University Press, 2024-05-07)

Enterococcus faecium is an opportunistic pathogen able to colonize the intestines of hospitalized patients. This initial colonization is an important step in the downstream pathogenesis, which includes outgrowth of the ...
The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus

INFORM-RSV Study Group (Nature Publishing Group, 2024-04-10)

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied ...
Dose–effect relationships in neuroendocrine tumour liver metastases treated with [166Ho]-radioembolization

Ramdhani, K.; Beijer-Verduin, J.; Ebbers, S. C.; van Rooij, R.; Smits, M. L.J.; Bruijnen, R. C.G.; de Jong, H. W.A.M.; Lam, M. G.E.H.; Braat, A. J.A.T. (Springer-Verlag, 2024-06)

Purpose: Aim of this study was to investigate a dose-response relationship, dose-toxicity relationship, progression free survival (PFS) and overall survival (OS) in neuroendocrine tumour liver metastases (NELM) treated ...
T2-FLAIR Mismatch: An Imaging Biomarker for Children's MYB/MYBL1-Altered Diffuse Astrocytoma or Angiocentric Glioma.

van Maren, E A; Dankbaar, J W; Wesseling, P; Plasschaert, S; Muhlebner, A; Hoving, E W; Robe, P A; Snijders, T J; Hoogendijk, R; Kranendonk, M E G; Lequin, M H (American Society of Neuroradiology, 2024-06-01)

BACKGROUND AND PURPOSE: T2-FLAIR mismatch is a highly specific imaging biomarker of IDH-mutant diffuse astrocytoma in adults. It has however also been described in MYB/MYBL1-altered low grade tumors. Our aim was to assess ...
Finding the balance between person-centred and treatment-centred discussions in advance care planning-a qualitative analysis of conversations within the MUTUAL (Multidisciplinary Timely Undertaken Advance Care Planning conversations) intervention using a narrative analysis

van Lummel, Eline V T J; Ietswaard, Larissa; Rigter, Marloes; Tjan, Dave H T; van Delden, Johannes J M; Milota, Megan (Oxford University Press, 2024-03-01)

INTRODUCTION: Advance care planning (ACP) aims to create conditions for more person-centred care. We aimed to explore variations in person-centred care discussions and treatment-centred care discussions within ACP conversations ...
Generalisability of trials on antithrombotic treatment intensification in patients with cardiovascular disease

Castelijns, Maria C; Hageman, Steven H J; Teraa, Martin; van der Meer, Manon G; Westerink, Jan; Ten Berg, Jurrien; Visseren, Frank L J (BMJ Publishing Group, 2024-03-12)

OBJECTIVE: Assessment of generalisability of guideline-informing trials on antithrombotic treatment intensification to real-world patients with cardiovascular disease (CVD). METHODS: Inclusion and exclusion criteria of the ...
The relation between usage of an eHealth intervention for stress urinary incontinence and treatment outcomes: an observational study

Firet, Lotte; Teunissen, Theodora Alberta Maria; Kool, Rudolf Bertijn; Akkermans, Reinier Peter; Lagro-Janssen, Antoinette Leonarda Maria; van der Vaart, Huub; Assendelft, Willem Jan Jozef (BioMed Central Ltd., 2024-03-16)

Background: Stress urinary incontinence (SUI), though a prevalent condition among women, is undertreated in primary care. EHealth with pelvic floor muscle training is an evidence-based alternative to care-as-usual. It is ...
Health-related quality of life during the COVID-19 pandemic: The impact of restrictive measures using data from two Dutch population-based cohort studies

van Hagen, Cheyenne C E; Huiberts, Anne J; Mutubuki, Elizabeth N; de Melker, Hester E; Vos, Eric R A; van de Wijgert, Janneke H H M; van den Hof, Susan; Knol, Mirjam J; van Hoek, Albert Jan (Public Library of Science, 2024-03-18)

Objectives We describe health-related quality of life during the COVID-19 pandemic in the general Dutch population and correlations with restrictive measures. Methods Data were obtained from 18–85 year-old participants of ...

Now showing items 6961-6980 of 40729