INTRODUCTION: Modified Vaccinia Virus Ankara (MVA) is a safe vaccine vector inducing long- lasting and potent immune responses. MVA-mediated CD8 +T cell responses are optimally induced, if both, direct- and cross-presentation ...

Background Highly accessible youth initiatives worldwide aim to prevent worsening of mental health problems, but research into outcomes over time is scarce. Aims This study aimed to evaluate outcomes and support use in 12- ...

Variants in the CNNM2 gene are causative for hypomagnesaemia, seizures and intellectual disability, although the phenotypes can be variable. This study aims to understand the genotype–phenotype relationship in affected ...

BACKGROUND: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between ...

Background: Shared decision-making has become of increased importance in choosing the most suitable treatment strategy for early rectal cancer, however, clinical decision-making is still primarily based on physicians’ ...

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer’s Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually ...

Aims: Little is known about the population pharmacokinetics (PPK) of vancomycin in neonates with perinatal asphyxia treated with therapeutic hypothermia (TH). We aimed to describe the PPK of vancomycin and propose an initial ...

GE-BOLD contrast stands out as the predominant technique in functional MRI experiments for its high sensitivity and straightforward implementation. GE-BOLD exhibits rather similar sensitivity to vessels independent of their ...

Background: Limited data are available on characteristics associated with antipsychotic use in multimorbid older adults. Aim: Primary: to identify patient characteristics associated with antipsychotic prescribing in a ...