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Now showing items 6441-6460 of 40729

Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting

Aristin Revilla, Sonia; Kranenburg, Onno; Coffer, Paul J. (Frontiers Media S. A., 2022-07-08)

Colorectal cancer (CRC) is a heterogeneous disease with one of the highest rates of incidence and mortality among cancers worldwide. Understanding the CRC tumor microenvironment (TME) is essential to improve diagnosis and ...
Estimated Life-Years Gained Free of New or Recurrent Major Cardiovascular Events With the Addition of Semaglutide to Standard of Care in People With Type 2 Diabetes and High Cardiovascular Risk

Westerink, Jan; Matthiessen, Kasper Sommer; Nuhoho, Solomon; Fainberg, Udi; Lyng Wolden, Michael; Østergaard, Helena Bleken; Sattar, Naveed; Visseren, FL (American Diabetes Association Inc., 2022-05-01)

OBJECTIVE: Semaglutide, a glucagon-like peptide 1 receptor agonist, reduced major adverse cardiovascular events (MACE) in people with type 2 diabetes (T2D) at high risk of cardiovascular disease (CVD) in a post hoc analysis ...
Light-based vat-polymerization bioprinting

Levato, Riccardo; Dudaryeva, Oksana; Garciamendez-Mijares, Carlos Ezio; Kirkpatrick, Bruce E.; Rizzo, Riccardo; Schimelman, Jacob; Anseth, Kristi S.; Chen, Shaochen; Zenobi-Wong, Marcy; Zhang, Yu Shrike (Springer Nature, 2023-12)

Light-based vat-polymerization bioprinting enables computer-aided patterning of 3D cell-laden structures in a point-by-point, layer-by-layer or volumetric manner, using vat (vats) filled with photoactivatable bioresin ...
Contribution of Influenza Viruses, Other Respiratory Viruses and Viral Co-Infections to Influenza-like Illness in Older Adults

Kaaijk, Patricia; Swaans, Niels; Nicolaie, Alina M.; Bruin, Jacob P.; Van Boxtel, Renée A.J.; De Lange, Marit M.A.; Meijer, Adam; Sanders, Elisabeth A.M.; van Houten, Marianne A.; Rots, Nynke Y.; Luytjes, Willem; van Beek, Josine (Multidisciplinary Digital Publishing Institute (MDPI), 2022-04)

Influenza-like illness (ILI) can be caused by a range of respiratory viruses. The present study investigates the contribution of influenza and other respiratory viruses, the occurrence of viral co-infections, and the ...
Author Correction: A comprehensive multi-domain dataset for mitotic figure detection (Scientific Data, (2023), 10, 1, (484), 10.1038/s41597-023-02327-4)

Aubreville, Marc; Wilm, Frauke; Stathonikos, Nikolas; Breininger, Katharina; Donovan, Taryn A.; Jabari, Samir; Veta, Mitko; Ganz, Jonathan; Ammeling, Jonas; van Diest, Paul J.; Klopfleisch, Robert; Bertram, Christof A. (Nature Research, 2024-07-02)

A bug in the original code for calculating the average precision values, reported as mean and standard deviation in Tables 5 and 7, meant that these values were incorrect in the original work. They have been updated in the ...
Approaches to SARS-CoV-2 and other vaccinations in children with a history of multisystem inflammatory syndrome (MIS-C): An international survey

Minoia, Francesca; Lucioni, Federica; Heshin-Bekenstein, Merav; Vastert, Sebastiaan; Kessel, Christoph; Uziel, Yosef; Lamot, Lovro; Ruperto, Nicolino; Gattorno, Marco; Bracaglia, Claudia; Toplak, Natasa; the MAS/sJIA and Vaccination Working Parties of the Pediatric Rheumatology European Society (Frontiers Media S. A., 2022-11-09)

Background: Following the Coronavirus Disease-19 (COVID-19) pandemic outbreaks, the hyperinflammatory condition termed Multisystem Inflammatory Syndrome in Children (MIS-C) became a healthcare issue worldwide. Since December ...
How does age determine the development of human immune-mediated arthritis?

Degboe, Yannick; Vastert, Sebastiaan J.; Prakken, Berent J.; McInnes, Iain B. (Nature Research, 2022-09)

Does age substantially affect the emergence of human immune-mediated arthritis? Children do not usually develop immune-mediated articular inflammation during their first year of life. In patients with juvenile idiopathic ...
Correction to: Light-based vat-polymerization bioprinting (Nature Reviews Methods Primers, (2023), 3, 1, (47), 10.1038/s43586-023-00231-0)

Levato, Riccardo; Dudaryeva, Oksana; Garciamendez-Mijares, Carlos Ezio; Kirkpatrick, Bruce E.; Rizzo, Riccardo; Schimelman, Jacob; Anseth, Kristi S.; Chen, Shaochen; Zenobi-Wong, Marcy; Zhang, Yu Shrike (Springer Nature, 2024)

Correction to: Nature Reviews Methods Primershttps://doi.org/10.1038/s43586-023-00231-0, published online 22 June 2023 In the version of the article initially published, the orientation of the dose test panels in Fig. 3c ...
It is about time: The first validated biomarker for early diagnosis of systemic juvenile idiopathic arthritis

Pardeo, Manuela; Vastert, Sebastiaan J.; De Benedetti, Fabrizio (Meditsiinski Unversitet-Sofia, 2022-07-01)
Generalized div-curl based regularization for physically constrained deformable image registration

Tzitzimpasis, Paris; Ries, Mario; Raaymakers, Bas W.; Zachiu, Cornel (Nature Publishing Group, 2024)

Variational image registration methods commonly employ a similarity metric and a regularization term that renders the minimization problem well-posed. However, many frequently used regularizations such as smoothness or ...
Therapeutic drug monitoring-based precision dosing of oral targeted therapies in oncology: a prospective multicenter study

Groenland, S. L.; van Eerden, R. A.G.; Westerdijk, K.; Meertens, M.; Koolen, S. L.W.; Moes, D. J.A.R.; de Vries, N.; Rosing, H.; Otten, H.; Vulink, A. J.E.; Desar, I. M.E.; Imholz, A. L.T.; Gelderblom, H.; van Erp, N. P.; Beijnen, J. H.; Mathijssen, R. H.J.; Huitema, A. D.R.; Steeghs, N.; Dutch Pharmacology Oncology Group (DPOG) (Oxford University Press, 2022-10)

Background: Oral targeted therapies show a high pharmacokinetic (PK) interpatient variability. Even though exposure has been positively correlated with efficacy for many of these drugs, these are still dosed using a ...
The Authors Respond

Traini, Eugenio; Huss, Anke; Portengen, Lützen; Rookus, Matti; Verschuren, W. M.Monique; Vermeulen, Roel C.H.; Bellavia, Andrea (Lippincott Williams & Wilkins, 2022-11-01)
Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts

Fraszczyk, Eliza; Spijkerman, Annemieke M.W.; Zhang, Yan; Brandmaier, Stefan; Day, Felix R.; Zhou, Li; Wackers, Paul; Dollé, Martijn E.T.; Bloks, Vincent W.; Gào, Xīn; Gieger, Christian; Kooner, Jaspal; Kriebel, Jennifer; Picavet, H. Susan J.; Rathmann, Wolfgang; Schöttker, Ben; Loh, Marie; Verschuren, W. M.Monique; van Vliet-Ostaptchouk, Jana V.; Wareham, Nicholas J.; Chambers, John C.; Ong, Ken K.; Grallert, Harald; Brenner, Hermann; Luijten, Mirjam; Snieder, Harold (Springer-Verlag, 2022-05)

Aims/hypothesis: Type 2 diabetes is a complex metabolic disease with increasing prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic markers could help tailor prevention efforts to ...
A kaleidoscopic view of extracellular vesicles in lysosomal storage disorders

Hegeman, Charlotte V.; de Jong, Olivier G.; Lorenowicz, Magdalena J. (OAE Publishing Inc., 2022)

Extracellular vesicles (EVs) are a heterogeneous population of stable lipid membrane particles that play a critical role in the regulation of numerous physiological and pathological processes. EV cargo, which includes ...
Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies

van Eijk, Maarten; Yu, Huixin; Sawicki, Emilia; de Weger, Vincent A.; Nuijen, Bastiaan; Dorlo, Thomas P.C.; Beijnen, Jos H.; Huitema, Alwin D.R. (Springer-Verlag, 2022-07)

Purpose: Orally administered paclitaxel offers increased patient convenience while providing a method to prolong exposure without long continuous, or repeated, intravenous infusions. The oral bioavailability of paclitaxel ...
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

HGID Lab (National Academy of Sciences, 2022-05-24)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found ...
A Single-arm Phase II Study Combining NLG207, a Nanoparticle Camptothecin, with Enzalutamide in Advanced Metastatic Castration-resistant Prostate Cancer Post-Enzalutamide

Schmidt, Keith T.; Karzai, Fatima; Bilusic, Marijo; Cordes, Lisa M.; Chau, Cindy H.; Peer, Cody J.; Wroblewski, Susan; Huitema, Alwin D.R.; Schellens, Jan H.M.; Gulley, James L.; Dahut, William L.; Figg, William D.; Madan, Ravi A. (AlphaMed Press, 2022-09-02)

BACKGROUND: Despite the clinical efficacy of enzalutamide monotherapy in patients with advanced prostate cancer, therapeutic resistance and disease progression are inevitable. We proposed a study to evaluate NLG207, a ...
The effect of endovascular baroreflex amplification on central sympathetic nerve circuits and cerebral blood flow in patients with resistant hypertension: A functional MRI study

Groenland, Eline H; van Kleef, Monique E A M; Hendrikse, Jeroen; Spiering, Wilko; Siero, Jeroen C W (2022-07-25)

BACKGROUND: Endovascular baroreflex amplification (EVBA) by implantation of the MobiusHD is hypothesized to lower blood pressure by decreasing sympathetic activity through the mechanism of the baroreflex. In the present ...
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models

Dejanovic, Borislav; Wu, Tiffany; Tsai, Ming-Chi; Graykowski, David; Gandham, Vineela D; Rose, Christopher M; Bakalarski, Corey E; Ngu, Hai; Wang, Yuanyuan; Pandey, Shristi; Rezzonico, Mitchell G; Friedman, Brad A; Edmonds, Rose; De Mazière, Ann; Rakosi-Schmidt, Raphael; Singh, Tarjinder; Klumperman, Judith; Foreman, Oded; Chang, Michael C; Xie, Luke; Sheng, Morgan; Hanson, Jesse E (Springer, 2022-09)

Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in Tau P301S synapse fractions ...
Dedicated teams to optimize quality and safety of surgery: A systematic review

Lentz, C. M.; De Lind Van Wijngaarden, R. A.F.; Willeboordse, F.; Hooft, L.; Van Der Laan, M. J. (Oxford University Press, 2022-10)

Background: A dedicated operating team is defined as a surgical team consisting of the same group of people working together over time, optimally attuned in both technical and/or communicative aspects. This can be achieved ...

Now showing items 6441-6460 of 40729