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Inborn errors of the malate aspartate shuttle – Update on patients and cellular models

Koch, Jasmine; Broeks, Melissa H.; Gautschi, Matthias; Jans, Judith; Laemmle, Alexander (Academic Press Inc., 2024-08)

The malate aspartate shuttle (MAS) plays a pivotal role in transporting cytosolic reducing equivalents – electrons – into the mitochondria for energy conversion at the electron transport chain (ETC) and in the process of ...
Dairy product consumption and incident prediabetes in Dutch middle-aged adults: the Hoorn Studies prospective cohort

Slurink, Isabel A L; den Braver, Nicolette R; Rutters, Femke; Kupper, Nina; Smeets, Tom; Elders, Petra J M; Beulens, Joline W J; Soedamah-Muthu, Sabita S (Springer Science and Business Media Deutschland GmbH, 2022-02)

PURPOSE: Our aim was to investigate prospective associations of consumption of total dairy and dairy types with incident prediabetes in a Dutch population-based study. METHODS: Two enrolment waves of the Hoorn Studies were ...
Dairy Product Consumption in Relation to Incident Prediabetes and Longitudinal Insulin Resistance in the Rotterdam Study

Slurink, Isabel A L; Voortman, Trudy; Ochoa-Rosales, Carolina; Ahmadizar, Fariba; Kavousi, Maryam; Kupper, Nina; Smeets, Tom; Soedamah-Muthu, Sabita S (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-01)

Evidence suggests neutral or moderately beneficial effects of dairy intake on type 2 diabetes mellitus risk. Nevertheless, evidence on associations with early phases of type 2 diabetes remains inconsistent. We aimed to ...
TRIB3 Modulates PPARγ-Mediated Growth Inhibition by Interfering with the MLL Complex in Breast Cancer Cells

Hernández-Quiles, Miguel; Baak, Rosalie; Orea-Soufi, Alba; Borgman, Anouska; den Haan, Suzanne; Sobrevals Alcaraz, Paula; Jongejan, Aldo; van Es, Robert; Velasco, Guillermo; Vos, Harmjan; Kalkhoven, Eric (Multidisciplinary Digital Publishing Institute (MDPI), 2022-09-11)

Aberrant expression or activity of proteins are amongst the best understood mechanisms that can drive cancer initiation and progression, as well as therapy resistance. TRIB3, a member of the Tribbles family of pseudokinases, ...
Mechanically Derived Tissue Stromal Vascular Fraction Acts Anti-inflammatory on TNF Alpha-Stimulated Chondrocytes In Vitro

van Boxtel, Joeri; Vonk, Lucienne A.; Stevens, Hieronymus P.; van Dongen, Joris A. (MDPI AG, 2022-08)

Enzymatically isolated stromal vascular fraction (SVF) has already shown to be effective as a treatment for osteoarthritis (OA). Yet, the use of enzymes for clinical purpose is highly regulated in many countries. Mechanical ...
On the interrelation between alcohol addiction–like behaviors in rats

Smeets, Johanna A.S.; Minnaard, A. Maryse; Ramakers, Geert M.J.; Adan, Roger A.H.; Vanderschuren, Louk J.M.J.; Lesscher, Heidi M.B. (Springer-Verlag, 2022-04)

Rationale: Alcohol use disorder (AUD) is a complex, heterogeneous disorder that only occurs in a minority of alcohol users. Various behavioral constructs, including excessive intake, habit formation, motivation for alcohol ...
What Factors Affect Outcome in the Treatment of Fracture-Related Infection?

McNally, Martin; Corrigan, Ruth; Sliepen, Jonathan; Dudareva, Maria; Rentenaar, Rob; IJpma, Frank; Atkins, Bridget L; Wouthuyzen-Bakker, Marjan; Govaert, Geertje (Multidisciplinary Digital Publishing Institute (MDPI), 2022-07-14)

This international, multi-center study investigated the effect of individual components of surgery on the clinical outcomes of patients treated for fracture-related infection (FRI). All patients with surgically treated ...
Increased elasticity of sucrose demand during hyperdopaminergic states in rats

Minnaard, A. Maryse; Luijendijk, Mieneke C.M.; Baars, Annemarie M.; Drost, Lisa; Ramakers, Geert M.J.; Adan, Roger A.H.; Lesscher, Heidi M.B.; Vanderschuren, Louk J.M.J. (Springer-Verlag, 2022-03)

Rationale: Deficits in cost–benefit decision-making are a core feature of several psychiatric disorders, including substance addiction, eating disorders and bipolar disorder. Mesocorticolimbic dopamine signalling has been ...
Does the Use of Local Antibiotics Affect Clinical Outcome of Patients with Fracture-Related Infection?

Sliepen, Jonathan; Corrigan, Ruth A; Dudareva, Maria; Wouthuyzen-Bakker, Marjan; Rentenaar, Rob J; Atkins, Bridget L; Govaert, Geertje A M; McNally, Martin A; IJpma, Frank F A (Multidisciplinary Digital Publishing Institute (MDPI), 2022-10)

This international, multi-center study evaluated the effect of antibiotic-loaded carriers (ALCs) on outcome in patients with a fracture-related infection (FRI) and evaluated whether bacterial resistance to the implanted ...
GoCART

Terwel, Sofie R.; Kuball, Jürgen; Dreyling, Martin; Cerisoli, Francesc (Springer International Publishing, 2022-02-07)

Cellular therapies manufactured from cells of haematopoietic origin, such as CAR-T-cell therapies, provide a revolutionary treatment for patients suffering from haematological diseases. Nonetheless, there are considerable ...
Co-Expression of TIGIT and Helios Marks Immunosenescent CD8+ T Cells During Aging

Pieren, Daan K J; Smits, Noortje A M; Postel, Rimke J; Kandiah, Vinitha; de Wit, Jelle; van Beek, Josine; van Baarle, Debbie; Guichelaar, Teun (Frontiers Media S. A., 2022-05-16)

Aging leads to alterations in the immune system that result in ineffective responsiveness against pathogens. Features of this process, collectively known as immunosenescence, accumulate in CD8+ T cells with age and have ...
Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food

Linders, Louisa E.; Patrikiou, Lefkothea; Soiza-Reilly, Mariano; Schut, Evelien H.S.; van Schaffelaar, Bram F.; Böger, Leonard; Wolterink-Donselaar, Inge G.; Luijendijk, Mieneke C.M.; Adan, Roger A.H.; Meye, Frank J. (Nature Publishing Group, 2022-12)

Stress can cause overconsumption of palatable high caloric food. Despite the important role of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms remain unclear. Here we demonstrate in ...
Diffuse gastric cancer: Emerging mechanisms of tumor initiation and progression

Monster, Jooske L; Kemp, Lars J S; Gloerich, Martijn; van der Post, Rachel S (Elsevier, 2022-05)

Gastric cancer is globally the fourth leading cause of cancer-related deaths. Patients with diffuse-type gastric cancer (DGC) particularly have a poor prognosis that only marginally improved over the last decades, as ...
The mobility assessment course: A ready-to-use dynamic measure of visuospatial neglect

Nelemans, Katinka N.; Nijboer, Tanja C.W.; Ten Brink, Antonia F.; Timmerarends, Anja; KnowledgeBrokers Neglect Study Group (Wiley-Blackwell, 2022-09)

The Mobility Assessment Course (MAC) is a tool to measure visuospatial neglect in a dynamic fashion. Although the MAC has been shown to dissociate between patients with and without neglect, it remains unclear whether it ...
Applying machine learning to dissociate between stroke patients and healthy controls using eye movement features obtained from a virtual reality task

Brouwer, Veerle H.E.W.; Stuit, Sjoerd; Hoogerbrugge, Alex; Ten Brink, Antonia F.; Gosselt, Isabel K.; Van der Stigchel, Stefan; Nijboer, Tanja C.W. (Elsevier, 2022-04)

Conventional neuropsychological tests do not represent the complex and dynamic situations encountered in daily life. Immersive virtual reality simulations can be used to simulate dynamic and interactive situations in a ...
Effects of the Moderate CYP3A4 Inhibitor Erythromycin on the Pharmacokinetics of Palbociclib: A Randomized Crossover Trial in Patients With Breast Cancer

Molenaar-Kuijsten, Laura; Braal, C. Louwrens; Groenland, Stefanie L.; de Vries, Niels; Rosing, Hilde; Beijnen, Jos H.; Koolen, Stijn L.W.; Vulink, Annelie J.E.; van Dongen, Marloes G.J.; Mathijssen, Ron H.J.; Huitema, Alwin D.R.; Steeghs, Neeltje; the Dutch Pharmacology Oncology Group (DPOG) (Wiley-Blackwell, 2022-02)

Palbociclib is an oral inhibitor of cyclin-dependent kinases 4 and 6 used in the treatment of locally advanced and metastatic breast cancer, and is extensively metabolized by cytochrome P450 enzyme 3A4 (CYP3A4). A ...
Linee guida ESC 2021 per la prevenzione delle malattie cardiovascolari nella pratica clinica elaborate dalla Task Force per la prevenzione delle malattie cardiovascolari nella pratica clinica costituita da rappresentanti della Società Europea di Cardiologia e di 12 società medico-scientifiche con il contributo straordinario dell’Associazione Europea di Cardiologia Preventiva (EAPC)

ESC Scientific Document Group (CEPI s.r.l., 2022-06-01)
Hyperresponsive cytosolic DNA-sensing pathway in monocytes from primary Sjögren's syndrome

Huijser, Erika; Bodewes, Iris L.A.; Lourens, Mirthe S.; Van Helden-Meeuwsen, Cornelia G.; Van Den Bosch, Thierry P.P.; Grashof, Dwin G.B.; Van De Werken, Harmen J.G.; Lopes, Ana P.; Van Roon, Joel A.G.; Van Daele, Paul L.A.; Brkic, Zana; Dik, Willem A.; Versnel, Marjan A. (Oxford University Press, 2022-08-01)

Objectives: Cytosolic DNA-sensing pathway stimulation prompts type I IFN (IFN-I) production, but its role in systemic IFN-I pathway activation in primary SS (pSS) is poorly studied. Here we investigate the responsiveness ...
Development and preliminary validation of the Sjögren's Tool for Assessing Response (STAR): a consensual composite score for assessing treatment effect in primary Sjögren's syndrome

Seror, Raphaele; Baron, Gabriel; Camus, Marine; Cornec, Divi; Perrodeau, Elodie; Bowman, Simon J.; Bombardieri, Michele; Bootsma, Hendrika; Gottenberg, Jacques Eric; Fisher, Benjamin; Hueber, Wolfgang; Van Roon, Joel A.; Devauchelle-Pensec, Valérie; Gergely, Peter; Mariette, Xavier; Porcher, Raphael (Elsevier, 2022-07-01)

Objective To develop a composite responder index in primary Sjögren's syndrome (pSS): the Sjögren's Tool for Assessing Response (STAR). Methods To develop STAR, the NECESSITY (New clinical endpoints in primary Sjögren's ...
Longitudinal nonlinear mixed effects modeling of EGFR mutations in ctDNA as predictor of disease progression in treatment of EGFR-mutant non-small cell lung cancer

Janssen, Julie M.; Verheijen, Remy B.; van Duijl, Tirsa T.; Lin, Lishi; van den Heuvel, Michel M.; Beijnen, Jos H.; Steeghs, Neeltje; van den Broek, Daan; Huitema, Alwin D.R.; Dorlo, Thomas P.C. (John Wiley & Sons Inc., 2022-08)

Correlations between increasing concentrations of circulating tumor DNA (ctDNA) in plasma and disease progression have been shown. A nonlinear mixed effects model to describe the dynamics of epidermal growth factor receptor ...

Now showing items 6361-6380 of 40729