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UMC Repository: Recent submissions

  • Patient, caregiver and other knowledge user engagement in consensus-building healthcare initiatives: a scoping review protocol 
    Munce, Sarah E.P.; Wong, Elliott; Luong, Dorothy; Rao, Justin; Cunningham, Jessie; Bailey, Katherine; John, Tomisin; Barber, Claire; Batthish, Michelle; Chambers, Kyle; Cleverley, Kristin; Crabtree, Marilyn; Diaz, Sanober; Dimitropoulos, Gina; Gorter, Jan Willem; Grahovac, Danijela; Grimes, Ruth; Guttman, Beverly; Hébert, Michèle L.; Henze, Megan; Higgins, Amanda; Khodyakov, Dmitry; Li, Elaine; Lo, Lisha; MacGregor, Laura; Mooney, Sarah; Severino, Samadhi Mora; Mukerji, Geetha; Penner, Melanie; Pidduck, Jacklynn; Shulman, Rayzel; Stromquist, Lisa; Trbovich, Patricia; Wan, Michelle; Williams, Laura; Yates, Darryl; Toulany, Alene (BMJ Publishing Group, 2024-05-08)
    Introduction Patient engagement and integrated knowledge translation (iKT) processes improve health outcomes and care experiences through meaningful partnerships in consensus-building initiatives and research. Consensus-building ...
  • Co-creation of a toolkit to assist risk communication and clinical decision-making in severe preeclampsia: SPOT-Impact study design 
    Amoakoh, Hannah Brown; De Kok, Bregje C.; Yevoo, Linda Lucy; Olde Loohuis, Klaartje M.; Srofenyoh, Emmanuel K.; Arhinful, Daniel K.; Koi-Larbi, Koiwah; Adu-Bonsaffoh, Kwame; Amoakoh-Coleman, Mary; Browne, Joyce L. (Taylor and Francis Ltd., 2024-05-08)
    Globally, the incidence of hypertensive disorders of pregnancy, especially preeclampsia, remains high, particularly in low- and middle-income countries. The burden of adverse maternal and perinatal outcomes is particularly ...
  • Favorable resuscitation characteristics in patients undergoing extracorporeal cardiopulmonary resuscitation: A secondary analysis of the INCEPTION-trial 
    Ubben, Johannes F.H.; Heuts, Samuel; Delnoij, Thijs S.R.; Suverein, Martje M.; Hermanides, Renicus C.; Otterspoor, Luuk C.; Kraemer, Carlos V.Elzo; Vlaar, Alexander P.J.; van der Heijden, Joris J.; Scholten, Erik; den Uil, Corstiaan; Dos Reis Miranda, Dinis; Akin, Sakir; de Metz, Jesse; van der Horst, Iwan C.C.; Winkens, Bjorn; Maessen, Jos G.; Lorusso, Roberto; van de Poll, Marcel C.G. (2024-06)
    Introduction: Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used as a supportive treatment for refractory out-of-hospital cardiac arrest (OHCA). Still, there is a paucity of data evaluating favorable ...
  • Layer 1 NDNF interneurons are specialized top-down master regulators of cortical circuits 
    Hartung, Jan; Schroeder, Anna; Péréz Vázquez, Rodrigo Alejandro; Poorthuis, Rogier B.; Letzkus, Johannes J. (Cell Press, 2024-05-28)
    Diverse types of inhibitory interneurons (INs) impart computational power and flexibility to neocortical circuits. Whereas markers for different IN types in cortical layers 2–6 (L2–L6) have been instrumental for generating ...
  • Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases 
    Bootsma, Sanne; Dings, Mark P.G.; Kesselaar, Job; Helderman, Roxan F.C.P.A.; van Megesen, Kyah; Constantinides, Alexander; Moreno, Leandro Ferreira; Stelloo, Ellen; Scutigliani, Enzo M.; Bokan, Bella; Torang, Arezo; van Hooff, Sander R.; Zwijnenburg, Danny A.; Wouters, Valérie M.; van de Vlasakker, Vincent C.J.; Galanos, Laskarina J.K.; Nijman, Lisanne E.; Logiantara, Adrian; Veenstra, Veronique L.; Schlingemann, Sophie; van Piggelen, Sterre; van der Wel, Nicole; Krawczyk, Przemek M.; Platteeuw, Johannes J.; Tuynman, Jurriaan B.; de Hingh, Ignace H.; Klomp, Jan P.G.; Oubrie, Arthur; Snaebjornsson, Petur; Medema, Jan Paul; Oei, Arlene L.; Kranenburg, Onno; Elbers, Clara C.; Lenos, Kristiaan J.; Vermeulen, Louis; Bijlsma, Maarten F. (Cell Press, 2024-05-21)
    Peritoneal metastases (PMs) from colorectal cancer (CRC) respond poorly to treatment and are associated with unfavorable prognosis. For example, the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive ...
  • Do efficacy results obtained from randomized controlled trials translate to effectiveness data from observational studies for relapsing–remitting multiple sclerosis? 
    Verweij, Stefan; Ahmed, Wouter; Zhou, Guiling; Mavridis, Dimitris; Nikolakopoulos, Stavros; Elferink, Andre J.; Rengerink, Katrien Oude; Bijlsma, Maarten J.; Mol, Peter G.M.; Hak, Eelko (John Wiley & Sons Inc., 2024-05)
    Background: Randomized controlled trials are considered the gold standard in regulatory decision making, as observational studies are known to have important methodological limitations. However, real-world evidence may be ...
  • Under pressure - A historical vignette on surgical timing in traumatic spinal cord injury 
    ter Wengel, Paula Valerie; Reith, Florence; Adegeest, Charlotte Y.; Fehlings, Michael G.; Kwon, Brian K.; Vandertop, W. Peter; Öner, Cumhur F. (Elsevier, 2024)
    Introduction: It was not even a century ago when a spinal cord injury (SCI) would inevitably result in a fatal outcome, particularly for those with complete SCI. Throughout history, there have been extensive endeavours to ...
  • Targeted Combined Endpoint Improvement in Patient and Disease Domains in Atopic Dermatitis: A Treat-to-Target Analysis of Adults with Moderate-to-Severe Atopic Dermatitis Treated with Upadacitinib 
    Kwatra, Shawn G.; DE BRUIN-WELLER, Marjolein; Silverberg, Jonathan I.; Lio, Peter; Deleuran, Mette; Aydin, Handan; Calimlim, Brian M.; Lane, Michael C.; Liu, Yingyi; Ofori, Sarah; Weidinger, Stephan (Medical Journals Sweden AB, 2024)
    A treat-to-target approach was recently developed to guide systemic treatment for adults with atopic dermatitis (AD). Recommendations outlined criteria for a 3-month initial acceptable treatment target and a 6-month optimal ...
  • Influence of learned landmark correspondences on lung CT registration 
    Bhat, Ishaan; Kuijf, Hugo J.; Viergever, Max A.; Pluim, Josien P.W. (John Wiley & Sons Inc., 2024-08)
    Background: Disease or injury may cause a change in the biomechanical properties of the lungs, which can alter lung function. Image registration can be used to measure lung ventilation and quantify volume change, which can ...
  • The Ability to Sustain Facial Expressions 
    Schutte, Hilde; Bielevelt, Freek; Emohamadian, Hafsa; Muradin, Marvick S.M.; Bleys, Ronald L.A.W.; Rosenberg, Antoine J.W.P. (Lippincott Williams & Wilkins, 2024-05-01)
    To gain more insight into facial muscle function, imaging during action would be optimal. Magnetic resonance imaging is highly suitable for visualizing facial muscles. However, magnetic resonance imaging requires the ...
  • Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome 
    Efthymiou, Stephanie; Scala, Marcello; Nagaraj, Vini; Ochenkowska, Katarzyna; Komdeur, Fenne L.; Liang, Robin A.; Abdel-Hamid, Mohamed S.; Sultan, Tipu; Barøy, Tuva; Van Ghelue, Marijke; Vona, Barbara; Maroofian, Reza; Zafar, Faisal; Alkuraya, Fowzan S.; Zaki, Maha S.; Severino, Mariasavina; Duru, Kingsley C.; Tryon, Robert C.; Brauteset, Lin Vigdis; Ansari, Morad; Hamilton, Mark; Van Haelst, Mieke M.; Van Haaften, Gijs; Zara, Federico; Houlden, Henry; Samarut, Éric; Nichols, Colin G.; Smeland, Marie F.; McClenaghan, Conor (Oxford University Press, 2024-05-01)
    Loss-of-function mutation of ABCC9, the gene encoding the SUR2 subunit of ATP sensitive-potassium (KATP) channels, was recently associated with autosomal recessive ABCC9-related intellectual disability and myopathy syndrome ...
  • Unveiling Trichosporon austroamericanum sp. nov.: A Novel Emerging Opportunistic Basidiomycetous Yeast Species 
    Francisco, Elaine C.; Desnos-Ollivier, Marie; Dieleman, Chendo; Boekhout, Teun; Santos, Daniel Wagner de C.L.; Medina-Pestana, José O.; Colombo, Arnaldo L.; Hagen, Ferry (Springer Netherlands, 2024-06)
    During an epidemiological survey, a potential novel species within the basidiomycetous yeast genus Trichosporon was observed. The clinical strain was obtained from a urine sample taken from a Brazilian kidney transplant ...
  • Incidence, Risk Factors, and Survival of Bone Metastases and Skeletal-Related Events in Melanoma Patients: A Systematic Review and Quality Assessment of 29 Studies 
    Shimizu, Michelle R.; van de Langerijt, Olaf N.; Torres, Daniel; de Groot, Tom; Groot, Olivier Q. (Elsevier, 2024-06)
    Background: Skeletal metastases make up 17% of all metastases from advanced-stage melanoma. Bone metastases are associated with increased morbidity and mortality and decreased quality of life due to their association with ...
  • Cell-induced collagen alignment in a 3D in vitro culture during extracellular matrix production 
    Schaart, Judith M.; Kea-te Lindert, Mariska; Roverts, Rona; Nijhuis, Wouter H.; Sommerdijk, Nico; Akiva, Anat (Academic Press Inc., 2024-06)
    The bone extracellular matrix consists of a highly organized collagen matrix that is mineralized with carbonated hydroxyapatite. Even though the structure and composition of bone have been studied extensively, the mechanisms ...
  • The role of the mineralocorticoid receptor in steroidinduced cytotoxicity in pediatric acute lymphoblastic leukemia 
    Van Hulst, Annelienke M.; Van der Zwet, Jordy C.G.; Buijs-Gladdines, Jessica G.C.A.M.; Smits, Willem K.; Fiocco, Marta; Pieters, Rob; Van Leeuwen, Frank N.; Van den Heuvel-Eibrink, Marry M.; Van den Akker, Erica L.T.; Meijerink, Jules P.P. (Ferrata Storti Foundation, 2024-05-01)
  • Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients 
    Vernooij, Robin W.M.; Michael, Mini; Ladhani, Maleeka; Webster, Angela C.; Strippoli, Giovanni F.M.; Craig, Jonathan C.; Hodson, Elisabeth M. (John Wiley & Sons Inc., 2024-05-03)
    Background: The risk of cytomegalovirus (CMV) infection in solid organ transplant recipients has resulted in the frequent use of prophylaxis to prevent the clinical syndrome associated with CMV infection. This is an update ...
  • Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study) 
    Kinos, Sampsa; Hagman, Helga; Halonen, Päivi; Soveri, Leena Maija; O'Reilly, Mary; Pfeiffer, Per; Frödin, Jan Erik; Sorbye, Halfdan; Heervä, Eetu; Liposits, Gabor; Kallio, Raija; Ålgars, Annika; Ristamäki, Raija; Salminen, Tapio; Bärlund, Maarit; Shah, Carl Henrik; McDermott, Ray; Röckert, Rebecka; Flygare, Petra; Kwakman, Johannes; Teske, Arco; Punt, Cornelis; Glimelius, Bengt; Österlund, Pia (2024-05-02)
    BACKGROUND AND PURPOSE: The CardioSwitch-study demonstrated that patients with solid tumors who develop cardiotoxicity on capecitabine or 5-fluorouracil (5-FU) treatment can be safely switched to S-1, an alternative ...
  • Long-term outcomes of bilateral medialisation thyroplasty in patients with vocal fold atrophy with or without sulcus 
    Van Den Broek, Emke M.J.M.; Heijnen, Bas J.; Van Der Valk, Jens C.; Hendriksma, Martine; Langeveld, Antonius P.M.; Van Benthem, Peter Paul G.; Sjögren, Elisabeth V. (Cambridge University Press, 2024-05-02)
    Objective Evaluate long-term voice outcome after bilateral medialisation thyroplasty in glottic insufficiency due to vocal fold atrophy with or without sulcus. Methods Patients after medialisation thyroplasty for vocal ...
  • Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokineticpharmacodynamic model 
    Verrest, Luka; Monnerat, Séverine; Musa, Ahmed M.; Mbui, Jane; Khalil, Eltahir A.G.; Olobo, Joseph; Wasunna, Monique; Chu, Wan Yu; Huitema, Alwin D.R.; Schallig, Henk D.F.H.; Alves, Fabiana; Dorlo, Thomas P.C. (Public Library of Science, 2024-04)
    Background With the current treatment options for visceral leishmaniasis (VL), recrudescence of the parasite is seen in a proportion of patients. Understanding parasite dynamics is crucial to improving treatment efficacy ...
  • Sex differences in blood pressure phenotypes over time - The HELIUS study 
    Vriend, Esther M.C.; Bouwmeester, Thomas A.; Franco, Oscar H.; Galenkamp, Henrike; Zwinderman, Aeilko H.; Van Den Born, Bert Jan H.; Collard, Didier (Lippincott Williams & Wilkins, 2024-06-01)
    Background:Hypertension can be classified into different phenotypes according to systolic and diastolic blood pressure (BP). In younger adults, these phenotypical differences have different prognostic value for men and ...