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Now showing items 5181-5200 of 40729

Adaptive brachytherapy for cervical cancer in combined 1.5 T MR/HDR suite: Impact of repeated imaging

Van Vliet-van den Ende, Katelijne M.; Hoogendoorn-Mulder, Paulien G.; Schokker, Rogier I.; Moerland, Marinus A.; Kroon, Petra S.; Roesink, Judith M.; Fajardo, Raquel Dávila; Van der Leij, Femke; Jürgenliemk-Schulz, Ina M. (Elsevier Ireland Ltd, 2024-09)

Introduction: At our department we have a dedicated 1.5 Tesla MRI/HDR brachytherapy suite, which provides the possibility of repeated MRI scanning before, during and after applicator insertion and before and/or after ...
Treatment patterns and survival outcomes of patients admitted to the intensive care unit due to immune-related adverse events of immune checkpoint inhibitors

Lin, Lishi; Houwink, Aletta P.I.; van Dieren, Jolanda M.; Wolthuis, Esther K.; van Thienen, Johannes V.; van der Heijden, Michiel S.; Haanen, John B.A.G.; Beijnen, Jos H.; Huitema, Alwin D.R. (John Wiley & Sons Inc., 2024-06)

Introduction: Severe immune-related adverse events (irAEs) due to immune checkpoint inhibitors (ICIs) can lead to admission to the intensive care unit (ICU). In this retrospective study, we determined the incidence, treatment ...
Adverse Events in Anti-PD-1-Treated Adjuvant and First-Line Advanced Melanoma Patients

Rauwerdink, Daan Jan Willem; Not, Olivier van; de Meza, Melissa; Doorn, Remco van; Hage, Jos van der; Eertwegh, A J M van den; Haanen, John B; Aarts, Maureen J B; Berkmortel, Franchette W P J van den; Blank, Christiaan U; Boers-Sonderen, Marye J; Groot, Jan Willem B de; Hospers, Geke A P; Piersma, Djura; van Rijn, Rozemarijn S; Stevense-den Boer, A M; Veldt, Astrid A M van der; Vreugdenhil, Gerard; Wouters, Michel W J M; Suijkerbuijk, Karijn P M; Kapiteijn, Ellen (Multidisciplinary Digital Publishing Institute (MDPI), 2024-07-26)

Introduction: The difference in incidence and severity of anti-PD-1 therapy-related adverse events (irAEs) between adjuvant and advanced treated melanoma patients remains unclear, as no head-to-head studies have compared ...
Associations of social determinants of health with life expectancy and future health risks among individuals with type 2 diabetes: two nationwide cohort studies in the UK and USA

Zhong, Jiale; Zhang, Yanbo; Zhu, Kai; Li, Rui; Zhou, Xiaotao; Yao, Pang; Franco, Oscar H.; Manson, Jo Ann E.; Pan, An; Liu, Gang (Elsevier, 2024-08)

Background: Social determinants of health (SDHs) are the primary drivers of preventable health inequities, and the associations between SDHs and health outcomes among individuals with type 2 diabetes remain unclear. This ...
The aperiodic exponent of neural activity varies with vigilance state in mice and men

Østergaard, Freja Gam; Penninx, Brenda W.J.H.; Das, Neetha; Arango, Celso; van der Wee, Nic; Winter-Van Rossum, Inge; Ayuso-Mateos, Jose Luis; Dawson, Gerard R.; Marston, Hugh; Kas, Martien J.H. (Public Library of Science, 2024-08)

Recently the 1/f signal of human electroencephalography has attracted attention, as it could potentially reveal a quantitative measure of neural excitation and inhibition in the brain, that may be relevant in a clinical ...
A multiplex UPLC-MS/MS method for the quantification of three PD-L1 checkpoint inhibitors, atezolizumab, avelumab, and durvalumab, in human serum

Buitelaar, Pauline L.M.; de Jong, Karen A.M.; Aardenburg, Leon; van der Heijden, Michiel S.; Huitema, Alwin D.R.; Beijnen, Jos H.; Rosing, Hilde (Elsevier, 2024-06-15)

Background and aim: To support pharmacokinetic studies, a multiplex UPLC-MS/MS assay was developed and validated to quantify PD-L1 checkpoint inhibitors atezolizumab, avelumab, and durvalumab in serum. Methods: A bottom-up ...
Hemoglobin and Its Relationship with Fatigue in Long-COVID Patients Three to Six Months after SARS-CoV-2 Infection

Bazdar, Somayeh; Bloemsma, Lizan D.; Baalbaki, Nadia; Blankestijn, Jelle M.; Cornelissen, Merel E.B.; Beijers, Rosanne J.H.C.G.; Sondermeijer, Brigitte M.; van Wijck, Yolanda; Downward, George S.; Maitland-van der Zee, Anke H.; on behalf of the P4O2 Consortium (MDPI AG, 2024-06)

Background: While some long-term effects of COVID-19 are respiratory in nature, a non-respiratory effect gaining attention has been a decline in hemoglobin, potentially mediated by inflammatory processes. In this study, ...
Facilitating flexibility in postgraduate nursing education through entrustable professional activities to address nursing shortages and career prospects

Pool, Inge A.; van Zundert, Helma; ten Cate, Olle (Wiley-Blackwell, 2024-09)

Aim: To communicate how the Dutch postgraduate nursing education landscape was redesigned using entrustable professional activities (EPAs). The goal of this initiative was to reduce training time, enhance transfer across ...
Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses

van den Berg, Daan F.; Costa, Ana Rita; Esser, Jelger Q.; Stanciu, Ilinka; Geissler, Jasper Q.; Zoumaro-Djayoon, Adja Damba; Haas, Pieter Jan; Brouns, Stan J.J. (Cell Press, 2024-08-14)

Prokaryotes have evolved a multitude of defense systems to protect against phage predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here, we set out to systematically project the current ...
Undernutrition as a risk factor for tuberculosis disease

Franco, Juan V.A.; Bongaerts, Brenda; Metzendorf, Maria Inti; Risso, Agostina; Guo, Yang; Peña Silva, Laura; Boeckmann, Melanie; Schlesinger, Sabrina; Damen, Johanna A.A.G.; Richter, Bernd; Baddeley, Annabel; Bastard, Mathieu; Carlqvist, Anna; Garcia-Casal, Maria Nieves; Hemmingsen, Bianca; Mavhunga, Farai; Manne-Goehler, Jennifer; Viney, Kerri (John Wiley & Sons Inc., 2024-06-11)

Background: Tuberculosis (TB) is a leading cause of mortality due to an infectious disease, with an estimated 1.6 million deaths due to TB in 2022. Approximately 25% of the global population has TB infection, giving rise ...
Accuracy of routine laboratory tests to predict mortality and deterioration to severe or critical COVID-19 in people with SARS-CoV-2

Cochrane COVID-19 Diagnostic Test Accuracy Group (John Wiley & Sons Inc., 2024-08-06)

Background: Identifying patients with COVID-19 disease who will deteriorate can be useful to assess whether they should receive intensive care, or whether they can be treated in a less intensive way or through outpatient ...
Patient reported outcomes following MR-guided radiotherapy for prostate cancer: a systematic review and meta-analysis

Westerhoff, J M; Lalmahomed, T A; Meijers, L; Henke, L; Teunissen, F R; Bruynzeel, A M E; Alongi, F; Hall, W A; Kishan, A U; Intven, M P W; Verkooijen, H M; van der Voort van Zyp, J R N; Daamen, L A (Elsevier, 2024-09-01)

PURPOSE: This systematic review provides an overview of literature on the impact of MR-guided radiotherapy (MRgRT) on patient reported outcomes (PROs) in patients with prostate cancer (PC). METHODS: A systematic search was ...
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype

Rademakers, Timo; Manca, Marco; Jin, Han; Orban, Tanguy; Perisic, Ljubica Matic; Frissen, Hubertus J.M.; Rühle, Frank; Hautvast, Petra; van Rijssel, Jos; van Kuijk, Kim; Mees, Barend M.E.; Peutz-Kootstra, Carine J.; Heeneman, Sylvia; Daemen, Mat J.A.P.; Pasterkamp, Gerard; Stoll, Monika; van Zandvoort, Marc A.M.J.; Hedin, Ulf; Dequiedt, Franck; van Buul, Jaap D.; Sluimer, Judith C.; Biessen, Erik A.L. (Springer Netherlands, 2024-08)

The presence of atherosclerotic plaque vessels is a critical factor in plaque destabilization. This may be attributable to the leaky phenotype of these microvessels, although direct proof for this notion is lacking. In ...
"Filling in the gap": A qualitative case study about identity construction of siblings of youth with a neurodisability

Nguyen, Linda; Jack, Susan M; Davis, Hanae; Bellefeuille, Samantha; Arafeh, Dana; Di Rezze, Briano; Ketelaar, Marjolijn; Gorter, Jan Willem (John Wiley & Sons Inc., 2024-08)

INTRODUCTION: In families of children with a neurodisability, siblings have unique experiences that can shape their identity. There is limited information about the developmental process of how siblings form their identity. ...
A Multidisciplinary Approach: Management and Rehabilitation of Children With Pediatric Post-COVID-19 Condition

Noij, Lieke; Terheggen-Lagro, Suzanne; Muselaers, Eefje; Whittaker, Elizabeth; Gosling, Justine; Brackel, Caroline; Oostrom, Kim; Alsem, Mattijs (Lippincott Williams & Wilkins, 2024-09)

Post-COVID-19 condition in children is a still largely unknown syndrome with a diverse pattern of symptoms, which can have a major impact on daily life. Currently, there are no evidence-based proven treatments, and the ...
Differences in checkpoint-inhibitor-induced hypophysitis: mono- versus combination therapy induced hypophysitis

van der Leij, Stephanie; Suijkerbuijk, Karijn P M; van den Broek, Medard F M; Valk, Gerlof D; Dankbaar, Jan Willem; van Santen, Hanneke M (Frontiers Media S. A., 2024-07-29)

OBJECTIVE: Immune checkpoint inhibitors (ICIs) are revolutionary in oncology but may cause immune-related (IR) side effects, such as hypophysitis. Treatment with anti-PD-(L)1, anti-CTLA-4 or anti-CLTA-4/PD-1 may induce ...
Depressive Symptoms and Plasma Markers of Alzheimer's Disease and Neurodegeneration: A Coordinated Meta-Analysis of 8 Cohort Studies

Twait, Emma L; Kamarioti, Maria; Verberk, Inge M W; Teunissen, Charlotte E; Nooyens, Astrid C J; Monique Verschuren, W M; Visser, Pieter Jelle; Huisman, Martijn; Kok, Almar A L; Eline Slagboom, P; Beekman, Marian; Vojinovic, Dina; Lakenberg, Nico; Arfan Ikram, M; Schuurmans, Isabel K; Wolters, Frank J; Moonen, Justine E F; Gerritsen, Lotte; van der Flier, Wiesje M; Geerlings, Mirjam I; NCDC Consortium (Lippincott Williams & Wilkins, 2024-09)

BACKGROUND: Depressive symptoms are associated with an increased risk of Alzheimer's disease (AD). There has been a recent emergence in plasma biomarkers for AD pathophysiology, such as amyloid-beta (Aβ) and phosphorylated ...
Tocilizumab Dose Tapering Based on a Model-Based Algorithm is Feasible in Clinical Practice: A Short Communication

Hooijberg, Femke; Layegh, Zohra; Leeuw, Maureen; Boekel, Laura; Van Den Berg, Stefan P.H.; Ruwaard, Jill; Bastida, Carla; Huitema, Alwin D.R.; Pel, Sara; Elkayam, Ori; De Vries, Annick; Nurmohamed, Mike; Rispens, Theo; Dorlo, Thomas P.C.; Wolbink, Gertjan (Lippincott Williams & Wilkins, 2024-06-01)

Background:Tocilizumab in the treatment of rheumatoid arthritis (RA) is a potential candidate for concentration-guided tapering because the standard dose of tocilizumab results in a wide range of serum concentrations, ...
Delineating genotype and parent-of-origin effect on the phenotype in MSH6-associated Lynch syndrome

van der Werf-'t Lam, Anne Sophie; Rodriguez-Girondo, Mar; Villasmil, Mandy; Tops, Carli M.; van Hest, Liselotte; Gille, Hans J.P.; Duijkers, Floor A.M.; Wagner, Anja; Eikenboom, Ellis; Letteboer, Tom G.W.; de Jong, Mirjam M.; Bajwa-ten Broeke, Sanne W.; Bleeker, Fonnet; Gomez Garcia, Encarna B.; Dominguez-Valentin, Mev; Møller, Pal; Suerink, Manon; Nielsen, Maartje (Wiley-Liss Inc., 2024-05)

Background: This study investigates the potential influence of genotype and parent-of-origin effects (POE) on the clinical manifestations of Lynch syndrome (LS) within families carrying (likely) disease-causing MSH6 germline ...
ASO Visual Abstract: High Community-Level Social Vulnerability is Associated with Worse Recurrence-Free Survival Following Resection of Extremity and Truncal Soft-Tissue Sarcoma

Traweek, Raymond S.; Lyu, Heather; Witt, Russell G.; Snyder, Rebecca A.; Nassif, Elise F.; Krijgh, David D.; Smith, Jeffrey M.; Tilney, Gordon S.; Feng, Chun; Chiang, Yi Ju; Torres, Keila E.; Roubaud, Margaret J.; Scally, Christopher P.; Hunt, Kelly K.; Keung, Emily Z.; Mericli, Alexander F.; Roland, Christina L. (Springer New York, 2024-06-01)

Now showing items 5181-5200 of 40729