Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Quality control, data cleaning, imputation 
    Liu, Dawei; Oberman, Hanne I.; Muñoz, Johanna; Hoogland, Jeroen; Debray, Thomas P.A. (Springer, 2023-11-05)
    This chapter addresses important steps during the quality assurance and control of RWD, with particular emphasis on the identification and handling of missing values. A gentle introduction is provided on common statistical ...
  • Statistical analysis-measurement error 
    Brakenhoff, Timo B.; van Smeden, Maarten; Oberski, Daniel L. (Springer, 2023-11-05)
    An important aspect of data quality when conducting clinical analyses using real-world data is how variables in the data have been recorded or measured. The discrepancy between an observed value and the true value is called ...
  • Machine learning in practice-Evaluation of clinical value, guidelines 
    Juarez-Orozco, Luis Eduardo; Ruijsink, Bram; Yeung, Ming Wai; Benjamins, Jan Walter; van der Harst, Pim (Springer, 2023-11-05)
    Machine learning research in health care literature has grown at an unprecedented pace. This development has generated a clear disparity between the number of first publications involving machine learning implementations ...
  • Ethnic Differences in Carotid Intima-Media Thickness and Plaque Presence: The HELIUS Study 
    Vriend, Esther M.C.; Bouwmeester, Thomas A.; Artola Arita, Vicente; Bots, Michiel L.; Meijer, Rudy; Galenkamp, Henrike; Stronks, Karien; Collard, Didier; Moll Van Charante, Eric P.; Van Den Born, Bert Jan H.; Franco, Oscar H. (S. Karger AG, 2024-10)
    Introduction: In the Netherlands, the prevalence of cardiovascular diseases (CVDs) is higher among South-Asian Surinamese and lower among Moroccans compared to the Dutch. Traditional risk factors for atherosclerotic CVD ...
  • RSV and rhinovirus increase pneumococcal carriage acquisition and density, whereas nasal inflammation is associated with bacterial shedding 
    Mitsi, Elena; Nikolaou, Elissavet; Goncalves, Andre; Blizard, Annie; Hill, Helen; Farrar, Madlen; Hyder-Wright, Angela; Akeju, Oluwasefunmi; Hamilton, Josh; Howard, Ashleigh; Elterish, Filora; Solorzano, Carla; Robinson, Ryan; Reiné, Jesus; Collins, Andrea M.; Gordon, Stephen B.; Moxon, Richard E.; Weiser, Jeffrey N.; Bogaert, Debby; Ferreira, Daniela M. (Cell Press, 2024-09-11)
    Epidemiological studies report the impact of co-infection with pneumococcus and respiratory viruses upon disease rates and outcomes, but their effect on pneumococcal carriage acquisition and bacterial load is scarcely ...
  • Explainable artificial intelligence for the electrocardiogram 
    van de Leur, Rutger Roel (Utrecht University, 2024-10-10)
    The 12-lead electrocardiogram (ECG) is a crucial diagnostic tool in clinical practice, used to identify various cardiac abnormalities. However, interpreting ECGs is complex, with significant variability between and within ...
  • LNPs for targeted siRNA delivery to leukemic tissue 
    Swart, Laura Elise (Utrecht University, 2024-10-07)
    Leukemias are often driven by the expression of leukemic-specific fusion genes. Exclusive targeting of these fusion genes using RNA interference is therefore an attractive therapeutic concept. Lipid nanoparticles (LNPs) ...
  • Oligometastatic disease in esophagogastric cancer 
    Kroese, Tiuri (Utrecht University, 2024-10-24)
    Patients with limited metastatic esophageal or gastric cancer (oligometastatic esophagogastric cancer) may benefit from local treatment of oligometastases combined with systemic therapy. This PhD thesis investigates the ...
  • Automated Surgical Urethral Length Estimation for Robot-Assisted Radical Prostatectomy 
    De Nijs, Joris V.; Jaspers, Tim J.M.; Bakker, Aron F.H.A.; Brinkman, Willem M.; De With, Peter H.N.; Van Der Sommen, Fons (IEEE Computer Society Press, 2024-05-27)
    Urinary Incontinence (UI) is a major side effect of Robot-Assisted Radical Prostatectomy (RARP). The surgical Urethra Length (SUL) emerges as a crucial predictive factor for postoperative-RARP UI. In response, this study ...
  • Cue and reward evoked dopamine activity is necessary for maintaining learned pavlovian associations 
    Van Zessen, Ruud; Flores-Dourojeanni, Jacques P.; Eekel, Timon; van den Reijen, Siem; Lodder, Bart; Omrani, Azar; Smidt, Marten P.; Ramakers, Geert M.J.; van der Plasse, Geoffrey; Stuber, Garret D.; Adan, Roger A.H. (Society for Neuroscience, 2021-06-09)
    Associating natural rewards with predictive environmental cues is crucial for survival. Dopamine (DA) neurons of the ventral tegmental area (VTA) are thought to play a crucial role in this process by encoding reward ...
  • An Organoid for Woven Bone 
    Akiva, Anat; Melke, Johanna; Ansari, Sana; Liv, Nalan; van der Meijden, Robin; van Erp, Merijn; Zhao, Feihu; Stout, Merula; Nijhuis, Wouter H.; de Heus, Cilia; Muñiz Ortera, Claudia; Fermie, Job; Klumperman, Judith; Ito, Keita; Sommerdijk, Nico; Hofmann, Sandra (Wiley-VCH Verlag, 2021-04-22)
    Bone formation (osteogenesis) is a complex process in which cellular differentiation and the generation of a mineralized organic matrix are synchronized to produce a hybrid hierarchical architecture. To study the mechanisms ...
  • Role of matrix‐associated autologous chondrocyte implantation with spheroids in the treatment of large chondral defects in the knee: A systematic review 
    Vonk, Lucienne Angela; Roël, Giulietta; Hernigou, Jacques; Kaps, Christian; Hernigou, Philippe (Multidisciplinary Digital Publishing Institute (MDPI), 2021-07-01)
    Autologous chondrocyte implantation (ACI) is a cell therapy for the treatment of focal cartilage defects. The ACI product that is currently approved for use in the European Union (EU) consists of spheroids of autologous ...
  • False amoxicillin/clavulanic acid susceptibility in Bacteroides fragilis using gradient strip tests 
    Rentenaar, Rob J; Bovo-Heijmans, Bianca; Diggle, Joanna; Fluit, Ad C; Wootton, Mandy (Academic Press, 2021-06)
    BACKGROUND: Repeatedly, too low MIC results were obtained in Bacteroides fragilis quality assessment strains, using gradient strip tests with a ratio of amoxicillin:clavulanic acid of 2:1. We aimed to find the most accurate ...
  • Author Correction: Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features (Nature Communications, (2021), 12, 1, (574), 10.1038/s41467-020-20887-6) 
    Mendelaar, Pauline A.J.; Smid, Marcel; van Riet, Job; Angus, Lindsay; Labots, Mariette; Steeghs, Neeltje; Hendriks, Mathijs P.; Cirkel, Geert A.; van Rooijen, Johan M.; Ten Tije, Albert J.; Lolkema, Martijn P.; Cuppen, Edwin; Sleijfer, Stefan; Martens, John W.M.; Wilting, Saskia M. (Nature Publishing Group, 2021-05-26)
    The original version of this Article contained an error in Table 4, in which the coefficients of the LASSO regression model of treatment response corresponded to a version that was performed without non-coding genes. The ...
  • Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer 
    van Brummelen, Emilie M.J.; Huijberts, Sanne; van Herpen, Carla; Desar, Ingrid; Opdam, Frans; van Geel, Robin; Marchetti, Serena; Steeghs, Neeltje; Monkhorst, Kim; Thijssen, Bas; Rosing, Hilde; Huitema, Alwin; Beijnen, Jos; Bernards, Rene; Schellens, Jan (2021-04)
    Lessons Learned: Afatinib and selumetinib can be combined in continuous and intermittent dosing schedules, albeit at lower doses than approved for monotherapy. Maximum tolerated dose for continuous and intermittent schedules ...
  • Therapeutic drug monitoring of oral targeted antineoplastic drugs 
    Mueller-Schoell, Anna; Groenland, Stefanie L.; Scherf-Clavel, Oliver; van Dyk, Madelé; Huisinga, Wilhelm; Michelet, Robin; Jaehde, Ulrich; Steeghs, Neeltje; Huitema, Alwin D.R.; Kloft, Charlotte (Springer-Verlag, 2021-04)
    Purpose: This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM). Factors influencing the ...
  • Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB 
    Heeman, Fiona; Hendriks, Janine; Lopes Alves, Isadora; Tolboom, Nelleke; van Berckel, Bart N M; Yaqub, Maqsood; Lammertsma, Adriaan A (Springer New York, 2021-06)
    PURPOSE: Moderate-to-high correlations have been reported between the [11C]PiB PET-derived relative tracer delivery rate R1 and relative CBF as measured using [15O]H2O PET, supporting its use as a proxy of relative CBF. ...
  • Strategies to reduce sample sizes in Alzheimer's disease primary and secondary prevention trials using longitudinal amyloid PET imaging 
    Lopes Alves, Isadora; Heeman, Fiona; Collij, Lyduine E; Salvadó, Gemma; Tolboom, Nelleke; Vilor-Tejedor, Natàlia; Markiewicz, Pawel; Yaqub, Maqsood; Cash, David; Mormino, Elizabeth C; Insel, Philip S; Boellaard, Ronald; van Berckel, Bart N M; Lammertsma, Adriaan A; Barkhof, Frederik; Gispert, Juan Domingo (BioMed Central, 2021-12)
    Background: Detecting subtle-to-moderate biomarker changes such as those in amyloid PET imaging becomes increasingly relevant in the context of primary and secondary prevention of Alzheimer’s disease (AD). This work aimed ...
  • Corrigendum: Evidence for a genetic contribution to the ossification of spinal ligaments in ossification of posterior longitudinal ligament and diffuse idiopathic skeletal hyperostosis: a narrative review(Front. Genet., (2022), 13, (987867), 10.3389/fgene.2022.987867) 
    Couto, Ana Rita; Parreira, Bruna; Power, Deborah M; Pinheiro, Luís; Madruga Dias, João; Novofastovski, Irina; Eshed, Iris; Sarzi-Puttini, Piercarlo; Pappone, Nicola; Atzeni, Fabiola; Verlaan, Jorrit-Jan; Kuperus, Jonneke; Bieber, Amir; Ambrosino, Pasquale; Kiefer, David; Khan, Muhammad Asim; Mader, Reuven; Baraliakos, Xenofon; Bruges-Armas, Jácome (Frontiers Media S. A., 2024-08-30)
    In the published article, there was an error in Affiliation number 2. Instead of “CHRC Campus Nova Medical School, Lisboa, Portugal”, it should be “Comprehensive Health Research Centre, Hospital de Santo Espírito da Ilha ...
  • More Time Spent with Clear Skin and No Itch with Upadacitinib versus Dupilumab for Atopic Dermatitis 
    Blauvelt, Andrew; Eyerich, Kilian; Irvine, Alan D.; de Bruin-Weller, Marjolein; Kwatra, Shawn G.; Gooderham, Melinda; Kim, Brian; Calimlim, Brian M.; Lee, Wan Ju; Raymundo, Eliza M.; Liu, Yingyi; Ofori, Sarah; Platt, Andrew M.; Silverberg, Jonathan I. (Springer-Verlag, 2024-09)
    Introduction: Atopic dermatitis (AD), with its hallmark symptoms of pruritus and skin lesions, often impairs patients’ quality of life. We assessed time spent with clear/almost clear skin and no/minimal itch during ...