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UMC Repository: Recent submissions

  • Outcomes in lung-only metastatic rhabdomyosarcoma: An analysis of data from the European paediatric Soft tissue sarcoma Study Group MTS 2008 study 
    Chisholm, Julia C.; Schoot, Reineke A.; Cameron, Alison L.; Casanova, Michela; Minard-Colin, Veronique; Coppadoro, Beatrice; Garrido, Marta; Rogers, Timothy; Orbach, Daniel; Glosli, Heidi; Ben-Arush, Miriam; Ferman, Sima; Scarzello, Giovanni; van Rijn, Rick R.; Hladun, Raquel; Corradini, Nadege; Ferrari, Andrea; Jenney, Meriel; Bisogno, Gianni; Merks, Johannes H.M. (Elsevier, 2023-12)
    Purpose: Patients with metastatic rhabdomyosarcoma (MTS RMS) and lung as the only metastatic site have better reported outcomes than other patients with MTS RMS. We analysed patients with lung-only MTS RMS receiving standard ...
  • Acquired fluconazole resistance and genetic clustering in Diutina (Candida) catenulata from clinical samples 
    Nourrisson, Céline; Moniot, Maxime; Lavergne, Rose Anne; Robert, Estelle; Bonnin, Virginie; Hagen, Ferry; Grenouillet, Frédéric; Cafarchia, Claudia; Butler, Geraldine; Cassaing, Sophie; Sabou, Marcela; Le Pape, Patrice; Poirier, Philippe; Morio, Florent (Elsevier, 2023-02)
    Objectives: Diutina (Candida) catenulata is an ascomycetous yeast isolated from environmental sources and animals, occasionally infecting humans. The aim of this study is to shed light on the in vitro antifungal susceptibility ...
  • MHCII expression on gut macrophages supports T cell homeostasis and is regulated by microbiota and ontogeny 
    Guillaume, Joël; Leufgen, Andrea; Hager, Fabian T.; Pabst, Oliver; Cerovic, Vuk (Nature Publishing Group, 2023-12)
    Macrophages are traditionally considered antigen-presenting cells. However, their ability to present antigen and the factors regulating macrophage MHCII expression are poorly understood. Here, we demonstrate that MHCII ...
  • Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS 
    Agrafiotis, Andreas; Dizerens, Raphael; Vincenti, Ilena; Wagner, Ingrid; Kuhn, Raphael; Shlesinger, Danielle; Manero-Carranza, Marcos; Cotet, Tudor Stefan; Hong, Kai Lin; Page, Nicolas; Fonta, Nicolas; Shammas, Ghazal; Mariotte, Alexandre; Piccinno, Margot; Kreutzfeldt, Mario; Gruntz, Benedikt; Ehling, Roy; Genovese, Alessandro; Pedrioli, Alessandro; Dounas, Andreas; Franzenburg, Sören; Tumani, Hayrettin; Kümpfel, Tania; Kavaka, Vladyslav; Gerdes, Lisa Ann; Dornmair, Klaus; Beltrán, Eduardo; Oxenius, Annette; Reddy, Sai T.; Merkler, Doron; Yermanos, Alexander (Springer, 2023-03)
    B cells contribute to the pathogenesis of both cellular- and humoral-mediated central nervous system (CNS) inflammatory diseases through a variety of mechanisms. In such conditions, B cells may enter the CNS parenchyma and ...
  • Sleep problems and impact of obstructive hydrocephalus in newly diagnosed pediatric brain tumor patients 
    Hooft van Huijsduijnen, Eva; Partanen, Marita; Grootenhuis, Martha; Hoving, Eelco; Nuijts, Myrthe; van Litsenburg, Raphaële (Elsevier, 2023-12)
    Background: Pediatric brain tumor patients are at risk of developing sleep problems. Previous studies were conducted in longer-term survivors or without comprehensive sleep evaluations, therefore it remains unclear whether ...
  • Nuts and bolts of professionalism remediation 
    Mak-van der Vossen, Marianne; van den Broek, Sjoukje; van Mook, Walther; Wolters, Marian (Springer, 2023-08-23)
    This chapter describes a structured, evidence-based approach to professionalism remediation in four phases: 'Identify and Evaluate', 'Explore and understand', 'Remediate', and 'Gather evidence for dismissal'. Illustrative ...
  • Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells 
    van 't Erve, Iris; Medina, Jamie E.; Leal, Alessandro; Papp, Eniko; Phallen, Jillian; Adleff, Vilmos; Chiao, Elaine Jiayuee; Arun, Adith S.; Bolhuis, Karen; Simmons, John K.; Karandikar, Aanavi; Valkenburg, Kenneth C.; Sausen, Mark; Angiuoli, Samuel V.; Scharpf, Robert B.; Punt, Cornelis J.A.; Meijer, Gerrit A.; Velculescu, Victor E.; Fijneman, Remond J.A. (American Association for Cancer Research Inc., 2023-03-01)
    Purpose: Circulating tumor DNA (ctDNA) has the potential to guide therapy selection and monitor treatment response in patients with metastatic cancer. However, germline and clonal hematopoiesis- associated alterations can ...
  • Heritable defects in telomere and mitotic function selectively predispose to sarcomas 
    Ballinger, Mandy L.; Pattnaik, Swetansu; Mundra, Piyushkumar A.; Zaheed, Milita; Rath, Emma; Priestley, Peter; Baber, Jonathan; Ray-Coquard, Isabelle; Isambert, Nicholas; Causeret, Sylvain; van der Graaf, Winette T.A.; Puri, Ajay; Duffaud, Florence; Le Cesne, Axel; Seddon, Beatrice; Chandrasekar, Coonoor; Schiffman, Joshua D.; Brohl, Andrew S.; James, Paul A.; Kurtz, Jean Emmanuel; Penel, Nicolas; Myklebost, Ola; Meza-Zepeda, Leonardo A.; Pickett, Hilda; Kansara, Maya; Waddell, Nicola; Kondrashova, Olga; Pearson, John V.; Barbour, Andrew P.; Li, Shuai; Nguyen, Tuong L.; Fatkin, Diane; Graham, Robert M.; Giannoulatou, Eleni; Green, Melissa J.; Kaplan, Warren; Ravishankar, Shyamsundar; Copty, Joseph; Powell, Joseph E.; Cuppen, Edwin; van Eijk, Kristel; Veldink, Jan; Ahn, Jin Hee; Kim, Jeong Eun; Lor Randall, R.; Tucker, Kathy; Judson, Ian; Sarin, Rajiv; Ludwig, Thomas; Genin, Emmanuelle; the French Exome Project Consortium; the International Sarcoma Kindred Study (American Association for the Advancement of Science, 2023-01-20)
    Cancer genetics has to date focused on epithelial malignancies, identifying multiple histotype-specific pathways underlying cancer susceptibility. Sarcomas are rare malignancies predominantly derived from embryonic mesoderm. ...
  • Silicone radial head prostheses revisited: do they have a role in today’s practice? A systematic review of literature on clinical outcomes 
    van Bussel, Erik M.; Lindenhovius, Anneluuk L.; The, Bertram; Eygendaal, Denise (2023-09)
    Background: Silicone radial head prostheses (SRHP) are considered obsolete due to reports of frequent failure and destructive silicone-in-duced synovitis. Considering the good outcomes of modern non-radial silicone joint ...
  • Time to broaden the eligibility criteria in paediatric oncology trials? An analysis of patients with rhabdomyosarcoma non-eligible to the EpSSG RMS2005 trial 
    Bisogno, Gianni; De Salvo, Gian Luca; Minard-Colin, Veronique; Fajardo, Raquel Davila; Coppadoro, Beatrice; Jenney, Meriel; Ferrari, Andrea; Alvaro, Raquel Hladun; Dall'Igna, Patrizia; Glosli, Heidi; Merks, Johannes H.M. (Elsevier, 2023-01)
    Purpose: Clinical trials include a series of eligibility and exclusion criteria that define the study population to reduce inter-patient heterogeneity and increase safety. Little is known about children with oncological ...
  • Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells 
    Visser, Lindy L.; Bleijs, Margit; Margaritis, Thanasis; van de Wetering, Marc; Holstege, Frank C.P.; Clevers, Hans (American Association for Cancer Research Inc., 2023-10)
    Novel therapeutic strategies are urgently needed for patients with high-risk Ewing sarcoma and for the reduction of severe side effects for all patients. Immunotherapy may fill this need, but its successful application has ...
  • Molecular taxonomy 
    Hagen, Ferry; Walther, Grit; Houbraken, Jos; Scott, James; Summerbell, Richard; Boekhout, Teun (Springer, 2023-09-15)
    The wide-scale use of molecular phylogenetic studies in mycology has significantly changed our understanding of the relationships between fungal taxa at all levels, including species, genera, families, and beyond. After ...
  • (Dis)entangling ALS 
    Westeneng, Henk-Jan (Utrecht University, 2024-10-01)
    The aim of this thesis is to investigate neurodegeneration in amyotrophic lateral sclerosis (ALS) from the presymptomatic phase through symptom onset, disease progression, and ultimately death, employing an integrative ...
  • Decreasing incidence of dialysis in older patients in The Netherlands as compared with other European countries: an international perspective 
    van Oevelen, Mathijs; Abrahams, Alferso C.; Hoekstra, Tiny; ten Dam, Marc A.G.J.; Kramer, Anneke; Jager, Kitty J.; Ocak, Gurbey; van Buren, Marjolijn; Bos, Willem Jan W. (Oxford University Press, 2023-07)
    Introduction. After decades of increasing dialysis incidence, we observed a decreasing trend in the Netherlands in the last decade. We compared this trend with trends in other European countries. Materials and Methods. ...
  • Impact of immunosuppressive treatment and type of SARS-CoV-2 vaccine on antibody levels after three vaccinations in patients with chronic kidney disease or kidney replacement therapy 
    the RECOVAC Collaborators (Oxford University Press, 2023-03)
    Background. Patients with chronic kidney disease (CKD) or kidney replacement therapy demonstrate lower antibody levels after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination compared with healthy ...
  • Coordinating efforts to optimize next-generation kidney replacement therapies: the European Kidney Health Alliance Work Group ‘Breakthrough Innovation’ 
    Wieringa, Fokko; Søndergaard, Henning; Ortiz, Alberto (Oxford University Press, 2023-06)
    Chronic kidney disease (CKD) is one of the fastest growing health problems, set to become the fifth global death cause by 2040. Factors contributing to this fast growth include increased survival from other diseases (cancer, ...
  • Cause specific under-five mortality rates and associated risk factors among children in northern Ghana between 2007 and 2012 using survival analysis techniques 
    Oladokun, Samuel T.; Welaga, Paul; Nonterah, Engelbert A.; Ansah, Patrick; Oduro, Abraham; Chirwa, Tobias (Union for African Population Studies, 2023-12)
    This study assessed the causes of under-five (U5) deaths and examined the associated risk factors in northern Ghana. The study analyzed prospectively collected longitudinal data of children born between 1st January 2007 ...
  • Clinical applications of artificial intelligence in real-world data 
    Asselbergs, Folkert W.; Denaxas, Spiros; Oberski, Daniel L.; Moore, Jason H. (Springer, 2023-11-05)
    This book is a thorough and comprehensive guide to the use of modern data science within health care. Critical to this is the use of big data and its analytical potential to obtain clinical insight into issues that would ...
  • Machine learning-basic unsupervised methods (Cluster analysis methods, t-SNE) 
    Espadoto, M.; Martins, S. B.; Branderhorst, W.; Telea, A. (Springer, 2023-11-05)
    Understanding how trained deep neural networks achieve their inferred results is challenging but important for relating how patterns in the input data affect other patterns in the output results. We present a visual analytics ...
  • Deep learning-Prediction 
    Gerges, Chris Al; Vessies, Melle B.; van de Leur, Rutger R.; van Es, René (Springer, 2023-11-05)
    Deep learning is a subfield of artificial intelligence (AI) that is concerned with developing large and complex neural networks for various tasks. As of today, there exists a wide variety of DL models yielding promising ...