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UMC Repository: Recent submissions

  • Associations between disturbed sleep and attenuated psychotic experiences in people at clinical high risk for psychosis 
    Formica, M J C; Fuller-Tyszkiewicz, M; Reininghaus, U; Kempton, M; Delespaul, P; de Haan, L; Nelson, B; Mikocka-Walus, A; Olive, L; Ruhrmann, S; Rutten, B; Riecher-Rössler, A; Sachs, G; Valmaggia, L; van der Gaag, M; McGuire, P; van Os, J; Hartmann, J A; EU-GEI High Risk Study (Cambridge University Press, 2024-07)
    BACKGROUND: Pre-diagnostic stages of psychotic illnesses, including 'clinical high risk' (CHR), are marked by sleep disturbances. These sleep disturbances appear to represent a key aspect in the etiology and maintenance ...
  • A multi-dimensional Sustainable Diet Index (SDI) for Ghanaian adults under transition: the RODAM Study 
    Okekunle, Akinkunmi Paul; Nicolaou, Mary; De Allegri, Manuela; Meeks, Karlijn A.C.; Osei-Kwasi, Hibbah; Stockemer, Julia; de-Graft Aikins, Ama; Agbemafle, Isaac; Bahendeka, Silver; Boateng, Daniel; Klipstein-Grobusch, Kerstin; Beune, Erik; Agyemang, Charles; Schulze, Matthias B.; Danquah, Ina (BioMed Central, 2024-10-01)
    Background: The sustainability of diets consumed by African populations under socio-economic transition remains to be determined. This study developed and characterized a multi-dimensional Sustainable Diet Index (SDI) ...
  • Correction to: A comprehensive overview of liquid biopsy applications in pediatric solid tumors (npj Precision Oncology, (2024), 8, 1, (172), 10.1038/s41698-024-00657-z) 
    Janssen, Ferdinand W.; Lak, Nathalie S.M.; Janda, Claudia Y.; Kester, Lennart A.; Meister, Michael T.; Merks, Johannes H.M.; van den Heuvel-Eibrink, Marry M.; van Noesel, Max M.; Zsiros, Jozsef; Tytgat, Godelieve A.M.; Looijenga, Leendert H.J. (Springer Nature, 2024-09-25)
    Correction to:npj Precision Oncologyhttps://doi.org/10.1038/s41698-024-00657-z, published online 03 August 2024 In the original version of this article, an incorrect Supplementary material references file was provided. The ...
  • The epidemiology of von Hippel-Lindau disease 
    van Leeuwaarde, Rachel S.; Halperin, Reut (Springer, 2024-04-06)
    von Hippel-Lindau disease (VHL) is an autosomal dominant disease with a penetrance of nearly 100% by age 70 years. The prevalence is about one in 39,000 to 85,000 people. VHL is characterized by the development of benign ...
  • The use of imputation in clinical decision support systems: a cardiovascular risk management pilot vignette study among clinicians 
    Haitjema, Saskia; Nijman, Steven W.J.; Verkouter, Inge; Jacobs, John J.L.; Asselbergs, Folkert W.; Moons, Karel G.M.; Beekers, Ines; Debray, Thomas P.A.; Bots, Michiel L. (Oxford University Press, 2024-09-01)
    Aims: A major challenge of the use of prediction models in clinical care is missing data. Real-time imputation may alleviate this. However, to what extent clinicians accept this solution remains unknown. We aimed to assess ...
  • The intangible outcomes of an intergenerational hackathon for active aging: A case study 
    Wang, Gubing; Kasraian, Dena; Lu, Yuan; Hurst, William; Jambroes, Marielle; Van Wesemael, Pieter (Association for Computing Machinery, Inc, 2024-08-11)
    Ensuring the design process aligns with active aging is as crucial as designing products for older adults promoting active aging. An emerging approach is to bring together OA with younger generations to collaborate on ...
  • NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities 
    Rasouli, Milad; Troester, Selina; Grebien, Florian; Goemans, Bianca F.; Zwaan, C. Michel; Heidenreich, Olaf (Wolters Kluwer Health, 2024-09)
    Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a heterogeneous molecular landscape. In the pediatric context, the NUP98 gene is a frequent target of chromosomal rearrangements that are linked ...
  • Adding ethnicity to cardiovascular risk prediction: External validation and model updating of SCORE2 using data from the HELIUS population cohort 
    van Apeldoorn, Joshua A N; Hageman, Steven H J; Harskamp, Ralf E; Agyemang, Charles; van den Born, Bert-Jan H; van Dalen, Jan Willem; Galenkamp, Henrike; Hoevenaar-Blom, Marieke P; Richard, Edo; van Valkengoed, Irene G M; Visseren, Frank L J; Dorresteijn, Jannick A N; Moll van Charante, Eric P (Elsevier Ireland Ltd, 2024-12-15)
    BACKGROUND: Current prediction models for mainland Europe do not include ethnicity, despite ethnic disparities in cardiovascular disease (CVD) risk. SCORE2 performance was evaluated across the largest ethnic groups in the ...
  • Outcomes of CEM43 in Predicting Thermal Damage Induced by Focal Laser Ablation in Controlled Ex Vivo Experiments: A Comparison to Histology and MRI 
    de Bie, K C C; van Kollenburg, R A A; van Riel, L A M J G; Almasian, M; Freund, J E; Bloemen, P R; Zweije, R; Crezee, J; Coolen, B F; Strijkers, G J; de Reijke, T M; Oddens, J R; van Leeuwen, A G J M; de Bruin, D M (Wiley-Liss Inc., 2024-10)
    BACKGROUND: Focal laser ablation (FLA) serves as a targeted therapy for prostate cancer (PCa). Clinical studies have demonstrated significant variations in ablation volumes with consistent fiber configurations. Consequently, ...
  • Quantitative MRI assessment of joint effusion using T2-relaxometry at 3 Tesla: a feasibility and reproducibility study 
    van Leeuwen, Flora H P; Lena, Beatrice; van Bergen, Eline D P; van Klei, Janoah J; Timmer, Merel A; van Vulpen, Lize F D; Fischer, Kathelijn; de Jong, Pim A; Bos, Clemens; Foppen, Wouter (Springer-Verlag, 2024-11)
    OBJECTIVE: T2-relaxometry could differentiate between physiological and haemorrhagic joint effusion (≥ 5% blood) in vitro. Are quantitative T2-relaxation time measurements of synovial fluid feasible and reproducible in ...
  • Parents’ and healthcare professionals’ experiences with the content of an individual care plan for pediatric palliative care: a mixed-method study 
    Joren, Chantal Y.; Kars, Marijke C.; Kremer, Leontien C.M.; Hofman, Suzanne C.; Rippen-Wagner, Hester; Slingerland-Blom, Ria; van der Velden, Chantal; Schuiling-Otten, Meggi; Verhagen, A. A.Eduard; Aris-Meijer, Judith L. (SAGE Publications Ltd, 2024-12)
    Background: The Individual Care Plan (ICP) for pediatric palliative care translates the general guideline recommendations into a personalized plan for the child. Various documents exist in pediatrics globally, aimed at ...
  • Efficacy of a decision aid in breast cancer patients considering immediate reconstruction: results of a randomized controlled trial 
    Ter Stege, Jacqueline A; Woerdeman, Leonie A E; Kieffer, Jacobien M; Sherman, Kerry A; Agelink van Rentergem, Joost A; van Duijnhoven, Frederieke H; van Huizum, Martine A; Gerritsma, Miranda A; Kuenen, Marianne; Corten, Eveline M L; Kimmings, Nikola A N; Ruhé, Quinten P Q; Krabbe-Timmerman, Irene S; van 't Riet, Martijne; Hahn, Daniela E E; Witkamp, Arjen J; Oldenburg, Hester S A; Bleiker, Eveline M A (Lippincott Williams & Wilkins, 2024-10)
    Background: Breast cancer patients face complex decisions about immediate breast reconstruction (BR) after mastectomy. The authors evaluated the efficacy of an online decision aid in improving the decision-making process, ...
  • Post-Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient-Limited Cancer Cells 
    Güleç Taşkıran, Aliye Ezgi; Hüsnügil, Hepşen H.; Soltani, Zahra E.; Oral, Göksu; Menemenli, Nazlı S.; Hampel, Chuanpit; Huebner, Kerstin; Erlenbach-Wuensch, Katharina; Sheraj, Ilir; Schneider-Stock, Regine; Akyol, Aytekin; Liv, Nalan; Banerjee, Sreeparna (Blackwell Munksgaard, 2024-09)
    Limited nutrient availability in the tumor microenvironment can cause the rewiring of signaling and metabolic networks to confer cancer cells with survival advantages. We show here that the limitation of glucose, glutamine ...
  • Effect of statins on mitochondrial function and contractile force in human skeletal and cardiac muscle 
    Somers, Tim; Siddiqi, Sailay; Janssen, Margit C.M.; Morshuis, Wim J.; Maas, Renee G.C.; Buikema, Jan W.; van den Broek, Petra H.H.; Schirris, Tom J.J.; Russel, Frans G.M. (Elsevier Masson, 2024-11)
    Objectives and Background: The success of statin therapy in reducing cardiovascular morbidity and mortality is contrasted by the skeletal muscle complaints, which often leads to nonadherence. Previous studies have shown ...
  • Can hemophilia be cured? It depends on the definition 
    Baas, Lieke; van der Graaf, Rieke; Meijer, Karina (Elsevier, 2024-08)
    Over the years, the palette of treatment options for hemophilia has grown extensively, leading to an increased life expectancy and quality of life for people living with hemophilia. Nonetheless, it is frequently emphasized ...
  • Applying natural language processing to patient messages to identify depression concerns in cancer patients 
    van Buchem, Marieke M.; de Hond, Anne A.H.; Fanconi, Claudio; Shah, Vaibhavi; Schuessler, Max; Kant, Ilse M.J.; Steyerberg, Ewout W.; Hernandez-Boussard, Tina (Oxford University Press, 2024-10-01)
    OBJECTIVE: This study aims to explore and develop tools for early identification of depression concerns among cancer patients by leveraging the novel data source of messages sent through a secure patient portal. MATERIALS ...
  • Artificial intelligence in interventional radiotherapy (brachytherapy): Enhancing patient-centered care and addressing patients’ needs 
    Fionda, Bruno; Placidi, Elisa; de Ridder, Mischa; Strigari, Lidia; Patarnello, Stefano; Tanderup, Kari; Hannoun-Levi, Jean Michel; Siebert, Frank André; Boldrini, Luca; Antonietta Gambacorta, Maria; De Spirito, Marco; Sala, Evis; Tagliaferri, Luca (Elsevier Ireland Ltd, 2024-11)
    This review explores the integration of artificial intelligence (AI) in interventional radiotherapy (IRT), emphasizing its potential to streamline workflows and enhance patient care. Through a systematic analysis of 78 ...
  • Real-World Implementation of a Genotype-Guided P2Y12 Inhibitor De-Escalation Strategy in Acute Coronary Syndrome Patients 
    Azzahhafi, Jaouad; van den Broek, Wout W.A.; Chan Pin Yin, Dean R.P.P.; van der Sangen, Niels M.R.; Sivanesan, Shabiga; Bofarid, Salahodin; Peper, Joyce; Claassens, Daniel M.F.; Janssen, Paul W.A.; Harmsze, Ankie M.; Walhout, Ronald J.; Tjon Joe Gin, Melvyn; Nicastia, Deborah M.; Langerveld, Jorina; Vlachojannis, Georgios J.; van Bommel, Rutger J.; Appelman, Yolande; van Schaik, Ron H.N.; Henriques, José P.S.; Kikkert, Wouter J.; ten Berg, Jurriën M. (Elsevier, 2024-09-09)
    Background: CYP2C19 genotype–guided de-escalation from ticagrelor or prasugrel to clopidogrel may optimize the balance between ischemic and bleeding risk in patients with acute coronary syndrome (ACS). Objectives: This ...
  • Antecedent and persistent symptoms in COVID-19 and other respiratory illnesses: insights from prospectively collected data in the BRACE trial 
    McDonald, Ellie; Pittet, Laure F; Barry, Simone E; Bonten, Marc; Campbell, John; Croda, Julio; Croda, Mariana G; Dalcolmo, Margareth Pretti; Davidson, Andrew; de Almeida E Val, Fernando F; Dos Santos, Ms Glauce; Gardiner, Ms Kaya; Gell, Ms Grace; Gwee, Amanda; Krastev, Ms Ann; Lacerda, Marcus Vinícius Guimaraes; Lucas, Michaela; Lynn, David J; Manning, Laurens; McPhate, Mr Nick; Perrett, Kirsten P; Post, Jeffrey J; Prat-Aymerich, Cristina; Quinn, Ms Lynne E; Richmond, Peter C; Wood, Nicholas J; Messina, Nicole L; Curtis, Nigel; BRACE trial Consortium Group (W.B. Saunders Ltd, 2024-11)
    Background: Some individuals have a persistence of symptoms following both COVID-19 (post-acute COVID-19 syndrome; PACS) and other viral infections. This study used prospectively collected data from an international trial ...
  • A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B-containing lipoprotein secretion 
    Meurs, Amber; Ndoj, Klevis; van den Berg, Marlene; Marinković, Goran; Tantucci, Matteo; Veenendaal, Tineke; Kuivenhoven, Jan Albert; Klumperman, Judith; Zelcer, Noam (Oxford University Press, 2024-07)
    Aims: Apolipoprotein B (APOB)-containing very LDL (VLDL) production, secretion, and clearance by hepatocytes is a central determinant of hepatic and circulating lipid levels. Impairment of any of the aforementioned processes ...