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UMC Repository: Recent submissions

  • Regulatory readiness to facilitate the appropriate use of innovation in clinical trials: The case of decentralized clinical trial approaches 
    de Jong, Amos J; Zuidgeest, Mira G P; Santa-Ana-Tellez, Yared; de Boer, Anthonius; Gardarsdottir, Helga; Trials@Home Consortium (Elsevier Limited, 2024-11)
    Methodological and operational clinical trial innovation is needed to address key challenges associated with clinical trials, including limited generalizability and (s)low recruitment rates. In this article, we discuss how ...
  • Oral HIV pre-exposure prophylaxis use and resistance-associated mutations among men who have sex with men and transgender persons newly diagnosed with HIV in the Netherlands: results from the ATHENA cohort, 2018 to 2022 
    Jongen, Vita W.; Bezemer, Daniela; van Sighem, Ard; Boyd, Anders; Rokx, Casper; Grintjes, Karin; Cents-Bosma, Aafke; Coul, Eline Op de; van Benthem, Birgit; Wensing, Annemarie; Wit, Ferdinand WNM; van der Valk, Marc; on behalf of the ATHENA national observational HIV cohort (Centre Europeen pour la Surveillance Epidemiologique du SIDA, 2024-09-19)
    Background: In the Netherlands, HIV pre-exposure prophylaxis (PrEP) has been available since 2019. However, the extent of PrEP use prior to HIV diagnosis and development of PrEP-resistance-associated mutations (RAMs) is ...
  • Germline mutations in a G protein identify signaling cross-talk in T cells 
    Ham, Hyoungjun; Jing, Huie; Lamborn, Ian T.; Kober, Megan M.; Koval, Alexey; Berchiche, Yamina A.; Anderson, D. Eric; Druey, Kirk M.; Mandl, Judith N.; Isidor, Bertrand; Ferreira, Carlos R.; Freeman, Alexandra F.; Ganesan, Sundar; Karsak, Meliha; Mustillo, Peter J.; Teo, Juliana; Zolkipli-Cunningham, Zarazuela; Chatron, Nicolas; Lecoquierre, François; Oler, Andrew J.; Schmid, Jana Pachlopnik; Kuhns, Douglas B.; Xu, Xuehua; Hauck, Fabian; Al-Herz, Waleed; Wagner, Matias; Terhal, Paulien A.; Muurinen, Mari; Barlogis, Vincent; Cruz, Phillip; Danielson, Jeffrey; Stewart, Helen; Loid, Petra; Rading, Sebastian; Keren, Boris; Pfundt, Rolph; Zarember, Kol A.; Vill, Katharina; Potocki, Lorraine; Olivier, Kenneth N.; Lesca, Gaetan; Faivre, Laurence; Wong, Melanie; Puel, Anne; Chou, Janet; Tusseau, Maud; Moutsopoulos, Niki M.; Matthews, Helen F.; Simons, Cas; Taft, Ryan J.; Soldatos, Ariane; Masle-Farquhar, Etienne; Pittaluga, Stefania; Brink, Robert; Fink, Danielle L.; Kong, Heidi H.; Kabat, Juraj; Kim, Woo Sung; Bierhals, Tatjana; Meguro, Kazuyuki; Hsu, Amy P.; Gu, Jingwen; Stoddard, Jennifer; Banos-Pinero, Benito; Slack, Maria; Trivellin, Giampaolo; Mazel, Benoît; Soomann, Maarja; Li, Samuel; Watts, Val J.; Stratakis, Constantine A.; Rodriguez-Quevedo, Maria F.; Bruel, Ange Line; Lipsanen-Nyman, Marita; Saultier, Paul; Jain, Rashmi; Lehalle, Daphne; Torres, Daniel; Sullivan, Kathleen E.; Barbarot, Sébastien; Neu, Axel; Duffourd, Yannis; Similuk, Morgan; McWalter, Kirsty; Blanc, Pierre; Bézieau, Stéphane; Jin, Tian; Geha, Raif S.; Casanova, Jean Laurent; Makitie, Outi M.; Kubisch, Christian; Edery, Patrick; Christodoulou, John; Germain, Ronald N.; Goodnow, Christopher C.; Sakmar, Thomas P.; Billadeau, Daniel D.; Küry, Sébastien; Katanaev, Vladimir L.; Zhang, Yu; Lenardo, Michael J.; Su, Helen C. (American Association for the Advancement of Science, 2024-09-20)
    Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in GNAI2, which encodes Gαi2, a key component in heterotrimeric ...
  • Strengthening NVVC endorsements for ESC guidelines 
    van der Harst, Pim (Bohn Stafleu van Loghum, 2024-10)
  • New phenotyping questionnaire for diagnosing sarcoidosis-Associated small fiber neuropathy 
    Raasing, Lisette R.M.; Vogels, Oscar J.M.; Datema, Mirjam; Ambarus, Carmen A.; Tannemaat, Martijn R.; Grutters, Jan C.; Veltkamp, Marcel (Oxford University Press, 2024-08-28)
    Small fiber neuropathy is a common complication in patients with sarcoidosis and its prevalence is estimated at 40-86%. The underlying mechanism influences the presentation of small fiber neuropathy. For example, patients ...
  • Mitigating the risk of inflammatory type primary graft dysfunction by applying an integrated approach to assess, modify and match risk factors in lung transplantation 
    Braithwaite, Sue A.; Berg, Elize M.; de Heer, Linda M.; Jennekens, Jitte; Neyrinck, Arne; van Hooijdonk, Elise; Luijk, Bart; Buhre, Wolfgang F.F.A.; van der Kaaij, Niels P. (2024-08-20)
    Long-term outcome following lung transplantation remains one of the poorest of all solid organ transplants with a 1- and 5-year survival of 85% and 59% respectively for adult lung transplant recipients and with 50% of ...
  • The effectiveness of Function Focused Care among patients acutely admitted to hospital: A stepped wedge cluster trial 
    Kok, Selma; Schoonhoven, Lisette; Vernooij, Lisette M.; Reitsma, Johannes B.; Verstraten, Carolien; Metzelthin, Silke F.; Bleijenberg, Nienke; de Man-van Ginkel, Janneke M. (Elsevier Limited, 2024-12)
    Background: During acute hospital admission, patients often experience loss of functional status. A low level of physical activity is associated with higher levels of loss of functional status. Stimulating physical activity ...
  • Cumulative live birth rate of a blastocyst versus cleavage stage embryo transfer policy during in vitro fertilisation in women with a good prognosis: multicentre randomised controlled trial 
    Cornelisse, Simone; Fleischer, Kathrin; van der Westerlaken, Lucette; de Bruin, Jan Peter; Vergouw, Carlijn; Koks, Carolien; Derhaag, Josien; Visser, Jantien; van Echten-Arends, Jannie; Slappendel, Els; Arends, Brigitte; van der Zanden, Moniek; van Dongen, Angelique; Brink-van der Vlugt, Janneke; de Hundt, Marcella; Curfs, Max; Verhoeve, Harold; Traas-Hofmans, Maaike; Wurth, Yvonne; Manger, Petra; Pieterse, Quirine; Braat, Didi; van Wely, Madelon; Ramos, Liliana; Mastenbroek, Sebastiaan (BMJ Publishing Group, 2024-09-16)
    OBJECTIVES: To evaluate whether embryo transfers at blastocyst stage improve the cumulative live birth rate after oocyte retrieval, including both fresh and frozen-thawed transfers, and whether the risk of obstetric and ...
  • Germline variant affecting p53β isoforms predisposes to familial cancer 
    Schubert, Stephanie A.; Ruano, Dina; Joruiz, Sebastien M.; Stroosma, Jordy; Glavak, Nikolina; Montali, Anna; Pinto, Lia M.; Rodríguez-Girondo, Mar; Barge-Schaapveld, Daniela Q.C.M.; Nielsen, Maartje; van Nesselrooij, Bernadette P.M.; Mensenkamp, Arjen R.; van Leerdam, Monique E.; Sharp, Thomas H.; Morreau, Hans; Bourdon, Jean Christophe; de Miranda, Noel F.C.C.; van Wezel, Tom (Nature Publishing Group, 2024-09-18)
    Germline and somatic TP53 variants play a crucial role during tumorigenesis. However, genetic variations that solely affect the alternatively spliced p53 isoforms, p53β and p53γ, are not fully considered in the molecular ...
  • The value of splenectomy during left-sided pancreatectomy for pancreatic ductal adenocarcinoma: Predefined subanalysis in the DIPLOMA randomized trial 
    Bruna, Caro L.; Van Hilst, Jony; Esposito, Alessandro; Kleive, Dyre; Falconi, Massimo; Primrose, John N.; Korrel, Maarten; Bianchi, Denise; Zerbi, Alessando; Kokkola, Arto; Butturini, Giovanni; Björnsson, Bergthor; Morone, Mario; Casadei, Riccardo; Marudanayagam, Ravi; Besselink, Marc G.; Abu Hilal, Mohammad; European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS) (John Wiley & Sons Inc., 2024-09-01)
  • Use of Guideline-Recommended Heart Failure Drugs in High-Middle- and Low-Income Countries: A Systematic Review and Meta-Analysis 
    Satheesh, Gautam; Dhurjati, Rupasvi; Alston, Laura; Tesfay, Fisaha; Pant, Rashmi; Bahiru, Ehete; Bambs, Claudia; Agarwal, Anubha; Peters, Sanne A.E.; Salam, Abdul; Johansson, Isabelle (Elsevier Science & Technology, 2024-09)
    Optimal use of guideline-directed medical therapy (GDMT) can prevent hospitalization and mortality among patients with heart failure (HF). We aimed to assess the prevalence of GDMT use for HF across geographic regions and ...
  • Global Challenges After a Global Challenge: Lessons Learned from the COVID-19 Pandemic 
    Yazdanpanah, Niloufar; Sedikides, Constantine; Ochs, Hans D.; Camargo, Carlos A.; Darmstadt, Gary L.; Cerda, Artemi; Cauda, Valentina; Peters, Godefridus J.; Sellke, Frank; Wong, Nathan D.; Comini, Elisabetta; Jimeno, Alberto Ruiz; Glover, Vivette; Hatziargyriou, Nikos; Vincenot, Christian E.; Bordas, Stéphane P.A.; Rao, Idupulapati M.; Abolhassani, Hassan; Gharehpetian, Gevork B.; Weiskirchen, Ralf; Gupta, Manoj; Chandel, Shyam Singh; Olusanya, Bolajoko O.; Cheson, Bruce; Pomponio, Alessio; Tanzer, Michael; Myles, Paul S.; Ma, Wen Xiu; Bella, Federico; Ghavami, Saeid; Moein Moghimi, S.; Pratico, Domenico; Hernandez, Alfredo M.; Martinez-Urbistondo, Maria; Urbistondo, Diego Martinez; Fereshtehnejad, Seyed Mohammad; Ali, Imran; Kimura, Shinya; Wallace Hayes, A.; Cai, Wenju; Ernest, Chua K.J.; Thomas, Sabu; Rahimi, Kazem; Sorooshian, Armin; Schreiber, Michael; Kato, Koichi; Luong, John H.T.; Pluchino, Stefano; Lozano, Andres M.; Leemans, Alexander; USERN Advisory Board (Springer New York, 2024-09-17)
    Coronavirus disease 2019 (COVID-19) has affected not only individual lives but also the world and global systems, both natural and human-made. Besides millions of deaths and environmental challenges, the rapid spread of ...
  • SGLT2 Inhibitor Use and Risk of Dementia and Parkinson Disease Among Patients With Type 2 Diabetes 
    Kim, Hae Kyung; Biessels, Geert Jan; Yu, Min Heui; Hong, Namki; Lee, Yong Ho; Lee, Byung Wan; Kang, Eun Seok; Cha, Bong Soo; Lee, Eun Jig; Lee, Minyoung (Lippincott Williams & Wilkins, 2024-10-22)
    BACKGROUND AND OBJECTIVES: Despite the mechanistic potential of sodium-glucose cotransporter 2 inhibitor (SGLT2i) to improve neurologic outcomes, the efficacy of SGLT2i in neurodegenerative disorders among patients with ...
  • Electroconvulsive therapy and cognitive performance from the Global ECT MRI Research Collaboration 
    Kiebs, Maximilian; Farrar, Danielle C.; Yrondi, Antoine; Cardoner, Narcis; Tuovinen, Noora; Redlich, Ronny; Dannlowski, Udo; Soriano-Mas, Carles; Dols, Annemiek; Takamiya, Akihiro; Tendolkar, Indira; Narr, Katherine L.; Espinoza, Randall; Laroy, Maarten; van Eijndhoven, Philip; Verwijk, Esmée; van Waarde, Jeroen; Verdijk, Joey; Maier, Hannah B.; Nordanskog, Pia; van Wingen, Guido; van Diermen, Linda; Emsell, Louise; Bouckaert, Filip; Repple, Jonathan; Camprodon, Joan A.; Wade, Benjamin S.C.; Donaldson, K. Tristan; Oltedal, Leif; Kessler, Ute; Hammar, Åsa; Sienaert, Pascal; Hebbrecht, Kaat; Urretavizcaya, Mikel; Belge, Jean Baptiste; Argyelan, Miklos; Baradits, Mate; Obbels, Jasmien; Draganski, Bogdan; Philipsen, Alexandra; Sartorius, Alexander; Rhebergen, Didericke; Ousdal, Olga Therese; Hurlemann, René; McClintock, Shawn; Erhardt, Erik B.; Abbott, Christopher C. (Elsevier Limited, 2024-11)
    The Global ECT MRI Research Collaboration (GEMRIC) has collected clinical and neuroimaging data of patients treated with electroconvulsive therapy (ECT) from around the world. Results to date have focused on neuroimaging ...
  • Intra-prostatic recurrences after radiotherapy with focal boost: Location and dose mapping in the FLAME trial 
    Menne Guricová, K.; Pos, F. J.; Schoots, I. G.; Vogel, W. V.; Kerkmeijer, L. G.W.; Monninkhof, E. M.; de Boer, J. C.J.; van der Voort van Zyp, J. R.N.; Kunze-Busch, M.; Smeenk, R. J.; Draulans, C.; Haustermans, K.; van Houdt, P. J.; van der Heide, U. A. (Elsevier Ireland Ltd, 2024-12)
    Introduction: The FLAME trial demonstrated that the dose to the gross tumor volume (GTV) is associated with tumour control in prostate cancer patients. This raises the question if dose de-escalation to the remaining prostate ...
  • Nigeria sodium study 2023 policy meeting on dietary sodium reduction in Nigeria 
    Ojo, Adedayo E.; Alfa, Vanessa O.; Huffman, Mark D.; Ojji, Dike B. (BioMed Central Ltd., 2024-09)
    Background: In line with the WHO Global Action Plan’s objective to achieve a 30% relative reduction in the mean population intake of sodium by 2025, the Nigeria Sodium Study (NaSS) team, which aimed to evaluate the ...
  • Childhood cancer care beyond the ‘six common and curable types’: A comparative case series on acute myeloid leukemia in Kenya and the Netherlands 
    Wijnen, Noa; Klootwijk, Larissa; Gichemi, Alice; Apadet, Lilian; Njuguna, Festus; Klein, Kim; Huibers, Minke; Goemans, Bianca F.; Mostert, Saskia; Kaspers, Gertjan (Asian Onscology Nursing Society, 2024-10)
    Annually, over 400,000 children develop cancer, with the majority living in low- and middle-income countries (LMICs). Survival rates in high-income countries (HICs; ≥ 75%–80%) significantly exceed those in LMICs (< 30%). ...
  • Pulling the Strings: Exploiting Metabolic Dependencies in Pediatric Cancer 
    Tee, Trisha Michael (Utrecht University, 2024-10-24)
    Cancer is highly complex and variable, encompassing hundreds of diseases that share key features called "hallmarks,” which help explain how cancer develops, grows, and spreads. This thesis highlights one of these hallmarks, ...
  • Memories that last: Dynamics of memory cells in mice, dirty mice, and men 
    Derksen, Lyanne (Utrecht University, 2024-10-22)
    One of the major qualities of the immune system is its ability to remember a pathogen for when it is encountered again in the future. We can think of immunological memory as a library filled with books (cells) that remember ...
  • Management of patients with atrial fibrillation 
    Joosten, Linda (Utrecht University, 2024-10-15)
    This thesis is about the management of atrial fibrillation (AF), one of the most common cardiac conditions. AF mainly affects older people with a prevalence rising to 17.8% in those aged 85 years and older. AF can at least ...