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Imaging of laryngeal tumors from macro to micro

Smits, Hilde (Utrecht University, 2025-02-06)

This thesis takes a closer look at the radiological and histopathological characteristics of laryngeal and hypopharyngeal tumors. In the first part of this thesis, we looked at the prognostic value of imaging biomarkers ...
Holmium-166 radioembolization in HCC: advances in personalized treatment

Reinders-Hut, Margot (Utrecht University, 2025-01-23)

Liver cancer is the second most common cause of cancer-related death. In most cases it regards hepatocellular carcinoma (HCC). People who are diagnosed with cancer usually do not live long. Furthermore, they usually ...
Life after Childhood Cancer: Long-Term Psychosocial Outcomes and Risk and Protective Factors in Adult Survivors of Childhood Cancer

Maas, Anne (Utrecht University, 2025-03-05)

Thanks to advancements in the treatment of childhood cancer, the five-year survival rate has increased to approximately 80%, leading to a growing number of childhood cancer survivors (CCS). These CCS may experience long-term ...
Assessing and minimizing the risk of cerebrospinal fluid leakage after intradural surgery

Kinaci, Ahmet (Utrecht University, 2025-01-28)

This thesis evaluated the effectiveness of current sealants in preventing incisional CSF leakage. Subsequently, we developed a new dural sealant patch (Liqoseal) which should ultimately prevent incisional CSF leakage in ...
Clinical Outcome after Cellular Therapies in Children with Acute Leukemia: the Bumpy Road to Recovery

Dekker, Linde (Utrecht University, 2025-02-03)

Immunotherapy has significantly improved overall survival of pediatric patients with acute leukemia. Nevertheless, procedure-related life-threatening complications, together with relapsed disease, hamper the life-saving ...
Signaling and damage by localized reactive oxygen species production

van Soest, Daan (Utrecht University, 2025-01-30)

The work in this thesis aimed to shed light on how compartmentalization of the subcellular source of reactive oxygen species (ROS) is involved in differential signaling and damage in the context of tumor biology. In the ...
From User Experience to Data-Driven: Asparaginase Treatment for Pediatric Acute Lymphoblastic Leukemia

Brigitha, Leiah J. (Utrecht University, 2025-01-30)

My thesis explores the optimization of asparaginase treatment for children with acute lymphoblastic leukemia (ALL) by integrating clinical data and advanced modeling techniques. Asparaginase, an enzyme that depletes ...
Optimizing survivorship care

de Beijer, Ismay Anna Elisa (Utrecht University, 2025-01-21)

Each year, 400,000 children and adolescents up to the age of 19 are diagnosed with cancer worldwide. In high-income countries, more than 80% of these patients survive, thanks to advancements in treatment. However, many ...
Epitranscriptomic regulation in immunity and autoimmune disease: Unraveling novel implications of RNA modification m6A

van Vroonhoven, Ellen (Utrecht University, 2025-02-04)

The immune system protects the human body against pathogens such as viruses, bacteria, and parasites. It has innate and acquired components, which together recognize and eliminate these threats. When the immune system ...
Assessment of imaging markers for intracranial aneurysms using artificial intelligence

Vos, Iris (Utrecht University, 2025-01-28)

Intracranial aneurysms are bulges in brain blood vessels that, while often harmless, can rupture and cause a life-threatening subarachnoid hemorrhage. Since unruptured intracranial aneurysms are generally asymptomatic and ...
Extracellular vesicles as drug delivery systems: Molecular mechanisms and therapeutic applications

Elsharkasy, Omnia (Utrecht University, 2025-01-21)

RNA therapeutics play a pivotal role in the treatment of various diseases by modulating disease-related gene expression. These therapies utilize RNA sequences to regulate the expression or activity of target proteins. While ...
Tracing Heterogeneity in T-cell Malignancies in Time and Space: Unveiling phenotypic plasticity and migration dynamics through single-cell multi-omics

Poort, Vera M. (Utrecht University, 2025-01-16)

Our bodies renew some organs frequently, such as the intestines and skin, while others, like the brain and heart, rarely renew. This renewal process involves cell division, during which mutations can occur. While many ...
Searching for the representation of fatigue in the brain

de Dreu, Miek (Utrecht University, 2025-01-14)

This research project was aimed at improving our understanding of the neuronal mechanism that causes fatigue in patients with a brain tumor. In chapter one, we aimed to better understand the neuronal representation of an ...
Neuroinflammation in the acute phase after subarachnoid hemorrhage: A translational approach

Koopman, Inez (Utrecht University, 2025-01-21)

A subarachnoid haemorrhage from a ruptured aneurysm is a severe type of stroke that affects approximately 1000 patients every year in the Netherlands. Neuroinflammation is one of the mechanisms that may contribute to brain ...
Cardiovascular Disease Prevention in Indonesia: Epidemiology, Risk Factors, Organization of Care and Prevention

Sidik Arsyad, Dian (Utrecht University, 2024-01-14)

This thesis explores the epidemiology, risk factors, and healthcare services associated with cardiovascular disease (CVD) in Indonesia, focusing on the disease burden and the capacity of healthcare systems. The first part ...
The role of business model-building and model-changing in driving healthcare value: A physiotherapy primary healthcare organisation perspective

IJntema, Rutger (Utrecht University, 2025-01-22)

The general purpose of this thesis is to gain insights into business model-building and model-changing related to healthcare value for physiotherapy primary healthcare organisation (PTPHO) within the context of Dutch PTPHOs. ...
The SuSPeCT Study: Getting Insight into Stress, Sleep and Cognitive Functioning: Improving care for children with a brain tumor

Kremer - Hooft van Huijsduijnen, Eva Adriane Barbara (Utrecht University, 2024-09-04)
Aneurysmal Subarachnoid Haemorrhage: Insights through Data-Driven Population Studies

Kanning, Jos (Utrecht University, 2025-01-14)

Aneurysmal Subarachnoid Haemorrhage (aSAH) is a severe type of stroke caused by the rupture of an intracranial aneurysm, leading to bleeding in the subarachnoid space. Despite accounting for only a small percentage of ...
Towards implementation of molecular biomarkers for personalized treatment of colorectal cancer

Rubio Alarcón, Carmen (Utrecht University, 2025-01-10)

This thesis explores the identification and validation of prognostic and predictive biomarkers to inform adjuvant treatment decisions in non-metastatic colorectal cancer (CRC). The first part investigates circulating tumor ...
Methodological Advances in Ultra-high Field Metabolic MRI in Cancer

Shams, Z (Utrecht University, 2025-01-07)

The primary objective of this thesis was to develop and refine a range of proton (1H) MRS, 31P-MRSI, and 23Na-MRI methods at 7T for application in studies on brain tumors. The work in this thesis focuses on implementation ...

Now showing items 4041-4060 of 40729