Assessing and minimizing the risk of cerebrospinal fluid leakage after intradural surgery

Abstract

This thesis evaluated the effectiveness of current sealants in preventing incisional CSF leakage. Subsequently, we developed a new dural sealant patch (Liqoseal) which should ultimately prevent incisional CSF leakage in patients. However, before clinical application, the effectiveness and the safety of this sealant in preclinical studies had to be evaluated. In this thesis the in vitro effectiveness and in vivo safety of Liqoseal have been studied.