Osteoarthritis (OA) is a progressive and degenerative disease of the joints affecting over 500 million people worldwide, characterized by inflammation and loss of the cartilage. The aim of this thesis is to present the ...

Oral targeted therapies have significantly improved cancer treatment, but variability in drug exposure and narrow therapeutic windows can lead to suboptimal efficacy or increased toxicity. Therapeutic Drug Monitoring (TDM) ...

Immune checkpoint inhibition (ICI) has significantly improved survival for advanced melanoma patients, yet nearly half do not respond to treatment. Identifying predictive biomarkers remains a challenge, as no single marker ...

In the coming decades, the burden of mental illness and other chronic diseases will increase due to unhealthy lifestyles, aging populations, and climate change. People with severe mental illness face even greater challenges, ...

This thesis aimed to evaluate the nationwide clinical practice and oncologic outcomes in the treatment of LAPC. 2. This chapter provides an overview of the clinical practice of treatment of LAPC patients. Median overall ...

Amyotrophic lateral sclerosis (ALS) is an incompletely understood disease in which motor neurons and skeletal muscle cells are affected. One of the major hurdles that the field had to overcome, involved obtaining sufficient ...

End-stage heart failure occurs in 1-10% of cases of heart failure. There are two treatment options: mechanical support and heart transplantation. Both treatments have advantages and disadvantages. Heart transplantation is ...

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, with around 17.9 million deaths annually. In Europe, heart disease causes 3.6 million deaths each year, contributing to a significant healthcare ...

For decades, treatment choices were few, and those available were tailored merely to a patient’s age and comorbidities. Currently, treatment choices are adapted to clinical parameters and cytogenetic features. The work ...

This dissertation investigates the relationship between biomarkers and cardiovascular event risks after vascular surgeries on the carotid and femoral arteries. It aims to identify plaque-, plasma-, and extracellular ...