Healthcare innovations are advancing rapidly, significantly improving the prevention, diagnosis, and treatment of diseases. However, this progress also drives rising healthcare costs, with hospital expenses in the Netherlands ...

This theses describes: - the implementation of integrated CVRM care by the PoZoB care group - the steps taken to improve the CVRM care program and - an observational study comparing PoZoB patients with Julius GP Network-patients ...

The main objective of this thesis is to develop tools that enable the application of Deuterium Metabolic Imaging (DMI) in the abdomen, where diseases such as diabetes and metabolic dysfunction-associated fatty liver disease ...

In the Netherlands, over two million people regularly participate in running. While running offers numerous health benefits, it also leads to running-related injuries (RRIs). This thesis aims to understand RRI monitoring ...

The COVID-19 pandemic, declared in March 2020, significantly disrupted healthcare systems globally, with pregnant women facing heightened risks of severe illness. However, these women were largely excluded from clinical ...

Climate change has expanded tick habitats, leading to greater human exposure to ticks and the pathogens they carry, especially in areas where nature-preserving activities like reforestation and urban greenspaces create ...

The work described in this thesis sought to uncover genetic and epigenetic factors contributing to neurodegenerative disease, identify genes involved in epigenetic regulation, and develop methodology and tools to facilitate ...

Our research provides novel insights into how tumor cells alter folate metabolism to support growth and survival, revealing vulnerabilities that can be exploited for therapy. A key finding is the characterization of a novel ...

In recent years, cancer immunotherapy has emerged as a highly promising treatment option, aiming to harness the power of the immune system to combat cancer, especially for melanoma. However, the intricate nature of the ...

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that is characterized by progressive loss of central and peripheral motor neurons. Despite extensive efforts, clinical trials have been largely ...