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UMC Repository: Recent submissions

  • Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines 
    Hooykaas, Marjolein J G; Kruse, Elisabeth; Wiertz, Emmanuel J H J; Lebbink, Robert Jan (BioMed Central, 2016-08-17)
    BACKGROUND: Epstein-Barr virus (EBV) establishes lifelong infections in its human host. The virus is associated with a broad range of malignancies of lymphoid and epithelial origin, including Burkitt's lymphoma, post-transplant ...
  • The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein 
    van de Weijer, Michael L; van Muijlwijk, Guus H; Visser, Linda J; Costa, Ana I; Wiertz, Emmanuel J H J; Lebbink, Robert Jan (Multidisciplinary Digital Publishing Institute (MDPI), 2016-11-15)
    Misfolded proteins from the endoplasmic reticulum (ER) are transported back into the cytosol for degradation via the ubiquitin-proteasome system. The human cytomegalovirus protein US11 hijacks this ER-associated protein ...
  • RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo 
    Alkasalias, Twana; Alexeyenko, Andrey; Hennig, Katharina; Danielsson, Frida; Lebbink, Robert Jan; Fielden, Matthew; Turunen, S Pauliina; Lehti, Kaisa; Kashuba, Vladimir; Madapura, Harsha S; Bozoky, Benedek; Lundberg, Emma; Balland, Martial; Guvén, Hayrettin; Klein, George; Gad, Annica K B; Pavlova, Tatiana (National Academy of Sciences, 2017-02-21)
    Fibroblasts are a main player in the tumor-inhibitory microenvironment. Upon tumor initiation and progression, fibroblasts can lose their tumor-inhibitory capacity and promote tumor growth. The molecular mechanisms that ...
  • A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape 
    Lebbink, Robert Jan; de Jong, Dorien C M; Wolters, Femke; Kruse, Elisabeth M; van Ham, Petra M; Wiertz, Emmanuel J H J; Nijhuis, Monique (Nature Publishing Group, 2017-02-08)
    HIV presents one of the highest evolutionary rates ever detected and combination antiretroviral therapy is needed to overcome the plasticity of the virus population and control viral replication. Conventional treatments ...
  • IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP 
    Jønsson, K L; Laustsen, A; Krapp, C; Skipper, K A; Thavachelvam, K; Hotter, D; Egedal, J H; Kjolby, M; Mohammadi, P; Prabakaran, T; Sørensen, L K; Sun, C; Jensen, S B; Holm, C K; Lebbink, R J; Johannsen, M; Nyegaard, M; Mikkelsen, J G; Kirchhoff, F; Paludan, S R; Jakobsen, M R (Nature Publishing Group, 2017-02-10)
    Innate immune activation by macrophages is an essential part of host defence against infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of interferons and cytokines through activation of ...
  • EBV MicroRNA BART16 suppresses Type i IFN signaling 
    Hooykaas, Marjolein J.G.; Van Gent, Michiel; Soppe, Jasper A.; Kruse, Elisabeth; Boer, Ingrid G.J.; Van Leenen, Dik; Groot Koerkamp, Marian J.A.; Holstege, Frank C.P.; Ressing, Maaike E.; Wiertz, Emmanuel J.H.J.; Lebbink, Robert Jan (American Association of Immunologists, 2017-05-15)
    Type I IFNs play critical roles in orchestrating the antiviral defense by inducing direct antiviral activities and shaping the adaptive immune response. Viruses have evolved numerous strategies to specifically interfere ...
  • DUCK study 
    Wisse, R.; van Vossen, M.; Muijzer, B.; Soeters, N.; Godefrooij, D.; van Luijk, C.; Koppen, C.; Nuijts, R. (Wiley-Blackwell, 2017-04)
  • Abstracts of the Netherlands Ophthalmological Society (NOG) Annual Congress, 29-31 March 2017, Maastricht, Holland: CRISPR/Cas9, a powerful tool to target human herpesviruses 
    Imhof, S.; de Boer, J.; Wisse, R.; Wiertz, E. J. H. J.; van Diemen, F. F.; Lebbink, R. J. (Wiley-Blackwell, 2017-04)
  • Age-specific incidence and prevalence of keratoconus: a nationwide registration study 
    Godefrooij, D. A.; de Wit, G. A.; Uiterwaal, C. S.; Imhof, S. M.; Wisse, R. P. L. (Wiley-Blackwell, 2017-04)
  • The effect of adipose tissue-derived stem cells in a middle cerebral artery occlusion stroke model depends on their engraftment rate 
    Grudzenski, Saskia; Baier, Sebastian; Ebert, Anne; Pullens, Pim; Lemke, Andreas; Bieback, Karen; Dijkhuizen, Rick M.; Schad, Lothar R.; Alonso, Angelika; Hennerici, Michael G.; Fatar, Marc (BioMed Central, 2017-04-26)
    Background: In the field of experimental stem cell therapy, intra-arterial (IA) delivery yields the best results concerning, for example, migrated cell number at the targeted site. However, IA application also appears to ...
  • Electromagnetic-guided bedside placement of nasoenteral feeding tubes by nurses is non-inferior to endoscopic placement by gastroenterologists: A multicenter randomized controlled trial 
    Gerritsen, Arja; De Rooij, Thijs; Dijkgraaf, Marcel G.; Busch, Olivier R.; Bergman, Jacques J.; Ubbink, Dirk T.; Van Duijvendijk, Peter; Erkelens, G. Willemien; Klos, Mariël; Kruyt, Philip M.; Bac, Dirk Jan; Rosman, Camiel; Tan, Adriaan C.; Molenaar, I. Quintus; Monkelbaan, Jan F.; Mathus-Vliegent, Elisabeth M.; Besselink, Marc G. (Wolters Kluwer Health, 2016-08-01)
    OBJECTIVES: Electromagnetic (EM)-guided bedside placement of nasoenteral feeding tubes by nurses may improve efficiency and reduce patient discomfort and costs compared with endoscopic placement by gastroenterologists. ...
  • Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies 
    Ramanan, Vyas; Trehan, Kartik; Ong, Mei Lyn; Luna, Joseph M.; Hoffmann, Hans Heinrich; Espiritu, Christine; Sheahan, Timothy P.; Chandrasekar, Hamsika; Schwartz, Robert E.; Christine, Kathleen S.; Rice, Charles M.; van Oudenaarden, Alexander; Bhatia, Sangeeta N. (Academic Press Inc., 2016-07-01)
    Hepatitis C virus (HCV) is a positive single-stranded RNA virus of enormous global health importance, with direct-acting antiviral therapies replacing an immunostimulatory interferon-based regimen. The dynamics of HCV ...
  • Designer matrices for intestinal stem cell and organoid culture 
    Gjorevski, Nikolce; Sachs, Norman; Manfrin, Andrea; Giger, Sonja; Bragina, Maiia E.; Ordóñez-Morán, Paloma; Clevers, Hans; Lutolf, Matthias P. (Nature Research, 2016-11-24)
    Epithelial organoids recapitulate multiple aspects of real organs, making them promising models of organ development, function and disease. However, the full potential of organoids in research and therapy has remained ...
  • Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience 
    De Sousa, Paul A.; Steeg, Rachel; Wachter, Elisabeth; Bruce, Kevin; King, Jason; Hoeve, Marieke; Khadun, Shalinee; McConnachie, George; Holder, Julie; Kurtz, Andreas; Seltmann, Stefanie; Dewender, Johannes; Reimann, Sascha; Stacey, Glyn; O'Shea, Orla; Chapman, Charlotte; Healy, Lyn; Zimmermann, Heiko; Bolton, Bryan; Rawat, Trisha; Atkin, Isobel; Veiga, Anna; Kuebler, Bernd; Serano, Blanca Miranda; Saric, Tomo; Hescheler, Jürgen; Brüstle, Oliver; Peitz, Michael; Thiele, Cornelia; Geijsen, Niels; Holst, Bjørn; Clausen, Christian; Lako, Majlinda; Armstrong, Lyle; Gupta, Shailesh K.; Kvist, Alexander J.; Hicks, Ryan; Jonebring, Anna; Brolén, Gabriella; Ebneth, Andreas; Cabrera-Socorro, Alfredo; Foerch, Patrik; Geraerts, Martine; Stummann, Tina C.; Harmon, Shawn; George, Carol; Streeter, Ian; Clarke, Laura; Parkinson, Helen; Harrison, Peter W.; Faulconbridge, Adam; Cherubin, Luca; Burdett, Tony; Trigueros, Cesar; Patel, Minal J.; Lucas, Christa; Hardy, Barry; Predan, Rok; Dokler, Joh; Brajnik, Maja; Keminer, Oliver; Pless, Ole; Gribbon, Philip; Claussen, Carsten; Ringwald, Annette; Kreisel, Beate; Courtney, Aidan; Allsopp, Timothy E. (Elsevier, 2017-04-01)
    A fast track “Hot Start” process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent ...
  • Monitoring tumor response to neoadjuvant chemotherapy using MRI & 18F-FDG PET/CT in breast cancer subtypes 
    Schmitz, Alexander M Th; Teixeira, Suzana C; Pengel, Kenneth E; Loo, Claudette E; Vogel, Wouter V; Wesseling, Jelle; Rutgers, Emiel J Th; Valdés Olmos, Renato A; Sonke, Gabe S; Rodenhuis, Sjoerd; Vrancken Peeters, Marie Jeanne T F D; Gilhuijs, Kenneth G A (Public Library of Science, 2017-05)
    PURPOSE: To explore guidelines on the use of MRI and PET/CT monitoring primary tumor response to neoadjuvant chemotherapy (NAC), taking breast cancer subtype into account. MATERIALS AND METHODS: In this prospective cohort ...
  • Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18 
    Ravà, Micol; D'Andrea, Aleco; Doni, Mirko; Kress, Theresia R.; Ostuni, Renato; Bianchi, Valerio; Morelli, Marco J.; Collino, Agnese; Ghisletti, Serena; Nicoli, Paola; Recordati, Camilla; Iascone, Maria; Sonzogni, Aurelio; D'Antiga, Lorenzo; Shukla, Ruchi; Faulkner, Geoffrey J.; Natoli, Gioacchino; Campaner, Stefano; Amati, Bruno (John Wiley & Sons Inc., 2017-05-01)
    The ST18 gene has been proposed to act either as a tumor suppressor or as an oncogene in different human cancers, but direct evidence for its role in tumorigenesis has been lacking thus far. Here, we demonstrate that ST18 ...
  • Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling 
    Janda, Claudia Y.; Dang, Luke T.; You, Changjiang; Chang, Junlei; Lau, Wim De; Zhong, Zhendong A.; Yan, Kelley S.; Marecic, Owen; Siepe, DIrk; Li, Xingnan; Moody, James D.; Williams, Bart O.; Clevers, Hans; Piehler, Jacob; Baker, David; Kuo, Calvin J.; Garcia, K. Christopher (Nature Research, 2017-05-11)
    Wnt proteins modulate cell proliferation and differentiation and the self-renewal of stem cells by inducing β-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the co-receptors LRP5 and LRP6 to ...
  • Ankyrin repeat and zinc-finger domain-containing 1 mutations are associated with infantile-onset inflammatory bowel disease 
    Van Haaften-Visser, Désirée Y.; Harakalova, Magdalena; Mocholi, Enric; Van Montfrans, Joris M.; Elkadri, Abdul; Rieter, Ester; Fiedler, Karoline; Van Hasselt, Peter M.; Triffaux, Emily M.M.; Van Haelst, Mieke M.; Nijman, Isaac J.; Kloosterman, Wigard P.; Nieuwenhuis, Edward E S; Muise, Aleixo M.; Cuppen, Edwin; Houwen, Roderick H.J.; Coffer, Paul J. (American Society for Biochemistry and Molecular Biology Inc., 2017-05-12)
    Infantile-onset inflammatory bowel disease (IO IBD) is an invalidating illness with an onset before 2 years of age and has a complex pathophysiology in which genetic factors are important. Homozygosity mapping and whole-exome ...
  • Second salvage high-dose-rate brachytherapy for radiorecurrent prostate cancer 
    Maenhout, Metha; Van Vulpen, Marco; Moerland, Marinus; Peters, Max; Meijer, Richard; Van Den Bosch, Maurice; Nguyen, Paul; Frank, Steven; Van Der Voort Van Zyp, Jochem (Termedia Publishing House Ltd., 2017-04-28)
    Purpose: Salvage treatments for localized radiorecurrent prostate cancer can be performed safely when a focal and image guided approach is used. Due to the low toxicity, the opportunity exists to investigate a second salvage ...
  • Within-host selection of drug resistance in a mouse model of repeated interrupted treatment of Plasmodium yoelii infection 
    Nuralitha, Suci; Siregar, Josephine E; Syafruddin, Din; Hoepelman, Andy I M; Marzuki, Sangkot (BioMed Central, 2017)
    BACKGROUND: To study within-host selection of resistant parasites, an important factor in the development of resistance to anti-malarial drugs, a mouse model of repeated interrupted malaria treatment (RIT) has been developed. ...