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UMC Repository: Recent submissions

  • Automatic identification of variables in epidemiological datasets using logic regression 
    Lorenz, Matthias W.; Abdi, Negin Ashtiani; Scheckenbach, Frank; Pflug, Anja; Bülbül, Alpaslan; Catapano, Alberico L.; Agewall, Stefan; Ezhov, Marat; Bots, Michiel L.; Kiechl, Stefan; Orth, Andreas; Norata, Giuseppe D.; Empana, Jean Philippe; Lin, Hung Ju; McLachlan, Stela; Bokemark, Lena; Ronkainen, Kimmo; Amato, Mauro; Schminke, Ulf; Srinivasan, Sathanur R.; Lind, Lars; Kato, Akihiko; Dimitriadis, Chrystosomos; Przewlocki, Tadeusz; Okazaki, Shuhei; Stehouwer, C. D.A.; Lazarevic, Tatjana; Willeit, Peter; Yanez, David N.; Steinmetz, Helmuth; Sander, Dirk; Poppert, Holger; Desvarieux, Moise; Ikram, M. Arfan; Bevc, Sebastjan; Staub, Daniel; Sirtori, Cesare R.; Iglseder, Bernhard; Engström, Gunnar; Tripepi, Giovanni; Beloqui, Oscar; Lee, Moo Sik; Friera, Alfonsa; Xie, Wuxiang; Grigore, Liliana; Plichart, Matthieu; Su, Ta Chen; Robertson, Christine; Schmidt, Caroline; Tuomainen, Tomi Pekka; Veglia, Fabrizio; Völzke, Henry; Nijpels, Giel; Jovanovic, Aleksandar; Willeit, Johann; Sacco, Ralph L.; Franco, Oscar H.; Hojs, Radovan; Uthoff, Heiko; Hedblad, Bo; Park, Hyun Woong; Suarez, Carmen; Zhao, Dong; Catapano, Alberico; Ducimetiere, Pierre; Chien, Kuo Liong; Price, Jackie F.; Bergström, Göran; Kauhanen, Jussi; Tremoli, Elena; Dörr, Marcus; Berenson, Gerald; Papagianni, Aikaterini; Kablak-Ziembicka, Anna; Kitagawa, Kazuo; Dekker, Jaqueline M.; Stolic, Radojica; Polak, Joseph F.; Sitzer, Matthias; Bickel, Horst; Rundek, Tatjana; Hofman, Albert; Ekart, Robert; Frauchiger, Beat; Castelnuovo, Samuela; Rosvall, Maria; Zoccali, Carmine; Landecho, Manuel F.; Bae, Jang Ho; Gabriel, Rafael; Liu, Jing; Baldassarre, Damiano; Kavousi, Maryam (BioMed Central, 2017-04-13)
    Background: For an individual participant data (IPD) meta-analysis, multiple datasets must be transformed in a consistent format, e.g. using uniform variable names. When large numbers of datasets have to be processed, this ...
  • Circulating microRNAs as Potential Biomarkers of Differential Susceptibility to Traumatic Stress 
    de Nijs, Laurence; Krauskopf, Julian; Kleinjans, Jos; Machiels, Barbie; Snijders, Clara; Smeets, Bert; Kenis, Gunter; van den Hove, Daniel; Vinkers, Christiaan; Geuze, Elbert; Boks, Marco; Vermetten, Eric; Rutten, Bart (Elsevier, 2017-05-15)
  • Age-specific vascular risk factor profiles according to stroke subtype 
    Hauer, Allard J.; Ruigrok, Ynte M.; Algra, Ale; van Dijk, Ewoud J.; Koudstaal, Peter J.; Luijckx, Gert Jan; Nederkoorn, Paul J.; van Oostenbrugge, Robert J.; Visser, Marieke C.; Wermer, Marieke J.; Jaap Kappelle, L.; Klijn, Catharina J.M. (Wiley-Blackwell, 2017-05-01)
    BACKGROUND: Ischemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age ...
  • Innovative Perspective: Gadolinium-Free Magnetic Resonance Imaging in Long-Term Follow-Up after Kidney Transplantation 
    van Eijs, Mick J M; van Zuilen, Arjan D; de Boer, Anneloes; Froeling, Martijn; Nguyen, Tri Q; Joles, Jaap A; Leiner, Tim; Verhaar, Marianne C (Frontiers Research Foundation, 2017-05-16)
    Since the mid-1980s magnetic resonance imaging (MRI) has been investigated as a non- or minimally invasive tool to probe kidney allograft function. Despite this long-standing interest, MRI still plays a subordinate role ...
  • Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction? 
    Stampalija, Tamara; Arabin, Birgit; Wolf, Hans; Bilardo, Caterina M.; Lees, Christoph; Brezinka, C.; Derks, J. B.; Diemert, A.; Duvekot, J. J.; Ferrazzi, E.; Frusca, T.; Ganzevoort, W.; Hecher, K.; Kingdom, J.; Marlow, N.; Marsal, K.; Martinelli, P.; Ostermayer, E.; Papageorghiou, A. T.; Schlembach, D.; Schneider, K. T.M.; Thilaganathan, B.; Thornton, J.; Todros, T.; Valcamonico, A.; Valensise, H.; van Wassenaer-Leemhuis, A.; Visser, GHA; Aktas, A.; Borgione, S.; Chaoui, R.; Cornette, J. M.J.; Diehl, T.; van Eyck, J.; Fratelli, N.; van Haastert, I. C.; Lobmaier, S.; Lopriore, E.; Missfelder-Lobos, H.; Mansi, G.; Martelli, P.; Maso, G.; Maurer-Fellbaum, U.; Mensing van Charante, N.; Mulder-de Tollenaer, S.; Napolitano, R.; Oberto, M.; Oepkes, D.; Ogge, G.; van der Post, J. A.M.; Prefumo, F.; Preston, L.; Raimondi, F.; Reiss, I. K.M.; Scheepers, L. S.; Skabar, A.; Spaanderman, M.; Weisglas-Kuperus, N.; Zimmermann, A. (Mosby Inc., 2017-05-01)
    Background Reduced fetal middle cerebral artery Doppler impedance is associated with hypoxemia in fetal growth restriction. It remains unclear as to whether this finding could be useful in timing delivery, especially in ...
  • PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial 
    de Ridder, Inger R.; den Hertog, Heleen M.; van Gemert, H. Maarten A.; Schreuder, A. H. C. M. L. (Tobien); Ruitenberg, Annemieke; Maasland, E. (Lisette); Saxena, Ritu; van Tuijl, Jordie H.; Jansen, Ben P. W.; Van den Berg-Vos, Renske M.; Vermeij, Frederique; Koudstaal, Peter J.; Kappelle, L. Jaap; Algra, Ale; van der Worp, H. Bart; Dippel, Diederik W. J. (Lippincott Williams & Wilkins, 2017-04)
    Background and Purpose—Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with ...
  • Robot-assisted minimally invasive esophagectomy 
    van Hillegersberg, R.; Seesing, M. F. J.; Brenkman, H. J. F.; Ruurda, J. P. (Springer-Verlag, 2017-01)
    Esophagolymphadenectomy is the cornerstone of multimodality treatment for resectable esophageal cancer. The preferred surgical approach is transthoracic, with a two-field lymph node dissection and gastric conduit reconstruction. ...
  • Current status of laparoscopic transhiatal esophagectomy for esophageal cancer patients: a systematic review of the literature 
    Parry, K.; Ruurda, J. P.; van der Sluis, P. C.; van Hillegersberg, R. (Wiley-Blackwell, 2017-01)
    Minimally invasive techniques in transhiatal esophagectomy (THE) were introduced to reduce morbidity and enhance postoperative recovery. Aim of this study was to systematically review the current status and possible ...
  • Prognostic gene expression profiling in esophageal cancer: a systematic review 
    Visser, Els; Franken, Ingrid A.; Brosens, Lodewijk A. A.; Ruurda, Jelle P.; van Hillegersberg, Richard (Impact Journals, 2017-01-17)
    Background: Individual variability in prognosis of esophageal cancer highlights the need for advances in personalized therapy. This systematic review aimed at elucidating the prognostic role of gene expression profiles and ...
  • Childhood tumours with a high probability of being part of a tumour predisposition syndrome; reason for referral for genetic consultation 
    Postema, Floor A M; Hopman, Saskia M J; Aalfs, Cora M; Berger, Lieke P V; Bleeker, Fonnet E; Dommering, Charlotte J; Jongmans, Marjolijn C J; Letteboer, Tom G W; Olderode-Berends, Maran J W; Wagner, Anja; Hennekam, Raoul C; Merks, Johannes H M (Elsevier Limited, 2017)
    INTRODUCTION: Recognising a tumour predisposition syndrome (TPS) in childhood cancer patients is of major clinical relevance. The presence of a TPS may be suggested by the type of tumour in the child. We present an overview ...
  • Additional value of (18)F-FDG PET/CT response evaluation in axillary nodes during neoadjuvant therapy for triple-negative and HER2-positive breast cancer 
    van Ramshorst, Mette S; Teixeira, Suzana C; Koolen, Bas B; Pengel, Kenneth E; Gilhuijs, Kenneth G; Wesseling, Jelle; Rodenhuis, Sjoerd; Valdés Olmos, Renato A; Rutgers, Emiel J; Vogel, Wouter V; Sonke, Gabe S; Vrancken Peeters, Marie-Jeanne T (e-med, 2017)
    BACKGROUND: (18)F-FDG PET/CT can monitor metabolic activity in early breast cancer during neoadjuvant systemic therapy (NST), but it is unknown if the metabolic breast and axillary response differ. We evaluated the correlation ...
  • Expert Review of Clinical Immunology 10-year anniversary issue. Foreword 
    Forsthuber, Thomas G; Radstake, Timothy R D J (Taylor and Francis Ltd., 2015-01)
  • The detection of monosodium urate crystals in synovial fluid after long-term and varying storage conditions 
    Kienhorst, Laura B E; Janssens, Hein J E M; Eijgelaar, Roelant S; Radstake, Tim R D J; van Riel, Piet L C M; Janssen, Matthijs (Elsevier Masson, 2015-12)
  • Update on biomarkers in systemic sclerosis: tools for diagnosis and treatment 
    Affandi, Alsya J; Radstake, Timothy R D J; Marut, Wioleta (Springer-Verlag, 2015-09)
    Systemic sclerosis (SSc) is a complex autoimmune disease in which immune activation, vasculopathy, and extensive fibrosis of the skin and internal organs are among the principal features. SSc is a heterogeneous disease ...
  • Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease 
    Kienhorst, Laura B E; van Lochem, Ellen; Kievit, Wietske; Dalbeth, Nicola; Merriman, Marilyn E; Phipps-Green, Amanda; Loof, Arnoud; van Heerde, Waander; Vermeulen, Sita; Stamp, Lisa K; van Koolwijk, Elly; de Graaf, Jacqueline; Holzinger, Dirk; Roth, Johannes; Janssens, Hein J E M; Merriman, Tony R; Broen, Jasper C A; Janssen, Matthijs; Radstake, Timothy R D J (John Wiley & Sons Inc., 2015-12)
    OBJECTIVE: The frequent association of gout with metabolic syndrome and cardiovascular disease (CVD) suggests that it has a systemic component. Our objective was to study whether circulating proinflammatory cytokines are ...
  • Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway 
    López-Isac, Elena; Campillo-Davo, Diana; Bossini-Castillo, Lara; Guerra, Sandra G; Assassi, Shervin; Simeón, Carmen Pilar; Carreira, Patricia; Ortego-Centeno, Norberto; García de la Peña, Paloma; Beretta, Lorenzo; Santaniello, Alessandro; Bellocchi, Chiara; Lunardi, Claudio; Moroncini, Gianluca; Gabrielli, Armando; Riemekasten, Gabriela; Witte, Torsten; Hunzelmann, Nicolas; Kreuter, Alexander; Distler, Jörg Hw; Voskuyl, Alexandre E; de Vries-Bouwstra, Jeska; Herrick, Ariane; Worthington, Jane; Denton, Christopher P; Fonseca, Carmen; Radstake, Timothy Rdj; Mayes, Maureen D; Martín, Javier; Spanish Scleroderma Group (Elsevier, 2016-08)
    OBJECTIVES: TYK2 is a common genetic risk factor for several autoimmune diseases. This gene encodes a protein kinase involved in interleukin 12 (IL-12) pathway, which is a well-known player in the pathogenesis of systemic ...
  • Drug Survival and Predictors of Drug Survival for Methotrexate Treatment in a Retrospective Cohort of Adult Patients with Localized Scleroderma 
    Mertens, Jorre S; van den Reek, Juul M; Kievit, Wietske; van de Kerkhof, Peter C M; Thurlings, Rogier M; Radstake, Tim R D; Seyger, Marieke M B; de Jong, Elke M G J (Medical Journals Sweden AB, 2016-11-02)
    Data regarding the efficacy and safety of methotrexate (MTX) in adults with localized scleroderma (LoS) is scarce. This study gathered data from a retrospective cohort of adult patients with LoS (n?=?107), treated with MTX ...
  • Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses 
    Holm, Christian K; Rahbek, Stine H; Gad, Hans Henrik; Bak, Rasmus O; Jakobsen, Martin R; Jiang, Zhaozaho; Hansen, Anne Louise; Jensen, Simon K; Sun, Chenglong; Thomsen, Martin K; Laustsen, Anders; Nielsen, Camilla G; Severinsen, Kasper; Xiong, Yingluo; Burdette, Dara L; Hornung, Veit; Lebbink, Robert Jan; Duch, Mogens; Fitzgerald, Katherine A; Bahrami, Shervin; Mikkelsen, Jakob Giehm; Hartmann, Rune; Paludan, Søren R (Nature Publishing Group, 2016-02-19)
    Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase ...
  • The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells 
    Gram, Anna M; Oosenbrug, Timo; Lindenbergh, Marthe F S; Büll, Christian; Comvalius, Anouskha; Dickson, Kathryn J I; Wiegant, Joop; Vrolijk, Hans; Lebbink, Robert Jan; Wolterbeek, Ron; Adema, Gosse J; Griffioen, Marieke; Heemskerk, Mirjam H M; Tscharke, David C; Hutt-Fletcher, Lindsey M; Wiertz, Emmanuel J H J; Hoeben, Rob C; Ressing, M.E. (Public Library of Science, 2016-04)
    Cell-mediated immunity plays a key role in host control of viral infection. This is exemplified by life-threatening reactivations of e.g. herpesviruses in individuals with impaired T-cell and/or iNKT cell responses. To ...
  • CRISPR/Cas9, a powerful tool to target human herpesviruses 
    van Diemen, Ferdy R; Lebbink, Robert Jan (Wiley-Blackwell, 2017-02)
    Over 90% of the adult population is infected with one or multiple herpesviruses. These viruses are characterized by their ability to establish latency, where the host is unable to clear the invader from infected cells ...