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UMC Repository: Recent submissions

  • Resistant Hypertension: consequences and treatment options 
    de Beus, E. (Utrecht University, 2017-06-29)
    Resistant hypertension, uncontrolled blood pressure despite use of ≥3 antihypertensives including a diuretic or use of ≥4 antihypertensives regardless of blood pressure (BP), was studied. In this thesis, 1/3 of patients ...
  • Clinical characteristics and treatment of chronic urticaria and angioedema: Dwelling on swelling, dealing with whealing 
    van den Elzen, M.T. (Utrecht University, 2017-07-04)
    The occurrence of wheals, angioedema or both for at least 6 weeks is diagnosed as chronic spontaneous urticaria in (inter) national guidelines - after excluding other illnesses. The underlying mechanism of angioedema without ...
  • Operative treatment of displaced clavicle fractures: optimising treatment options 
    Hulsmans, M.H.J. (Utrecht University, 2017-06-06)
    With an overall incidence of 29 to 64 per 100.000 people a year, clavicle fractures are one of the most common fractures around the shoulder girdle. They account for 2.6% to 4% of all fractures in adults. About 80% of all ...
  • Indirect recognition of HLA epitopes in solid organ transplantation 
    Geneugelijk, C.C.A. (Utrecht University, 2017-06-27)
    Alloreactivity due to HLA mismatches between donor and recipient remains the major limiting factor in successful graft outcome after solid organ transplantation. However, the immunogenicity of individual HLA mismatches is ...
  • Optimized strategies for the management of Mitral Valve Disease 
    Jansen, R. (Utrecht University, 2017-06-20)
    Mitral valve disease is one of the most prevalent valvular heart diseases. This thesis aims to investigate and optimize the management of mitral valve disease, focusing on the improvement of current diagnostic and treatment ...
  • Samenvatting richtlijn chronische spontane urticaria 
    Urgert, M. C.; Knulst, A. C. (DCHG Partners in Mediscne Communicatie, 2016-01)
  • The Knowledge-about-Older-Patients - Quiz (KOP-Q) for nurses: Cross-cultural validation between the Netherlands and United States of America 
    Dikken, Jeroen; Hoogerduijn, Jita G.; Klaassen, Sharon; Lagerwey, Mary D; Shortridge-Baggett, Lillie; Schuurmans, Marieke J. (Churchill Livingstone, 2017-08-01)
    Background The Knowledge about Older Patients-Quiz (KOP-Q) is designed as a unidimensional scale measuring knowledge of hospital nurses about older patients. Furthermore, the KOP-Q measures a second unidimensional construct, ...
  • Examining the construct and known-group validity of a composite endpoint for the Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A largescale data sharing initiative 
    Hofman, Cynthia S.; Lutomski, Jennifer E.; Boter, Han; Buurman, Bianca M.; De Craen, Anton J M; Donders, A Rogier T; Rikkert, Marcel G M Olde; Makai, Peter; Melis, René J.F.; Bleijenberg, N.; Blom, J. W.; Kempen, G. I J M; Krabbe, P. F M; Moll van Charante, E.P.; Muntinga, M. E.; Steyerberg, Ewout W.; Gussekloo, J.; van der Horst, H.E.; Olde Rikkert, Marcel G M; de Rooij, S.E.J.A.; Schols, Jos M. G. A.; Schuurmans, M. J.; Smilde, D. A.; Van Den Brink, D.; Qin, L.; TOPICS-MDS research consortium, Steering Committee, Working group (Public Library of Science, 2017-03-01)
    Background Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey Composite ...
  • Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS 
    Lutomski, Jennifer E.; Krabbe, Paul F M; Bleijenberg, N.; Blom, Jeanett; Kempen, Gertrudis I J M; MacNeil-Vroomen, Janet; Muntinga, Maaike E.; Steyerburg, Ewout; Olde Rikkert, Marcel G M; Melis, René J.F.; Bleijenberg, N.; Blom, J. W.; Melis, R.J.F.; Muntinga, M. E.; Steyerberg, Ewout W.; Gussekloo, J.; Olde Rikkert, Marcel G M; van den Brink, D.; Lutomski, J.E.; Qin, L.; Kempen, G. I.J.M.; Krabbe, P. F M; Buurman, B.M.; van der Horst, H.E.; de Rooij, S.E.J.A.; Schols, Jos M. G. A.; Schuurmans, M. J.; Smilde, D. A.; TOPICS Consortium (BioMed Central, 2017-03-03)
    Background: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D ...
  • Nurse-perceived quality of care in intensive care units and associations with work environment characteristics: a multicentre survey study 
    Stalpers, Dewi; Van Der Linden, Dimitri; Kaljouw, Marian J.; Schuurmans, Marieke J. (Wiley-Blackwell, 2017-06-01)
    Aims: To examine nurse-perceived quality of care, controlling for overall job satisfaction among critical care nurses and to explore associations with work environment characteristics. Background: Nurse-perceived quality ...
  • Quantification of metabolites in dried blood spots by direct infusion high resolution mass spectrometry 
    de Sain-van der Velden, Monique G M; van der Ham, Maria; Gerrits, Johan; Prinsen, Hubertus C M T; Willemsen, Marcel; Pras-Raves, Mia L; Jans, Judith J; Verhoeven-Duif, Nanda M (Elsevier, 2017-08-01)
    Diagnosis and treatment of inborn errors of metabolism (IEM) require the analysis of a variety of metabolites. These compounds are usually quantified by targeted platforms. High resolution mass spectrometry (HRMS) has the ...
  • Novel algorithms for improved sensitivity in non-invasive prenatal testing 
    Johansson, Lennart F.; De Boer, E. N.; De Weerd, H. A.; van Dijk, F.; Elferink, M. G.; Schuring-Blom, G. H.; Suijkerbuijk, Ron F; Sinke, Richard J.; Te Meerman, G. J.; Sijmons, Rolf H.; Swertz, Morris A.; Sikkema-Raddatz, B. (Nature Publishing Group, 2017-12-01)
    Non-invasive prenatal testing (NIPT) of cell-free DNA in maternal plasma, which is a mixture of maternal DNA and a low percentage of fetal DNA, can detect fetal aneuploidies using massively parallel sequencing. Because of ...
  • A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions 
    Sameith, Katrin; Amini, Saman; Groot Koerkamp, Marian J A; van Leenen, Dik; Brok, Mariel; Brabers, Nathalie; Lijnzaad, Philip; van Hooff, Sander R; Benschop, Joris J.; Lenstra, Tineke L.; Apweiler, Eva; van Wageningen, Sake; Snel, Berend; Holstege, Frank C P; Kemmeren, Patrick (BioMed Central Ltd., 2015-12-23)
    Background: Genetic interactions, or non-additive effects between genes, play a crucial role in many cellular processes and disease. Which mechanisms underlie these genetic interactions has hardly been characterized. ...
  • Determinants of the postpericardiotomy syndrome: A systematic review 
    van Osch, Dirk; Nathoe, Hendrik M.; Jacob, Kirolos A.; Doevendans, Pieter A.; van Dijk, Diederik; Suyker, Willem J.; Dieleman, Jan M. (Wiley-Blackwell, 2017-06)
    Background: Postpericardiotomy syndrome (PPS) is a common complication following cardiac surgery; however, the exact pathogenesis remains uncertain. Identifying risk factors of PPS might help to better understand the ...
  • CT-Based Local Distribution Metric Improves Characterization of COPD 
    Hoff, Benjamin A; Pompe, Esther; Galbán, Stefanie; Postma, Dirkje S; Lammers, Jan-Willem J; Ten Hacken, Nick H T; Koenderman, Leo; Johnson, Timothy D; Verleden, Stijn E; de Jong, Pim A; Mohamed Hoesein, Firdaus; van den Berge, Maarten; Ross, Brian D; Galbán, Craig J (Nature Publishing Group, 2017-06-07)
    Parametric response mapping (PRM) of paired CT lung images has been shown to improve the phenotyping of COPD by allowing for the visualization and quantification of non-emphysematous air trapping component, referred to as ...
  • Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis 
    Lamberink, Herm J; Otte, Willem M; Geerts, Ada T; Pavlovic, Milen; Ramos-Lizana, Julio; Marson, Anthony G; Overweg, Jan; Sauma, Letícia; Specchio, Luigi M; Tennison, Michael; Cardoso, Tania M O; Shinnar, Shlomo; Schmidt, Dieter; Geleijns, Karin; Braun, Kees P J (Elsevier Limited, 2017-07)
    BACKGROUND: People with epilepsy who became seizure-free while taking antiepileptic drugs might consider discontinuing their medication, with the possibility of increased quality of life because of the elimination of adverse ...
  • Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort 
    Molina-Montes, Esther; Sánchez, María José; Buckland, Genevieve; Bueno-de-Mesquita, H. Bas; Weiderpass, Elisabete; Amiano, Pilar; Wark, Petra A.; Kühn, Tilman; Katzke, Verena; Huerta, José María; Ardanaz, Eva; Quirós, José Ramón; Affret, Aurélie; His, Mathilde; Boutron-Ruault, Marie Christine; Peeters, Petra H.; Ye, Weimin; Sund, Malin; Boeing, Heiner; Iqbal, Khalid; Ohlsson, Bodil; Sonestedt, Emily; Tjønneland, Anne; Petersen, Kristina EN; Travis, Ruth C.; Skeie, Guri; Agnoli, Claudia; Panico, Salvatore; Palli, Domenico; Tumino, Rosario; Sacerdote, Carlotta; Freisling, Heinz; Huybrechts, Inge; Overvad, Kim; Trichopoulou, Antonia; Bamia, Christina; Vasilopoulou, Effie; Wareham, Nick; Khaw, Kay Tee; Cross, Amanda J.; Ward, Heather A.; Riboli, Elio; Duell, Eric J. (Springer Nature, 2017-02-07)
    Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between ...
  • Anatomical integration and rich-club connectivity in euthymic bipolar disorder 
    O'Donoghue, S.; Kilmartin, L.; O'Hora, D.; Emsell, L.; Langan, C.; McInerney, S.; Forde, N. J.; Leemans, A.; Jeurissen, B.; Barker, G. J.; McCarthy, P.; Cannon, D. M.; McDonald, C. (Cambridge University Press, 2017-07)
    Background: Although repeatedly associated with white matter microstructural alterations, bipolar disorder (BD) has been relatively unexplored using complex network analysis. This method combines structural and diffusion ...
  • ICS teaching module: Artefacts in urodynamic pressure traces (basic module) 
    Gammie, Andrew; D'Ancona, Carlos; Kuo, Hann Chorng; Rosier, Peter F W (John Wiley & Sons Inc., 2017-01)
    Aims: To present the ICS Teaching Module on artefacts in urodynamics pressure traces. Methods: Slides from three urodynamics centres were assembled. Descriptions and labels were agreed by the authors and the module presented ...
  • Continuous urethral pressure measurements; measurement techniques; pressure variations; clinical interpretations; and clinical relevance: A Systematic Literature Analysis 
    Kummeling, Maxime T M; Rosier, Peter F W M; Elzevier, Henk W.; Groenendijk, Pieter M. (John Wiley & Sons Inc., 2017-01)
    Aims: The clinical relevance of urethral pressure variations (UPV) in the pathophysiology of over active bladder syndrome (OAB) has remained controversial to date. Some studies report an association with OAB and/or detrusor ...