Examining the construct and known-group validity of a composite endpoint for the Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A largescale data sharing initiative
Hofman, Cynthia S.; Lutomski, Jennifer E.; Boter, Han; Buurman, Bianca M.; De Craen, Anton J M; Donders, A Rogier T; Rikkert, Marcel G M Olde; Makai, Peter; Melis, René J.F.; Bleijenberg, N.; Blom, J. W.; Kempen, G. I J M; Krabbe, P. F M; Moll van Charante, E.P.; Muntinga, M. E.; Steyerberg, Ewout W.; Gussekloo, J.; van der Horst, H.E.; Olde Rikkert, Marcel G M; de Rooij, S.E.J.A.; Schols, Jos M. G. A.; Schuurmans, M. J.; Smilde, D. A.; Van Den Brink, D.; Qin, L.; TOPICS-MDS research consortium, Steering Committee, Working group
(2017) PLoS ONE [E], volume 12, issue 3
(Article)
Abstract
Background Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in geriatric care as it combines multiple outcomes relevant to older persons in a single
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metric. The objective of this study was to validate TOPICS-CEP across different study settings (general population, primary care and hospital). Methods Data were extracted from TOPICS Minimum Dataset (MDS), a pooled public-access national database with information on older persons throughout the Netherlands. Data of 17,603 older persons were used. Meta-correlations were performed between TOPICS-CEP indexed scores, EuroQol5-D utility scores and Cantril's ladder life satisfaction scores. Mixed linear regression analyses were performed to compare TOPICS-CEP indexed scores between known groups, e.g. persons with versus without depression. Results In the complete sample and when stratified by study setting TOPICS-CEP and Cantril's ladder were moderately correlated, whereas TOPICS-CEP and EQ-5D were highly correlated. Higher mean TOPICS-CEP scores were found in persons who were: married, lived independently and had an education at university level. Moreover, higher mean TOPICS-CEP scores were found in persons without dementia, depression, and dizziness with falls, respectively. Similar results were found when stratified by subgroup. Conclusion This study supports that TOPICS-CEP is a robust measure which can potentially be used in broad settings to identify the effect of intervention or of prevention in elderly care.
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Author keywords: Medicine(all), Biochemistry, Genetics and Molecular Biology(all), Agricultural and Biological Sciences(all), Journal Article
ISSN: 1932-6203
(Publisher version, Peer reviewed)
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