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UMC Repository: Recent submissions

  • The value of case management in paediatric palliative care 
    Verberne, L.M. (Utrecht University, 2017-08-31)
    In the Netherlands around 4000 – 6700 children with life-limiting diseases could benefit from paediatric palliative care (PPC). However, adequate PPC is often absent due to the lack of continuity and coordination of care ...
  • Orthopedic injury, classification of the patient and the fracture 
    Briët, J.P. (Utrecht University, 2017-06-26)
    In this thesis clinical studies and literature research were presented to assist physicians in the decision-making process for treatment of orthopaedic trauma patients Part 1 - Classification of the patient Pain and ...
  • Zooming in on cerebral small vessels in ageing and dementia 
    Bouvy, W.H. (Utrecht University, 2017-06-07)
    Ziekten van de kleine bloedvaatjes in de hersenen zijn een belangrijke oorzaak van cognitieve achteruitgang, dementie en beroerte. Door het maken van MRI-scans kan vaatschade van de hersenen worden vastgesteld. Echter, ...
  • Dietary fatty acids and cardiovascular disease risk in observational studies 
    Praagman, J. (Utrecht University, 2017-06-01)
    Dietary fat is a valuable component of the diet and essential for the human body. Over time it has become clear that certain types of fat(ty acids) are also potentially harmful for our health. For example, we know from ...
  • Forkhead box O and the control of cellular oxidative stress 
    Essers, M.A.G. (Febodruk bv, 2004-11-25)
    FOXO Forkhead transcription factors are a subfamily of the large superfamily of Forkhead transcription factors, which consists of over 100 different members, expressed in species ranging from yeast to humans. Members of ...
  • Fruit allergy: from sensitization and symptoms to prevention and treatment 
    Bolhaar, S.T.H.P. (Optima BV Rotterdam, 2004-09-14)
    It is generally assumed that the incidence of allergies in the Western world has been rising over the past few decades. Apple allergy was chosen as a model system because apples are widely consumed in Europe and they ...
  • Iedereen is uniek 
    Asselbergs, FW (Utrecht University, 2016-05-10)
  • Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium 
    Stringer, S.; Minică, C. C.; Verweij, K. J.H.; Mbarek, Hamdi; Bernard, M.; Derringer, Jaime; van Eijk, K. R.; Isen, J. D.; Loukola, Anu; Maciejewski, D. F.; Mihailov, E.; van der Most, Peter J.; Sánchez-Mora, C.; Roos, L.; Sherva, R.; Walters, R.G.; Ware, James S.; Abdellaoui, A.; Bigdeli, T. B.; Branje, S. J.T.; Brown, A.S.; Bruinenberg, M.; Casas, M.; Esko, Tonu; Garcia-Martinez, I.; Gordon, Scott D.; Harris, Juliette M; Hartman, Catharine A; Henders, Anjali K.; Heath, Andrew C.; Hickie, Ian B.; Hickman, M.; Hopfer, C. J.; Hottenga, J.J.; Huizink, A.C.; Irons, D. E.; Kahn, R. S.; Korhonen, T.K.; Kranzler, H. R.; Krauter, K.; van Lier, P.A.C.; Lubke, G.H.; Madden, Pamela A. F.; Mägi, Reedik; McGue, M. K.; Medland, Sarah E.; Meeus, W.H.J.; Miller, Michael B.; Montgomery, Grant W.; Nivard, Michel G; Nolte, Ilja M.; Oldehinkel, Albertine J.; Pausova, Zdenka; Qaiser, B.; Quaye, Lydia; Ramos-Quiroga, J. A.; Richarte, V.; Rose, R.J.; Shin, J.J.; Stallings, M. C.; Stiby, A. I.; Wall, T. L.; Wright, Margaret J.; Koot, H.M.; Paus, T.; Hewitt, J. K.; Ribasés, M.; Kaprio, Jaakko; Boks, M. P.; Snieder, H.; Spector, T.D.; Munafò, M. R.; Metspalu, A.; Gelernter, J.; Boomsma, Dorret I.; Iacono, William G; Martin, Nicholas G.; Gillespie, N. A.; Derks, Eske M.; Vink, J. M. (Nature Publishing Group, 2016-03-29)
    Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and ...
  • Hydrogel-based reinforcement of 3D bioprinted constructs 
    Melchels, FPW; Blokzijl, M M; Levato, R; Peiffer, Q C; de Ruijter, M; Hennink, Wim E.; Vermonden, T.; Malda, J (IOP Publishing Ltd., 2016-07-19)
    Progress within the field of biofabrication is hindered by a lack of suitable hydrogel formulations. Here, we present a novel approach based on a hybrid printing technique to create cellularized 3D printed constructs. The ...
  • Liquid Biopsy: A Future Tool for Posttreatment Surveillance in Head and Neck Cancer? 
    van Ginkel, Joost H.; Huibers, Manon M. H.; Noorlag, Rob; de Bree, Remco; van Es, Robert J. J.; Willems, Stefan M. (S. Karger AG, 2017)
    The prognosis of head and neck squamous cell carcinoma (HNSCC) is largely based on disease stage. Despite improvements in treatment, recurrence rates are still considered high. Currently, disease progression or regression ...
  • SF3B1 and EIF1AX mutations occur in primary leptomeningeal melanocytic neoplasms; yet another similarity to uveal melanomas 
    Küsters-Vandevelde, Heidi V N; Creytens, David; van Engen-van Grunsven, Adriana C H; Jeunink, Marcel; Winnepenninckx, Veronique; Groenen, Patricia J T A; Küsters, Benno; Wesseling, Pieter; Blokx, Willeke A M; Prinsen, Clemens F.M. (BioMed Central, 2016-01-15)
    INTRODUCTION: Like uveal melanomas, primary leptomeningeal melanocytic neoplasms (LMNs) frequently carry GNAQ and GNA11 mutations. However, it is currently unknown whether these LMNs harbor mutations in BAP1, SF3B1 and/or ...
  • Maturation toward neuronal tissue in a Ewing sarcoma of bone after chemotherapy 
    Salet, Maria Carolina Wilhelmina; Vogels, Rob; Brons, Paul P. T.; Schreuder, Bart; Flucke, Uta (BioMed Central, 2016-08-09)
    Background: Ewing sarcoma is the second most common bone tumor, occurring mainly in children and young adults. It shows a typical primitive, small round cell morphology and a characteristic fusion oncogene involving EWSR1 ...
  • Myxoid liposarcoma of the foot: a study of 8 cases 
    Bekers, Elise M.; Song, Wangzhao; Suurmeijer, Albert JH; Bonenkamp, Johannes J.; van der Geest, Ingrid C.; Braam, Petra M.; Ploegmakers, Marieke JM; Desar, Ingrid ME; Tops, Bastiaan BJ; van Gorp, Joost M.; Creytens, David H.; Mentzel, Thomas; Flucke, Uta (W.B. Saunders, 2016-12-01)
    Introduction Myxoid liposarcoma is the only translocation-associated liposarcoma subtype. It classically originates in the deep soft tissues of the thigh. At distal sites of the extremities, this tumor is exceedingly rare. ...
  • Response to letter by Balta et al: Int J Cardiol 
    Emans, Mireille E.; Gaillard, C. A.; Pfister, R.; Tanck, M.W.; Boekholdt, S Mathijs; Wareham, Nick J.; Khaw, Kay T. (Elsevier Ireland Ltd, 2013-10)
  • Robot-assisted laparoscopic liver resection: a systematic review and pooled analysis of minor and major hepatectomies 
    Nota, Carolijn L.M.A.; Rinkes, Inne H.Borel; Molenaar, Izaak Q.; van Santvoort, Hjalmar C.; Fong, Yuman; Hagendoorn, Jeroen (John Wiley & Sons Inc., 2016-02)
    Background Robotic surgery has been introduced to overcome the limitations of conventional laparoscopy. A systematic review and meta-analysis were performed to assess the safety and feasibility for three subgroups of ...
  • Robotic liver resection including the posterosuperior segments: initial experience 
    Nota, Carolijn L.M.A.; Molenaar, I. Quintus; van Hillegersberg, Richard; Borel Rinkes, Inne H.M.; Hagendoorn, Jeroen (Academic Press Inc., 2016-11-01)
    Background Robot-assisted laparoscopy has been introduced to overcome the limitations of conventional laparoscopy. This technique has potential advantages over laparoscopy, such as increased dexterity, three-dimensional ...
  • Modified Appleby Procedure for Pancreatic Adenocarcinoma: Does Improved Neoadjuvant Therapy Warrant Such an Aggressive Approach? 
    Peters, Niek A; Javed, Ammar A; Cameron, John L; Makary, Martin A; Hirose, Kenzo; Pawlik, Timothy M; He, Jin; Wolfgang, Christopher L; Weiss, Matthew J (Springer New York, 2016-10)
    BACKGROUND: With improved neoadjuvant regimens, more aggressive surgical resections may be warranted for patients with locally advanced pancreatic cancer (LAPC) with focal encasement of the celiac axis (CA) and proximal ...
  • Long-term changes in renal function and perfusion in heart failure patients with reduced ejection fraction 
    Schroten, Nicolas F; Damman, Kevin; Valente, Mattia A. E.; Smilde, Tom D.; van Veldhuisen, Dirk J.; Navis, Gerjan J.; Gaillard, Carlo A.; Voors, Adriaan A; Hillege, Hans L. (Taylor and Francis Ltd., 2016-01)
    Little is known about the natural course of renal function and renal hemodynamics in heart failure patients with reduced ejection fraction (HFREF).We prospectively studied effective renal plasma flow (ERPF) and glomerular ...
  • Prevalence of intradialytic hypotension, clinical symptoms and nursing interventions - a three-months, prospective study of 3818 haemodialysis sessions 
    Kuipers, Johanna; Oosterhuis, Jurjen K.; Krijnen, Wim P.; Dasselaar, Judith J.; Gaillard, Carlo A. J. M.; Westerhuis, Ralf; Franssen, Casper F. M. (BioMed Central, 2016-02-27)
    Background: Intradialytic hypotension (IDH) is considered one of the most frequent complications of haemodialysis with an estimated prevalence of 20-50 %, but studies investigating its exact prevalence are scarce. A ...
  • Hepcidin Response to Iron Therapy in Patients with Non-Dialysis Dependent CKD 
    Gaillard, Carlo A.; Bock, Andreas H.; Carrera, Fernando; Eckardt, Kai-Uwe; Van Wyck, David B.; Bansal, Sukhvinder S.; Cronin, Maureen; Meier, Yvonne; Larroque, Sylvain; Roger, Simon D.; Macdougall, Iain C. (Public Library of Science, 2016-06-08)
    Hepcidin is the key regulator of iron homeostasis but data are limited regarding its temporal response to iron therapy, and response to intravenous versus oral iron. In the 56-week, open-label, multicenter, prospective, ...